Cell Mol Neurobiol 2021 Feb 18. Epub 2021 Feb 18.
Division of Functional Genomics, Life Science Support Center, Nagasaki University, 1-12-4, Sakamoto, Nagasaki, 852-8523, Japan.
REV-ERBs are heme-binding nuclear receptors that regulate the circadian rhythm and play important roles in the regulation of proliferation and the neuronal differentiation process in neuronal stem/progenitor cells in the adult brain. However, the effects of REV-ERB activation in the adult brain remain unclear. In this study, SR9009, a synthetic REV-ERB agonist that produces anxiolytic effects in mice, was used to treat undifferentiated and neuronally differentiated cultured rat adult hippocampal neural stem/progenitor cells (AHPs). Read More