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Comparison of Three Different Cord Clamping Techniques Regarding Oxidative-antioxidative Capacity in Term Newborns.

Am J Perinatol 2022 Jan 13. Epub 2022 Jan 13.

Biochemistry, Gaziantep University, Gaziantep, Turkey.

Objective As newborns are exposed to oxidative stress during delivery, cord clamping techniques play significant role on antioxidant status. In this study, we aimed to show the relationship between early cord clamping (ECC), delayed cord clamping (DCC) and cut umblical cord milking (C-UCM) techniques with total oxidant capacity (TOC), total antioxidant capacity (TAC) and peroxynitrite levels. Study Design Sixty-nine term infants were selected with APGAR score of 7 and above in the first and fifth minutes. Read More

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January 2022

Structure, Barrier Function, and Bioactivity of Platelet-Rich Fibrin Following Thermal Processing.

Tissue Eng Part C Methods 2021 11;27(11):605-615

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

Platelet-rich fibrin (PRF) has been utilized as a substitute for resorbable membranes during guided bone regeneration therapy as it is a more bioactive biomaterial with living cells and growth factors than resorbable membranes. Nevertheless, PRF poses obvious disadvantages in its mechanical strength since its rapid degradability has been shown to typically resorb within a 2-week time period. In the present study, the barrier function and biological and mechanical properties of PRF were investigated both as standard therapy and after thermal processing. Read More

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November 2021

Impact of Airway Humidification Strategy in the Mechanically Ventilated COVID-19 Patients.

Respir Care 2021 Oct 20. Epub 2021 Oct 20.

centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec City, Canada.

Background: Humidification of inspiratory gases is mandatory in all mechanically ventilated patients in ICUs, either with heated humidifiers (HHs) or with heat and moisture exchangers (HMEs). In patients with COVID-19, the choice of the humidification device may have relevant impact on patients' management as demonstrated in recent studies. We reported data from 2 ICUs using either HME or HH. Read More

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October 2021

Effects of Changes in Body Temperature on Perioperative Bleeding in Adolescent Idiopathic Scoliosis Surgery.

Ther Hypothermia Temp Manag 2021 Oct 18. Epub 2021 Oct 18.

Department of Anesthesiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Perioperative bleeding is a critical challenge in adolescent idiopathic scoliosis (AIS) surgery. Preventing hypothermia is associated with decreased development of coagulopathy, blood transfusion rate in various surgery groups. We hypothesized that blood loss would be reduced in patients who were kept normothermic by implementation of aggressive warming methods in AIS. Read More

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October 2021

Mycobacterium chimaera Outbreak Management and Outcomes at a Large Pediatric Cardiac Surgery Center.

Ann Thorac Surg 2021 Aug 26. Epub 2021 Aug 26.

Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: In 2012, a global outbreak of invasive Mycobacterium chimaera (M. chimaera) infection was identified in patients after cardiopulmonary bypass surgery. Investigations revealed the source to be heater-cooler unit (HCU) exhaust, with point-source contamination discovered at the LivaNova HCU manufacturing plant (London, UK). Read More

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Updated Experience of Infection: Diagnosis and Management in a Tertiary Care Center.

Open Forum Infect Dis 2021 Aug 1;8(8):ofab348. Epub 2021 Jul 1.

Department of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.

Background: Despite safety communications from the Food and Drug Administration (FDA) regarding the outbreak of infections (MCIs) from contaminated heater-cooler devices, new cases continue to be identified.

Methods: We retrospectively reviewed confirmed cases of MCI that were managed at Mayo Clinic sites (Arizona, Florida, and Minnesota) from 09/2015 to 01/2021. Clinical histories including prior cardiovascular surgery were recorded. Read More

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Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis.

Elife 2021 07 13;10. Epub 2021 Jul 13.

Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, Australia.

The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-stimulated recruitment of Akt to the plasma membrane has previously been reported, which is indicative of negative feedback operating on acute timescales. Here, we show that Akt itself engages this negative feedback by phosphorylating insulin receptor substrate (IRS) 1 and 2 on a number of residues. Read More

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Breast tumor parameter estimation and interactive 3D thermal tomography using discrete thermal sensor data.

Biomed Phys Eng Express 2020 12 8;7(1). Epub 2020 Dec 8.

Centre for Materials for Electronics Technology (C-MET), Thrissur, Kerala, India.

This work uses a simple low-cost wearable device embedded with discrete thermal sensors to map the breast skin surface temperature. A methodology has been developed to estimate diameter, blood perfusion, metabolic heat generation and location in X, Y, Z coordinate of tumor from this discrete set of data. An interactive 3D thermal tomography was developed which provides a detailed 3D thermal view of the breast anatomy. Read More

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December 2020

ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding.

