1,036 results match your criteria heme hand

Heme Oxygenase-1 Induction in Human BeWo Trophoblast Cells Decreases Proliferation in Association With the Upregulation of p38 MAPK Phosphorylation and IL-6 Production.

Front Microbiol 2021 12;12:659028. Epub 2021 Apr 12.

Laboratory of Immunopathology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Brazil.

Heme oxygenase-1 (HO-1) enzyme exerts beneficial effects at the maternal-fetal interface, especially in trophoblasts, being involved in survival and maturation of these cell phenotypes. Trophoblast cells play essential roles throughout pregnancy, being the gateway for pathogens vertically transmitted, such as . It was previously shown that HO-1 activity was involved in the control of infection ; however, its contribution in trophoblast cells during infection, remain undefined. Read More

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Probing the role of Val228 on the catalytic activity of Scytalidium catalase.

Biochim Biophys Acta Proteins Proteom 2021 Apr 19;1869(8):140662. Epub 2021 Apr 19.

Department of Biology, Kocaeli University, Umuttepe, Kocaeli 41380, Turkey. Electronic address:

Scytalidium catalase is a homotetramer including heme d in each subunit. Its primary function is the dismutation of HO to water and oxygen, but it is also able to oxidase various small organic compounds including catechol and phenol. The crystal structure of Scytalidium catalase reveals the presence of three linked channels providing access to the exterior like other catalases reported so far. Read More

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Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells.

Phytomedicine 2021 May 18;85:153551. Epub 2021 Mar 18.

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China. Electronic address:

Background: Triple-negative breast cancer (TNBC), lacking targeted therapies currently, is susceptible to ferroptosis, a recently defined form of cell death.

Purpose: To evaluate the anticancer activity of Shuganning injection (SGNI), a traditional Chinese patent medicine, on TNBC cells; To elucidate the mechanism of SGNI induced ferroptosis.

Methods: The anticancer activity of SGNI was examined via in vitro cell proliferation assays and in vivo xenograft growth assay. Read More

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Role of Heme-Oxygenase-1 in Biology of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells.

Cells 2021 Mar 1;10(3). Epub 2021 Mar 1.

Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Krakow, Poland.

Heme oxygenase-1 (HO-1, encoded by ) is a cytoprotective enzyme degrading heme into CO, Fe, and biliverdin. HO-1 was demonstrated to affect cardiac differentiation of murine pluripotent stem cells (PSCs), regulate the metabolism of murine adult cardiomyocytes, and influence regeneration of infarcted myocardium in mice. However, the enzyme's effect on human cardiogenesis and human cardiomyocytes' electromechanical properties has not been described so far. Read More

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New Insights Into the Evolution of the Electron Transfer from Cytochrome f to Photosystem I in the Green and Red Branches of Photosynthetic Eukaryotes.

Plant Cell Physiol 2021 Mar 27. Epub 2021 Mar 27.

Instituto de Bioquímica Vegetal y Fotosíntesis, CSIC and Universidad de Sevilla, cicCartuja, Sevilla, Spain.

In cyanobacteria and most green algae of the eukaryotic green lineage, the copper-protein plastocyanin alternatively replaces the heme-protein cytochrome c  6 as the soluble electron carrier from cytochrome f to photosystem I. The functional and structural equivalence of "green" plastocyanin and cytochrome c  6 has been well established, representing an example of convergent evolution of two unrelated proteins. However, plants only produce plastocyanin, despite having evolved from green algae. Read More

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Dietary bisdemethoxycurcumin supplementation attenuates lipopolysaccharide-induced damages on intestinal redox potential and redox status of broilers.

Poult Sci 2021 May 19;100(5):101061. Epub 2021 Feb 19.

