83,311 results match your criteria hemolytic anemia


Cross-sectional study of approaches to diagnosis and management of dogs with immune-mediated haemolytic anaemia in primary care and referral veterinary practices in the United Kingdom.

PLoS One 2021 20;16(9):e0257700. Epub 2021 Sep 20.

Department of Clinical Science and Services, Royal Veterinary College, Hatfield, United Kingdom.

Objectives: To determine whether veterinarians in primary care practices (PCPs) and board-certified clinicians (BCCs) approach treatment of dogs with immune-mediated haemolytic anaemia (IMHA) similarly, and whether practitioners with more experience treat similarly to those with less experience. We hypothesised those in PCPs would show more variation in their approach to similar cases than BCCs.

Methods: A cross-sectional study was conducted by distributing a questionnaire to BCCs and veterinarians in PCPs. Read More

View Article and Full-Text PDF
September 2021

Mechanism of megaloblastic anemia combined with hemolysis.

Bioengineered 2021 Dec;12(1):6703-6712

Department of Hematology, The First Affliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China.

Megaloblastic anemia (MA) patients often exhibit hemolysis, but it is not clear whether there are other hemolytic mechanisms in addition to intramedullary hemolysis. We retrospectively analyzed the clinical characteristics of 124 MA patients, measured erythrocyte physical parameters in two patients with hemolysis and one healthy volunteer by atomic force microscopy, and measured 18F-FDG uptake in one MA patient with hemolysis. In multivariate analysis, hemolysis was associated with mean corpuscular volume (MCV) and indirect bilirubin. Read More

View Article and Full-Text PDF
December 2021

Pseudothrombotic Microangiopathy as a Rare Presentation of Cobalamin Deficiency.

Cureus 2021 Aug 14;13(8):e17184. Epub 2021 Aug 14.

Internal Medicine, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, PRT.

The hematological manifestations of cobalamin (vitamin B12) deficiency may range from asymptomatic to life-threatening forms. Pseudothrombotic microangiopathy is a rare but severe presentation, characterized by the presence of hemolysis and schistocytosis, that is completely reversible after vitamin supplementation. We present a challenging diagnostic approach of a 55-year-old man who presented with high hemolytic markers, pancytopenia, and schistocytes on the peripheral smear due to acquired cobalamin deficiency. Read More

View Article and Full-Text PDF

P-Null Phenotype Due to a Rare Frame-Shift Mutation and with Allo-Anti-PP1Pk Causing a Severe Hemolytic Transfusion Reaction: A Case Report with Clinical Management.

Transfus Med Hemother 2021 Aug 25;48(4):240-243. Epub 2021 Feb 25.

Lok Samarpan Regional Blood Center, Surat, India.

Introduction: The identification of alloantibodies to high-frequency antigens (HFA) and subsequent transfusion management can be challenging and often poses a problem in finding the compatible blood for transfusion. The aim of this study was to investigate the specificity of the antibody to the HFA causing a hemolytic transfusion reaction (HTR) and procure the compatible blood unit for future transfusion.

Case Presentation: A 4-year-old female met with a head injury that led to intracranial bleeding and surgical intervention was required to remove blood clots. Read More

View Article and Full-Text PDF

COVID-19 Infection in Sickle Cell Patients in a Developing Country: A Case Series.

Acta Haematol 2021 Sep 17:1-4. Epub 2021 Sep 17.

Regional Blood Center, Ribeirão Preto School of Medicine, University of São Paulo, São Paulo, Brazil.

Sickle cell disease is characterized by vaso-occlusive phenomena and haemolytic anaemia. There is a significant concern that the overlap of COVID-19 lung disease with acute chest syndrome that occurs in sickle cell patients may result in serious complications. Case reports of sickle cell patients with COVID-19 have been published. Read More

View Article and Full-Text PDF
September 2021

Epidemiological shift of glucose-6-phosphate dehydrogenase mutations in northern Italy in the last 15 years.

Ann Hematol 2021 Sep 17. Epub 2021 Sep 17.

Department of Medicine and Medical Specialties, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive hemolytic anemia caused by mutations in G6PD gene. The distribution and frequency of genetic variants differ depending on ethnicity and geographical areas. Because of new migrations different variants are now present in Europe. Read More

View Article and Full-Text PDF
September 2021

HK1 haemolytic anaemia in association with a neurological phenotype and co-existing CEP290 Meckel-Gruber in a Romani family.

Clin Genet 2021 Sep 16. Epub 2021 Sep 16.

Clinical Genetics, CHI Crumlin, Dublin, Ireland.

HK1 deficient Haemolytic Anaemia in association with a Neurological Phenotype & co-existing Meckel-Gruber due to CEP290 in a Romani family. Read More

View Article and Full-Text PDF
September 2021

Modeling human glucose-6-phosphate dehydrogenase mutations using GSPD-1.

