3,829 results match your criteria hemodiafiltration


Severe hand sanitiser (isopropanol) toxicity managed with continuous venovenous haemodiafiltration and angiotensin II.

Clin Toxicol (Phila) 2021 Apr 13:1-2. Epub 2021 Apr 13.

Victorian Poisons Information Centre, Austin Toxicology and Emergency Department, Austin Health, Heidelberg, Australia.

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Bisphenol S is a haemodialysis-associated xenobiotic that is less toxic than bisphenol A.

Clin Kidney J 2021 Apr 8;14(4):1147-1155. Epub 2020 Jun 8.

Renal, Vascular and Diabetes Laboratory, IIS-Fundación Jimenez Diaz UAM, Madrid, Spain.

Background: Bisphenol S (BPS) is a structural analogue of bisphenol A (BPA) that is found in the environment. BPS may accumulate in anuric patients due to decreased urinary excretion. The toxicity and health effects of BPS are poorly characterized. Read More

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Efficacy of enoxaparin in preventing coagulation during high-flux haemodialysis, expanded haemodialysis and haemodiafiltration.

Clin Kidney J 2021 Apr 22;14(4):1120-1125. Epub 2020 Jun 22.

Nephrology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Low-molecular-weight heparins (LMWHs) are easily dialysable with high-flow membranes; however, it is not clear whether the LMWH dose should be adjusted according to the membrane type and dialysis technique. This study aimed to evaluate the influence of the dialyser on anticoagulation of the extracorporeal dialysis circuit.

Methods: Thirteen patients received the same dose of LMWH through the arterial port via three dialysis techniques: high-flux haemodialysis (HF-HD), online haemodiafiltration (HDF) and expanded haemodialysis (HDx). Read More

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Reconsidering adsorption in hemodialysis: is it just an epiphenomenon? A narrative review.

J Nephrol 2021 Apr 10. Epub 2021 Apr 10.

Department of Nephrology, Dialysis and Hypertension, Edouard Herriot Hospital, Hospices Civils de Lyon, 5 Place d'Arsonval, Cedex 03, 6943769003, Lyon, France.

Since the first attempt at extracorporeal renal replacement therapy, renal replacement therapy has been constantly improved. In the field of hemodialysis, substantial efforts have been made to improve toxin removal and biocompatibility. The advent of hemodiafiltration (HDF) and, more recently, of mid cut-off membranes have contributed to management of patients with end-stage renal disease (ESRD). Read More

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Inappropriate Heart Rate Response to Hypotension in Critically Ill COVID-19-Associated Acute Kidney Injury.

J Clin Med 2021 Mar 23;10(6). Epub 2021 Mar 23.

Service de Médecine Intensive Réanimation, Hôpital Tenon, Département Médico-Universitaire APPROCHES, Assistance Publique-Hôpitaux de Paris (AP-HP), 75020 Paris, France.

Angiotensin-converting enzyme 2 (ACE2) receptor of severe acute respiratory syndrome coronavirus 2 is involved in baroreflex control mechanisms. We hypothesize that severe coronavirus infectious disease 2019 (COVID-19) patients may show an alteration in baroreflex-mediated heart rate changes in response to arterial hypotension. A pilot study was conducted to assess the response to hypotension in relation to continuous venovenous hemodiafiltration (CVVHDF) in critically ill patients with PCR-confirmed COVID-19 (from February to April 2020) and in critically ill non-COVID-19 patients with sepsis (from February 2018 to February 2020). Read More

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Medium Cut-Off Dialysis Membrane and Dietary Fiber Effects on Inflammation and Protein-Bound Uremic Toxins: A Systematic Review and Protocol for an Interventional Study.

Toxins (Basel) 2021 Mar 29;13(4). Epub 2021 Mar 29.

Department of Nephrology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.

The aim of this systematic review is to investigate the effects of the use of a medium cut-off membrane (MCO) and dietary fiber on the concentration of protein-bound uremic toxins (PBUTs) and inflammatory markers in hemodialysis (HD) patients. Of 11,397 papers originally found, eight met the criteria of randomized controlled trial design. No study examined the effects of MCO membranes on PBUTs. Read More

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Effectiveness of fibroblast growth factor 23 lowering modalities in chronic kidney disease: a systematic review and meta-analysis.

Int Urol Nephrol 2021 Apr 2. Epub 2021 Apr 2.

Division of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, 1873 RAMA IV, Bangkok, 10330, Thailand.

Introduction: The heightened fibroblast growth factor 23 (FGF23) level in patients with chronic kidney disease (CKD) is associated with increased cardiovascular disease and mortality. We performed a systematic review and meta-analysis to synthesize the available strategies to reduce FGF23 in CKD patients.

