13,305 results match your criteria heme oxygenase-1

Antioxidant effects on hypoxia-induced oxidative stress and apoptosis in rat rotator cuff fibroblasts.

Eur Cell Mater 2021 Jun 11;41:680-693. Epub 2021 Jun 11.

Department of Orthopaedic Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, 11 Samjeongja-ro, Seongsan-gu, Changwon 51472, Republic of [email protected] gmail.com.

Most cells, highly sensitive to oxygen levels, undergo apoptosis under hypoxia. Therefore, the involvement of hypoxia in rotator cuff tendon degeneration has been proposed. While previous studies have reported that hypoxia induces apoptosis in rotator cuff fibroblasts (RCFs), little research has investigated whether antioxidants have cytoprotective effects against RCF apoptosis. Read More

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4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response.

Front Pharmacol 2021 25;12:651444. Epub 2021 May 25.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The liver is an important metabolic organ, and acute liver injury (ALI) is potentially lethal. Itaconate, a metabolic intermediate from the tricarboxylic acid cycle, showed emerging anti-oxidative and anti-inflammation properties, and an accumulating protective effect in multiple diseases, but its role in ALI still needs to be further explored. Here we established an ALI model induced by carbon tetrachloride in mice. Read More

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CORM-2 inhibits intracerebral hemorrhage-mediated inflammation.

Neurol Res 2021 Jun 10:1-8. Epub 2021 Jun 10.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

: Low-dose of carbon monoxide delivered by CO-releasing molecule-2 (CORM-2) had been confirmed having anti-inflammatory efficacy in some inflammatory diseases. Herein, we assessed the usefulness of CORM-2 in correcting intracerebral hemorrhage (ICH)-mediated inflammation.: Healthy male Sprague Dawley (SD) rats randomly entered into four groups: sham-ICH, ICH, ICH+CORM-2, and ICH+ inactive carbon monoxide releasing molecule 2 (iCORM-2). Read More

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Dasatinib protects against acute respiratory distress syndrome via Nrf2-regulated M2 macrophages polarization.

Drug Dev Res 2021 Jun 9. Epub 2021 Jun 9.

Intensive Care Unit, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Dasatinib, a tyrosine kinase inhibitor, has a protective effect on experimental acute respiratory distress syndrome (ARDS). This study investigated the effect and mechanism of dasatinib in ARDS. C57BL/6 mice were administered with dasatinib (1 and 10 mg/kg) after lipopolysaccharide (LPS) treatment to evaluate the effect of dasatinib on white blood cells (WBC), neutrophils, lymphocytes and macrophages in bronchoalveolar lavage fluid (BALF). Read More

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Antioxidant and Anti-Inflammatory Profiles of Spent Coffee Ground Extracts for the Treatment of Neurodegeneration.

Oxid Med Cell Longev 2021 19;2021:6620913. Epub 2021 May 19.

School of Pharmacy, University of Camerino, Via Sant' Agostino 1, I-62032 Camerino (MC), Italy.

Spent coffee grounds (SCGs), waste products of coffee beverage production, are rich in organic compounds such as phenols. Different studies have demonstrated phenol beneficial effects in counteracting neurodegenerative diseases. These diseases are associated with oxidative stress and neuroinflammation, which initiates the degeneration of neurons by overactivating microglia. Read More

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HO-1/CO Maintains Intestinal Barrier Integrity through NF-B/MLCK Pathway in Intestinal HO-1 Mice.

Oxid Med Cell Longev 2021 19;2021:6620873. Epub 2021 May 19.

Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.

Background: Intestinal barrier injury is an important contributor to many diseases. We previously found that heme oxygenase-1 (HO-1) and carbon monoxide (CO) protect the intestinal barrier. This study is aimed at elucidating the molecular mechanisms of HO-1/CO in barrier loss. Read More

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Inhibition of Lipopolysaccharide-Induced Inflammatory and Oxidative Responses by -cinnamaldehyde in C2C12 Myoblasts.

Int J Med Sci 2021 23;18(12):2480-2492. Epub 2021 Apr 23.

Anti-Aging Research Center, Dong-eui University, Busan 47340, Republic of Korea.

