138,023 results match your criteria hearts rats


Impacts of Yangxin decoction on the expressions of MMP-9, CaN, NFAT3 and GATA4 in myocardial tissue of rats with chronic heart failure.

Pak J Pharm Sci 2021 Sep;34(5(Special)):2059-2064

Department of Experimental Teaching Center of Basic Medicine Kunming Medical University, Kunming, China.

To investigate the impacts of Yangxin decoction on the expressions of matrix metalloproteinase 9 (MMP-9), calcineurin (CaN), T cell activated nuclear factor 3 (NFAT3) and zinc finger transcription factor 4 (GATA4) in myocardial tissue of rats with chronic heart failure (CHF). 50 healthy SD rats were randomly divided into the normal control group (n = 10) and the operation group (n = 40). After successful modeling, the rats were randomly divided into 4 groups. Read More

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September 2021

The adducin saga: Pleiotropic genomic targets for precision medicine in human hypertension; vascular, renal, and cognitive diseases.

Physiol Genomics 2021 Dec 3. Epub 2021 Dec 3.

Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, United States.

Hypertension is a leading risk factor for stroke, heart disease, chronic kidney disease, vascular cognitive impairment, and Alzheimer's disease. Previous genetic studies have nominated hundreds of genes linked to hypertension and renal and cognitive diseases. Some have been advanced as candidate genes by showing that they can alter blood pressure or renal and cerebral vascular function in knockout animals; however, final validation of the causal variants and underlying mechanisms have remained elusive. Read More

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December 2021

Sleeve Gastrectomy Ameliorates Diabetes-Induced Cardiac Hypertrophy Correlates With the MAPK Signaling Pathway.

Front Physiol 2021 11;12:785799. Epub 2021 Nov 11.

Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.

Cardiac hypertrophy as a main pathological manifestation of diabetic cardiomyopathy (DCM), is a significant complication of diabetes. Bariatric surgery has been proven to relieve DCM; however, whether it can alleviate diabetes-induced cardiac hypertrophy is undefined. Diabetic and obese rats were performed sleeve gastrectomy (SG) after having diabetes for 16weeks. Read More

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November 2021

Hypotensive effect of captopril on deoxycorticosterone acetate-salt-induced hypertensive rat is associated with gut microbiota alteration.

Hypertens Res 2021 Dec 2. Epub 2021 Dec 2.

Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

The role of the gut microbiota in various metabolic diseases has been widely studied. This study aims to test the hypothesis that gut microbiota dysbiosis is associated with DOCA-salt-induced hypertension, while captopril, an antihypertensive drug, is able to rebalance the gut microbiota alterations caused by hypertension. Treatment with captopril resulted in an approximate 32 mmHg reduction in systolic blood pressure (162. Read More

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December 2021

OCT2013, AN ISCHAEMIA-ACTIVATED ANTIARRHYTHMIC PRODRUG, DEVOID OF THE SYSTEMIC SIDE EFFECTS OF LIDOCAINE.

Br J Pharmacol 2021 Dec 2. Epub 2021 Dec 2.

King's College London, Cardiovascular Division, Faculty of Life Sciences and Medicine, The Rayne Institute, St Thomas' Hospital, UK.

Background And Purpose: Sudden cardiac death (SCD) caused by acute myocardial ischaemia and ventricular fibrillation (VF) is an unmet therapeutic need. Lidocaine suppresses ischaemia-induced VF, but utility is limited by side effects and a narrow therapeutic index. Here we characterise OCT2013, a putative ischaemia-activated prodrug of lidocaine. Read More

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December 2021

Intrathecal IGF2 siRNA injection provides long-lasting anti-allodynic effect in a spared nerve injury rat model of neuropathic pain.

PLoS One 2021 2;16(12):e0260887. Epub 2021 Dec 2.

Department of Anesthesiology, National Defense Medical Center, Taipei, Taiwan.

Previous studies have shown an increase of insulin-like growth factor-2 (IGF2) in animal models of neuropathic pain. We aimed to examine the hypothesis that reducing the expression of IGF2 using intrathecal IGF2 small-interfering RNA (siRNA) would attenuate the development of neuropathic pain in rats after spared nerve injury (SNI). Male Wistar rats were divided into three groups: sham-operated group, in which surgery was performed to cut the muscles without injuring the nerves; SNI group, in which SNI surgery was performed to sever the nerves; and SNI + siRNA IGF2 group, in which SNI surgery was performed, and IGF2-siRNA was administered intrathecally 1 day after SNI. Read More

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December 2021

Effect of Clonidine Hydrochloride on Isolated Newborn Rat Heart.