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:

This study was conducted to investigate the beneficial effects of bisdemethoxycurcumin (BDC) on growth performance, glutathione (GSH) redox potential, antioxidant enzyme defense, and gene expression in lipopolysaccharide (LPS)-challenged broilers. A total of 320, male, 1-day-old broilers were randomly assigned to 4 treatment groups including 8 replicates with 10 birds per cage in a 2 × 2 factorial arrangement: BDC supplementation (a basal diet with 0 or 150 mg/kg BDC) and LPS challenge (intraperitoneal injection of 1 mg/kg body weight saline or LPS at 16, 18, and 20 d of age). Results showed that dietary BDC supplementation prevented the LPS-induced decrease in ADG of broilers (P < 0. Read More

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The Changes of Leukocytes in Brain and Blood After Intracerebral Hemorrhage.

Front Immunol 2021 15;12:617163. Epub 2021 Feb 15.

Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Preclinical and clinical research has demonstrated that inflammation is a critical factor regulating intracerebral hemorrhage (ICH)-induced brain injury. Growing evidence suggests that myeloid cells and lymphocytes have an effect on the pathophysiological processes associated with ICH, such as inflammation, immune responses, perihematomal edema formation, blood-brain barrier (BBB) integrity, and cell death. However, the underlying mechanisms remain largely unknown. Read More

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February 2021

AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts.

Respir Res 2021 Feb 12;22(1):51. Epub 2021 Feb 12.

Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.

Background: Little is known on the role of transient receptor potential ankyrin 1 (TRPA1) in fibroblast-myofibroblast transition (FMT) that can lead to airway remodeling which is a major problem for severe asthma and fibrosis. Thus, this study investigated the effect of TRPA1 modulators on transforming growth factor beta 1(TGF-β1) -treated lung fibroblasts.

Methods: MRC-5 cells were preincubated with TGF-β1 for 24 h. Read More

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February 2021

Hyperbaric Oxygen Preconditioning Upregulates Heme OxyGenase-1 and Anti-Apoptotic Bcl-2 Protein Expression in Spontaneously Hypertensive Rats with Induced Postischemic Acute Kidney Injury.

Int J Mol Sci 2021 Jan 30;22(3). Epub 2021 Jan 30.

Institute for Medical Research, Department of Cardiovascular Physiology, University of Belgrade, 11129 Belgrade, Serbia.

Renal ischemia and reperfusion (I/R) injury is the most common cause of acute kidney injury (AKI). Pathogenesis of postischemic AKI involves hemodynamic changes, oxidative stress, inflammation process, calcium ion overloading, apoptosis and necrosis. Up to date, therapeutic approaches to treat AKI are extremely limited. Read More

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January 2021

Mycobacterial and Human Ferrous Nitrobindins: Spectroscopic and Reactivity Properties.

Int J Mol Sci 2021 Feb 7;22(4). Epub 2021 Feb 7.

Laboratorio Interdipartimentale di Microscopia Elettronica, Università Roma Tre, 00146 Roma, Italy.

Structural and functional properties of ferrous (-Nb) and human (-Nb) nitrobindins (Nbs) were investigated. At pH 7.0 and 25. Read More

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February 2021

Heme oxygenase‑1 improves the survival of ischemic skin flaps (Review).

Mol Med Rep 2021 04 4;23(4). Epub 2021 Feb 4.

Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

Heat shock protein 32 (Hsp32), also known as heme oxygenase‑1 (HO‑1), is an enzyme that exists in microsomes. HO‑1 can be induced by a variety of stimuli, including heavy metals, heat shock, inflammatory stimuli, heme and its derivatives, stress, hypoxia, and biological hormones. HO‑1 is the rate‑limiting enzyme of heme catabolism, which splits heme into biliverdin, carbon monoxide (CO) and iron. Read More

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Hypoxia-inducible factor (HIF): The link between obesity and COVID-19.

Obes Med 2021 Mar 30;22:100317. Epub 2020 Dec 30.

Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

The COVID-19 death toll has involved to date more than 1 million confirmed deaths. The death rate is even higher in the obese COVID-19 patients, as a result of hypoxia, due to the interplay between adipose tissue hypoxia and obstructive sleep apnea. The discrepancy of manifestations seen in COVID-19 seems to be mediated by a differential immune response rather than a differential viral load. Read More

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Thermal denaturation and autoxidation profiles of carangid fish myoglobins.

