77,125 results match your criteria heart transplantation


Middle Meningeal Artery Embolization of a Pediatric Patient With Progressive Chronic Subdural Hematoma.

Oper Neurosurg (Hagerstown) 2021 May 6. Epub 2021 May 6.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Background And Importance: Evidence suggests middle meningeal artery (MMA) embolization benefits adult patients with chronic subdural hematoma (CSDH) at high risk for recurrence or hemorrhagic complications. Yet, there has not been any report discussing MMA embolization in the pediatric population. Thus, we present a case of an infant with CSDH successfully managed with MMA embolization without surgical management. Read More

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Heart Transplantation of a Preterm Infant With HLHS.

World J Pediatr Congenit Heart Surg 2021 May 6:2150135120979847. Epub 2021 May 6.

Department of Cardiovascular Surgery, Rady Children's Hospital, University of California, San Diego, CA, USA.

A 33-week gestation, 1.75-kg female infant with mitral stenosis/aortic atresia variant of hypoplastic left heart syndrome and severe ventriculo-coronary connections underwent surgical septectomy and bilateral pulmonary artery banding at five weeks of age (2.10 kg). Read More

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Pre-transplant Amiodarone Use Does Not Affect Long-Term Heart Transplant Survival.

Pharmacotherapy 2021 May 6. Epub 2021 May 6.

Hartford HealthCare Heart and Vascular Institute, Hartford Hospital, Hartford, CT, USA.

Purpose: Effect of pre-transplant amiodarone use on post heart transplant (HT) survival is not well established. We therefore sought to examine the effect of amiodarone use on post HT survival.

Methods: We stratified adults who underwent HT between January 2000 and August 2018 in the Scientific Registry of Transplant Recipients according to pre-transplant amiodarone use and used recipient and donor characteristics to calculate propensity scores. Read More

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Mesenchymal Stem Cells for Cardiac Regeneration: from Differentiation to Cell Delivery.

Stem Cell Rev Rep 2021 May 5. Epub 2021 May 5.

Stem Cell and Molecular Biology Laboratory, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology-Madras, Chennai, Tamil Nadu, 600036, India.

Mesenchymal stem cells (MSCs) are so far the most widely researched stem cells in clinics and used as an experimental cellular therapy module, particularly in cardiac regeneration and repair. Ever since the discovery of cardiomyogenesis induction in MSCs, a wide variety of differentiation protocols have been extensively used in preclinical models. However, pre differentiated MSC-derived cardiomyocytes have not been used in clinical trials; highlighting discrepancies and limitations in its use as a source of derived cardiomyocytes for transplantation to improve the damaged heart function. Read More

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Giant cell myocarditis.

Proc (Bayl Univ Med Cent) 2021 Jan 22;34(3):401-402. Epub 2021 Jan 22.

Department of Cardiology, Trinity Health of New England, Hartford, Connecticut.

Giant cell myocarditis (GCM) usually affects previously healthy adults and is a rapidly progressive and frequently fatal disease. It has a median survival of 3 months to death or transplant without appropriate therapy. Hence, early diagnosis is critical, with evidence showing rapidly instituted cyclosporine-based immunosuppression can improve transplant-free survival. Read More

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January 2021

Flecainide toxicity late after liver transplantation.

Proc (Bayl Univ Med Cent) 2021 Jan 22;34(3):378-379. Epub 2021 Jan 22.

Division of Cardiology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.

Flecainide is an antiarrhythmic agent indicated for patients with supraventricular arrhythmias without ischemic or structural heart disease. Flecainide toxicity is a rare condition in which patients may present with bradycardia, widening of QRS, PR prolongation, ventricular tachycardia, syncope, malaise, dizziness, visual disturbance, nausea, vomiting, and/or lethargy. It carries an associated mortality rate of approximately 10%. Read More

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January 2021

Trends in post-heart transplant biopsies for graft rejection versus nonrejection.

Proc (Bayl Univ Med Cent) 2021 Jan 26;34(3):345-348. Epub 2021 Jan 26.

Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, Texas.

With alternatives such as gene profiling available for surveillance after orthotopic heart transplantation, we sought to evaluate the utilization of endomyocardial biopsies (EMBs) for hospitalized patients after heart transplantation. Surveillance EMBs in patients with and without complications were evaluated from the 2004 to 2014 National Inpatient Sample. Over the study period, there was no significant change in the number of EMB procedures performed ( = 0. Read More

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January 2021

Bridging With Extracorporeal Membrane Oxygenation Under the New Heart Allocation System: A United Network for Organ Sharing Database Analysis.

Circ Heart Fail 2021 May 6:CIRCHEARTFAILURE120007966. Epub 2021 May 6.

Department of Cardiac Surgery, Tufts Medical Center, Boston, MA. (T.N., S.H.M., F.Y.C., G.S.C., M.K.).