-cinnamaldehyde (tCA), a bioactive component found in , has been reported to exhibit anti-inflammatory and antioxidant effects, but its efficacy in muscle cells has yet to be found. In this study, we investigated the inhibitory effect of tCA on inflammatory and oxidative stress induced by lipopolysaccharide (LPS) in C2C12 mouse skeletal myoblasts. To investigate the anti-inflammatory and antioxidant effects of tCA in LPS-treated C2C12 cells, we measured the levels of pro-inflammatory mediator, cytokines, and reactive oxygen species (ROS). Read More

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Dapsone Ameliorates Isoproterenol-Induced Myocardial Infarction Nrf2/ HO-1; TLR4/ TNF-α Signaling Pathways and the Suppression of Oxidative Stress, Inflammation, and Apoptosis in Rats.

Front Pharmacol 2021 19;12:669679. Epub 2021 May 19.

Department of Pharmacology, Faculty of Medicine, Cairo University, Giza, Egypt.

Myocardial infarction (MI) is a critical condition that can happen with high doses or rapid termination of beta blockers therapy. The study aimed to evaluate the potential anti-toxic value of DAP against isoproterenol (ISO) - induced MI. Twenty-eight male Wistar rats were used for the study. Read More

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Heme oxygenase-1: Equally important in allogeneic hematopoietic stem cell transplantation and organ transplantation?

Transpl Immunol 2021 Jun 2;68:101419. Epub 2021 Jun 2.

Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam, the Netherlands. Electronic address:

The intracellular enzyme heme oxygenase-1 (HO-1) is responsible for the degradation of cell-free (cf) heme. Cfheme, released upon cell damage and cell death from hemoglobin, mitochondria and myoglobin, functions as a powerful damage-associated molecular pattern (DAMP). Indeed, cfheme plays a role in a myriad of diseases characterized by (systemic) inflammation, and its rapid degradation by HO-1 is pivotal to maintain homeostasis. Read More

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Dihydroartemisinin overcomes the resistance to osimertinib in EGFR-mutant non-small-cell lung cancer.

Pharmacol Res 2021 Jun 1:105701. Epub 2021 Jun 1.

Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China; College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing 211166, China. Electronic address:

Osimertinib, a third-generation EGFR tyrosine kinase inhibitor (TKI), is commonly used to treat EGFR-mutant non-small-cell lung cancer (NSCLC). However, acquired resistance to mutant EGFR (T790M) can evolve following osimertinib treatment. High reactive oxygen species (ROS) levels in lung cancer cells can influence heme levels and have an impact on osimertinib resistance. Read More

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Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.

PLoS One 2021 4;16(6):e0252642. Epub 2021 Jun 4.

Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, California, United States of America.

Heme oxygenase-1 (HO-1) is an evolutionarily conserved stress response enzyme and important in pregnancy maintenance, fetal and neonatal outcomes, and a variety of pathologic conditions. Here, we investigated the effects of an exposure to systemic inflammation late in gestation [embryonic day (E)15.5] on wild-type (Wt) and HO-1 heterozygous (Het, HO-1+/-) mothers, fetuses, and offspring. Read More

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HO-1: A new potential therapeutic target to combat osteoporosis.

Eur J Pharmacol 2021 May 31;906:174219. Epub 2021 May 31.

Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, Guangdong, 518057, China; Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China. Electronic address:

Heme oxygenase-1 (HO-1) exerts a protective effect against cell damage and induces the activity of many enzymes involved in the treatment of many human diseases, including osteoporosis. The increasing prevalence of osteoporosis and the limitations of the current treatments available led to a continuous occurrence of bone loss and osteoporotic fractures, highlighting the need of a better understanding of the mechanism and function of HO-1. Many factors cause osteoporosis, including lack of estrogen, aging, and iron overload, and they either cause the increase in inflammatory factors or the increase in reactive oxygen species to break bone reconstruction balance. Read More

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Combination of cyanidin-3-O-glucoside and cisplatin induces oxidative stress and apoptosis in HeLa cells by reducing activity of endogenous antioxidants, increasing bax/bcl-2 mRNA expression ratio, and downregulating Nrf2 expression.

J Food Biochem 2021 Jun 2:e13806. Epub 2021 Jun 2.

College of Food Science, Shenyang Agricultural University, Shenyang, China.

