15,880 results match your criteria hepatic encephalopathy


Use of intravenous N-acetylcysteine in acute severe hepatitis due to severe dengue infection: a case series.

BMC Infect Dis 2021 Sep 20;21(1):978. Epub 2021 Sep 20.

Department of Community Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.

Background: Dengue fever is a common mosquito borne viral infection. Severe dengue fever associated severe hepatitis carries high mortality. Based on the beneficial effect of N-acetylcysteine (NAC) in paracetamol poisoning and non-acetaminophen induced liver failure, it is used in dengue fever associated hepatitis in clinical practice. Read More

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September 2021

The improvement in body composition including subcutaneous and visceral fat reduces ammonia and hepatic encephalopathy after transjugular intrahepatic portosystemic shunt.

Liver Int 2021 Sep 20. Epub 2021 Sep 20.

Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.

Background: Sarcopenia and myosteatosis have been associated to a poor prognosis of cirrhosis and to a higher incidence of hepatic encephalopathy (HE). The prognostic implications of visceral and subcutaneous adiposity are less known.

Aim: to evaluate the modifications of visceral and subcutaneous adipose tissue after TIPS and to investigate their relationships with the modification of muscle mass and with the incidence of post-TIPS HE. Read More

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September 2021

Efficacy and Safety of Treatments for Patients With Portal Hypertension and Cirrhosis: A Systematic Review and Bayesian Network Meta-Analysis.

Front Med (Lausanne) 2021 3;8:712918. Epub 2021 Sep 3.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Viral hepatitis are one of the main causes of liver cirrhosis. The treatment of portal hypertension caused by liver cirrhosis is difficult and diverse, and the therapeutic effect is unknown. Bayesian network meta-analysis was performed to compare the efficacy and safety of treatments for patients with portal hypertension and cirrhosis, including a transjugular intrahepatic portosystemic shunt (TIPS), endoscopic therapy, surgical therapy and medications. Read More

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September 2021

Relationship Between Sleep-Wake Disturbance and Risk of Malnutrition in Hospitalized Patients With Cirrhosis.

Front Nutr 2021 31;8:719176. Epub 2021 Aug 31.

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China.

Both sleep-wake disturbance and malnutrition are common in cirrhosis and might be associated with similar adverse outcomes, such as impaired health-related quality of life, hepatic encephalopathy, and sarcopenia, but there is no study investigating the relationship between these two. We aimed to explore the relationship between sleep-wake disturbance [estimated by the Pittsburgh Sleep Quality Index (PSQI)] and malnutrition risk [estimated by the Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT)]. About 150 patients with cirrhosis were prospectively recruited. Read More

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Outcomes of Patients with Acute Hepatotoxicity Caused by Mushroom-Induced Poisoning.

Turk J Gastroenterol 2021 Aug;32(8):678-684

Division of Gastroenterology, Department of Internal Medicine, Ege University School of Medicine, İzmir, Turkey.

Background: This study aimed to investigate the characteristics of severe hepatitis (SH), acute liver injury (ALI), and acute liver failure (ALF) in patients with mushroom-induced hepatotoxicity.

Methods: Data of patients between 2010 and 2019 were retrospectively reviewed. Twenty-four patients with mushroom-induced hepatotoxicity were included and divided into 3 groups: SH, ALI, and ALF. Read More

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Pathological Significance and Prognostic Roles of Indirect Bilirubin/Albumin Ratio in Hepatic Encephalopathy.

Front Med (Lausanne) 2021 30;8:706407. Epub 2021 Aug 30.

Guangzhou Municipal and Guangdong Provincial Key Lab of Protein Modification and Degradation Lab, State Key Lab of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.

Hepatic encephalopathy (HE) is a neurological disease caused by severe liver disease. Early identification of the risk factor is beneficial to the prevention and treatment of HE. Free bilirubin has always been considered to be the culprit of neonatal kernicterus, but there is no research to explore its role in HE. Read More

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Psoas Muscle Density Predicts Occurrences of Hepatic Encephalopathy in Patients Receiving Transjugular Intrahepatic Portosystemic Shunts within 1 year.

