56,458 results match your criteria heme


Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Tumor Necrosis Factor Alpha Protein (TNF-α), Heme Oxygenase-1 (HO-1) Gene Expressions during Cardiopulmonary Bypass.

Gene 2021 May 4:145690. Epub 2021 May 4.

Medical Promotion and Marketing Program, Health Services Vocational School, Harran University, Department of Biochemistry, Medical Faculty, Harran University, Şanlıurfa, Turkey. Electronic address:

View Article and Full-Text PDF

Seed 'primeomics': plants memorize their germination under stress.

Biol Rev Camb Philos Soc 2021 May 7. Epub 2021 May 7.

Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Mumbai, 400085, India.

Seed priming is a pre-germination treatment administered through various chemical, physical and biological agents, which induce mild stress during the early phases of germination. Priming facilitates synchronized seed germination, better seedling establishment, improved plant growth and enhanced yield, especially in stressful environments. In parallel, the phenomenon of 'stress memory' in which exposure to a sub-lethal stress leads to better responses to future or recurring lethal stresses has gained widespread attention in recent years. Read More

View Article and Full-Text PDF

Biochanin A Mitigates Atherosclerosis by Inhibiting Lipid Accumulation and Inflammatory Response.

Oxid Med Cell Longev 2020 11;2020:8965047. Epub 2020 Nov 11.

Department of Pathophysiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032 Anhui, China.

Biochanin A (BCA), a dietary isoflavone extracted from red clover and cabbage, has been shown to antagonize hypertension and myocardial ischemia/reperfusion injury. However, very little is known about its role in atherogenesis. The aim of this study was to observe the effects of BCA on atherosclerosis and explore the underlying mechanisms. Read More

View Article and Full-Text PDF
November 2020

Architecture of the membrane-bound cytochrome c heme lyase CcmF.

Nat Chem Biol 2021 May 6. Epub 2021 May 6.

Institut für Biochemie, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.

The covalent attachment of one or multiple heme cofactors to cytochrome c protein chains enables cytochrome c proteins to be used in electron transfer and redox catalysis in extracytoplasmic environments. A dedicated heme maturation machinery, whose core component is a heme lyase, scans nascent peptides after Sec-dependent translocation for CXCH-binding motifs. Here we report the three-dimensional (3D) structure of the heme lyase CcmF, a 643-amino acid integral membrane protein, from Thermus thermophilus. Read More

View Article and Full-Text PDF

Role of Ingestible Carotenoids in Skin Protection: A Review of Clinical Evidence.

Photodermatol Photoimmunol Photomed 2021 May 5. Epub 2021 May 5.

IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.

Carotenoids, a class of phytonutrients, have been well established to boost skin's innate resistance against Ultraviolet (UV) B-induced erythema (sunburn). Many of the published clinical studies thus far have focused on measurement of erythema as the primary clinical indicator of skin protection against UVB radiation. More recent studies have shown that carotenoid supplementation provides even more skin protection than previously shown as new clinical and molecular endpoints beyond UVB-induced erythema have been reported. Read More

View Article and Full-Text PDF

Pulmonary toxicity of actual alveolar deposition concentrations of ultrafine particulate matters in human normal bronchial epithelial cell.

Environ Sci Pollut Res Int 2021 May 5. Epub 2021 May 5.

Department of Biotechnology, National Formosa University, Yunlin, 63208, Taiwan.

Air pollution is a major worldwide concern, and exposure to particulate matter (PM) can increase the risks of pulmonary diseases. Normal human bronchial epithelial cells were applied to clarify the role of ultrafine PM (UFPM) in the pathogenesis of pulmonary toxic effects with realistic alveolar deposition doses. The UFPM used in this research originated from vehicular emissions and coal combustion. Read More

View Article and Full-Text PDF

Oral Administration of Gintonin Protects the Brains of Mice against A-Induced Alzheimer Disease Pathology: Antioxidant and Anti-Inflammatory Effects.

Oxid Med Cell Longev 2021 16;2021:6635552. Epub 2021 Apr 16.

Division of Life Science and Applied Life Science (BK21 FOUR), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.