Investigation on potentiation of existing drugs with natural compounds to enhance efficacy and reduce toxic effect of the drugs has been increasing in recent years. This paper reports cytotoxic effect (apoptosis-related and oxidative stress-related effect) of cyanidin-3-O-glucoside (C3G), cisplatin (DDP), and their combination (C3G-DDP) on cervical cancer HeLa cells. Concentration of intracellular reactive oxygen species (ROS) was determined by employing fluorescent marker 2',7'-dichlorodihydrofluorescein diacetate. Read More

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Gallic acid suppresses inflammation and oxidative stress through modulating Nrf2-HO-1-NF-κB signaling pathways in elastase-induced emphysema in rats.

Environ Sci Pollut Res Int 2021 Jun 2. Epub 2021 Jun 2.

Persian Gulf Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Emphysema is associated with an abnormal airspace enlargement distal to the terminal bronchioles accompanied by destructive changes in the alveolar walls and chronic inflammation. Air pollution can cause respiratory diseases such as chronic obstructive pulmonary disease (COPD) and emphysema in urban areas. As a natural antioxidant compound, gallic acid may be effective in controlling inflammation and preventing disease progression. Read More

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Loganin Inhibits Lipopolysaccharide-Induced Inflammation and Oxidative Response through the Activation of the Nrf2/HO-1 Signaling Pathway in RAW264.7 Macrophages.

Biol Pharm Bull 2021 ;44(6):875-883

Anti-Aging Research Center, Dong-eui University.

Inflammation caused by the excessive secretion of inflammatory mediators in abnormally activated macrophages promotes many diseases along with oxidative stress. Loganin, a major iridoid glycoside isolated from Cornus officinalis, has recently been reported to exhibit anti-inflammatory and antioxidant effects, whereas the underlying mechanism has not yet been fully clarified. Therefore, the aim of the present study is to investigate the effect of loganin on inflammation and oxidative stress in lipopolysaccharide (LPS)-stimulated RAW264. Read More

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January 2021

Ethyl pyruvate ameliorates heat stroke-induced multiple organ dysfunction and inflammatory responses by induction of stress proteins and activation of autophagy in rats.

Int J Hyperthermia 2021 ;38(1):862-874

Department and Graduate Institute of Pharmacology, National Defense Medical Center, Taipei, Taiwan.

Heat stroke (HS) elicits the systemic inflammatory responses that result in multiple organ dysfunction (MOD). Heat shock response and autophagy are activated during heat stress for removal of damaged organelles and proteins, emerging as a major regulator of cellular homeostasis. Ethyl pyruvate (EP) is a derivative of pyruvic acid and possesses antioxidant and anti-inflammatory effects. Read More

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January 2021

Hepatic oxidative damage and Nrf2 pathway protein changes in rats following long-term manganese exposure.

Toxicol Ind Health 2021 May;37(5):251-259

Department of Toxicology, School of Public Health, 66367Zunyi Medical University, Zunyi, People's Republic of China.

This study investigated hepatic oxidative damage in rats following long-term manganese (Mn) exposure and clarified the underlying mechanisms. Forty-eight rats (SPF, male) were randomly assigned to receive low (10 mg/kg, = 16) or high doses of Mn (50 mg/kg, = 16) or sterilized distilled water (control group, = 16). Rats were euthanized after 12 months, and liver Mn levels and histopathological changes were determined. Read More

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Antioxidant and Anti-inflammatory Activities of Oil in HepG2 Cells and Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.

J Med Food 2021 Jun 2. Epub 2021 Jun 2.

Food and Bio-industry Research Institute, School of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu, Korea.

Improvement of antioxidant and anti-inflammatory functions is believed to be an effective strategy for protection against various diseases such as cancer, aging, and neurodegenerative disease. This study focused on investigating antioxidant and anti-inflammatory abilities of oil (ZMO) extracted by the supercritical CO fluid system in HepG2 cells and lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Read More

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Ang(1-7) exerts Nrf2-mediated neuroprotection against amyloid beta-induced cognitive deficits in rodents.

Mol Biol Rep 2021 Jun 1. Epub 2021 Jun 1.

Division of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, 281406, India.

