52,723 results match your criteria heart tumors


Safety, Efficacy, and Pharmacodynamics of Tremelimumab Plus Durvalumab for Patients With Unresectable Hepatocellular Carcinoma: Randomized Expansion of a Phase I/II Study.

J Clin Oncol 2021 Jul 22:JCO2003555. Epub 2021 Jul 22.

Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: This phase I/II study evaluated tremelimumab (anticytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody) and durvalumab (antiprogrammed death ligand-1 monoclonal antibody) as monotherapies and in combination for patients with unresectable hepatocellular carcinoma (HCC), including a novel regimen featuring a single, priming dose of tremelimumab (ClinicalTrials.gov identifier: NCT02519348).

Patients And Methods: Patients with HCC who had progressed on, were intolerant to, or refused sorafenib were randomly assigned to receive T300 + D (tremelimumab 300 mg plus durvalumab 1,500 mg [one dose each during the first cycle] followed by durvalumab 1,500 mg once every 4 weeks), durvalumab monotherapy (1,500 mg once every 4 weeks), tremelimumab monotherapy (750 mg once every 4 weeks [seven doses] and then once every 12 weeks), or T75 + D (tremelimumab 75 mg once every 4 weeks plus durvalumab 1,500 mg once every 4 weeks [four doses] followed by durvalumab 1,500 mg once every 4 weeks). Read More

View Article and Full-Text PDF

Pulmonary angiosarcoma: A case report of surgical treatment.

J Card Surg 2021 Jul 21. Epub 2021 Jul 21.

Aorta and Coronary Artery Surgery Unit, E. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk, Russia.

Pulmonary angiosarcoma (PAS) is a malignant tumor of the vascular wall of mesenchymal origin. PAS is rare and has unknown etiology and poor prognosis. Depending on the location, angiosarcoma can lead to serious obstructive and embolic complications, as well as severe pulmonary hypertension and right ventricular heart failure. Read More

View Article and Full-Text PDF

Characterization of American Teduglutide Consumers from 2015-2020: A Large Database Study.

JPEN J Parenter Enteral Nutr 2021 Jul 21. Epub 2021 Jul 21.

Louis Stokes VA Medical Center, Cleveland, Ohio, United States.

Introduction: Teduglutide, a glucagon-like peptide-2 analog, is a novel therapy for intestinal failure that reduces need for parenteral support, especially in patients without a functional terminal ileum or colon. It can also predispose patients to accelerated progression of gastrointestinal malignancy and fluid overload. We demographically and clinically characterized American patients prescribed teduglutide using a large database. Read More

View Article and Full-Text PDF

Thrombotic and hemorrhagic events in 2016 World Health Organization-defined Philadelphianegative myeloproliferative neoplasm.

Korean J Intern Med 2021 Jul 22. Epub 2021 Jul 22.

Division of Hematology/Oncology, Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.

Background/aims: Recent changes in the diagnostic criteria for myeloproliferative neoplasms (MPNs) and increasing patient numbers necessitate updating of the data on vascular events in patients with such disorders.

Methods: In this single-center study, thrombotic and hemorrhagic events were retrospectively analyzed in patients diagnosed with essential thrombocythemia (ET), polycythemia vera (PV) prefibrotic/early primary myelofibrosis (pre-PMF), or PMF, based on the 2016 World Health Organization diagnostic criteria.

Results: Of a total of 335 consecutive patients (139 ET, 42 pre-PMF, 124 PV, and 30 PMF patients; 192 males and 143 females) of median age 64 years (range, 15 to 91), 112 (33. Read More

View Article and Full-Text PDF

Current development of sigma-2 receptor radioligands as potential tumor imaging agents.

Bioorg Chem 2021 Jul 13;115:105163. Epub 2021 Jul 13.

Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

Sigma receptors are transmembrane proteins with two different subtypes: σ and σ. Because of its overexpression in tumors, the σ receptor (σR) is a well-known biomarker for cancer cells. A large number of small-molecule ligands for the σRs have been identified and tested for imaging the proliferative status of tumors using single photon emission computed tomography (SPECT) and positron emission tomography (PET). Read More

View Article and Full-Text PDF

Anti-Mullerian Hormone Changes Following Laparoscopic Ovarian Cystectomy: A Prospective Comparative Study.

Int J Womens Health 2021 12;13:691-698. Epub 2021 Jul 12.

Department of Obstetrics & Gynecology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.

Purpose: To investigate whether laparoscopic ovarian cystectomy (LOC) affects ovarian reserve.