The study was aimed at analyzing the protective effects of gintonin in an amyloid beta- (A-) induced Alzheimer's disease (AD) mouse model. For the development of the A-induced AD mouse model, the amyloid- (A) peptide was stereotaxically injected into the brains of mice. Subsequently, gintonin was administered at a dose of 100 mg/kg/day/per oral (p. Read More

View Article and Full-Text PDF

Tauroursodeoxycholic acid alleviates pulmonary endoplasmic reticulum stress and epithelial-mesenchymal transition in bleomycin-induced lung fibrosis.

BMC Pulm Med 2021 May 5;21(1):149. Epub 2021 May 5.

Second Affiliated Hospital, Anhui Medical University, Hefei, 230032, China.

Background: Several studies demonstrate that endoplasmic reticulum (ER) stress-mediated epithelial-mesenchymal transition (EMT) is involved in the process of bleomycin (BLM)-induced pulmonary fibrosis. Tauroursodeoxycholic acid (TUDCA), a bile acid with chaperone properties, is an inhibitor of ER stress. This study aimed to investigate the preventive effects of TUDCA on BLM-induced EMT and lung fibrosis. Read More

View Article and Full-Text PDF

Neurovascular Interactions in Malaria.

Neuroimmunomodulation 2021 May 5:1-10. Epub 2021 May 5.

Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Fiocruz, Rio de Janeiro, Brazil.

Malaria is caused by Plasmodium infection and remains a serious public health problem worldwide, despite control efforts. Malaria can progress to severe forms, affecting multiple organs, including the brain causing cerebral malaria (CM). CM is the most severe neurological complication of malaria, and cognitive and behavior deficits are commonly reported in surviving patients. Read More

View Article and Full-Text PDF

Vitamin D deficiency exacerbates hepatic oxidative stress and inflammation during acetaminophen-induced acute liver injury in mice.

Int Immunopharmacol 2021 May 2;97:107716. Epub 2021 May 2.

First Affiliated Hospital, Anhui Medical University, Hefei 230032, China. Electronic address:

Several experiments confirmed that vitamin D3 protected against acetaminophen (APAP)-induced acute liver injury (ALI). This research aimed to evaluate the influence of vitamin D deficiency (VDD) on APAP-induced ALI. In VDD and VDD + APAP groups, mice were fed with VDD diet. Read More

View Article and Full-Text PDF

Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway.

CNS Neurosci Ther 2021 May 5. Epub 2021 May 5.

Department of Orthopedics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

Aim: Spinal cord injury (SCI) involves multiple pathological processes. Ferroptosis has been shown to play a critical role in the injury process. We wanted to explore whether zinc can inhibit ferroptosis, reduce inflammation, and then exert a neuroprotective effect. Read More

View Article and Full-Text PDF

Structural studies of hemoglobin from two flightless birds, ostrich and turkey: insights into their differing oxygen-binding properties.

Acta Crystallogr D Struct Biol 2021 May 26;77(Pt 5):690-702. Epub 2021 Apr 26.

Centre of Advanced Study in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai 600 025, India.

Crystal structures of hemoglobin (Hb) from two flightless birds, ostrich (Struthio camelus) and turkey (Meleagris gallopova), were determined. The ostrich Hb structure was solved to a resolution of 2.22 Å, whereas two forms of turkey Hb were solved to resolutions of 1. Read More

View Article and Full-Text PDF

β-Oxochlorin cobalt(II) complexes catalyze the electrochemical reduction of CO.

Chem Commun (Camb) 2021 May;57(36):4396-4399

Department of Chemistry, University of Connecticut, 55 N. Eagleville Road, Storrs, CT 06269, USA. and Institute of Materials Science, University of Connecticut, 97 N. Eagleville Road, Storrs, CT 06269, USA.

Inspired by the architecture of the macrocycle of heme d1, a series of synthetic mono-, di- and tri-β-oxo-substituted porphyrinoid cobalt(ii) complexes were evaluated as electrocatalytic CO2 reducers, identifying complexes of unusually high efficiencies in generating multi-electron reduction products, including CH4. Read More

View Article and Full-Text PDF

Absorption of non-heme iron during gastric acid suppression in patients with hereditary hemochromatosis and healthy controls.

