86,056 results match your criteria hemorrhagic disease

Anticoagulant-induced hemorrhagic cholecystitis with hemobilia after deceased donor kidney transplant and literature review.

Int J Surg Case Rep 2021 May 26;84:106027. Epub 2021 May 26.

Augusta University, Department of Surgery, United States of America. Electronic address:

Introduction And Importance: Hemobilia and hemorrhagic cholecystitis are uncommon causes of right upper quadrant abdominal pain. The development of intra-gallbladder and biliary bleeding has been primarily associated with abdominal trauma, malignancy, liver transplant, and iatrogenic injury to the biliary tree and vasculature. Spontaneous anticoagulant induced hemorrhagic cholecystitis and hemobilia are incredibly rare events and have only been documented by a handful of case reports. Read More

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Expression profiling, immune functions, and molecular characteristics of the tetraspanin molecule CD63 from Amphiprion clarkii.

Dev Comp Immunol 2021 Jun 9:104168. Epub 2021 Jun 9.

Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju 63333, Republic of Korea. Electronic address:

CD63, a member of the tetraspanin family, is involved in the activation of immune cells, antiviral immunity, and signal transduction. The economically important anemonefishes Amphiprion sp. often face disease outbreaks, and the present study aimed to characterize CD63 in Amphiprion clarkii (denoted AcCD63) to enable better disease management. Read More

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Incidence and risk factors of late-onset hemorrhagic cystitis after single umbilical cord blood transplantation with myeloablative conditioning regimen.

Int J Hematol 2021 Jun 12. Epub 2021 Jun 12.

Department of Hematology of Anhui Provincial Hospital, Anhui Medical University, Hefei, China.

Objective: To explore the incidence and risk factors of late-onset hemorrhagic cystitis (LOHC) in patients undergoing single umbilical cord blood transplantation for hematological malignancies.

Methods: Clinical data from 234 patients who consecutively underwent single UCBT using a myeloablative conditioning regimen without antithymocyte globulin in our center were retrospectively analyzed.

Results: In total, 64 (27. Read More

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Quantitative Susceptibility Mapping for Staging Acute Cerebral Hemorrhages: Comparing the Conventional and Multiecho Complex Total Field Inversion magnetic resonance imaging MR Methods.

J Magn Reson Imaging 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Background: The perceived acuity of intracerebral hemorrhage (ICH) impacts the management of patients, both within emergent and outpatient/urgent settings. Morphology enabled dipole inversion (MEDI) quantitative susceptibility imaging (QSM) has improved characterization of ICH acuity, despite outstanding limitations in distinguishing blood products.

Purpose/hypothesis: Using improved susceptibility quantification, novel postprocessing QSM method from multiecho complex total field inversion (mcTFI) may better discriminate between acute and subacute ICH, compared to MEDI. Read More

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Bleeding complications in patients with squamous cell carcinoma of the head and neck.

Head Neck 2021 Jun 12. Epub 2021 Jun 12.

Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Hemorrhage in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) may be attributed to chemotherapy and local tumor irradiation. Evidence of the relationship between hemorrhage in R/M HNSCC and targeted therapies, including epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) inhibitors, or immune checkpoint inhibitors, is limited. We aimed to identify epidemiological and clinical data related to the occurrence of hemorrhage in R/M HNSCC and to explore its relationship with various therapies. Read More

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Antibody-dependent enhancement representing in vitro infective progeny virus titer correlates with the viremia level in dengue patients.

Sci Rep 2021 Jun 11;11(1):12354. Epub 2021 Jun 11.

Mahidol-Osaka Center for Infectious Diseases, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok, 10400, Thailand.

Dengue virus (DENV) causes dengue fever (DF) and dengue hemorrhagic fever in humans. Some DF patients suddenly develop severe symptoms around the defervescent period. Although the pathogenic mechanism of the severe symptoms has not been fully elucidated, the viremia level in the early phase has been shown to correlate with the disease severity. Read More

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Performance of a Novel Temporary Arterial Shunt in a Military-Relevant Controlled Hemorrhage Swine Model.

J Trauma Acute Care Surg 2021 May 18. Epub 2021 May 18.

San Antonio Uniformed Services Health Education Consortium, JBSA Ft. Sam Houston, TX Brooke Army Medical Center, JBSA Ft. Sam Houston, TX Office of the Chief Scientist, Wilford Hall Ambulatory Surgical Center, JBSA Lackland, TX Uniformed Services University.