Am J Gastroenterol 2021 05;116(5):899-917

Division of Gastroenterology and Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

We performed systematic reviews addressing predefined clinical questions to develop recommendations with the GRADE approach regarding management of patients with overt upper gastrointestinal bleeding. We suggest risk assessment in the emergency department to identify very-low-risk patients (e.g. Read More

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Rare gastric neoplasm: Malignant glomus tumor of the stomach. A case report.

Int J Surg Case Rep 2021 Apr 23;81:105802. Epub 2021 Mar 23.

Department of General Surgery, Qatif Central Hospital, Qatif, Saudi Arabia.

Introduction: Glomus tumors are rare neoplasms that aris-e from neuromyoarterial canal or glomus body. They are mainly found in the peripheral soft tissue, extremities and rarely developed inside the gastrointestinal tract. In the gastrointestinal tract, the stomach is the most common site for the development of glomus tumors, and most often found in the antrum. Read More

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Rapid Characterization of Drugs in Biological Fluid and Seized Material Using Thermal-Assisted Carbon Fiber Ionization Mass Spectrometry.

J Am Soc Mass Spectrom 2021 Apr 28;32(4):969-976. Epub 2021 Mar 28.

Department of Forensic Toxicology, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.

Developing a rapid, simple, and sensitive method to analyze drugs is critical to forensic research study because of the widespread occurrence of the matrix effect. Herein, we develop a method using thermal-assisted carbon fiber ionization mass spectrometry that can be used to directly analyze drugs in biological fluid. The key feature of this technique is that the biological samples such as urine and blood can be achieved online as precipitated protein on the carbon fiber tip and thermally desorbed by the metal ceramics heater, which can reduce the matrix effects and improve the sensitivity. Read More

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HDAC3 inhibitor RGFP966 controls bacterial growth and modulates macrophage signaling during Mycobacterium tuberculosis infection.

Tuberculosis (Edinb) 2021 03 18;127:102062. Epub 2021 Feb 18.

Department of Medicine, University of Washington, Seattle, WA, USA.

Rationale: Host-directed therapeutics for Mycobacterium tuberculosis (Mtb) offer potential strategies for combatting antibiotic resistance and for killing non-replicating bacilli. Phenylbutyrate, a partially selective histone-deacetylase (HDAC) inhibitor, was previously shown to control Mtb growth and alter macrophage inflammatory pathways at 2-4 mM concentrations.

Objective: To identify a more potent and selective HDAC inhibitor that modulates macrophage responses to mycobacteria and has direct antibacterial effects against Mtb. Read More

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Correlation of Treatment of Peptic Ulcer Bleeding by Argon Plasma Coagulation (APC) via Contact Heat Probe Method (heater probe) with Epinephrine Injection.

Middle East J Dig Dis 2020 Oct;12(4):271-277

Associate Professor, Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

BACKGROUND This clinical investigation aimed to compare the efficacy of treatment of peptic ulcer hemorrhage by argon plasma coagulation (APC) via contact heat probe method (heater probe) along with epinephrine injection. METHODS 100 patients who underwent endoscopic treatment, were randomly divided into two groups consisting of 50 patients each. In the first group, an intervention was performed using foot pedal and 2. Read More

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October 2020

Temperature induced changes in the optical properties of skin in vivo.

Sci Rep 2021 01 12;11(1):754. Epub 2021 Jan 12.

Advanced Biophotonics Laboratory, University of Massachusetts Lowell, 175 Cabot Street, Lowell, MA, 01854, USA.

Knowledge of temperature-induced changes of skin optical properties is required for accurate dosimetry of photothermal treatments. We determined and compared in vivo optical properties of mouse ear skin at different temperatures. The diffuse reflectance, total and diffuse transmittance were measured in the spectral range from 400 to 1650 nm using an integrating sphere spectrometer at the temperatures of 25 °C, 36 °C and 60 °C. Read More

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January 2021

A Multi-Mode System for Myocardial Functional and Physiological Assessment during Ex Situ Heart Perfusion.

J Extra Corpor Technol 2020 Dec;52(4):303-313

Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Ex situ heart perfusion (ESHP) has proven to be an important and valuable step toward better preservation of donor hearts for heart transplantation. Currently, few ESHP systems allow for a convenient functional and physiological evaluation of the heart. We sought to establish a simple system that provides functional and physiological assessment of the heart during ESHP. Read More

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December 2020

Compressed Air-Driven Continuous-Flow Thermocycled Digital PCR for HBV Diagnosis in Clinical-Level Serum Sample Based on Single Hot Plate.

