29,857 results match your criteria hemorrhage major

Small Interfering RNA Targeting DMP1 Protects Mice Against Blood-Brain Barrier Disruption and Brain Injury After Intracerebral Hemorrhage.

J Stroke Cerebrovasc Dis 2021 Apr 9;30(6):105760. Epub 2021 Apr 9.

Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing 400016, China; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China. Electronic address:

Dentin matrix protein 1 (DMP1) is an extracellular matrix phosphoprotein that is known to facilitate mineralization of collagen in bone and promote osteoblast/odontoblast differentiation. Blood-brain barrier (BBB) disruption is the major pathogenesis in secondary brain injury after intracerebral hemorrhage (ICH). This study aimed to investigate the expression pattern of DMP1 in the mouse brain and explore the role of DMP1 in BBB disruption and brain injury in a mouse model of ICH. Read More

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Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke.

IBRO Neurosci Rep 2021 Jun 5;10:18-30. Epub 2021 Jan 5.

Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, United States.

Background: The absolute number of new stroke patients is annually increasing and there still remains only a few Food and Drug Administration (FDA) approved treatments with significant limitations available to patients. Tanshinone IIA (Tan IIA) is a promising potential therapeutic for ischemic stroke that has shown success in pre-clinical rodent studies but lead to inconsistent efficacy results in human patients. The physical properties of Tan-IIA, including short half-life and low solubility, suggests that Poly (lactic-co-glycolic acid) (PLGA) nanoparticle-assisted delivery may lead to improve bioavailability and therapeutic efficacy. Read More

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Associations of behaviors, biological phenotypes and cardiovascular health with risks of stroke and stroke subtypes: A prospective cohort study.

EClinicalMedicine 2021 Mar 18;33:100791. Epub 2021 Mar 18.

School of Public Health, Tianjin Medical University, Tianjin, China.

Background: Although many cardiovascular risk factors for stroke have been reported before, it has not been investigated comprehensively for all major stroke types in large datasets. This study aimed to evaluate the associations of healthy behaviors, biological phenotypes and cardiovascular health (CVH) with long-term risks of strokes events, overall and stroke subtypes (ischemic stroke [IS], intracerebral hemorrhage [ICH], subarachnoid hemorrhage [SAH], and unspecified stroke).

Methods: Between 2006 and 2010, a total of 354,976 participants (age 40-70 years) in the UK Biobank free of stroke and coronary heart disease were examined and thereafter followed up to 2020. Read More

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Divergent Functions of Tissue-Resident and Blood-Derived Macrophages in the Hemorrhagic Brain.

Stroke 2021 Apr 12:STROKEAHA120032196. Epub 2021 Apr 12.

Departments of Neurology (C.-F.C., M.H.A., H.E.B., A.O., J.H.D., M.D.H., J.M., M.L., L.H.S.).

Background And Purpose: Brain tissue-resident microglia and monocyte-derived macrophages (MDMs) are innate immune cells that contribute to the inflammatory response, phagocytosis of debris, and tissue repair after injury. We have previously reported that both microglia and MDMs transition from proinflammatory to reparative phenotypes over days after an intracerebral hemorrhage (ICH). However, their individual functional properties in the brain remain largely unknown. Read More

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New Developments in Fetal and Neonatal Alloimmune Thrombocytopenia.

Am J Obstet Gynecol 2021 Apr 8. Epub 2021 Apr 8.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology; Columbia Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.

Fetal and Neonatal AlloImmune Thrombocytopenia (FNAIT), the platelet equivalent of Hemolytic Disease of the Fetus and Newborn (HDFN), can have devastating effects on both the fetus and neonate. Current management of FNAIT in a subsequent affected pregnancy involves antenatal administration of IVIG and prednisone to the pregnant woman in order to prevent the development of severe fetal thrombocytopenia and secondary intracranial hemorrhage (ICH) in utero. That therapy has proven to be highly effective, but is associated with maternal side effects and is expensive. Read More

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Trade-off between the effects of embolic versus bleeding events on mortality in elderly patients with atrial fibrillation.

Rev Esp Cardiol (Engl Ed) 2021 Apr 7. Epub 2021 Apr 7.

Servicio de Cardiología, Hospital Universitario Álvaro Cunqueiro, Vigo, Pontevedra, Spain; Instituto de Investigación Sanitaria Galicia Sur, Vigo, Pontevedra, Spain.

Introduction And Objectives: Clinical decision-making on anticoagulation in elderly patients with atrial fibrillation (AF) requires clinicians to consider not only the incidence of embolic and bleeding events, but also the risk of death following these adverse events. We aimed to analyze the trade-off between embolic and bleeding events with respect to mortality in elderly patients with AF.

Methods: The study cohort comprised all patients aged ≥ 75 years from a Spanish health area diagnosed with AF between 2014 and 2017 (n=9365). Read More

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Delayed onset of tooth decay in a routine pediatric adenotonsillectomy.

Am J Otolaryngol 2021 Mar 31;42(5):103019. Epub 2021 Mar 31.