Methods: We conducted a meta-analysis by searching the databases of MEDLINE, Scopus, and Cochrane Central Register of Controlled Trials for randomized controlled trials (RCTs) and single-arm studies that examined the effects of dietary phosphate restriction, phosphate binders, iron supplements, calcimimetics, parathyroidectomy, dialysis techniques, and the outcome of preservation of residual renal function (RRF) on FGF23 levels in CKD patients. Read More

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Tocilizumab and PMX-DHP have efficacy for severe COVID-19 pneumonia.

SAGE Open Med Case Rep 2021 1;9:2050313X21991063. Epub 2021 Feb 1.

Department of Respiratory Medicine, Kanazawa Medical University, Kahokugun, Japan.

In coronavirus disease 2019 pneumonia, a cytokine storm resulting from an excessive inflammatory response to the viral infection is thought to play a role in the exacerbation of the pneumonia and its prognosis. Favipiravir and ciclesonide are not effective in the inhibition of the cytokine storm. In this case report, we describe the experience of tocilizumab administration and polymyxin B immobilized fiber direct hemoperfusion in severe coronavirus disease 2019 pneumonia patient. Read More

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February 2021

Continuous Renal Replacement Therapy (CRRT) for Nonrenal Indications among Critically Ill Children with Malignancy.

Case Rep Pediatr 2021 13;2021:6660466. Epub 2021 Mar 13.

Department of Paediatrics and Adolescent Medicine, The Hong Kong Children's Hospital, Hong Kong.

The role of continuous renal replacement therapy (CRRT) has been expanding beyond support for acute kidney injury (AKI) in recent years. Children with malignancy are particularly at risk of developing conditions that may require CRRT. We reported three children with malignancy who received CRRT for non-AKI indications. Read More

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Distinct Solute Removal Patterns by Similar Surface High-Flux Membranes in Haemodiafiltration: The Adsorption Point of View.

Blood Purif 2021 Mar 31:1-9. Epub 2021 Mar 31.

Department of Nephrology, Hospital Clinic de Barcelona, Barcelona, Spain.

Introduction: Haemodialysis (HD) allow depuration of uraemic toxins by diffusion, convection, and adsorption. Online haemodiafiltration (HDF) treatments add high convection to enhance removal. There are no prior studies on the relationship between convection and adsorption in HD membranes. Read More

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Early Detection of Arteriovenous Fistula Stenosis in Hemodialysis Patients through Routine Measurements of Dialysis Dose (Kt/V).

Blood Purif 2021 Mar 30:1-8. Epub 2021 Mar 30.

Medical Faculty, University of Maribor, Maribor, Slovenia.

Background: Monitoring of arteriovenous (AV) fistula to detect hemodynamically important stenosis is crucial for the prevention of AV fistula thrombosis. The aim of our study was to analyze the importance of dialysis dose (Kt/V) during online postdilution hemodiafiltration (HDF) for early detection of AV fistula stenosis.

Methods: Hemodialysis patients with AV fistula were included in this study. Read More

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Change in FGF23 concentration over time and its association with all-cause mortality in patients treated with haemodialysis or haemodiafiltration.

Clin Kidney J 2021 Mar 1;14(3):891-897. Epub 2020 Apr 1.

Department of Nephrology, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam, The Netherlands.

Background: Previous studies in patients on haemodialysis (HD) have shown an association of fibroblast growth factor 23 (FGF23) with all-cause mortality. As of yet, the result of FGF23 lowering on mortality is unknown in this population.

Methods: FGF23 was measured in a subset of 404 patients from the Dutch CONvective TRansport STudy (CONTRAST study) [a randomized trial in prevalent dialysis patients comparing HD and haemodiafiltration (HDF) with clinical outcome] at baseline and Months 6 and 12. Read More

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The difference between delivered and prescribed dialysate sodium in haemodialysis machines.

Clin Kidney J 2021 Mar 11;14(3):863-868. Epub 2020 Mar 11.

Department of Nephrology, Royal Free Hospital, University College London, London, UK.

Background: The choice of dialysate sodium (DNa) for haemodialysis (HD) patients remains controversial, with some studies reporting that a lower DNa improves blood pressure control and reduces intradialytic weight gain. Studies on DNa depend on the alignment of programmed to delivered DNa. We wished to determine whether there were differences between programmed and delivered DNa. Read More

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Stepwise achievement of high convection volume in post-dilution hemodiafiltration: A prospective observational study.

Semin Dial 2021 Mar 28. Epub 2021 Mar 28.

Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.