Fish Physiol Biochem 2021 Apr 30;47(2):487-498. Epub 2021 Jan 30.

Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, 980-8572, Japan.

Although myoglobin (Mb) has been considered to be one of the well-characterized proteins, screening of post-genomic era databases revealed the lack of adequate information on teleost Mbs. The present study was aimed to investigate stability and functional features of Mbs from three teleosts of the same family. To unfold how primary structure influences the stability and function of proteins, Mbs were purified from the dark muscles of three carangids, namely, yellowtail, greater amberjack, and silver trevally. Read More

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An unorthodox pathophysiology of severe cases of COVID-19 the weak heme hypothesis.

Am J Blood Res 2020 15;10(6):305-310. Epub 2020 Dec 15.

Laboratory of Cellular, Molecular, Inflammatory, Degenerative and Oncologic Pathophysiology (LCMIDOP), Faculty of Medicine and Pharmacy, Hassan II University Casablanca, Morocco.

Important amount of severe cases is the main concern in COVID-19 pandemic. It could be the running cause of the burn out of the health system in many countries. The aim of this paper is to suggest a pathophysiologic hypothesis to explain the main characteristics of severe cases of COVID-19 and its underlying conditions. Read More

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December 2020

PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from Eclipta prostrata L.

Biol Pharm Bull 2021 Mar 23;44(3):298-304. Epub 2020 Dec 23.

College of Pharmacy, Drug Research and Development Center, Daegu Catholic University.

The white-flowered leaves of Eclipta prostrata L. together with leaves of Scoparia dulcis and Cynodon dactylon are mixedly boiled in water and given to diabetic patients resulting in the significant improvement in the management of diabetes. However, the active constituents from this plant for antidiabetic and anti-obesity properties are remaining unclear. Read More

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Nephroprotective effect of exogenous hydrogen sulfide donor against cyclophosphamide-induced toxicity is mediated by Nrf2/HO-1/NF-κB signaling pathway.

Life Sci 2021 Jan 22;264:118630. Epub 2020 Oct 22.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, El-Minia, Egypt.

Aim: Cyclophosphamide (CP) is an effective anticancer and immunosuppressive agent. However, it induces nephrotoxicity that limits its use. This study explored the effect of HS, an important biological signaling molecule with a cytoprotective activity, on CP-induced nephrotoxicity. Read More

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January 2021

Vitamin D exerts neuroprotection via SIRT1/nrf-2/ NF-kB signaling pathways against D-galactose-induced memory impairment in adult mice.

Neurochem Int 2021 01 4;142:104893. Epub 2020 Nov 4.

Department of Biotechnology, Abdul Wali Khan University, Mardan, Pakistan. Electronic address:

Vitamin D (Vt. D) is one of the vital hormone having multiple functions in various tissues, including brain. Several evidences reported that Vt. Read More

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January 2021

Hormetic Effects of Binaphthyl Phosphonothioates as Pro-oxidants and Antioxidants.

Chem Res Toxicol 2020 Nov 29;33(11):2892-2902. Epub 2020 Oct 29.

Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, Gifu 501-1193, Japan.

Organophosphorous compounds with such a wide variety in structure, application, and biochemical activities include pesticides, herbicides, nerve agents, medicines, reagents in organic chemistry, and additives for polymers. Binaphthyl phosphono-, phosphorothioates, and their derivatives, are useful chiral catalysts for various asymmetric reactions and are expected to act as heavy metal scavengers. In this study, we aimed to evaluate the neurotoxicity and biochemical properties of a new series of binaphthyl phosphonothioates called KK compounds using the mouse hippocampal HT22 cells. Read More

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November 2020

A new paradigm for gaseous ligand selectivity of hemoproteins highlighted by soluble guanylate cyclase.

J Inorg Biochem 2021 Jan 16;214:111267. Epub 2020 Oct 16.