Am J Physiol Gastrointest Liver Physiol 2021 May 5. Epub 2021 May 5.

Department of Internal Medicine, Gastroenterology and Clinical Geriatrics, Zuyderland Medisch Centrum, Netherlandsgrid.416905.f.

Phlebotomies are performed in hereditary hemochromatosis (HH) to maintain normal iron concentrations. Proton pump inhibitors (PPIs) can reduce the number of phlebotomies in HH patients. However, in patients without HH, the iron concentrations do not appear to be compromised when using PPIs. Read More

View Article and Full-Text PDF

Divergent Cytochrome Maturation System in Kinetoplastid Protists.

mBio 2021 05 4;12(3). Epub 2021 May 4.

School of Applied Sciences, University of Huddersfield, Huddersfield, United Kingdom

In eukaryotes, heme attachment through two thioether bonds to mitochondrial cytochromes and is catalyzed by either multisubunit cytochrome maturation system I or holocytochrome synthetase (HCCS). The former was inherited from the alphaproteobacterial progenitor of mitochondria; the latter is a eukaryotic innovation for which prokaryotic ancestry is not evident. HCCS provides one of a few exemplars of protein innovation in eukaryotes, but structure-function insight of HCCS is limited. Read More

View Article and Full-Text PDF

A hafnium-based metal-organic framework for the entrapment of molybdenum hexacarbonyl and the light-responsive release of the gasotransmitter carbon monoxide.

Mater Sci Eng C Mater Biol Appl 2021 May 25;124:112053. Epub 2021 Mar 25.

CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal. Electronic address:

A carbon monoxide-releasing material (CORMA) has been prepared by inclusion of molybdenum hexacarbonyl in a hafnium-based metal-organic framework (MOF) with the UiO-66 architecture. Mo(CO) was adsorbed from solution to give supported materials containing 6.0-6. Read More

View Article and Full-Text PDF

Enigmatic Evolutionary History of Porphobilinogen Deaminase in Eukaryotic Phototrophs.

Biology (Basel) 2021 Apr 29;10(5). Epub 2021 Apr 29.

Biology Centre CAS, Institute of Parasitology, Branišovská 31, 370 05 České Budějovice, Czech Republic.

In most eukaryotic phototrophs, the entire heme synthesis is localized to the plastid, and enzymes of cyanobacterial origin dominate the pathway. Despite that, porphobilinogen deaminase (PBGD), the enzyme responsible for the synthesis of hydroxymethybilane in the plastid, shows phylogenetic affiliation to α-proteobacteria, the supposed ancestor of mitochondria. Surprisingly, no PBGD of such origin is found in the heme pathway of the supposed partners of the primary plastid endosymbiosis, a primarily heterotrophic eukaryote, and a cyanobacterium. Read More

View Article and Full-Text PDF

Arsenicals, the Integrated Stress Response, and Epstein-Barr Virus Lytic Gene Expression.

Viruses 2021 04 30;13(5). Epub 2021 Apr 30.

Departments of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Following our observation that clofoctol led to Epstein-Barr virus (EBV) lytic gene expression upon activation of the integrated stress response (ISR), we decided to investigate the impact of AsO on viral lytic gene expression. AsO has also been reported to activate the ISR pathway by its activation of the heme-regulated inhibitor (HRI). Our investigations show that AsO treatment leads to eIF2α phosphorylation, upregulation of ATF4 and TRB3 expression, and an increase of EBV Zta gene expression in lymphoid tumor cell lines as well as in naturally infected epithelial cancer cell lines. Read More

View Article and Full-Text PDF

Falls Prevention and Quality of Life Improvement by Square Stepping Exercise in People with Parkinson's Disease: Project Report.

J Pers Med 2021 Apr 30;11(5). Epub 2021 Apr 30.

HEME Research Group, Faculty of Sport Science, University of Extremadura, 10003 Cáceres, Spain.