Patients And Methods: In 46 premenopausal women, who underwent either LOC (study group, n=26) or laparoscopic myomectomy (LM) (control group, n=20), serum anti-Mullerian hormone (AMH) levels were measured pre-operatively (AMH0), and postoperatively at 7 days (AMH1), 2 months (AMH2), and 6 months (AMH3). Changes in AMH from baseline level (AMH0) in each group were compared. Read More

View Article and Full-Text PDF

An incidental finding of testicular seminoma in the context of acute pulmonary embolism: a case report.

J Med Case Rep 2021 Jul 20;15(1):354. Epub 2021 Jul 20.

University Hospital Wishaw, 50 Netherton Street, Wishaw, ML2 0DP, UK.

Background: Clinical guidelines do not recommend further investigation for occult malignancy in the scenario of unprovoked venous thromboembolism in the absence of additional clinical features suggestive of malignancy. We present the case of a young gentleman with pulmonary embolism who was diagnosed with testicular seminoma despite lack of symptoms or signs suggestive of malignancy. This is a unique case describing a scenario not well documented in existing literature where contravention of clinical guidelines had a potentially advantageous outcome for the patient. Read More

View Article and Full-Text PDF

Role of Vitamin E in Selected Malignant Neoplasms in Women.

Nutr Cancer 2021 Jul 19:1-8. Epub 2021 Jul 19.

Department of Medical Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland.

Vitamin E, which is actually a mixture of eight isoforms (four tocopherols and four tocotrienols), is a powerful antioxidant that protects polyunsaturated fatty acids against oxidation and has the ability to break the chain lipid peroxidation, which is used in the treatment of heart disease, atherosclerosis, muscle disorders or infertility among men. Studies in-vitro show that one of the effects of tocopherol is the reduction of cancer stem cell activity which is connected to poor clinical course. In the scientific literature, reports on the participation of vitamin E not only in protection against the mutagenic effects of reactive oxygen species, but also in its anti-angiogenic activity and the ability to inhibit the invasion and metastasis of neoplastic cells are increasingly common. Read More

View Article and Full-Text PDF

Nanomedicine in Oncocardiology: Contribution and Perspectives of Preclinical Studies.

Front Cardiovasc Med 2021 30;8:690533. Epub 2021 Jun 30.

PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France.

Cancer and cardiovascular diseases are the leading causes of death and morbidity worldwide. Strikingly, cardiovascular disorders are more common and more severe in cancer patients than in the general population, increasing incidence rates. In this context, it is vital to consider the anticancer efficacy of a treatment and the devastating heart complications it could potentially cause. Read More

View Article and Full-Text PDF

Determines Mesothelioma Cell Fate to EZH2 Inhibition.

Front Oncol 2021 1;11:678447. Epub 2021 Jul 1.

Department of Pharmaceutical Sciences, University of Piemonte Orientale (UPO), Novara, Italy.

Malignant pleural mesothelioma is an aggressive cancer, heterogeneous in its presentation and behaviour. Despite an increasing knowledge about molecular markers and their diagnostic and prognostic value, they are not used as much as they might be for treatment allocation. It has been recently reported that mesothelioma cells that lack BAP1 (BRCA1 Associated Protein) are sensitive to inhibition of the EZH2 (Enhancer of Zeste Homolog 2) histone methyltransferase. Read More

View Article and Full-Text PDF

[Comparison of the post-operative analgesic effect of ultrasound-guided serratus anterior plane block combined with pectoral nerves block Ⅰ and thoracic paravertebral block in radical mastectomy].

Zhonghua Yi Xue Za Zhi 2021 Jul;101(27):2147-2151

Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

To investigate the serratus anterior plane block combined with pectoral nerves block I can produce a non-inferior analgesic effect compared with thoracic paravertebral block for radical mastectomy. From October 2020 to February 2021, Sixty-four patients of Beijing Tongren Hospital, Capital Medical University scheduled for radical mastectomy with general anesthesia,were divided into two groups ( = 32 each) using a random number table method: thoracic paravertebral block group (TPVB group) and serratus anterior plane block combined with pectoral nerves block I group (S&P group). All patients received patient controlled intravenous analgesia (PCIA) postoperatively. Read More

View Article and Full-Text PDF

Development of health-based exposure limits for radiofrequency radiation from wireless devices using a benchmark dose approach.

Environ Health 2021 Jul 17;20(1):84. Epub 2021 Jul 17.