Molecules 2020 Nov 30;25(23). Epub 2020 Nov 30.

State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China.

We report a novel compressed air-driven continuous-flow digital PCR (dPCR) system based on a 3D microfluidic chip and self-developed software system to realize real-time monitoring. The system can ensure the steady transmission of droplets in long tubing without an external power source and generate stable droplets of suitable size for dPCR by two needles and a narrowed Teflon tube. The stable thermal cycle required by dPCR can be achieved by using only one constant temperature heater. Read More

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November 2020

Characteristics of clinical extrapulmonary nontuberculous mycobacteria isolates in Minnesota, 2013-2017.

Minn Med 2020 Jun;103(3):39-43

Minnesota Department of Health.

Approximately 80 species of nontuberculous mycobacteria (NTM) that cause disease are found environmentally and in animal reservoirs. Typically, pulmonary NTM infections are sporadic; extrapulmonary NTM (ENTM) infections are commonly outbreak associated. Recent sources of ENTM outbreaks in Minnesota include contaminated heater-cooler units used during cardiac surgery and contaminated hormone injections. Read More

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Mediastinal tissue friability-An unreported complication from Mycobacterium chimaera infection post-cardiac surgery.

J Card Surg 2020 Nov 2;35(11):3191-3194. Epub 2020 Aug 2.

Georgetown University School of Medicine, Washington, District of Columbia.

Mycobacterium chimaera can cause disseminated infection following cardiac surgery with cardiopulmonary bypass and contaminated heater-cooler devices. We discuss a 41-year-old man with a disseminated M. chimaera infection following surgery for a type A aortic dissection. Read More

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November 2020

Invasive Mycobacterium abscessus Complex Infection After Cardiac Surgery: Epidemiology, Management, and Clinical Outcomes.

Clin Infect Dis 2021 04;72(7):1232-1240

Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.

Background: We recently mitigated a clonal outbreak of hospital-acquired Mycobacterium abscessus complex (MABC), which included a large cluster of adult patients who developed invasive infection after exposure to heater-cooler units during cardiac surgery. Recent studies have detailed Mycobacterium chimaera infections acquired during cardiac surgery; however, little is known about the epidemiology and clinical courses of cardiac surgery patients with invasive MABC infection.

Methods: We retrospectively collected clinical data on all patients who underwent cardiac surgery at our hospital and subsequently had positive cultures for MABC from 2013 through 2016. Read More

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Wash-Free, Digital Immunoassay in Polydisperse Droplets.

Anal Chem 2020 03 12;92(5):3535-3543. Epub 2020 Feb 12.

Center for In Vitro Diagnostics, Intellectual Ventures Laboratory, Bellevue, Washington 98007, United States.

Immunoassays are important for the detection of proteins to enable disease identification and monitor treatment, but many immunoassays suffer from sensitivity limitations. The development of digital assays has enabled highly sensitive biomarker detection and quantification, but the necessary devices typically require precisely controlled volumes to reduce biases in concentration estimates from compartment size variation. These constraints have led to systems that are often expensive, cumbersome, and challenging to operate, confining many digital assays to centralized laboratories. Read More

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Evaluation of the immunobiological effects of a regenerative far-infrared heating system in pigs.

J Vet Sci 2019 Nov;20(6):e61

Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.

Thermal conditions are an important environmental factor in maintaining healthy pigs because they affect feed intake, growth efficiency, reproduction and immune responses in pigs. RAVI, a regenerative far-infrared heating system, can effect pig production by emitting an optimal far-infrared wavelength. Far-infrared radiation has been reported to increase microvascular dilation and vascular flow volume. Read More

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November 2019

Wirelessly Heating Stents via Radiofrequency Resonance toward Enabling Endovascular Hyperthermia.

Adv Healthc Mater 2019 11 18;8(22):e1900708. Epub 2019 Oct 18.

Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.

Thermal therapy known as hyperthermia has served as an effective method for cancer treatment. This therapeutic approach has also been attracting attention for treatment of in-stent restenosis, the most common complication of stenting. Mild heating of stents has been shown to be a possible path to addressing this problem. Read More

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November 2019

infections following cardiac surgery in Treviso Hospital, Italy, from 2016 to 2019: Cases report.

World J Clin Cases 2019 Sep;7(18):2776-2786

Infectious Diseases Unit, Treviso Hospital, Treviso 31100, Italy.