Cardiovasc Intervent Radiol 2021 Sep 14. Epub 2021 Sep 14.

Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, No. 2, Fuxue Lane, Wenzhou, 325000, China.

Purpose: We aimed to assess the efficacy of psoas density (PD) for predicting hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS) procedures.

Methods: Data were collected from patients who underwent TIPS procedures at a single institution between 2013 and 2019. PD was manually measured using software on unenhanced CT scans at the level of third lumbar vertebra. Read More

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September 2021

Association of Type 2 Diabetes and Hepatic Encephalopathy in Chronic Liver Disease Patients.

Cureus 2021 Aug 10;13(8):e17061. Epub 2021 Aug 10.

Department of Research, Saskatchewan Health Authority, Regina, CAN.

Background Hepatic encephalopathy (HE) is an important complication of hepatic cirrhosis and is an independent predictor of mortality in patients with cirrhosis. The prevalence of type 2 diabetes continues to increase at an alarming rate around the world, with even more people being affected by prediabetes. Diabetes leads to increased gastric transit and orocecal time, increased glutamase activity, and intestinal bacterial overgrowth, which may increase intestinal ammonia production. Read More

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Sarcopenia as a prognostic predictor of liver cirrhosis: a multicentre study in China.

J Cachexia Sarcopenia Muscle 2021 Sep 14. Epub 2021 Sep 14.

Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Background: Diagnostic criteria for sarcopenia have not been established in Chinese. This study established criteria based on the L3-skeletal muscle index (L3-SMI) and assessed its value for outcomes predicting in cirrhotic Chinese patients.

Methods: Totally 911 subjects who underwent a CT scan at two centres were enrolled in Cohort 1 (394 male and 417 female subjects, aged 20-80 years). Read More

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September 2021

[Analysis of the short-and medium-term curative effect of TIPS approach combined with AngioJet thrombus aspiration technology treatment in acute portal vein thrombosis].

Zhonghua Gan Zang Bing Za Zhi 2021 Aug;29(8):754-758

Department of Vascular Surgery, Henan Provincial People's Hospital; Department of Vascular Surgery, People's Hospital of Zhengzhou University; Henan Provincial Intervention Treatment Center, Zhengzhou 450003, China.

To evaluate the short- and medium-term clinical efficacy of TIPS approach combined with AngioJet thrombus aspiration technology treatment in acute portal vein thrombosis. 63 cases with acute portal vein thrombosis treated in our center from May 2017 to July 2019 were studied retrospectively, including 49 males and 14 females, aged 35-61 (46 ± 5) years. TIPS approach (with/without) combined with Angiojet thrombus aspiration and gastroesophageal varices embolization was performed simultaneously according to the patient's condition. Read More

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A systemic mechanism of increased transendothelial migration of leukocytes through the blood-brain barrier in hepatic encephalopathy.

Clin Res Hepatol Gastroenterol 2021 Sep 10:101801. Epub 2021 Sep 10.

Sorbonne Université, INSERM, Centre de recherche Saint-Antoine (CRSA), Institute of Cardiometabolism and Nutrition (ICAN), F-75012 Paris, France; AP-HP.Sorbonne Université, Hôpital Pitié-Salpêtrière, Service d'Hépato-Gastroentérologie, Unité de Soins Intensifs d'Hépatologie, Département de Neurologie, Unité de Médecine Intensive Réanimation à Orientation Neurologique, Brain Liver Pitié-Salpêtrière (BLIPS) Study Group, Groupe de Recherche Clinique en REanimation et Soins intensifs du Patient en Insuffisance Respiratoire aiguE (GRC-RESPIRE), F-75013 Paris, France. Electronic address:

Background: Hepatic encephalopathy (HE) is a frequent neurological complication of cirrhosis. Evidence suggests a synergic pathophysiological implication of hyperammonemia and systemic inflammation. In addition, the blood-brain barrier (BBB) permeability can be impaired in cirrhotic patients, notably in those displaying HE. Read More

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September 2021

Hepatogenous Diabetes: A Primer.