Environmental Working Group, 1250 I Street NW, Suite 1000, Washington, DC, 20005, USA.

Background: Epidemiological studies and research on laboratory animals link radiofrequency radiation (RFR) with impacts on the heart, brain, and other organs. Data from the large-scale animal studies conducted by the U.S. Read More

View Article and Full-Text PDF

[Primary delayed growth of the right and left atrial myxoma].

Khirurgiia (Mosk) 2021 (7):94-97

Petrovsky National Research Center of Surgery, Moscow, Russia.

There is more than 58-year experience of surgical treatment of patients with intracardiac myxomas at the Petrovsky National Research Center of Surgery. Primary delayed growth of the right and left atrial myxoma after 21 years and 5 months was observed only in 1 (0.36%) patient. Read More

View Article and Full-Text PDF

A Clinico-Pathologic Approach to the Differential Diagnosis of Pericardial Tumors.

Curr Cardiol Rep 2021 Jul 16;23(9):119. Epub 2021 Jul 16.

Department of Pathology, The Cleveland Clinic, 9500 Euclid Avenue/Desk L25, Cleveland, Ohio, 44195, USA.

Purpose Of Review: Tumors of the pericardium are rare, but a wide variety of congenital, infectious, inflammatory, and neoplastic processes have been reported. Pericardial tumors can be categorized as non-neoplastic or neoplastic. Neoplastic lesions can be further divided into benign or malignant, with malignancies being either primary or secondary (metastatic). Read More

View Article and Full-Text PDF

Changes in epilepsy causes of death: A US population study.

Acta Neurol Scand 2021 Jul 16. Epub 2021 Jul 16.

Department of Health Sciences Research, University of California, Los Angeles, CA, USA.

Objectives: Since 2000, medical treatment for epilepsy and cardiovascular risk-reduction strategies have advanced significantly in the United States (US). However, seizure-free rates remain unchanged, and people with epilepsy are at higher risk than the general population for heart disease and stroke. The purpose of this study is to determine how cardiovascular, epilepsy-related, and other causes of death are changing in epilepsy in comparison with the US population. Read More

View Article and Full-Text PDF

PM constituents and mortality from a spectrum of causes in Guangzhou, China.

Ecotoxicol Environ Saf 2021 Jul 12;222:112498. Epub 2021 Jul 12.

Institute for Environmental and Climate Research, Jinan University, Guangzhou 511443, China; JNU-QUT Joint Laboratory for Air Quality Science and Management, Jinan University, Guangzhou 511443, China; Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality, Guangzhou 511443, China. Electronic address:

As the major constituents of PM, carbonaceous constituents and inorganic ions have attracted emerging attentions on their health risks, particularly on cardiorespiratory diseases. However, evidences on the risks of PM constituents on other diseases (eg. nervous disease, genitourinary disease, neoplasms and endocrine disease) remain scarce. Read More

View Article and Full-Text PDF

Aromatase inhibitors use and risk for cardiovascular disease in breast cancer patients: A population-based cohort study.

Breast 2021 Jul 7;59:157-164. Epub 2021 Jul 7.

Department of Oncology, Faculty of Medicine and Health, Örebro University, SE 70182, Örebro, Sweden. Electronic address:

Background: Prior studies regarding use of Aromatase inhibitors (AIs) and risk for cardiovascular disease (CVD) have shown conflicting results. This retrospective cohort study aimed to investigate whether AIs use affects risk for CVD events in postmenopausal breast cancer survivors.

Methods: Using a retrospective cohort study design, four CVD outcomes; heart failure or cardiomyopathy, arrhythmia, acute ischemic heart disease and ischemic stroke or Transient Ischemic Attack were compared with uni- and multivariate Cox regression analyses according to exposure to endocrine therapy (use of AI, tamoxifen or AI/tamoxifen sequentially) or no endocrine therapy. Read More

View Article and Full-Text PDF

The cardiac toxicity of radiotherapy - a review of characteristics, mechanisms, diagnosis, and prevention.

Int J Radiat Biol 2021 Jul 15:1-22. Epub 2021 Jul 15.

Department of Radiation Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Purpose: Radiation-induced heart disease (RIHD) is one of the most serious complications of radiotherapy. The purpose of this paper is to review recent researches about cardiac toxicity of radiotherapy in clinical characteristics, mechanisms, diagnosis, and prevention.