Hematology Division, Department of Internal Medicine, the University of Texas - McGovern Medical School, 6431 Fannin Street, Houston, TX 77030, United States of America. Electronic address:

Nitric oxide (NO), carbon monoxide (CO), and oxygen (O) are important physiological messengers whose concentrations vary in a remarkable range, [NO] typically from nM to several μM while [O] reaching to hundreds of μM. One of the machineries evolved in living organisms for gas sensing is sensor hemoproteins whose conformational change upon gas binding triggers downstream response cascades. The recently proposed "sliding scale rule" hypothesis provides a general interpretation for gaseous ligand selectivity of hemoproteins, identifying five factors that govern gaseous ligand selectivity. Read More

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January 2021

Seed Dormancy: Molecular Control of Its Induction and Alleviation.

Angel J Matilla

Plants (Basel) 2020 Oct 21;9(10). Epub 2020 Oct 21.

Department of Functional Biology, Life Campus, Faculty of Pharmacy, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain.

A set of seed dormancy traits is included in this Special Issue. Thus, DELAY OF GERMINATION1 (DOG1) is reviewed in depth. Binding of DOG1 to Protein Phosphatase 2C ABSCISIC ACID (PP2C ABA) Hypersensitive Germination (AHG1) and heme are independent processes, but both are essential for DOG1's function in vivo. Read More

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October 2020

Cannabinoid-Induced Autophagy and Heme Oxygenase-1 Determine the Fate of Adipose Tissue-Derived Mesenchymal Stem Cells under Stressful Conditions.

Cells 2020 10 15;9(10). Epub 2020 Oct 15.

Institute of Pharmacology and Toxicology, Rostock University Medical Center, Schillingallee 70, D-18057 Rostock, Germany.

The administration of adipose tissue-derived mesenchymal stem cells (ADMSCs) represents a promising therapeutic option after myocardial ischemia or myocardial infarction. However, their potential is reduced due to the high post-transplant cell mortality probably caused by oxidative stress and mitogen-deficient microenvironments. To identify protection strategies for ADMSCs, this study investigated the influence of the non-psychoactive phytocannabinoid cannabidiol (CBD) and the endocannabinoid analogue R(+)-methanandamide (MA) on the induction of heme oxygenase-1 (HO-1) and autophagy under serum-free conditions. Read More

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October 2020

Iron-induced peroxidation of trilinolein nano-emulsions under model gastric conditions and its inhibition by dietary phenolic antioxidants.

Food Funct 2020 Oct;11(10):9144-9156

Avignon University, INRAE, UMR408, Safety & Quality of Plant Products, 84000 Avignon, France.

An early mechanism for the health benefits of dietary plant phenols is their antioxidant activity in the upper digestive tract. Indeed, these non-essential micronutrients abundant in fruits and vegetables can efficiently fight the iron-induced peroxidation of dietary lipids in the gastric compartment, a recognized form of postprandial oxidative stress. In this work, this phenomenon is investigated through a simple model based on nano-emulsions of trilinoleylglycerol, which permits a direct spectroscopic monitoring and mechanistic insights sustained by extensive kinetic analysis. Read More

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October 2020

Aged garlic extract rescues ethephon-induced kidney damage by modulating oxidative stress, apoptosis, inflammation, and histopathological changes in rats.

Ashraf Albrakati

Environ Sci Pollut Res Int 2021 Feb 3;28(6):6818-6829. Epub 2020 Oct 3.

Department of Human Anatomy, College of Medicine, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.

Ethephon is an organophosphorus plant growth regulator used to accelerate the ripening process and decrease the duration of cultivation. Here, the potential protective role of aged garlic extract (AGE) was investigated against ethephon-mediated nephrotoxicity. Four experimental groups were established (n = 15), including control, AGE (250 mg/kg), ethephon (200 mg/kg), and AGE + ethephon. Read More

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February 2021

TLR4 Signaling by Heme and the Role of Heme-Binding Blood Proteins.

Front Immunol 2020 27;11:1964. Epub 2020 Aug 27.