Parkinson's disease (PD) is a chronic neurodegenerative disorder that affects physical, psychological, and social quality of life. Square Stepping Exercise (SSE) is an effective balance training program to prevent falls and to stimulate cognitive function in the elderly; however, no study has analyzed the effect of SSE in people with PD. The main objective is to investigate whether the application of SSE is safe, applicable, and can improve balance, and is effective in preventing falls, improving cognitive and psychological aspects and thus maximize quality of life in people with PD. Read More

View Article and Full-Text PDF

Nanosized non-proteinaceous complexes III and IV mimicking electron transfer of mitochondrial respiratory chain.

J Colloid Interface Sci 2021 Apr 17;599:198-206. Epub 2021 Apr 17.

São Carlos Institute of Chemistry, University of São Paulo, São Carlos 13560-970, Brazil. Electronic address:

Synthetic biology pursues the understanding of biological processes and their possible mimicry with artificial bioinspired materials. A number of materials have already been used to mimic the active site of simple redox proteins, including nanosized iron oxides due to their redox properties. However, the mimicry of membrane redox protein complexes is still a challenge. Read More

View Article and Full-Text PDF

CD47 blocking antibody accelerates hematoma clearance and alleviates hydrocephalus after experimental intraventricular hemorrhage.

Neurobiol Dis 2021 May 1;155:105384. Epub 2021 May 1.

Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Background CD47, a glycoprotein on red blood cell membranes, inhibits phagocytosis via interaction with signal regulatory protein α on phagocytes. Our previous research has demonstrated that blocking CD47 accelerates hematoma clearance and reduces brain injury after intracerebral hemorrhage. The current study investigated whether phagocytosis or erythrocyte CD47 impacts hematoma resolution and hydrocephalus development after intraventricular hemorrhage (IVH). Read More

View Article and Full-Text PDF

Animal-free heme production for artificial meat in Corynebacterium glutamicum via systems metabolic and membrane engineering.

Metab Eng 2021 May 1. Epub 2021 May 1.

Department of Biotechnology, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

Recently, heme has attracted much attention as a main ingredient that mimics meat flavor in artificial meat in the food industry. Here, we developed Corynebacterium glutamicum capable of high-yield production of heme with systems metabolic engineering and modification of membrane surface. The combination of two precursor pathways based on thermodynamic information increased carbon flux toward heme and porphyrin intermediate biosynthesis. Read More

View Article and Full-Text PDF

Trends in childhood cancer incidence in sub-Saharan Africa: Results from 25 years of cancer registration in Harare (Zimbabwe) and Kyadondo (Uganda).

Int J Cancer 2021 May 4. Epub 2021 May 4.

Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

We examined trends in childhood cancer incidence in sub-Saharan Africa using data from two population-based cancer registries in Harare (Zimbabwe) and Kyadondo (Uganda) with cases classified according to the International Classification of Childhood Cancer and explored reasons for observed variations and changes. Over the whole 25-year period (1991-2015) studied, there were only small, and non-significant overall trends in incidence. Nevertheless, within the period, peaks in incidence occurred from 1996-2001 in Harare (Zimbabwe) and from 2003-2006 in Kyadondo (Uganda). Read More

View Article and Full-Text PDF

Conformational distortion in a fibril-forming oligomer arrests alpha-Synuclein fibrillation and minimizes its toxic effects.

Commun Biol 2021 May 3;4(1):518. Epub 2021 May 3.

Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.

The fibrillation pathway of alpha-Synuclein, the causative protein of Parkinson's disease, encompasses transient, heterogeneous oligomeric forms whose structural understanding and link to toxicity are not yet understood. We report that the addition of the physiologically-available small molecule heme at a sub-stoichiometric ratio to either monomeric or aggregated α-Syn, targets a His50 residue critical for fibril-formation and stabilizes the structurally-heterogeneous populations of aggregates into a minimally-toxic oligomeric state. Cryo-EM 3D reconstruction revealed a 'mace'-shaped structure of this monodisperse population of oligomers, which is comparable to a solid-state NMR Greek key-like motif (where the core residues are arranged in parallel in-register sheets with a Greek key topology at the C terminus) that forms the fundamental unit/kernel of protofilaments. Read More

View Article and Full-Text PDF

Anna Karenina and the subgingival microbiome associated with periodontitis.