High-volume online hemodiafiltration (HDF) has been reported to reduce the patient's mortality. However, achieving a high convection volume is challenging. In this prospective study, we investigated the feasibility of achieving high-volume HDF with ≥21 L substitution volume via modification of blood flow rate (BFR), needle size, and dialysis membrane. Read More

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On-line hemodiafiltration modulates atherosclerosis signaling in peripheral lymphomonocytes of hemodialysis patients.

J Nephrol 2021 Mar 24. Epub 2021 Mar 24.

Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari "A. Moro", Piazza G. Cesare 11, 70122, Bari, Italy.

Background: Hemodialysis patients present a dramatic increase in cardiovascular morbidity/mortality. Circulating immune cells, activated by both uremic milieu and dialysis, play a key role in the pathogenesis of dialysis-related vascular disease. The aim of our study was to identify, through a high-throughput approach, differences in gene expression profiles in the peripheral blood mononuclear cells (PBMCs) of patients treated with on-line hemodiafiltration and bicarbonate hemodialysis. Read More

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Regional citrate anticoagulation protocol suitable for intermittent hemodialysis and post-dilution hemodiafiltration.

Clin Nephrol 2021 Mar 22. Epub 2021 Mar 22.

Aims: Regional citrate anticoagulation (RCA) during intermittent hemodialysis (iHD) effectively prevents circuit clotting without systemic anticoagulation and is especially beneficial for patients at increased bleeding risk. The performance of RCA under different iHD modes is not well documented.

Materials And Methods: We retrospectively studied all consecutive iHD sessions with our RCA protocol during a 3-year period. Read More

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Targeting Cytokine Storm in COVID-19: A Role of Online Hemodiafiltration with Asymmetric Cellulose Triacetate in Maintenance Hemodialysis Patients-A Report of 10 Cases.

Case Rep Nephrol 2021 12;2021:5575928. Epub 2021 Mar 12.

Department of Nephrology, Central Defense Gomez Ulla Hospital, Madrid, Spain.

Early reports have suggested that maintenance hemodialysis (MHD) patients could be more susceptible to a severe course of COVID-19. Among the therapeutic approaches, the use of drugs that reduce the cytokine storm characteristic of this disease has been proposed. Some dialyzers, such as the new generation of asymmetric cellulose triacetate (ATA) membranes, could favor the effective elimination of medium-sized molecules and other inflammatory mediators. Read More

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Efficiency of continuous venous-venous hemodiafiltration in a life-threatening phenytoin poisoning: A case report.

Therapie 2021 Feb 22. Epub 2021 Feb 22.

Réanimation et surveillance continue médico-chirurgicales pédiatriques, AP-HP, hôpital Necker Enfants Malades, Université de Paris, 149, rue de Sèvres, 75015 Paris, France.

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February 2021

Procalcitonin serum levels in stage 5 chronic kidney disease children on hemodialysis.

Pediatr Nephrol 2021 Mar 17. Epub 2021 Mar 17.

Pediatric Nephrology Unit, Armand Trousseau Hospital, APHP, DMU Origyne, Sorbonne Université, 75012, Paris, France.

Background: Infections are responsible for morbidity and mortality in children on hemodialysis (HD). Procalcitonin (PCT) is rarely used in this population, even though it is an efficient biomarker of infection and sepsis. Our aim was to study PCT baseline level in uninfected children with stage 5 chronic kidney disease (CKD 5) on HD, and determine how to use it in this population. Read More

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The Use of Supra-Hemodiafiltration in Traumatic Rhabdomyolysis and Acute Kidney Injury: A Case Report.

Case Rep Nephrol Dial 2021 Jan-Apr;11(1):26-35. Epub 2021 Feb 3.

Nephrology Dialysis and Renal Transplantation Unit, Department of Experimental Diagnostic and Specialty Medicine (DIMES), St Orsola Hospital, University of Bologna, Bologna, Italy.

Oliguric acute kidney injury due to traumatic rhabdomyolysis can be potentially lethal if the proper medical therapy combined with extracorporeal detoxification is not performed. Different extracorporeal techniques are available to overcome this syndrome. Here, we report the first case of removal of myoglobin and successful recovery from acute kidney injury in an elderly septic patient using supra-hemodiafiltration with endogenous reinfusion technique (HFR-Supra) combined with the medical therapy. Read More

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February 2021

Liver transplantation for congenital protein C deficiency with initial poor graft function: a case report with literature review.

Int J Hematol 2021 Feb 26. Epub 2021 Feb 26.

Organ Transplantation Center, NCCHD, Tokyo, Japan.