Background: In military trauma, temporary vascular shunts (TVSs) restore arterial continuity until delayed vascular reconstruction, often for a period of hours. A novel US Air Force-developed trauma specific vascular injury shunt (TS-VIS) incorporates an accessible sideport for intervention or monitoring which may improve patency under adverse hemodynamic conditions. Our objective was to evaluate TS-VIS patency in the setting of volume-limited resuscitation from hemorrhagic shock. Read More

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Safety and Efficacy of the Woven EndoBridge Device for Treatment of Ruptured Intracranial Aneurysms: A Systematic Review and Meta-analysis.

AJNR Am J Neuroradiol 2021 Jun 11. Epub 2021 Jun 11.

From the Department of Neurosurgery (M.A.E., G.L., W.B.), Mayo Clinic, Rochester, Minnesota.

Background: The Woven EndoBridge device has been increasingly used to treat wide-neck aneurysms, particularly ruptured ones.

Purpose: Our aim was to investigate the safety and efficacy of the Woven EndoBridge device in the treatment of ruptured intracranial aneurysms.

Data Sources: All studies evaluating the outcomes of Woven EndoBridge device use in the treatment of ruptured intracranial aneurysms from inception through 2020 were searched on Ovid Evidence-Based Medicine Reviews, EMBASE, MEDLINE, Scopus, and the Web of Science Core Collection. Read More

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Kidney Injury in a Hemodilution Model of Hemorrhagic Shock and Fluid Resuscitation.

Am J Med Sci 2021 Jun 8. Epub 2021 Jun 8.

Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China. Electronic address:

Background: Fluid therapy is indispensable in treating patients with hemorrhagic shock. However, fluid overload correlates with kidney injury in patients with hemorrhagic shock. We hypothesized that hemodilution after fluid treatment contributes to the kidney injury. Read More

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Recurrent Epistaxis and Diffuse Hepatic and Splenic Vascular Malformations.

Gastroenterology 2021 Jun 8. Epub 2021 Jun 8.

Department of Radiology, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China. Electronic address:

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Hypotony-associated Complications after Deep Sclerectomy: Incidence, Risk Factors, and Long-Term Outcomes.

J Glaucoma 2021 Jun 10. Epub 2021 Jun 10.

Department of Ophthalmology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, United Kingdom Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele Scientific Institute, Milan, Italy Department of Ophthalmology, Calderdale and Huddersfield NHS Trust, Huddersfield, UK.

Precis: Chronic hypotony is not uncommon following deep sclerectomy, but only a minor proportion of patients develop hypotony-associated complications. Numerical hypotony does not affect the visual outcomes. This study identifies factors associated with hypotony. Read More

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Neurological disease caused by Oropouche virus in northern Brazil: should it be included in the scope of clinical neurological diseases?

J Neurovirol 2021 Jun 11. Epub 2021 Jun 11.

Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ananindeua, Pará, Brazil.

We describe two neurological cases of Oropouche virus infection in northern Brazil, where the virus is endemic but neglected as a pathogen. This study reiterates the necessity of developing protocols for diagnosing infections and training medical personnel to recognize the pathogenicity of Oropouche virus in neurological infections. Read More

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Efficacy of thromboelastography in the management of anticoagulation for veno-venous extracorporeal membrane oxygenation in a coronavirus disease 2019 patient: A case report.

Medicine (Baltimore) 2021 Jun;100(23):e26313

Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

Rationale: In coronavirus disease 2019 (COVID-19) patients with acute respiratory distress syndrome refractory to optimal conventional management, we should consider the indication for veno-venous extracorporeal membrane oxygenation (V-V ECMO). Growing evidence indicates that COVID-19 frequently causes coagulopathy, presenting as hypercoagulation and incidental thrombosis. For these reasons, a multifactorial approach with several anticoagulant markers should be considered in the management of anticoagulation using heparin in COVID-19 patients on V-V ECMO. Read More

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Off-label reduced-dose apixaban does not reduce hemorrhagic risk in Taiwanese patients with nonvalvular atrial fibrillation: A retrospective, observational study.

Medicine (Baltimore) 2021 Jun;100(23):e26272

Department of Internal Medicine, Division of Cardiology, National Cheng Kung University Hospital.

Abstract: East Asians are reportedly at high risk of anticoagulant-related bleeding; therefore, some physicians prefer to prescribe low-dose direct oral anticoagulants (DOACs). Little is known about the therapeutic effectiveness and safety of off-label reduced-dose apixaban in East Asians with nonvalvular atrial fibrillation (AF). We aimed to investigate the effectiveness and safety of off-label reduced-dose apixaban in Taiwanese patients with nonvalvular AF. Read More

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An evaluation of canagliflozin for the treatment of type 2 diabetes: an update.

Expert Opin Pharmacother 2021 Jun 11:1-8. Epub 2021 Jun 11.

Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Kanazawa-ku, Yokohama, Japan.