Microbiome 2021 04 30;9(1):97. Epub 2021 Apr 30.

Division of Periodontology, College of Dentistry, The Ohio State University, 3180 Postle Hall, 305 W 12th Avenue, Columbus, OH, 43210, USA.

Background: Although localized aggressive periodontitis (LAP), generalized aggressive periodontitis (GAP), and chronic periodontitis (CP) are microbially driven diseases, our inability to separate disease-specific associations from those common to all three forms of periodontitis has hampered biomarker discovery. Therefore, we aimed to map the genomic content of, and the biological pathways encoded by, the microbiomes associated with these clinical phenotypes. We also estimated the extent to which these biomes are governed by the Anna Karenina principle (AKP), which states that eubiotic communities are similar between individuals while disease-associated communities are highly individualized. Read More

View Article and Full-Text PDF

Iron-driven alterations on red blood cell-derived microvesicles amplify coagulation during hemolysis via the intrinsic tenase complex.

Thromb Haemost 2021 May 3. Epub 2021 May 3.

Department of Immunopathology, Sanquin-AMC Landsteiner Laboratory, Amsterdam, Netherlands.

Hemolytic disorders characterized by complement-mediated intravascular hemolysis, such as autoimmune hemolytic anemia and paroxysmal nocturnal hemoglobinuria, are often complicated by life-threatening thromboembolic complications. Severe hemolytic episodes result in the release of red blood cell (RBC)-derived pro-inflammatory and oxidatively reactive mediators (e.g. Read More

View Article and Full-Text PDF

Protective Effect of Pre-treatment Against Experimental Cerebral Ischemia Injury via Regulating GSK-3β/HO-1 Pathway.

Front Pharmacol 2021 16;12:640297. Epub 2021 Apr 16.

Department of Biology, Faculty of Science, Hong Kong Baptist University (HKBU), Hong Kong Special Administrative Region (HKSAR), Kowloon Tong, China.

() a famous formula in traditional Chinese medicine, has been clinically used for centuries for treating cerebral diseases, but the protective effects of pre-treatment with on cerebral ischemia have not yet been reported. The present study aimed to test such protective effects and elucidate the underlying mechanisms on cerebral ischemia in rats by phenotypic approaches (i.e. Read More

View Article and Full-Text PDF

Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection.

Arch Virol 2021 May 2. Epub 2021 May 2.

Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran.

The SARS-CoV-2 pandemic has become one of the most serious health concerns globally. Although multiple vaccines have recently been approved for the prevention of coronavirus disease 2019 (COVID-19), an effective treatment is still lacking. Our knowledge of the pathogenicity of this virus is still incomplete. Read More

View Article and Full-Text PDF

MicroRNA-760 resists ambient PM-induced apoptosis in human bronchial epithelial cells through elevating heme-oxygenase 1 expression.

Environ Pollut 2021 Apr 23;284:117213. Epub 2021 Apr 23.

School of Public Health, Qingdao University, Qingdao, China. Electronic address:

PM (particles matter smaller aerodynamic diameter of 2.5 μm) exposure, a major environmental risk factor for the global burden of diseases, is associated with high risks of respiratory diseases. Heme-oxygenase 1 (HMOX1) is one of the major molecular antioxidant defenses to mediate cytoprotective effects against diverse stressors, including PM-induced toxicity; however, the regulatory mechanism of HMOX1 expression still needs to be elucidated. Read More

View Article and Full-Text PDF

Correlation of Key Physiological Properties of Isolates with Environment of Origin.

Appl Environ Microbiol 2021 Apr 30. Epub 2021 Apr 30.

Department of Microbiology, University of Massachusetts-Amherst, Amherst, MA, USA.

It is known that the physiology of species can differ significantly, but the ecological impact of these differences is unclear. We recovered two strains of from two different ecosystems with a similar enrichment and isolation method. Both strains had the same ability to metabolize organic substrates and participate in direct interspecies electron transfer, but also had major physiological differences. Read More

View Article and Full-Text PDF