Bull Exp Biol Med 2021 Dec 2;172(2):121-124. Epub 2021 Dec 2.

Department of Normal Physiology, Kazan State Medical University, Ministry of the Health of the Russian Federation, Kazan, Republic of Tatarstan, Russia.

The concentration dependenies of the chronotropic response and changes in blood supply to the isolated heart of 7-day-old newborn rats induced by application of α2-adrenergic receptor agonist clonidine hydrochloride in concentrations of 10-10 M were revealed. The minimum concentration of α2-adrenergic receptor agonist caused tachycardia, while higher concentrations led to bradycardia. The maximum effect manifesting in a decrease in coronary flow was recorded at the minimum concentration of the agonist, while the highest concentration had no effect on the coronary flow. Read More

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December 2021

Pretreatment with Nicotinamide Mononucleotide Increases the Effect of Ischemic-Postconditioning on Cardioprotection and Mitochondrial Function Following ex vivo Myocardial Reperfusion Injury in Aged Rats.

Clin Exp Pharmacol Physiol 2021 Dec 1. Epub 2021 Dec 1.

Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The present study aims to evaluate the combined effect of ischemic-postconditioning (IPostC) and nicotinamide mononucleotide (NMN) on cardioprotection and mitochondrial function in aged rats subjected to myocardial ischemia-reperfusion (IR) injury. Sixty aged Wistar rats were randomly divided into 5 groups (n=12), including sham, control, NMN, IPostC, and NMN+IPostC. Regional ischemia was induced by 30-min occlusion of the left anterior descending coronary artery (LAD) followed by 60-min reperfusion. Read More

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December 2021

α1-Adrenergic receptor mediates adipose-derived stem cell sheet-induced protection against chronic heart failure after myocardial infarction in rats.

Hypertens Res 2021 Dec 1. Epub 2021 Dec 1.

Division of Cardiovascular Surgery, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan.

Cell-based therapy using adipose-derived stem cells (ADSCs) has emerged as a novel therapeutic approach to treat heart failure after myocardial infarction (MI). The purpose of this study was to determine whether inhibition of α1-adrenergic receptors (α1-ARs) in ADSCs attenuates ADSC sheet-induced improvements in cardiac functions and inhibition of remodeling after MI. ADSCs were isolated from fat tissues of Lewis rats. Read More

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December 2021

Nalfurafine, a G-Protein-Biased KOR (Kappa Opioid Receptor) Agonist, Enhances the Diuretic Response and Limits Electrolyte Losses to Standard-of-Care Diuretics.

Hypertension 2021 Dec 2:HYPERTENSIONAHA12118503. Epub 2021 Dec 2.

Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA. (J.K.M., J.C.S., J.G., D.R.K.).

Nalfurafine is a G-protein-biased KOR (kappa opioid receptor) agonist that produces analgesia and lacks CNS adverse effects. Here, we examined the cardiovascular and renal responses to intravenous and oral nalfurafine alone and in combination with furosemide, hydrochlorothiazide, or amiloride. We hypothesized that nalfurafine, given its distinct mechanism of vasopressin inhibition, would increase urine output to these diuretics and limit electrolyte loss. Read More

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December 2021

Air pollution-regulated E-cadherin mediates contact inhibition of proliferation via the hippo signaling pathways in emphysema.

Chem Biol Interact 2021 Nov 28:109763. Epub 2021 Nov 28.

School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address:

Air pollution has been linked to emphysema in chronic obstruction pulmonary disease (COPD). However, the underlying mechanisms in the development of emphysema due to air pollution remain unclear. The objective of this study was to investigate the role of components of the Hippo signaling pathway for E-cadherin-mediated contact inhibition of proliferation in the lungs after air pollution exposure. Read More

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November 2021

Cholinergic Elicitation Prevents Ventricular Remodeling via Alleviations of Myocardial Mitochondrial Injury Linked to Inflammation in Ischemia-Induced Chronic Heart Failure Rats.

Mediators Inflamm 2021 20;2021:4504431. Epub 2021 Nov 20.

Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China.

Background: Cholinergic anti-inflammatory pathway (CAP) is implicated in cardioprotection in chronic heart failure (CHF) by downregulating inflammation response. Mitochondrial injuries play an important role in ventricular remodeling of the CHF process. Herein, we aim to investigate whether CAP elicitation prevents ventricular remodeling in CHF by protecting myocardial mitochondrial injuries and its underlying mechanisms. Read More

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November 2021

Modifying naloxone to reverse fentanyl-induced overdose.