Background: An epidemic of () infections following cardiac surgery is ongoing worldwide. The outbreak was first discovered in 2011, and it has been traced to a point source contamination of the LivaNova 3T heater-cooler unit, which is used also in Italy. International data are advocated to clarify the spectrum of clinical features of the disease as well as treatment options and outcome. Read More

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September 2019

Detection and decontamination of and other non-tuberculosis mycobacteria in heater-cooler devices used in cardiopulmonary bypass: a Manufacturer and National guidelines summary, and a potential resolution to the problem requiring further investigation.

Perfusion 2020 04 30;35(3):190-196. Epub 2019 Aug 30.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Since 2011, invasive infections due to have been diagnosed in patients with previous cardiac surgery. The use of heating/cooling devices (heater-cooler units), necessary to regulate the blood temperature in extra-corporeal circulation, has been identified as a source of contaminated aerosol. Adhering to a strict maintenance program according to the manufacturer's instructions for use including sanitizing is essential to reduce the risk. Read More

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Wireless Hyperthermia Stent System for Restenosis Treatment and Testing With Swine Model.

IEEE Trans Biomed Eng 2020 04 23;67(4):1097-1104. Epub 2019 Aug 23.

This paper reports the first in vivo testing of a resonant-heating stent toward wireless hyperthermia treatment of in-stent restenosis. The stent, made of gold-coated medical-grade stainless steel, is designed to function as an electrical inductor and forms a radiofrequency (RF) resonant circuit with an integrated capacitor microchip. Upon implantation and deployment with the balloon catheter, the stent device serves as a wireless heater as part of the resonant wireless power transfer system, which allows for the device to produce mild heat only when the stent is resonated with a tuned RF electromagnetic field supplied from the external antenna. Read More

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Longitudinal evaluation of a household energy package on blood pressure, central hemodynamics, and arterial stiffness in China.

Environ Res 2019 10 18;177:108592. Epub 2019 Jul 18.

Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada; Institute for Health and Social Policy, McGill University, Montreal, Canada; Institute on the Environment, University of Minnesota, Minneapolis, USA. Electronic address:

Background: Cardiovascular diseases are the leading contributors to disease burden in China and globally, and household air pollution exposure is associated with risk of cardiovascular disease.

Objectives: We evaluated whether subclinical cardiovascular outcomes in adult Chinese women would improve after distribution of an energy package comprised of a semi-gasifier cookstove, water heater, chimney, and supply of processed biomass fuel.

Methods: We enrolled 204 households (n = 205 women) from 12 villages into a controlled before- and after-intervention study on cardiovascular health and air pollution in Sichuan Province. Read More

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October 2019

Devices for endoscopic hemostasis of nonvariceal GI bleeding (with videos).

VideoGIE 2019 Jul 27;4(7):285-299. Epub 2019 Jun 27.

Division of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Background: Endoscopic intervention is often the first line of therapy for GI nonvariceal bleeding. Although some of the devices and techniques used for this purpose have been well studied, others are relatively new, with few available outcomes data.

Methods: In this document, we review devices and techniques for endoscopic treatment of nonvariceal GI bleeding, the evidence regarding their efficacy and safety, and financial considerations for their use. Read More

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[Epidemiology, Clinical Presentation, Diagnosis and Treatment of Infections Caused by Mycobacterium chimaera].

Pneumologie 2019 Aug 10;73(8):474-481. Epub 2019 May 10.

Klinik für Innere Medizin V, Pneumologie, Allergologie, Beatmungs- und Umweltmedizin, Universitätsklinikum des Saarlandes, Homburg, Deutschland.

The recognition, correct diagnosis and adequate clinical management of infections caused by atypical mycobacteria are challenging tasks in clinical practice. Invasive infections caused by , a member of the complex, have been increasingly reported over the past few years. Most infections occurred in patients who had undergone open-chest cardiothoracic surgery. Read More

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Atrial fibrillation associated with carbon monoxide poisoning.

Undersea Hyperb Med 2019 Mar-Apr-May;46:203-206

Numune Education and Training Hospital, Ankara, Turkey.

Carbon monoxide intoxication occurs usually via inhalation of carbon monoxide that is emitted as a result of a fire, furnace, space heater, generator, motor vehicle. A 37-year-old male patient was admitted to the emergency department at about 5:00 a.m. Read More

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November 2019

Rapid detection of invasive Mycobacterium chimaera disease via a novel plasma-based next-generation sequencing test.

BMC Infect Dis 2019 May 2;19(1):371. Epub 2019 May 2.

Karius, Inc, 975 Island Drive, Suite 101, Redwood City, CA, 94065, USA.

Background: There is an ongoing outbreak of Mycobacterium chimaera infections among patients exposed to contaminated heater-cooler devices used during cardiac surgery. Recognition of M. chimaera infection is hampered by its long latency and non-specific symptoms. Read More

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