J Tradit Chin Med 2021 Jun;41(3):455-462
Institute of Internal medicine, Huangjiahu Hospital of Hubei University of Traditional Chinese Medicine, Wuhan 430065, China.
Objective: To investigate the protective efficacy of electroacupuncture (EA) pretreatment at Neiguan (PC6) on myocardial ischemia-reperfusion (I/R) in rats.
Methods: Fifty rats were randomly divided into five groups (n = 10): sham operation group, model group (underwent in vivo myocardial I/R), EA pretreatment group [EA at Neiguan (PC 6) 1 week before I/R], wortmannin group (1 week before I/R, the PI3K inhibitor, wortmannin, was injected), EA pretreatment + wortmannin group (both pretreatments were performed simultaneously). After establishing the I/R model, 2,3,5-triphenyltetrazolium chloride (TTC) staining was used to analyze the weight and area of the myocardial infarction tissue. Read More