Background: The effect of the new donor heart allocation system on survival following bridging to transplantation with venous-arterial extracorporeal membrane oxygenation remains unknown. The new allocation system places extracorporeal membrane oxygenation-supported candidates at the highest status.

Methods: The United Network for Organ Sharing database was queried for adults bridged to single-organ heart transplantation with extracorporeal membrane oxygenation from October 2006 to February 2020. Read More

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Effect of Inhibition of the JAK2/STAT3 Signaling Pathway on the Th17/IL-17 Axis in Acute Cellular Rejection After Heart Transplantation in Mice.

J Cardiovasc Pharmacol 2021 Apr 7;77(5):614-620. Epub 2021 Apr 7.

Department of Thoracic and Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.

Abstract: Acute immune rejection is one of the most serious complications of heart transplantation, and its mechanism has always been a hot spot. Th17 cells and cytokine interleukin-17 (IL-17) have been proved to be involved in acute immune rejection, and the signaling pathway mechanism has attracted our interest. It has been confirmed that the Janus kinase 2-signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway is involved in the differentiation of CD4+ T cells, so we focus on whether the JAK2/STAT3 signaling pathway is involved in the occurrence of acute immune rejection by regulating the Th17/IL-17 axis. Read More

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Cardiosphere-derived cells, with and without a biological scaffold, stimulate myogenesis and recovery of muscle function in mice with volumetric muscle loss.

Biomaterials 2021 Apr 27;274:120852. Epub 2021 Apr 27.

Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. Electronic address:

Extremity trauma to military personnel and civilians commonly results in volumetric muscle loss (VML), leaving patients suffering chronic physical disability. Biomaterial-based technologies such as extracellular matrices (ECMs) are currently in clinical testing for soft tissue repair, but, in preclinical models of VML, the efficacy of ECMs is equivocal. In a murine model of VML, we investigated the effects of ECM and/or cardiosphere-derived cell (CDC) therapy; the latter improves skeletal myogenesis and muscle function in mdx mice, so we reasoned that CDCs may exert disease-modifying bioactivity in VML. Read More

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Measurable Residual Disease Before Reduced-Intensity Allogeneic Transplantation in Patients With Myeloid Malignancy.

J Clin Oncol 2021 May 5:JCO2100255. Epub 2021 May 5.

Gege Gui, ScM, Laura W. Dillon, PhD, and ChristopherS. Hourigan, DM, DPhil, Laboratory of Myeloid Malignancy, Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD.

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Evaluation of safety of using incompatible plasma for therapeutic plasma exchange during shortage of AB plasma.

J Clin Apher 2021 May 5. Epub 2021 May 5.

Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: Criteria for selection of FFP blood type has not been clearly established and use of group AB plasma is preferred by numerous transplantation protocols.

Aims: This study assesses the safety and efficacy of alternative group A or B plasma in ABO incompatible solid organ transplantation.

Materials & Methods: Alternative use of group A or B plasma (incompatible plasma) was inevitable during the shortage of group AB plasma. Read More

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Isolation and expansion of thymus-derived regulatory T cells for use in paediatric heart transplant patients.

Eur J Immunol 2021 May 5. Epub 2021 May 5.

MRC Centre for Transplantation, School of Immunology and Microbial Sciences, King's, College London, Guy's Hospital, London, UK.

Regulatory T-cells (Tregs) are a subset of T-cells generated in the thymus with intrinsic immunosuppressive properties. Phase I clinical trials have shown safety and feasibility of Treg infusion to promote immune tolerance and new studies are ongoing to evaluate their efficacy. During heart transplantation, thymic tissue is routinely discarded providing an attractive source of Tregs. Read More

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Heart transplantation from donors with left ventricular ejection fraction under 40.

Clin Transplant 2021 May 4:e14341. Epub 2021 May 4.

Schumakov National Medical Research Center, Moscow, Russia.

Background: Heart transplantation (HTx) remains the treatment of choice for patients with end-stage advanced heart failure. In 2016 the Schumakov National Medical Research Center commenced performing HTx from donors with abnormal left ventricular systolic function (LVEF <40%). The aim of this study was to evaluate early and late outcomes of recipients after HTx from donors with abnormal LV systolic function. Read More

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Impact of Diabetes and Chronic Dialysis on Post Transplant Survival in Combined Heart-Kidney Transplant Recipients.

Clin Transplant 2021 May 4:e14338. Epub 2021 May 4.

University of California San Diego, Department of Surgery, Division of Transplantation, United States.

Growing research supports an increased survival benefit of combined heart and kidney transplantation in patients with both heart and renal failure. As a result, the frequency of these combined transplants continues to increase. Despite this trend, little has been done to quantify the impact of chronic illness in this population. Read More

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Preclinical evaluation for engraftment of CD34 cells gene-edited at the sickle cell disease locus in xenograft mouse and non-human primate models.