Sodium-glucose cotransporter-2 inhibitors (SGLT2is) are proven to ameliorate kidney and heart failure in patients with type 2 diabetes (T2D), in addition to improving glycemic controls. Canagliflozin is a SGLT2i and has proved beneficial for kidney and heart diseases in addition to decreasing the incidence of the composite outcomes of cardiovascular diseases and stroke.This paper reviews the development of canagliflozin and its effects on renal dysfunction, heart failure, and vascular diseases. Read More

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Correlation of CD38 expression with the progression of hemorrhagic fever with renal syndrome.

Arch Virol 2021 Jun 10. Epub 2021 Jun 10.

Department of Clinical Laboratory, Xi'an Forth Hospital, 21 Jiefang Road, Xi'an, 710004, China.

To assess the relationship between the expression of CD38 and the progression of hemorrhagic fever with renal syndrome (HFRS), we determined the levels of CD38 during different phases of HFRS and evaluated the relationship between changes in CD38 expression and the progression of HFRS. The expression of CD38 in 68 patients with HFRS was analyzed by flow cytometry, and this method was also used to determine the levels of CD4T, CD8T, and B lymphocytes and NK cells. Furthermore, creatinine (Cr), uric acid (UA), and urea in serum at each stage of HFRS were measured using commercial kits. Read More

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Diagnostic performance of single-phase dual-energy CT to differentiate vascular and nonvascular incidental renal lesions on portal venous phase: comparison with CT.

Eur Radiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ, 85259, USA.

Objectives: To determine whether single-phase dual-energy CT (DECT) differentiates vascular and nonvascular renal lesions in the portal venous phase (PVP). Optimal iodine threshold was determined and compared to Hounsfield unit (HU) measurements.

Methods: We retrospectively included 250 patients (266 renal lesions) who underwent a clinically indicated PVP abdominopelvic CT on a rapid-kilovoltage-switching single-source DECT (rsDECT) or a dual-source DECT (dsDECT) scanner. Read More

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Bariatric surgery to aLleviate OCcurrence of Atrial Fibrillation Hospitalization-BLOC-AF.

Heart Rhythm O2 2020 Jun 12;1(2):96-102. Epub 2020 May 12.

Department of Internal Medicine, University of California, Davis, School of Medicine, Sacramento, California.

Background: Obesity is associated with a higher incidence of atrial fibrillation (AF). Weight reduction improves outcomes in patients known to have AF.

Objective: The purpose of this study was to compare the incidence of heart failure (HF) or first-time AF hospitalization in obese patients undergoing bariatric surgery (BAS) vs other abdominal surgeries. Read More

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First Isolation and Molecular Characterization of -Producing O157:H7 From Cattle in Xinjiang, China.

Front Vet Sci 2021 25;8:574801. Epub 2021 May 25.

College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, China.

The bovine O157:H7 is a major foodborne pathogen causing severe bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome in humans. Cattle are recognized major reservoir and source of O157:H7. We investigated the antibiotic resistance, molecular profiles, and intrinsic relationship between 21 isolates of O157:H7 from cattle farms and slaughtering houses in Xinjiang. Read More

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The Presence of Circulating Nucleated Red Blood Cells Is Associated With Disease Severity in Patients of Hemorrhagic Fever With Renal Syndrome.

Front Med (Lausanne) 2021 25;8:665410. Epub 2021 May 25.

Department of Immunology, Basic Medicine School, Air Force Medical University, Xi'an, China.

Hemorrhagic fever with renal syndrome (HFRS) is a regional infectious disease of epidemic potential caused by the Hantaan virus (HTNV). Red blood cells (RBCs) are the major components of peripheral blood. However, pathological changes in RBCs and the underlying mechanisms during HTNV infection remain largely unclear. Read More

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The Effectiveness of Music Therapy on Hand Function in Patients With Stroke: A Systematic Review of Randomized Controlled Trials.

Front Neurol 2021 25;12:641023. Epub 2021 May 25.

Department of Rehabilitation Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.

This study aims to evaluate the efficacy of music-supported therapy for stroke patients' hand function. The databases used included Cumulative Index to Nursing and Allied Health Literature (CINAHL), MEDLINE, PubMed, Embase, Music Index, and Google Scholar. Studies published between January 2010 and August 2020 were included. Read More

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Predicting the need for massive transfusion: Prospective validation of a smartphone-based clinical decision support tool.

Surgery 2021 Jun 7. Epub 2021 Jun 7.

Uniformed Services University of the Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD.

Background: Improper or delayed activation of a massive transfusion protocol may have consequences to individuals and institutions. We designed a complex predictive algorithm that was packaged within a smartphone application. We hypothesized it would accurately assess the need for massive transfusion protocol activation and assist clinicians in that decision. Read More

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NAPG mutation in family members with hereditary hemorrhagic telangiectasia in China.