J Clin Exp Hepatol 2021 Sep-Oct;11(5):603-615. Epub 2021 May 1.

Department of Gastroenterology & Hepatology, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha 751024, India.

As liver is one of the primary organs involved in glucose homeostasis, it is not surprising that patients with liver dysfunction in chronic liver disease usually develop impaired glucose tolerance and subsequently overt diabetes later in their natural course. Diabetes that develops after the onset of cirrhosis of liver is usually referred to as hepatogenous diabetes (HD). It is an underrecognized and a hallmark endocrinological event in chronic liver disease. Read More

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Usefulness of the Stroop Test in Diagnosing Minimal Hepatic Encephalopathy and Predicting Overt Hepatic Encephalopathy.

Hepatol Commun 2021 Sep 13;5(9):1518-1526. Epub 2021 May 13.

Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Minimal hepatic encephalopathy (MHE) adversely affects the clinical outcomes of patients with liver cirrhosis. This prospective study aimed to evaluate the utility of the Stroop test in the diagnosis of MHE and prediction of overt hepatic encephalopathy (OHE) in Japanese patients with cirrhosis. We enrolled 152 patients who underwent the Stroop test between November 2018 and February 2020. Read More

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September 2021

A mini-review on the impact of COVID 19 on vital organs.

Biomed Pharmacother 2021 Sep 4;143:112158. Epub 2021 Sep 4.

Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia. Electronic address:

COVID-19 (Corona Virus Disease-2019) is an infectious disease caused by a novel coronavirus, known as the acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This is a highly contagious disease that has already affected more than 220 countries globally, infecting more than 212 million people and resulting in the death of over 4.4 million people. Read More

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September 2021

Standardization of the psychometric hepatic encephalopathy score in a French population.

PLoS One 2021 10;16(9):e0257136. Epub 2021 Sep 10.

Brain Liver Pitié-Salpêtrière (BLIPS) Study Group, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Sorbonne Université, Paris, France.

The Psychometric Hepatic Encephalopathy Score (PHES) has previously been standardized in thirteen countries on three continents, confirming its status of gold standard test to detect minimal hepatic encephalopathy (MHE). In the meantime, performance has also been shown to vary with variables such as age, education, and barely sex. The present study aimed at standardizing the PHES in a French population. Read More

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September 2021

ALBI grade: Evidence for an improved model for liver functional estimation in patients with hepatocellular carcinoma.

JHEP Rep 2021 Oct 5;3(5):100347. Epub 2021 Aug 5.

Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.

Hepatocellular carcinoma (HCC) usually arises in the context of a chronically damaged liver. Liver functional estimation is of paramount importance in clinical decision making. The Child-Pugh score (CPS) can be used to categorise patients into 3 classes (A to C) based on the severity of liver functional impairment according to 5 parameters (albumin, bilirubin, prothrombin time, presence of ascites and hepatic encephalopathy). Read More

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October 2021

Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE.

Sci Rep 2021 Sep 9;11(1):17988. Epub 2021 Sep 9.

CIBM Center for Biomedical Imaging, Lausanne, Switzerland.

Type C hepatic encephalopathy (HE) is a neuropsychiatric disease caused by chronic liver disease. Management of type C HE remains an important challenge because treatment options are limited. Both the antibiotic rifaximin and probiotics have been reported to reduce the symptoms of HE, but longitudinal studies assessing their effects on brain metabolism are lacking and the molecular mechanisms underpinning their effects are not fully understood. Read More

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September 2021

Therapeutic Applications of Resveratrol in Hepatic Encephalopathy through Its Regulation of the Microbiota, Brain Edema, and Inflammation.

J Clin Med 2021 Aug 25;10(17). Epub 2021 Aug 25.