Institute for Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hanover, Germany.

Toll-like receptors (TLRs), also known as pattern recognition receptors, respond to exogenous pathogens and to intrinsic danger signals released from damaged cells and tissues. The tetrapyrrole heme has been suggested to be an agonist for TLR4, the receptor for the pro-inflammatory bacterial component lipopolysaccharide (LPS), synonymous with endotoxin. Heme is a double-edged sword with contradictory functions. Read More

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Heme on Pulmonary Malaria: Friend or Foe?

Front Immunol 2020 25;11:1835. Epub 2020 Aug 25.

Laboratory of Applied Pharmacology, Institute of Drug Technology (Farmanguinhos), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Malaria is a hemolytic disease that, in severe cases, can compromise multiple organs. Pulmonary distress is a common symptom observed in severe malaria caused by or . However, biological components involved in the development of lung malaria are poorly studied. Read More

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Ru(II)-diimine complexes and cytochrome P450 working hand-in-hand.

J Inorg Biochem 2020 12 12;213:111254. Epub 2020 Sep 12.

San José State University, Department of Chemistry, One Washington Square, San José, CA 95192-0101, USA. Electronic address:

With a growing interest in utilizing visible light to drive biocatalytic processes, several light-harvesting units and approaches have been employed to harness the synthetic potential of heme monooxygenases and carry out selective oxyfunctionalization of a wide range of substrates. While the fields of cytochrome P450 and Ru(II) photochemistry have separately been prolific, it is not until the turn of the 21st century that they converged. Non-covalent and subsequently covalently attached Ru(II) complexes were used to promote rapid intramolecular electron transfer in bacterial P450 enzymes. Read More

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December 2020

Cannabidiol Promotes Endothelial Cell Survival by Heme Oxygenase-1-Mediated Autophagy.

Cells 2020 07 16;9(7). Epub 2020 Jul 16.

Institute of Pharmacology and Toxicology, Rostock University Medical Center, Schillingallee 70, D-18057 Rostock, Germany.

Cannabidiol (CBD), a non-psychoactive cannabinoid, has been reported to mediate antioxidant, anti-inflammatory, and anti-angiogenic effects in endothelial cells. This study investigated the influence of CBD on the expression of heme oxygenase-1 (HO-1) and its functional role in regulating metabolic, autophagic, and apoptotic processes of human umbilical vein endothelial cells (HUVEC). Concentrations up to 10 µM CBD showed a concentration-dependent increase of HO-1 mRNA and protein and an increase of the HO-1-regulating transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). Read More

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Preconditioning with L-Ala-Gln reduces the expression of inflammatory markers (TNF-α, NF-κB, IL-6 and HO-1) in an injury animal model of cerebrovascular ischemia in Meriones unguiculatus (gerbils).

Acta Cir Bras 2020 20;35(6):e202000601. Epub 2020 Jul 20.

Department of Medical Surgical Science, UFC, Fortaleza, CE, Brazil.

Purpose To evaluate the neuroprotective effect of L-alanyl-glutamine in a gerbil model of brain ischemia-reperfusion injury based on immunohistochemical quantification of pro-inflammatory and cell activation biomarkers (TNF-α, NF-κB, IL-6 and HO-1). Methods Male gerbils weighing 100-180 g were pretreated with either 0.75 g/kg L-Ala-Gln (n=18) or 2. Read More

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Flipped regiospecificity in L434F mutant of 8-lipoxygenase.

Phys Chem Chem Phys 2020 Jul;22(28):16013-16022

Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, 721302, India.

Lipoxygenases are non-heme iron containing enzymes that catalyze oxygenation of poly-unsaturated fatty acids in different animal and plant species with extremely high regio- and stereospecificity. Nature employs 8-lipoxygenase to produce 8R-hydroperoxide from the oxygenation of arachidonic acid. A single-point L434F mutation of 8-lipoxygenase alters the regio- and stereospecificity of the final products, with a product ratio of 66 : 34 for 8R- and 12S-hydroperoxide, respectively. Read More

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