Conclusions: Powered by the rapid development of medicine, the overall survival (OS) of cancer has been improved significantly. Read More

View Article and Full-Text PDF

Synthesis of [1- C-5- C]-alpha-ketoglutarate enables noninvasive detection of 2-hydroxyglutarate.

NMR Biomed 2021 Jul 14:e4588. Epub 2021 Jul 14.

Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Isocitrate dehydrogenase 1 (IDH1) mutations that generate the oncometabolite 2-hydroxyglutarate (2-HG) from α-ketoglutarate (α-KG) have been identified in many types of tumors and are an important prognostic factor in gliomas. 2-HG production can be determined by hyperpolarized carbon-13 magnetic resonance spectroscopy (HP- C-MRS) using [1- C]-α-KG as a probe, but peak contamination from naturally occurring [5- C]-α-KG overlaps with the [1- C]-2-HG peak. Via a newly developed oxidative-Stetter reaction, [1- C-5- C]-α-KG was synthesized. Read More

View Article and Full-Text PDF

Crossing the blood-brain barrier with carbon dots: uptake mechanism and cargo delivery.

Nanoscale Adv 2021 Jun 31;3(13):3942-3953. Epub 2021 May 31.

Department of Chemistry, University of Miami 1301 Memorial Dr. Coral Gables FL 33146 USA

The blood-brain barrier (BBB) is a major obstacle for drug delivery to the central nervous system (CNS) such that most therapeutics lack efficacy against brain tumors or neurological disorders due to their inability to cross the BBB. Therefore, developing new drug delivery platforms to facilitate drug transport to the CNS and understanding their mechanism of transport are crucial for the efficacy of therapeutics. Here, we report (i) carbon dots prepared from glucose and conjugated to fluorescein (GluCD-F) cross the BBB in zebrafish and rats without the need of an additional targeting ligand and (ii) uptake mechanism of GluCDs is glucose transporter-dependent in budding yeast. Read More

View Article and Full-Text PDF

Cardiac Metastasis in a Living Patient With Laryngeal Squamous Cell Carcinoma.

Cureus 2021 Jul 6;13(7):e16214. Epub 2021 Jul 6.

Oncology/Hematology, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, USA.

Metastatic cardiac tumors are mainly diagnosed postmortem, while cardiac metastases of laryngeal cancer are exceedingly rare. We report a case of laryngeal carcinoma with subsequent metastatic disease to the heart diagnosed nine months after surgical resection of laryngeal cancer. Additionally, we attempted tosummarize published case reports of laryngeal cancer with cardiac metastasis. Read More

View Article and Full-Text PDF

Survey of cancer cell anatomy in non-adhesive confinement reveals a role for filamin-A and fascin-1 in leader bleb-based migration.

Mol Biol Cell 2021 Jul 14:mbcE21040174. Epub 2021 Jul 14.

Cell and Developmental Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.

Cancer cells migrating in confined microenvironments exhibit plasticity of migration modes. Confinement of contractile cells in a non-adhesive environment drives 'leader bleb-based migration' (LBBM), morphologically characterized by a long bleb that points in the direction of movement separated from a cell body by a contractile neck. Although cells undergoing LBBM have been visualized within tumors, the organization of organelles and actin regulatory proteins mediating LBBM is unknown. Read More

View Article and Full-Text PDF

Chemical Autophagy Regulators.

Adv Exp Med Biol 2021 ;1208:289-309

Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Autophagy is a catabolic process that removes aggregated proteins and damaged organelles via lysosomal degradation. Increasing evidence suggests that dysfunction of autophagy is associated with a variety of human pathologies, including aging, cancer, neurodegenerative diseases, heart diseases, diabetes, and other metabolic diseases. Current research suggests that the regulation of autophagy may be a novel target for the treatment of these diseases. Read More

View Article and Full-Text PDF

Juxtaglomerular cell tumor diagnosed preoperatively by renal tumor biopsy.

IJU Case Rep 2021 Jul 7;4(4):207-209. Epub 2021 Apr 7.

Department of Urology Kyoto Prefectural University of Medicine Kyoto-City Kyoto Japan.

Introduction: Diagnosis of small renal tumor from imaging analysis is limited. We report a case of juxtaglomerular cell tumor diagnosed preoperatively by renal tumor biopsy.

Case Presentation: A 17-year-old male was urgently hospitalized for acute-onset congestive heart failure. Read More

View Article and Full-Text PDF

A rare case of cardiac metastasis from uterine cervical adenocarcinoma.

J Cardiol Cases 2021 Jul 13;24(1):30-33. Epub 2020 Dec 13.