Int J Pharm 2021 Nov 27:121326. Epub 2021 Nov 27.

Serodopa Therapeutics Inc., 747 SW 2nd Ave, IMB #41, Ste 342, Gainesville, FL 32601.

Developing an effective antidote for fentanyl-induced overdose (OD) is an unmet medical need that requires both lipophilicity comparable to fentanyl and fast onset of overdose reversal. We synthesized and evaluated a bioreversible derivative of naloxone (NX-90) in silico, in vitro and in vivo to yield a robust reversal of fentanyl-induced OD in rats. All monitored reflexes along with the heart rate (HR) and respiratory rate (RR) were fully restored faster in the NX-90 groups than in naloxone groups on equimolar bases when given intranasally. Read More

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November 2021

A Reactivity-Based F-Labeled Probe for PET Imaging of Oxidative Stress in Chemotherapy-Induced Cardiotoxicity.

Mol Pharm 2021 Nov 30. Epub 2021 Nov 30.

School of Biomedical Engineering & Imaging Sciences, King's College London, King's Health Partners, St Thomas' Hospital, London SE1 7EH, United Kingdom.

Oxidative stress underlies the pathology of many human diseases, including the doxorubicin-induced off-target cardiotoxicity in cancer chemotherapies. Since current diagnostic procedures are only capable of monitoring cardiac function, a noninvasive means of detecting biochemical changes in redox status prior to irreversible functional changes is highly desirable for both early diagnosis and prognosis. We designed a novel F-labeled molecular probe, F-FPBT, for the direct detection of superoxide using positron emission tomography (PET). Read More

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November 2021

Increased Lung Uric Acid Deteriorates Pulmonary Arterial Hypertension.

J Am Heart Assoc 2021 Nov 30:e022712. Epub 2021 Nov 30.

Department of Cardiovascular Medicine Kyushu University Graduate School of Medical Sciences Fukuoka Japan.

Background Recent studies have demonstrated that uric acid (UA) enhances arginase activity, resulting in decreased NO in endothelial cells. However, the role of lung UA in pulmonary arterial hypertension (PAH) remains uncertain. We hypothesized that increased lung UA level contributes to the progression of PAH. Read More

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November 2021

Electrocardiographic and histopathological characterizations of diabetic cardiomyopathy in rats.

Environ Sci Pollut Res Int 2021 Nov 30. Epub 2021 Nov 30.

Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology Gamasa, Talkha, Egypt.

Diabetes is a clinical condition that is associated with insulin deficiency and hyperglycemia. Cardiomyopathy, retinopathy, neuropathy, and nephropathy are well known complications of the elevated blood glucose. Diabetic cardiomyopathy is a clinical disorder that is associated with systolic and diastolic dysfunction along with cardiac fibrosis, inflammation, and elevated oxidative stress. Read More

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November 2021

PEGylated Graphene Quantum Dot Improved Cardiac Function in Rats with Myocardial Infarction: Morphological, Oxidative Stress, and Toxicological Evidences.

Oxid Med Cell Longev 2021 20;2021:8569225. Epub 2021 Nov 20.

Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Introduction: The biocompatibility and potential application of graphene-based nanomaterials in biomedicine have been documented. The effects of polyethylene glycol-graphene quantum dots (GQDs-PEG) on cardiac function in rats with myocardial infarction (MI) were examined.

Methods: Wistar rats were randomly assigned to two main groups, each consisting of sham-Veh. Read More

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November 2021

Plasmacytoid dendritic cells mediate the tolerogenic effect of CD8regulatory T cells in a rat tolerant liver transplantation model.

Transpl Immunol 2021 Nov 26:101508. Epub 2021 Nov 26.

Department of Hepatobiliary and Pancreaticosplenic Surgery, Beijing ChaoYang Hospital, Capital Medical University, Beijing 100020, China. Electronic address:

Background: Tolerance is more easily induced in liver transplant models than in other organs; CD8CD45RCregulatory T cells (Tregs) have been shown to induce tolerance in heart allografts. Whether CD8CD45RCTregs could induce tolerance in a liver transplant model and how dendritic cells (DCs) mediate the CD8CD45RCTregs effect remains to be investigated.

Methods: A rat liver transplantation model was established and used to test tolerance and acute rejection compared to control groups. Read More

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November 2021

The effect of spironolactone on cardiac and renal fibrosis following myocardial infarction in established hypertension in the transgenic Cyp1a1Ren2 rat.

PLoS One 2021 29;16(11):e0260554. Epub 2021 Nov 29.