BMC Pulm Med 2021 Jun 10;21(1):197. Epub 2021 Jun 10.

Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, 100044, People's Republic of China.

Background: Hereditary hemorrhagic telangiectasia (HHT) is a disease characterized by arteriovenous malformations in the skin and mucous membranes. We enrolled a large pedigree comprising 32 living members, and screened for mutations responsible for HHT.

Methods: We performed whole-exome sequencing to identify novel mutations in the pedigree after excluding three previously reported HHT-related genes using Sanger sequencing. Read More

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Risk of Cardiovascular Complications in Patients with Persistent Atrial Fibrillation after Dissolution of a Thrombus in the Left Atrial Appendage.

Kardiologiia 2021 May 31;61(5):17-22. Epub 2021 May 31.

Tver State Medical University, Tver.

Aim      To compare the incidence of cardiovascular complications (CVC) in patients with persistent atrial fibrillation (AF) following thrombus dissolution in the left atrial appendage (LAA) and in patients with persistent AF without preceding LAA thrombosis.Material and methods  The main group included 43 patients who had been diagnosed with LAA thrombosis on the first examination, transesophageal echocardiography, and who showed dissolution of the thrombus on a repeated study performed after 7.1+2. Read More

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From birth to adulthood: An analysis of the Brazilian lancehead (Bothrops moojeni) venom at different life stages.

PLoS One 2021 10;16(6):e0253050. Epub 2021 Jun 10.

Laboratório de Herpetologia, Instituto Butantan, São Paulo, Brazil.

The Brazilian lancehead (Bothrops moojeni) has a wide distribution in Brazil and represents a serious public health hazard. Previous works reported that the symptoms of snakebites caused by B. moojeni juveniles' bites were mainly related to coagulation, while those caused by adults' bites had a more prominent local damage. Read More

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Variability of treatment modalities and intensity in patients with severe haemophilia A on prophylaxis: results from the Italian national registry.

Eur J Haematol 2021 Jun 10. Epub 2021 Jun 10.

Value-Based Healthcare Unit, IRCCS Multi Medica, Sesto San Giovanni, Italy.

Background: A shift from a standard to a personalized prophylaxis has been increasingly adopted in patients with severe haemophilia A (SHA). This approach has raised the likelihood of a significant variability in the prophylactic approaches and the relative Factor VIII (FVIII) consumptions. The aim of our study is to assess the treatment variability of SHA patients without inhibitors and on prophylaxis regimen in Italy. Read More

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Complications of cholecystitis: a comprehensive contemporary imaging review.

Emerg Radiol 2021 Jun 10. Epub 2021 Jun 10.

Department of Radiology, Emory University Hospital, Atlanta, GA, USA.

Acute cholecystitis is a common cause of right upper quadrant pain in patients presenting to the emergency department. Ultrasound, computed tomography, HIDA scans, and magnetic resonance imaging are increasingly utilized to evaluate suspected cases. The prognosis of acute cholecystitis is usually excellent with timely diagnosis and management. Read More

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Infectious agents including COVID-19 and the involvement of blood coagulation and fibrinolysis. A narrative review.

Eur Rev Med Pharmacol Sci 2021 May;25(10):3886-3897

Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.

Objective: Platelets, blood coagulation along with fibrinolysis are greatly involved in the pathophysiology of infectious diseases induced by bacteria, parasites and virus. This phenomenon is not surprising since both the innate immunity and the hemostatic systems are two ancestral mechanisms which closely cooperate favoring host's defense against foreign invaders. However, the excessive response of these systems may be dangerous for the host itself. Read More

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Evaluation of rivaroxaban-, apixaban- and dabigatran-associated hemorrhagic events using the FDA-Adverse event reporting system (FAERS) database.

Int J Clin Pharm 2021 Jun 9. Epub 2021 Jun 9.

Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Road, Xicheng District, Beijing, China.

Background Rivaroxaban, apixaban and dabigatran are non-vitamin K antagonist oral anticoagulants (NOACs) that are widely used for treatment or prevention of venous thromboembolism and stroke in patients with atrial fibrillation. Objective To estimate and compare hemorrhagic events report of rivaroxaban, apixaban and dabigatran. Setting FDA Adverse Event Reporting System (FAERS) database. Read More

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Kidney Biopsy in Patients With Monoclonal Gammopathy: A Multicenter Retrospective Cohort Study.

Front Med (Lausanne) 2021 24;8:687149. Epub 2021 May 24.

State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Guangdong Provincial Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China.

To analyze the clinical characteristics and renal pathological manifestations of patients with monoclonal gammopathy (MG) and kidney injury. This was a multicenter retrospective cohort study conducted at four tertiary hospitals in China. The study population comprised patients with MG admitted from January 1 2013 to December 31 2020. Read More

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