MicroPubl Biol 2021 10;2021. Epub 2021 Sep 10.

Division of Natural Sciences, New College of Florida, Sarasota, FL, USA.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked, recessive condition that causes intermittent jaundice or hemolytic anemia because of low NADPH levels in red blood cells. We performed steady-state enzyme kinetics with the recombinant ortholog of human G6PD, GSPD-1, and two mutants containing amino acid changes found in human patients. The values for glucose-6-phosphate were 100 ± 27 µM, 80 ± 22 µM, and 1000 ± 300 µM for the wild-type, D60N, and R252L GSPD-1 enzymes, respectively. Read More

View Article and Full-Text PDF
September 2021

Acute hemolytic anemia and acute kidney injury induced by non-high-dose ascorbic acid in a Child with glucose-6-phosphate dehydrogenase deficiency.

Pediatr Neonatol 2021 Sep 2. Epub 2021 Sep 2.

Department of Pediatrics, Ningbo Women and Children's Hospital, No. 339 Liuting Street, Haishu District, Ningbo, Zhejiang, China. Electronic address:

View Article and Full-Text PDF
September 2021

Cefoperazone/sulbactam-induced hemolytic anemia.

J Postgrad Med 2021 Sep 13. Epub 2021 Sep 13.

Department of Pharmacy, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.

Drug-induced hemolytic anemia (DIHA) is a rare complication of drug therapy and usually underdiagnosed. Cefoperazone/sulbactam is a compound prepared from the third generation of cephalosporin and β-lactamase inhibitor. There are limited data of DIHA induced from cefoperazone/sulbactam. Read More

View Article and Full-Text PDF
September 2021

Comparison of a modified flow cytometry osmotic fragility test with the classical method for the diagnosis of hereditary spherocytosis.

Cytometry B Clin Cytom 2021 Sep 16. Epub 2021 Sep 16.

Hematology Laboratory, flow cytometry unit, Rabin Medical Center Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel.

Background: Hereditary spherocytosis (HS) is the most common inherited hemolytic anemia. The flow cytometric test using eosin-5'maleimide (EMA) is a well-established diagnostic method. However, in order to improve HS detection, it is recommended that EMA and an osmotic fragility test (OFT) both be performed. Read More

View Article and Full-Text PDF
September 2021

Investigation of Genes Associated With Atherosclerosis in Patients With Systemic Lupus Erythematosus.

Arch Rheumatol 2021 Jun 27;36(2):287-295. Epub 2021 Jan 27.

Department of Medical Genetics, Trakya University, Faculty of Medicine, Edirne, Turkey.

Objectives: In this study, we aimed to identify patients with systemic lupus erythematosus (SLE) who are genetically at risk for developing atherosclerosis.

Patients And Methods: Between November 2014 and May 2016, a total of 38 patients with SLE (36 females, 2 males; mean age: 37.6 years; range, 18 to 71 years) and 32 healthy females (mean age: 31. Read More

View Article and Full-Text PDF

Severe Haemolytic Anaemia Resulting from a Malpositioned Haemodialysis Catheter.

Eur J Case Rep Intern Med 2021 26;8(8):002789. Epub 2021 Aug 26.

Internal Medicine, Rochester General Hospital, Rochester, New York, USA.

Severe haemolytic anaemia is a rare complication of haemodialysis that is often difficult to recognize, especially when there are other potential differential diagnoses. Here, we present the case of 19-year-old man on haemodialysis who developed severe haemolytic anaemia while recovering from acute renal failure secondary to rhabdomyolysis. Other causes of haemolytic anaemia such as thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome were ruled out. Read More

View Article and Full-Text PDF

Severe Vitamin B12 Deficiency Mimicking Microangiopathic Hemolytic Anemia.

J Hematol 2020 Aug 30;10(4):202-205. Epub 2021 Aug 30.

Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, VA 23298, USA.

Most individuals with vitamin B12 deficiency present with anemia, fatigue, and neurologic disturbances such as paresthesia and loss of sensory function if chronic. However, in severe states, it may manifest as hemolytic anemia, thrombocytopenia, schistocytosis, elevated lactate dehydrogenase, and low reticulocyte production. This phenomenon is known as pseudo-thrombotic microangiopathy (TMA), and is most commonly due to pernicious anemia. Read More

View Article and Full-Text PDF

Infection as Trigger for Congenital Thrombotic Thrombocytopenic Purpura in an Adult Patient.

J Med Cases 2021 Sep 25;12(9):339-342. Epub 2021 Aug 25.

Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Congenital thrombotic thrombocytopenic purpura (cTTP) is an inherited disease that is sometimes fatal in early childhood. cTTP is similar to idiopathic thrombotic thrombocytopenic purpura (iTTP); both are characterized by varying levels of thrombocytopenia, microangiopathic hemolytic anemia (MAHA), and end-organ damage secondary to occlusion of the microvasculature. cTTP is caused by a partial or total deficiency or loss of function of ADAMTS-13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13). Read More

View Article and Full-Text PDF
September 2021

Poloxamer 188 vs Placebo for Painful Vaso-occlusive Episodes in Children and Adults With Sickle Cell Disease.

Authors:
Umut A Gurkan

JAMA 2021 09;326(10):975

Mechanical and Aerospace Engineering Department, Case Western Reserve University, Cleveland, Ohio.

View Article and Full-Text PDF
September 2021

Late-Onset Systemic Lupus Erythematosus Associated with Autoimmune Hemolytic Anemia and Sixth Cranial Nerve Palsy.

Am J Case Rep 2021 Sep 14;22:e932959. Epub 2021 Sep 14.

Department of Rheumatology, Okinawa Chubu Hospital, Uruma, Okinawa, Japan.

BACKGROUND Patients with late-onset systemic lupus erythematosus (SLE) do not present with typical SLE symptoms or serology, and this can lead to a major delay in diagnosis. We report a complex case of an older woman who developed autoimmune hemolytic anemia and sixth cranial nerve palsy that posed considerable challenges in diagnosing late-onset SLE. CASE REPORT A 78-year-old Japanese woman presented with polyarthritis associated with generalized fatigue for 2 months, who later developed diplopia. Read More

View Article and Full-Text PDF
September 2021

Evaluation and Management of Thrombotic Thrombocytopenic Purpura in the Emergency Department.

J Emerg Med 2021 Sep 10. Epub 2021 Sep 10.

Department of Emergency Medicine, Rush University Medical Center, Chicago, Illinois.

Background: Thrombotic thrombocytopenic purpura (TTP) is a dangerous condition that can be misdiagnosed in the emergency department.

Objective: The purpose of this narrative review article is to provide a summary of the background, pathophysiology, diagnosis, and management of TTP, with a focus on emergency clinicians.

Discussion: TTP is a disorder with microangiopathic hemolytic anemia, severe thrombocytopenia, and multiorgan ischemic injury. Read More

View Article and Full-Text PDF
September 2021

Preclinical studies of efficacy thresholds and tolerability of a clinically ready lentiviral vector for pyruvate kinase deficiency treatment.

Mol Ther Methods Clin Dev 2021 Sep 29;22:350-359. Epub 2021 Jul 29.

Hematopoietic Innovative Therapies Division, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 28040 Madrid, Spain.

Pyruvate kinase deficiency (PKD) is a rare autosomal recessive disorder caused by mutations in the gene. PKD is characterized by non-spherocytic hemolytic anemia of variable severity and may be fatal in some cases during early childhood. Although not considered the standard of care, allogeneic stem cell transplantation has been shown as a potentially curative treatment, limited by donor availability, toxicity, and incomplete engraftment. Read More

View Article and Full-Text PDF
September 2021

The Spectrum of Hemolytic Disease of the Newborn: Evaluating the Etiology of Unconjugated Hyperbilirubinemia Among Neonates Pertinent to Immunohematological Workup.

Cureus 2021 Aug 6;13(8):e16940. Epub 2021 Aug 6.

Department of Transfusion Medicine, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, IND.

Background and objective The exact burden of hemolytic disease of the newborn (HDN) attributed to neonatal unconjugated hyperbilirubinemia (NUH) in developing nations is still unclear. Still, anti-D is reported to be the most common cause of HDN in India. ABO incompatibility has emerged as a leading cause of exchange transfusion (ET) in many countries. Read More

View Article and Full-Text PDF

A Novel Fragmentation Sensitivity Index Determines the Susceptibility of Red Blood Cells to Mechanical Trauma.

Front Physiol 2021 25;12:714157. Epub 2021 Aug 25.

Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, Turkey.

Supraphysiological shear stresses (SSs) induce irreversible impairments of red blood cell (RBC) deformability, overstretching of RBC membrane, or fragmentation of RBCs that causes free hemoglobin to be released into plasma, which may lead to anemia. The magnitude and exposure tisme of the SSs are two critical parameters that determine the hemolytic threshold of a healthy RBC. However, impairments in the membrane stability of damaged cells reduce the hemolytic threshold and increase the susceptibility of the cell membrane to supraphysiological SSs, leading to cell fragmentation. Read More

View Article and Full-Text PDF

Genotypes of thalassemia in children: an analysis of 30 417 cases.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Aug;23(8):841-847

Department of Clinical Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530012, China.

Objectives: To investigate the distribution of genotypes of thalassemia in children in Guangxi, China.