Alzheimer's disease (AD) is a neurodegenerative disorder with cognitive deficits in an individual. Ang(1-7) exhibits neuroprotection against amyloid beta (Aβ)-induced mitochondrial dysfunction and neurotoxicity in experimental conditions. Further, Ang(1-7) also exhibits nrf2-mediated antioxidant activity in experimental conditions. Read More

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Nrf2/HO-1 Signaling Activator Acetyl-11-keto-beta Boswellic Acid (AKBA)-Mediated Neuroprotection in Methyl Mercury-Induced Experimental Model of ALS.

Neurochem Res 2021 Jun 1. Epub 2021 Jun 1.

Neuropharmacology Division, Department of Pharmacology, ISF College of Pharmacy, Moga, 142001, Punjab, India.

Methylmercury (MeHg) is a potent neurotoxin that causes neurotoxicity and neuronal cell death. MeHg exposure also leads to oligodendrocyte destruction, glial cell overactivation, and demyelination of motor neurons in the motor cortex and spinal cord. As a result, MeHg plays an important role in the progression of amyotrophic lateral sclerosis (ALS)-like neurocomplications. Read More

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Significance of Heme and Heme Degradation in the Pathogenesis of Acute Lung and Inflammatory Disorders.

Stefan W Ryter

Int J Mol Sci 2021 May 24;22(11). Epub 2021 May 24.

Proterris, Inc., Boston, MA 02118, USA.

The heme molecule serves as an essential prosthetic group for oxygen transport and storage proteins, as well for cellular metabolic enzyme activities, including those involved in mitochondrial respiration, xenobiotic metabolism, and antioxidant responses. Dysfunction in both heme synthesis and degradation pathways can promote human disease. Heme is a pro-oxidant via iron catalysis that can induce cytotoxicity and injury to the vascular endothelium. Read More

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Cardamonin Attenuates Inflammation and Oxidative Stress in Interleukin-1β-Stimulated Osteoarthritis Chondrocyte through the Nrf2 Pathway.

Antioxidants (Basel) 2021 May 27;10(6). Epub 2021 May 27.

Department of Orthopedics, National Defense Medical Center, Tri-Service General Hospital, Taipei 114, Taiwan.

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the deterioration of articular cartilage. The progression of OA leads to an increase in inflammatory mediators in the joints, thereby promoting the destruction of the cartilage matrix. Recent studies have reported on the anti-inflammatory and antioxidant properties of cardamonin, which also appears to interact with cellular targets, such as nuclear erythroid 2-related factor 2 (Nrf2), extracellular signal-regulated kinase (ERK), and mammalian target of rapamycin (mTOR) during the progression of tumors. Read More

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The Anti-Oxidative and Anti-Neuroinflammatory Effects of by Heme Oxygenase-1 Induction in BV2 and HT22 Cells.

Antioxidants (Basel) 2021 May 27;10(6). Epub 2021 May 27.

College of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Korea.

is used as a traditional medicinal agent and exhibits various pharmacological effects. In this study, we found that the 70% EtOH extract contained 34.37 ± 0. Read More

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(-)-Loliolide Isolated from Suppressed Oxidative Stress and Inflammation by Activating Nrf2/HO-1 Signaling in IFN-γ/TNF-α-Stimulated HaCaT Keratinocytes.

Antioxidants (Basel) 2021 May 27;10(6). Epub 2021 May 27.

Department of Food Technology and Nutrition, Chonnam National University, Yeosu 59626, Korea.

The present study evaluated the effects of (-)-loliolide isolated from () against oxidative stress and inflammation, and its biological mechanism in interferon (IFN)-γ/tumor necrosis factor (TNF)-α-stimulated HaCaT keratinocytes. The results showed that (-)-loliolide improved the cell viability by reducing the production of intracellular reactive oxygen species (ROS) in IFN-γ/TNF-α-stimulated HaCaT keratinocytes. In addition, (-)-loliolide effectively decreased the expression of inflammatory cytokines (interleukin (IL)-4 IL-6, IL-13, IFN-γ and TNF-α) and chemokines (CCL11 (Eotaxin), macrophage-derived chemokine (MDC), regulated on activation, normal T cell expressed and secreted (RANTES), and thymus and activation-regulated chemokine (TARC)), by downregulating the expression of epidermal-derived initial cytokines (IL-25, IL-33 and thymic stromal lymphopoietin (TSLP)). Read More

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Pharmacological and Clinical Significance of Heme Oxygenase-1.