Boston Medical Center- Department of Otolaryngology- Head and Neck Surgery, United States of America. Electronic address:

Adenotonsillectomy is a common pediatric surgical procedure with a well-defined safety profile. Major complications from this procedure include bleeding/hemorrhage, infection, pain leading to dehydration, and airway obstruction or edema. Though rare, oral endotracheal intubation and oral retractor placement may result in injuries to the teeth and the surrounding soft tissue. Read More

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ECMO (extra corporeal membrane oxygenation) in major trauma: A 10 year single centre experience.

Injury 2021 Apr 2. Epub 2021 Apr 2.

National Trauma Research Institute, Australia; Trauma Services, The Alfred, Australia.

Aim To review the indications, complications and outcomes of extracorporeal membrane oxygenation (ECMO) in major trauma patients. Methods Single centre, retrospective, cohort study. Results Over a ten year period, from 13,420 major trauma patients, 11 were identified from our institutional trauma registry as having received ECMO. Read More

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ApoA1 neutralizes pro-inflammatory effects of Dengue virus NS1 protein and modulates the viral immune evasion.

J Virol 2021 Apr 7. Epub 2021 Apr 7.

Laboratório de Biotecnologia e Bioengenharia Estrutural, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-590, Brazil.

Dengue is a mosquito-borne infectious disease highly endemic to tropical and subtropical countries. Symptomatic patients can rapidly progress to severe conditions of hemorrhage, plasma extravasation and hypovolemic shock that leads to death. Severe dengue patients' blood tests typically report low levels of high-density lipoprotein (HDL), that is responsible for reverse cholesterol transport (RCT) and regulation of lipid composition on peripheral tissues. Read More

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Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability.

Arterioscler Thromb Vasc Biol 2021 Apr 8:ATVBAHA121316091. Epub 2021 Apr 8.

Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Germany (M.K.G., Y.A., M.D.).

Objective: To determine whether MCP-1 (monocyte chemoattractant protein 1) levels in human atherosclerotic plaques associate with plaque vulnerability features. Approach and Results: We measured MCP-1 levels in human atherosclerotic plaque samples from 1199 patients in the Athero-EXPRESS Biobank who underwent endarterectomy for treatment of carotid stenosis. We explored associations with histopathologic and molecular features of plaque vulnerability, clinical plaque manifestations, and vascular events up to 3 years after endarterectomy. Read More

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J Zoo Wildl Med 2021 Apr;52(1):357-365

Indianapolis Zoo, Indianapolis, IN 46222, USA.

Acute hemorrhagic disease caused by elephant endotheliotropic herpesvirus (EEHV) infection is well recognized as a major threat to young Asian elephants () but has been less frequently documented in African elephants (). This report describes five sequential cases of EEHV3A infection in African elephants in managed care at one institution. All elephants developed disease within a 4-mo period. Read More

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Diverging trends for onset of acute myocardial infarction, heart failure, stroke and mortality in young males: role of changes in obesity and fitness.

J Intern Med 2021 Apr 7. Epub 2021 Apr 7.

Region Västra Götaland, Sahlgrenska University Hospital, Östra/MGAÖ, Gothenburg, Sweden.

Background: As opposed to the decreasing overall rates of coronary heart disease (CHD) incidence and overall cardiovascular disease (CVD) mortality, heart failure (HF) and stroke incidence are increasing in young people, potentially due to rising rates of obesity and reduced cardiorespiratory fitness (CRF).

Objectives: We investigated trends in early major CVD outcomes in a large cohort of young men.

Methods: Successive cohorts of Swedish military conscripts from 1971 to 1995 (N = 1,258,432; mean age, 18. Read More

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Neurology of Preeclampsia and Related Disorders: an Update in Neuro-obstetrics.

Curr Pain Headache Rep 2021 Apr 7;25(6):40. Epub 2021 Apr 7.

Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.

Purpose Of Review: Preeclampsia and related hypertensive disorders of pregnancy affect up to 10% of pregnancies. Neurological complications are common and neurologists often become involved in the care of obstetric patients with preeclampsia. Here, we review the definition(s), epidemiology, clinical features, and pathophysiology of preeclampsia, focusing on maternal neurological complications and headache as a common presenting symptom of preeclampsia. Read More

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[Coronary artery bypass grafting in myocardial infarction and unstable angina pectoris: in-hospital outcomes. Part 2].

Angiol Sosud Khir 2021 ;27(1):151-157

Cardiosurgical Department, Scientific Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia.

Aim: To assess in-hospital outcomes of coronary artery bypass grafting in patients with acute coronary syndrome, depending on the presence or absence of myocardial infarction.

Patients And Methods: Over the period from 2017 to 2018 within the framework of a single-centre register, the study enrolled a total of 166 consecutive patients admitted with non-ST segment elevation acute coronary syndrome and subjected to coronary artery bypass grafting. Depending on the outcome of acute coronary syndrome, the patients were divided into 2 groups: Group One included 98 (59%) patients with unstable angina pectoris and Group Two comprised 68 (41%) patients with myocardial infarction, who underwent surgery at an average of 16 (11; 20) days after manifestation of the clinical signs of myocardial infarction. Read More

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Efficacy of extract from Ononis spinosa L. on ethanol-induced gastric ulcer in rats.

J Tradit Chin Med 2021 04;41(2):270-275

Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan.

Objective: To investigate the efficacy of the extract from Ononis spinosa L. (O. spinosa) on ethanol-induced gastric ulcer in rats. Read More

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