Resident of Cardiology, Department of Cardiovascular Disease, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran.

Metastatic cardiac tumors are rare and are usually from lung, breast, and esophageal cancers. Although uterine cervical cancer is relatively common, its metastasis to the heart is extremely rare. Herein, we report an unusual case of metastatic cervical adenocarcinoma to the heart presenting with a huge right atrial mass and tamponade. Read More

View Article and Full-Text PDF

Influence of Ile655Val polymorphism on trastuzumab-induced cardiotoxicity in early-stage HER2 positive breast cancer.

Sci Rep 2021 Jul 13;11(1):14395. Epub 2021 Jul 13.

Faculty of Pharmacy and Biochemistry, Clinical Institute of Chemistry, University Hospital Center "Sestre Milosrdnice", University of Zagreb, Zagreb, Croatia.

Trastuzumab has improved the prognosis of HER2 positive breast cancer, but cardiotoxicity remains a concern. We aimed to identify risk factors for trastuzumab-induced cardiotoxicity, with an emphasis on the HER2 Ile655Val single nucleotide polymorphism. This single-center case-control study included 1056 patients with early-stage HER2 positive breast cancer that received adjuvant trastuzumab. Read More

View Article and Full-Text PDF

Surgical treatment of primary cardiac tumors in the contemporary era: A single-centre analysis.

J Card Surg 2021 Jul 12. Epub 2021 Jul 12.

Department of Surgical and Morphological Sciences, Circolo Hospital, University of Insubria, Varese, Italy.

Background: Primary cardiac tumors (PCT) are rare lesions but have the potential to cause significant morbidity if not timely treated. We reviewed our single-center experience in the surgical treatment of PCT with a focus on the long-term outcome.

Methods: From 2001 to 2020, 57 consecutive patients underwent surgical resection of PCT at our Institution. Read More

View Article and Full-Text PDF

Testosterone strongly enhances azoxymethane/dextran sulfate sodium-induced colorectal cancer development in C57BL/6 mice.

Am J Cancer Res 2021 15;11(6):3145-3162. Epub 2021 Jun 15.

Tumor Microenvironment Global Core Research Center, Seoul National University College of Pharmacy Seoul, South Korea.

Colorectal cancer (CRC) is known to occur more frequently in males than in females, with sex hormones reportedly influencing the development. The purpose of the study was to investigate whether orchiectomy in C57BL/6 male mice reduces colorectal tumorigenesis and whether testosterone administration increases tumorigenesis after orchiectomy in an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model. Clinical symptoms, including colitis and tumor incidence, were evaluated in the absence or presence of testosterone in AOM/DSS-treated male, as well as orchiectomized (ORX) male and female mice. Read More

View Article and Full-Text PDF

[ANATOMICAL AND CLINICAL EXAMINATION OF THE INFERIOR VENA CAVA AND VENOUS RETURN IN CONDITIONS OF TUMOR VENOUS THROMBOSIS].

Georgian Med News 2021 May(314):13-20

State Higher Educational Establishment "Uzhhorod National University", Ukraine.

The aim of the study was to conduct an anatomical and clinical study of IVC and its tributaries, and to determine the pathways of collateral venous blood flow to improve the results of surgical treatment of patients with kidney cancer complicated by venous tumor thrombosis. The anatomical examination of the IVC and its tributaries included the results of autopsy of 27 corpses. The clinical part of the study is based on the results of examination and surgical treatment of 147 patients with renal cell carcinoma complicated by venous tumor thrombosis. Read More

View Article and Full-Text PDF

Venous thrombotic events in patients treated with immune checkpoint inhibitors for non-small cell lung cancer: A retrospective multicentric cohort study.

Thromb Res 2021 Jun 29;205:29-39. Epub 2021 Jun 29.

University of Montreal Research Center (CRCHUM), 900 Saint-Denis Street, Montreal, Quebec H2X 0A9, Canada; Hematology-Oncology Division, University of Montreal Health Centre (CHUM), 1000 Saint-Denis Street, Montreal, Quebec H2X 0A9, Canada. Electronic address:

Objectives: Venous thrombotic events (VTEs) are a frequent complication of non-small cell lung cancer (NSCLC) and are associated with increased morbidity. Immune checkpoint inhibitors (ICIs) are revolutionizing the management of NSCLC, but little is known about their impact on thrombosis. This study aims to define the incidence and clinical relevance of VTEs in NSCLC patients receiving these treatments. Read More

View Article and Full-Text PDF