Department of Anatomy, Chonnam National University Medical School, Hwasun 58128, Jeollanam-do, Korea.

Hepatic encephalopathy is a common complication in patients with liver cirrhosis and portosystemic shunting. Patients with hepatic encephalopathy present a variety of clinical features, including neuropsychiatric manifestations, cognitive dysfunction, impaired gut barrier function, hyperammonemia, and chronic neuroinflammation. These pathogeneses have been linked to various factors, including ammonia-induced oxidative stress, neuronal cell death, alterations in the gut microbiome, astrocyte swelling, and blood-brain barrier disruptions. Read More

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Clinical efficacy of antiviral therapy in patients with hepatitis B-related cirrhosis after transjugular intrahepatic portosystemic shunt.

World J Gastroenterol 2021 Aug;27(30):5088-5099

Department of Gastroenterology, General Hospital of Western Theater Command, Chengdu 610083, Sichuan Province, China.

Background: As a country with a high burden of hepatitis B, China has about 86 million cases of hepatitis B virus infection, ranking the first in the world. Currently, there are about 390000 deaths due to hepatitis B-related complications such as liver cirrhosis and liver cancer every year. Consequently, how to control portal hypertension, improve liver functional reserve, and reduce the incidence of hepatic failure and liver cancer in such patients is the focus of current clinical attention. Read More

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A novel, simplified, and reproducible porcine model of acute ischemic liver failure with portal vein preservation.

Exp Anim 2021 Sep 8. Epub 2021 Sep 8.

General Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University.

The current ischemic models of liver failure are difficult and usually time-consuming to produce. The aim of this study was to develop a simplified and reproducible porcine model of acute liver failure for use in preclinical research. Eighteen Bama miniature pigs were randomly divided into Groups A, B, and C. Read More

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September 2021

Derivation and validation of prognostic models for predicting survival outcomes in Acute-on-chronic liver failure (ACLF) patients.

J Viral Hepat 2021 Sep 8. Epub 2021 Sep 8.

Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.

Acute-on-chronic liver failure (ACLF) is a syndrome characterised by acute decompensation of chronic liver disease associated with high bacterial infection (BI) and short term mortality. However, many ACLF prognostic predictive modelsare complicated. The aim of this study is to develop prognostic models for ACLF patients to predict BI and mortality. Read More

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September 2021

Rifaximin microbial resistance and its efficacy and safety as a secondary prophylaxis of hepatic encephalopathy in patients with hepatitis C virus-related cirrhosis.

Int J Clin Pract 2021 Sep 6:e14807. Epub 2021 Sep 6.

Clinical Pharmacy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Background And Aim: Rifaximin is an oral antibiotic with promising efficacy in the reduction of hepatic encephalopathy (HE) recurrence. Development of microbial resistance to rifaximin is not studied yet in HE. The study aim was to assess the microbial resistance, safety and efficacy of rifaximin as secondary prophylaxis of HE. Read More

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September 2021

Eltrombopag-Induced Metabolic Acidosis and Hepatic Encephalopathy in Pediatric ITP.

J Pediatr Hematol Oncol 2021 Sep 6. Epub 2021 Sep 6.

Caylor School of Nursing, Lincoln Memorial University, Knoxville, TN Division of Pediatric Hematology and Oncology, University of Minnesota, Minneapolis, MN.

Eltrombopag is approved for the treatment of chronic immune thrombocytopenia purpura (ITP) in pediatric patients 1 year and older who have demonstrated an insufficient response to corticosteroids and intravenous immunoglobulin. We present the case of a 2-year-old boy with chronic immune thrombocytopenia purpura who developed life-threatening adverse effects of acute liver failure, metabolic acidosis and encephalopathy with standard drug dosing. To our knowledge, this is the first case of eltrombopag-induced hepatic encephalopathy highlighting the critical need for prescribers to exercise caution when prescribing eltrombopag in the pediatric setting. Read More

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September 2021

[F]PBR146 and [F]DPA-714 Imaging of Neuroinflammation in Chronic Hepatic Encephalopathy Rats.