Antioxidants (Basel) 2021 May 27;10(6). Epub 2021 May 27.

Department of Medicine, New York Medical College, Valhalla, NY 10595, USA.

This Special Issue collates and updates the current knowledge of the pharmacology and clinical applications concerning the enzyme heme oxygenase (HO) [... Read More

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Topically Applied Taurine Chloramine Protects against UVB-Induced Oxidative Stress and Inflammation in Mouse Skin.

Antioxidants (Basel) 2021 May 28;10(6). Epub 2021 May 28.

Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea.

Excessive exposure to solar light, especially its UV component, is a principal cause of photoaging, dermatitis, and photocarcinogenesis. In searching for candidate substances that can effectively protect the skin from photodamage, the present study was conducted with taurine chloramine (TauCl), formed from taurine in phagocytes recruited to inflamed tissue. Irradiation with ultraviolet B (UVB) of 180 mJ/cm intensity caused oxidative damage and apoptotic cell death in the murine epidermis. Read More

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Chorioamnionitis Precipitates Perinatal Alterations of Heme-Oxygenase-1 (HO-1) Homeostasis in the Developing Rat Brain.

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Department of Pediatrics, Neonatal-Perinatal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Chorioamnionitis (CHORIO), placental insufficiency, and preterm birth are well-known antecedents of perinatal brain injury (PBI). Heme-oxygenase-1 (HO-1) is an important inducible enzyme in oxidative and inflammatory conditions. In the brain, HO-1 and the iron regulatory receptor, transferrin receptor-1 (TfR1), are known to be involved in iron homeostasis, oxidative stress, and cellular adaptive mechanisms. Read More

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Mitigation of Aflatoxin B Hepatoxicity by Dietary Is Associated with Activation of NRF2/ARE Signaling in Chicks.

Antioxidants (Basel) 2021 May 30;10(6). Epub 2021 May 30.

Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.

The objective of this study was to explore the mechanism of (HD) in mediating the detoxification of aflatoxin B (AFB)-induced hepatic injury in chicks. A total of 144 one-day-old male broilers (Cobb 500) were randomly assigned to four treatment groups ( = 6 cages/diet, 6 chicks/cage). After three days of acclimation, the broilers were fed either a control diet (Control), Control plus 0. Read More

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Activation of Nrf2/HO-1 by Peptide YD1 Attenuates Inflammatory Symptoms through Suppression of TLR4/MYyD88/NF-κB Signaling Cascade.

Int J Mol Sci 2021 May 13;22(10). Epub 2021 May 13.

Department of Pharmacy, College of Pharmacy, Chosun University, Gwangju 501-759, Korea.

In this study, we investigate the immunomodulatory effects of a novel antimicrobial peptide, YD1, isolated from Kimchi, in both in vitro and in vivo models. We establish that YD1 exerts its anti-inflammatory effects via up-regulation of the Nrf2 pathway, resulting in the production of HO-1, which suppresses activation of the NF-κB pathway, including the subsequent proinflammatory cytokines IL-1β, IL-6, and TNF-α. We also found that YD1 robustly suppresses nitric oxide (NO) and prostaglandin E2 (PGE) production by down-regulating the expression of the upstream genes, iNOS and COX-2, acting as a strong antioxidant. Read More

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Clinical Significance of Heme Oxygenase 1 in Tumor Progression.

Antioxidants (Basel) 2021 May 17;10(5). Epub 2021 May 17.

Department of Experimental Medicine, University of Genoa, Via L.B. Alberti 2, 16132 Genova, Italy.

Heme oxygenase 1 (HO-1) plays a key role in cell adaptation to stressors through the antioxidant, antiapoptotic, and anti-inflammatory properties of its metabolic products. For these reasons, in cancer cells, HO-1 can favor aggressiveness and resistance to therapies, leading to poor prognosis/outcome. Genetic polymorphisms of HO-1 promoter have been associated with an increased risk of cancer progression and a high degree of therapy failure. Read More

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