Front Cell Neurosci 2018 5;12:182. Epub 2018 Jul 5.
Center for Interdisciplinary Research in Biology (CIRB), College de France, INSERM U1050, CNRS UMR7241, Paris Sciences et Lettres Research University, Paris, France.
Synaptic efficacy changes, long-term potentiation (LTP) and depression (LTD), underlie various forms of learning and memory. Synaptic plasticity is generally assessed under prolonged activation, whereas learning can emerge from few or even a single trial. Here, we investigated the existence of rapid responsiveness of synaptic plasticity in response to a few number of spikes, in neocortex in a synaptic Hebbian learning rule, the spike-timing-dependent plasticity (STDP). Read More