Front Neurosci 2021 16;15:678144. Epub 2021 Aug 16.

Department of Diagnostic Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Neuroinflammation is an important pathogenesis of hepatic encephalopathy (HE). The upregulation of translocator protein (TSPO) during neuroinflammation provides an imaging molecular target to evaluate the severity of neuroinflammation in chronic HE rats. [18F]DPA-714 and [18F]PBR146 targeting TSPO are often used for neuroinflammation imaging. Read More

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Association Between Serum IL-6, IL-10, IL-12, and IL-23 Levels and Severity of Liver Cirrhosis.

Med Arch 2021 Jun;75(3):199-203

Division of Gastroenterohepatology, Department of Internal Medicine, Universitas Sumatera Utara, Medan, Indonesia.

Background: Liver cirrhosis contributes to high liver-related mortality globally. Systemic inflammation mediated by immune cells contributes to the progression of liver cirrhosis. Growing evidence shows that several pro- and anti-inflammatory cytokines might have an important role in liver cirrhosis. Read More

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Management of Acute Portal Vein Thrombosis With Serial Mechanical Thrombectomy and tPA in a Pediatric Liver Transplant Recipient: A Case Report.

Transplant Proc 2021 Sep 2. Epub 2021 Sep 2.

Baylor College of Medicine, Michael E. DeBakey Department of Surgery, Division of Abdominal Transplantation, Houston, Texas.

Background: Acute portal vein thrombosis is a major cause of fulminant allograft failure in pediatric liver transplantation. Timely intervention is critical to save the graft and patient. Serial interventional radiologic management of this condition is scarcely reported in the literature. Read More

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September 2021

Clinical characteristics of cirrhosis patients with umbilical vein recanalization: A retrospective analysis.

Medicine (Baltimore) 2021 Sep;100(35):e26774

The Department of Hepatology, the First People Hospital of JiuJiang, JiangXi, China.

Abstract: Umbilical Vein Recanalization (UVR) may occur in patients with long-standing portal hypertension and liver cirrhosis. This study aimed to investigate the clinical significance of UVR.Medical records of a cohort of patients with cirrhosis (n = 247) who were hospitalized at the Digestive Medicine Center of the Second Affiliated Hospital of Nanchang University from January 2012 to October 2015 were accessed. Read More

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September 2021

Kynurenic Acid and Its Synthetic Derivatives Protect Against Sepsis-Associated Neutrophil Activation and Brain Mitochondrial Dysfunction in Rats.

Front Immunol 2021 12;12:717157. Epub 2021 Aug 12.

Institute of Surgical Research, Faculty of Medicine, University of Szeged, Szeged, Hungary.

Background And Aims: The systemic host response in sepsis is frequently accompanied by central nervous system (CNS) dysfunction. Evidence suggests that excessive formation of neutrophil extracellular traps (NETs) can increase the permeability of the blood-brain barrier (BBB) and that the evolving mitochondrial damage may contribute to the pathogenesis of sepsis-associated encephalopathy. Kynurenic acid (KYNA), a metabolite of tryptophan catabolism, exerts pleiotropic cell-protective effects under pro-inflammatory conditions. Read More

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Primary Prophylaxis Patterns for Hepatic Encephalopathy in Patients with Liver Cirrhosis: What are the Current Prescribing Trends in Specialty Practice?

J Assoc Physicians India 2021 Aug;69(8):11-12

Fortis Memorial Research Institute, Gurugram, Haryana.

Introduction: Hepatic encephalopathy (HE) is a significant complication of severe chronic liver insufficiency characterized by altered sensorium, motor, and cognitive dysfunction. This was a cross-sectional multicenter, epidemiological study to understand the prescribing pattern for primary prophylaxis of overt HE (OHE) in patients with cirrhosis in India.

Methods: The study was conducted at eight centers across different geographical regions of India. Read More

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