Congenital deficiency of protein C (PC) is a rare disease that causes thrombophilia during the neonatal and infantile periods. Despite anticoagulative treatments, purpura fulminans and major vessel thrombosis often occur. We report a 7-year-old girl with congenital PC deficiency who underwent deceased donor liver transplantation (LT) and experienced complications accompanied by initial poor graft function (IPGF). Read More

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February 2021

The probability of receiving a kidney transplantation in end-stage kidney disease patients who are treated with haemodiafiltration or haemodialysis: a pooled individual participant data from four randomised controlled trials.

BMC Nephrol 2021 Feb 25;22(1):70. Epub 2021 Feb 25.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Background: Due to a critical shortage of available kidney grafts, most patients with Stage 5 Chronic Kidney Disease (CKD5) require bridging dialysis support. It remains unclear whether treatment by different dialysis modalities changes the selection and/or preparation of a potential transplant candidate. Therefore, we assessed whether the likelihood of receiving kidney transplant (both living or deceased kidney donors) differs between haemodialysis (HD) and online haemodiafiltration (HDF) in patients with CKD5D. Read More

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February 2021

Hemodiafiltration maintains a sustained improvement in blood pressure compared to conventional hemodialysis in children-the HDF, heart and height (3H) study.

Pediatr Nephrol 2021 Feb 24. Epub 2021 Feb 24.

University College London Great Ormond Street Hospital for Children and Institute of Child Health, London, UK.

Background: Hypertension is prevalent in children on dialysis and associated with cardiovascular disease. We studied the blood pressure (BP) trends and the evolution of BP over 1 year in children on conventional hemodialysis (HD) vs. hemodiafiltration (HDF). Read More

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February 2021

Arterial Versus Venous Port Site Administration of Nadroparin for Preventing Thrombosis of Extracorporeal Blood Circuits in Patients Receiving Hemodiafiltration Treatment.

Kidney Int Rep 2021 Feb 31;6(2):351-356. Epub 2020 Dec 31.

Global Medical Office, Fresenius Medical Care Deutschland, Bad Homburg, German.

Introduction: Administration of low-molecular-weight heparins (LMWHs) is necessary for preventing extracorporeal circuit thrombosis during hemodialysis. A substantial amount of LMWH is removed with online hemodiafiltration (OL-HDF) when administered through the inlet site of the extracorporeal circuit. Consequently, administration of LMWH at the outlet site appears to be more efficient. Read More

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February 2021

Severe liver injury associated with glecaprevir plus pibrentasvir therapy in a patient with treatment-naïve hepatitis C virus infection.

Intern Med 2021 Feb 22. Epub 2021 Feb 22.

Department of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Japan.

A 49-year-old man underwent treatment with glecaprevir plus pibrentasvir (G/P) for chronic hepatitis C infection. Six weeks later, he was admitted to our hospital because of jaundice and fatigue with no accompanying skin rash. A laboratory examination and evaluation of the patient's history resulted in a diagnosis of acute liver injury. Read More

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February 2021

Changes in extracellular water with hemodialysis and fall in systolic blood pressure.

Int J Artif Organs 2021 Feb 20:391398821995503. Epub 2021 Feb 20.

UCL Department of Nephrology, Royal Free Hospital, University College London, London, UK.

Introduction: Intra-dialytic hypotension (IDH) remains the most common complication with outpatient hemodialysis (HD) sessions. As fluid is removed during HD, there is contraction of the extracellular volume (ECW). We wished to determine whether the fall in ECW was associated with a fall in systolic blood pressure (SBP). Read More

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February 2021

The future of continuous renal replacement therapy.

Semin Dial 2021 Feb 20. Epub 2021 Feb 20.

Department of Intensive Care, Austin Hospital, Heidelberg, Vic., Australia.

Over the last 40 years, acute renal replacement therapy (RRT) in the intensive care units (ICUs) of high-income countries has transitioned from the predominant use of intermittent hemodialysis (and the much less common use of peritoneal dialysis) to the almost exclusive use of continuous renal replacement therapy (CRRT). Accordingly, CRRT has become the most common form of vital organ support delivered to critically ill patients. A series of clinical and technical advances has enabled the transformation of basic CRRT machines into highly sophisticated and customized devices. Read More

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February 2021

Recombinant Human Thrombomodulin has Additive Effects in Septic Patients Undergoing Continuous Hemodiafiltration due to Intestinal Perforation.

Shock 2021 Feb 15. Epub 2021 Feb 15.

First Department of Surgery, Faculty of Medicine, University of Yamanashi.

Background: Disseminated intravascular coagulation (DIC) is associated with high mortality in patients with severe sepsis. The purpose of this study was to investigate the effects of recombinant human thrombomodulin (rhTM) in septic patients undergoing continuous hemodiafiltration (CHDF). Furthermore, effects of rhTM in acute lung injury, the first target organ in sepsis, was investigated using a sepsis model in rats. Read More

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February 2021