Department of Medicine, University of Otago, Dunedin, New Zealand.

Aims: The renin-angiotensin-aldosterone axis plays a key role in mediating cardiac and kidney injury. Mineralocorticoid receptor antagonism has beneficial effects on cardiac dysfunction, but effects are less well quantified in the cardiorenal syndrome. This study investigated cardiac and kidney pathophysiology following permanent surgical ligation to induce myocardial infarction (MI) in hypertensive animals with or without mineralocorticoid receptor antagonism. Read More

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November 2021

Resistance training mitigates hepato-cardiac changes and muscle mitochondrial protein reductions in rats with diet-induced obesity.

Heliyon 2021 Nov 14;7(11):e08374. Epub 2021 Nov 14.

Department of Physiotherapy - School of Sciences and Technology - Sao Paulo, State University - UNESP, Campus Presidente Prudente, Brazil.

Aim: To investigate the effect of resistance training (RT) on hepatocardiovascular and muscle mitochondrial parameters in rats that were fed a high-calorie diet for 12 weeks.

Main Methods: The animals were divided into four groups: control (C), exercise (E), obese (O), and obese plus exercise (OE). Group E and OE rats performed resistance training by climbing on a vertical ladder with load attached to the end of the tail (1×/day, 3×/week, for 12 weeks). Read More

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November 2021

Potential Therapeutic Effect of Citronellal on Diabetic Cardiomyopathy in Experimental Rats.

Evid Based Complement Alternat Med 2021 17;2021:9987531. Epub 2021 Nov 17.

College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang 453003, China.

Diabetic cardiomyopathy (DCM), a cardiovascular complication of patients with diabetes, is a special cardiomyopathy that is independent of coronary heart disease, hypertension, and valvular disease. Citronellal (CT) is a monoterpene compound generated by the secondary metabolism of plants. In this work, the therapeutic effect and mechanism of CT in DCM were investigated. Read More

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November 2021

Pharmacological inhibition of mTOR attenuates DOCA-salt-induced hypertension and related pathophysiology: regulation of oxidative stress, inflammation and cardiovascular hypertrophy in male rats.

J Cardiovasc Pharmacol 2021 Nov 23. Epub 2021 Nov 23.

Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey; Department of Cardiovascular Surgery, Mersin State Hospital, Mersin, Turkey; Department of Cardiovascular Surgery, Faculty of Medicine, Mersin University, Mersin, Turkey; Department of Histology and Embryology, Faculty of Medicine, Mersin University, Mersin, Turkey; Department of Pharmacology, College of Medicine, University of Tennessee, Center for Health Sciences, Memphis, TN, USA.

Abstract: The present study aimed to explore the contribution of mTOR in deoxycorticosterone acetate (DOCA)-salt-induced hypertension and related pathophysiological changes in cardiovascular and renal tissues. DOCA-salt loading resulted in an increase in systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) along with the activity of ribosomal protein S6 (rpS6), the effector protein of mTOR. Treatment with rapamycin, the selective inhibitor of mTOR, initiated at the 4th week of DOCA-salt administration normalized the SBP and attenuated rpS6 activity in the heart, aorta, and kidney. Read More

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November 2021

[Neuroprotective mechanism of autophagy in bradykinin postconditioning after cardiac arrest in rats].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Sep;33(9):1099-1104

Provincial Clinical Medical College, Fujian Medical University, Fuzhou 350001, Fujian, China.

Objective: To explore the protective effects of bradykinin postconditioning on cardiopulmonary resuscitation (CPR) rats, and to assess the underlying mechanisms.

Methods: Forty-eight adult male Sprague-Dawley (SD) rats were randomly divided into four groups according to random number table: Sham operation group, cardiac arrest (CA) group, bradykinin treatment (BK) group, and AMP-activated protein kinase (AMPK) inhibitor Compound C+ bradykinin treatment (CP+BK) group, finally, 8 rats in each group were taken for follow-up experiment. CA was induced by asphyxia. Read More

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September 2021

Protective role of emodin in rats with post-myocardial infarction heart failure and influence on extracellular signal-regulated kinase pathway.

Bioengineered 2021 Dec;12(2):10246-10253

Department of Cardiovascular Medicine, Avic 363 Hospital, Chengdu, Sichuan Province, China.