Methods: A total of 30 417 children with positive results of thalassemia screening in the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region from January 2011 to December 2019 were enrolled. Single-tube multiplex PCR, agarose gel electrophoresis, and reverse dot blot hybridization technique were used for the detection of common α- and β-thalassemia genes. Read More

View Article and Full-Text PDF

Immune Thrombocytopenic Purpura as Initial Presentation of Paediatric SLE: A Case Report.

Authors:
Anjila Ghimire

JNMA J Nepal Med Assoc 2021 Jan 31;59(233):81-83. Epub 2021 Jan 31.

Department of Clinical Oncology, Bir Hospital, Kathmandu, Nepal.

The systemic lupus erythematosus (SLE) is a connective tissue disorder with variable presentations in children. The usual presentation includes arthritis, malar rash, nephritis, hemolytic anemia, and fever. Isolated hematologic abnormality as the only presentation of SLE is rare. Read More

View Article and Full-Text PDF
January 2021

Complement C5 inhibition protects against hemolytic anemia and acute kidney injury in anthrax peptidoglycan-induced sepsis in baboons.

Proc Natl Acad Sci U S A 2021 Sep;118(37)

Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104;

Late-stage anthrax infections are characterized by dysregulated immune responses and hematogenous spread of , leading to extreme bacteremia, sepsis, multiple organ failure, and, ultimately, death. Despite the bacterium being nonhemolytic, some fulminant anthrax patients develop a secondary atypical hemolytic uremic syndrome (aHUS) through unknown mechanisms. We recapitulated the pathology in baboons challenged with cell wall peptidoglycan (PGN), a polymeric, pathogen-associated molecular pattern responsible for the hemostatic dysregulation in anthrax sepsis. Read More

View Article and Full-Text PDF
September 2021

Herlyn Werner Wunderlich Syndrome Presenting with Ischemic Stroke due to Suspected Paroxysmal Nocturnal Hemoglobinuria: A Case Report.

JNMA J Nepal Med Assoc 2021 Feb 28;59(234):192-196. Epub 2021 Feb 28.

Department of Internal Medicine, Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.

Paroxysmal nocturnal hemoglobinuria can rarely present as cerebral ischemia and stroke due to arterial thrombosis. However, it should be considered in a young patient with bone marrow failure features, systemic thromboses, and hemolysis. The variants of paroxysmal nocturnal hemoglobinuria pose a diagnostic challenge and hence are important to recognize. Read More

View Article and Full-Text PDF
February 2021

Atypical Hemolytic Uremic Syndrome (aHUS) and Adenosine Deaminase (ADA)-Deficient Severe Combined Immunodeficiency (SCID)-Two Diseases That Exacerbate Each Other: Case Report.

Int J Mol Sci 2021 Aug 31;22(17). Epub 2021 Aug 31.

Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13/15, 41-800 Zabrze, Poland.

Hemolytic uremic syndrome (HUS) is defined by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI). Atypical HUS (aHUS), distinguished by its etiology, is caused by uncontrolled overactivation of the alternative complement pathway. The correct diagnosis of aHUS is complex and involves various gene mutations. Read More

View Article and Full-Text PDF

[Advances in research for pathogenesis of paroxysmal nocturnal hemoglobinuria].

Authors:
Yoshiko Murakami

Rinsho Ketsueki 2021 ;62(8):944-953

Research Institute for Microbial Diseases, Osaka University.

Paroxysmal Nocturnal hemoglobinuria, PNH is usually caused by the somatic mutation of X-linked PIGA gene followed by the clonal expansion of the GPI (glycosylphosphatidylinositol) anchor defective hematopoietic stem cell clone. There are two hypotheses for the mechanism of clonal expansion, one is selection theory, in which GPI deficient cells escape from attacks of cytotoxic cells, and another is benign tumor theory in which GPI deficient cells get the additional mutations and acquire proliferative nature. Recently, we identified two types of PNH patients caused by the biallelic mutation of PIGT on chromosome 20 and PIGB on chromosome 15. Read More

View Article and Full-Text PDF
September 2021

[Thalassemia in Japan].

Authors:
Hideho Wada

Rinsho Ketsueki 2021 ;62(8):914-921

Department of Hematology, Kawasaki Medical School.

Thalassemia is caused by a reduced production of one globin chain due to a quantitative imbalance between the α-globin and non-α-globin chains that make up the hemoglobin. It is classified into α- and β-thalassemia and characterized by microcytosis with polycythemia, and a Mentzer index of ≤13 aids in the diagnosis. In the genetic analysis of α-thalassemia, the Southeast Asian type was found to be the most common genetic subtype among Japanese and non-Japanese without a substantial difference. Read More

View Article and Full-Text PDF
September 2021