J Hematol 2020 Aug 30;10(4):202-205. Epub 2021 Aug 30.
Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, VA 23298, USA.
Most individuals with vitamin B12 deficiency present with anemia, fatigue, and neurologic disturbances such as paresthesia and loss of sensory function if chronic. However, in severe states, it may manifest as hemolytic anemia, thrombocytopenia, schistocytosis, elevated lactate dehydrogenase, and low reticulocyte production. This phenomenon is known as pseudo-thrombotic microangiopathy (TMA), and is most commonly due to pernicious anemia. Read More