We aimed to explore the effects of emodin on the energy metabolism of myocardial cells in rats with post-myocardial infarction (MI) heart failure (HF) and the extracellular signal-regulated kinase (ERK) pathway. The model of MI was established by ligation of the left anterior descending branch. After 4 weeks, the rats with left ventricular ejection fraction (LVEF) of ≤45% were used aspost-MI HF model animals and randomly divided into model, low-dose, middle-dose, high-dose and control groups (n=10). Read More

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December 2021

Progressive reorganization of mitochondrial apparatus in aging skeletal muscle of naked mole rats ( as revealed by electron microscopy: potential role in continual maintenance of muscle activity.

Aging (Albany NY) 2021 Nov 28;13(undefined). Epub 2021 Nov 28.

Lomonosov Moscow State University, Belozersky Research Institute of Physico-Chemical Biology, Moscow 119991, Russia.

The authors examined the ultrastructure of mitochondrial apparatus of skeletal muscles of naked mole rats () from the age of 6 months to 11 years. The obtained results have demonstrated that the mitochondria in skeletal muscles of naked mole rats aged below 5 years is not well-developed and represented by few separate small mitochondria. Mitochondrial reticulum is absent. Read More

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November 2021

Effect and mechanism of "Danggui-kushen" herb pair on ischemic heart disease.

Biomed Pharmacother 2021 Nov 25;145:112450. Epub 2021 Nov 25.

Heilongjiang University of Chinese Medicine, Harbin 150040, China. Electronic address:

Aims: The purpose of this study was to investigate the mechanism and effects of "Danggui-kushen" herb pair (DKHP) better than single drug in ischemic heart disease (IHD).

Methods: IHD model was established by left anterior descending branch of coronary artery in rats. Rats were randomized into six groups and oral administration for 7 days: control, model, Danshen dripping pills (DS) (5. Read More

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November 2021

Tongmai granules improve rat hippocampal injury by regulating TLR4/MyD88/AP-1 signaling pathway.

J Ethnopharmacol 2021 Nov 25;285:114874. Epub 2021 Nov 25.

Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address:

Ethnopharmacological Relevance: Tongmai granules (TMG) is composed of Salvia miltiorrhiza Bge., Radix puerariae Lobata., and Ligusticum chuanxiong hort. Read More

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November 2021

Mechanical strain triggers endothelial-to-mesenchymal transition of the endocardium in the immature heart.

Pediatr Res 2021 Nov 26. Epub 2021 Nov 26.

Department of Cardiac Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Background: Endothelial-to-mesenchymal-transition (EndMT) plays a major role in cardiac fibrosis, including endocardial fibroelastosis but the stimuli are still unknown. We developed an endothelial cell (EC) culture and a whole heart model to test whether mechanical strain triggers TGF-β-mediated EndMT.

Methods: Isolated ECs were exposed to 10% uniaxial static stretch for 8 h (stretch) and TGF-β-mediated EndMT was determined using the TGF-β-inhibitor SB431542 (stretch + TGF-β-inhibitor), BMP-7 (stretch + BMP-7) or losartan (stretch + losartan), and isolated mature and immature rats were exposed to stretch through a weight on the apex of the left ventricle. Read More

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November 2021

The Antiarrhythmic Activity of Novel Pyrrolidin-2-one Derivative S-75 in Adrenaline-Induced Arrhythmia.

Pharmaceuticals (Basel) 2021 Oct 20;14(11). Epub 2021 Oct 20.

Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.

Arrhythmia is a quivering or irregular heartbeat that can often lead to blood clots, stroke, heart failure, and other heart-related complications. The limited efficacy and safety of antiarrhythmic drugs require the design of new compounds. Previous research indicated that pyrrolidin-2-one derivatives possess an affinity for α-adrenergic receptors. Read More

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October 2021

Mitochondria Isolated from Hearts Subjected to Ischemia/Reperfusion Benefit from Adenine Nucleotide Translocase 1 Overexpression.

Membranes (Basel) 2021 Oct 29;11(11). Epub 2021 Oct 29.

Physiologisches Institut, Justus-Liebig-Universität Gießen, 35392 Gießen, Germany.

Reperfusion is the only feasible therapy following myocardial infarction, but reperfusion has been shown to damage mitochondrial function and disrupt energy production in the heart. Adenine nucleotide translocase 1 (ANT1) facilitates the transfer of ADP/ATP across the inner mitochondrial membrane; therefore, we tested whether ANT1 exerts protective effects on mitochondrial function during ischemia/reperfusion (I/R). The hearts of wild-type (WT) and transgenic ANT1-overexpressing (ANT1-TG) rats were exposed to I/R injury using the standard Langendorff technique, after which mitochondrial function, hemodynamic parameters, infarct size, and components of the contractile apparatus were determined. Read More

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October 2021