Cell Rep Med 2021 Apr 20;2(4):100247. Epub 2021 Apr 20.

Cellular and Molecular Therapeutics Branch, National Heart Lung and Blood Institutes (NHLBI)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD, USA.

Sickle cell disease (SCD) is caused by a 20A > T mutation in the β-globin gene. Genome-editing technologies have the potential to correct the SCD mutation in hematopoietic stem cells (HSCs), producing adult hemoglobin while simultaneously eliminating sickle hemoglobin. Here, we developed high-efficiency viral vector-free non-footprint gene correction in SCD CD34 cells with electroporation to deliver SCD mutation-targeting guide RNA, Cas9 endonuclease, and 100-mer single-strand donor DNA encoding intact β-globin sequence, achieving therapeutic-level gene correction at DNA (∼30%) and protein (∼80%) levels. Read More

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A challenging case of arrhythmogenic right ventricular cardiomyopathy presenting as fulminant myocarditis.

Oxf Med Case Reports 2021 Apr 28;2021(4):omab013. Epub 2021 Apr 28.

Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is known as a primary genetic heart disease that leading to the myocardial deposition of fibrofatty tissue in right ventricular (RV) wall. Sometimes, it occurs in the left ventricular (LV) subepicardial wall. This study introduces a child referred to our hospital with influenza-like symptoms and ventricular tachyarrhythmia, followed by cardiac failure. Read More

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Clinical outcomes of a nurse-led post-discharge education program for heart-transplant recipients: A retrospective cohort study.

Appl Nurs Res 2021 Jun 23;59:151427. Epub 2021 Mar 23.

Department of Nursing, Mo-Im Kim Nursing Research Institute, Yonsei University College of Nursing, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea. Electronic address:

Background: Advances in immunosuppressive therapeutics and medical technology have improved survival rates after heart transplantation. Although there is a rigorous schedule of outpatient visits and testing to detect early signs of rejection and other complications in the first year after transplantation, repeated unplanned readmissions of heart transplant recipients remains a challenge.

Objective: This study aimed to compare the effects of specialized nurse-led discharge education, including continuous post-transplant education and counselling, on heart transplant recipients' clinical outcomes, with the effects of existing discharge education. Read More

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Feasibility and impact of laparoscopic sleeve gastrectomy after renal transplantation on comorbidities, graft function and quality of life.

BMC Surg 2021 May 4;21(1):235. Epub 2021 May 4.

Department of General Surgery, Faculty of Medicine, Benha University Hospital, Benha University, Benha, Egypt.

Background: The aim of this study is to clarify the feasibility and effect of laparoscopic sleeve gastrectomy (LSG) on comorbidities, graft function and quality of life in patients who underwent renal transplantation (RT).

Methods: This is a retrospective review of five patients who underwent LSG after RT. Demographic data, anthropometric parameters, the effect on comorbidities, postoperative course, immunosuppressive medications, causes of RT, renal function, the survival of graft, and quality of life after SG in obese patients with a history of RT were assessed using BAROS-Moorhead-Ardelt survey RESULTS: From September 2015 to September 2019, 5 renal transplant patients underwent LSG; three female, and two male. Read More

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Immune-Associated Proteins Are Enriched in Lung Tissue-Derived Extracellular Vesicles during Allergen-Induced Eosinophilic Airway Inflammation.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Krefting Research Centre, Institute of Medicine, at Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.

Studying the proteomes of tissue-derived extracellular vesicles (EVs) can lead to the identification of biomarkers of disease and can provide a better understanding of cell-to-cell communication in both healthy and diseased tissue. The aim of this study was to apply our previously established tissue-derived EV isolation protocol to mouse lungs in order to determine the changes in the proteomes of lung tissue-derived EVs during allergen-induced eosinophilic airway inflammation. A mouse model for allergic airway inflammation was used by sensitizing the mice intraperitoneal with ovalbumin (OVA), and one week after the final sensitization, the mice were challenged intranasal with OVA or PBS. Read More

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High Rates of Liver Cirrhosis and Hepatocellular Carcinoma in Chronic Hepatitis B Patients with Metabolic and Cardiovascular Comorbidities.

Microorganisms 2021 Apr 30;9(5). Epub 2021 Apr 30.

Department of Internal Medicine, University Medical Hospital Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.

Background: The prevalence of metabolic and cardiovascular diseases is rising worldwide. However, little is known about the impact of such disorders on hepatic disease progression in chronic hepatitis B (CHB) during the era of potent nucleo(s)tide analogues (NAs).

Methods: We retrospectively analyzed a single-center cohort of 602 CHB patients, comparing the frequency of liver cirrhosis at baseline and incidences of liver-related events during follow-up (hepatocellular carcinoma, liver transplantation and liver-related death) between CHB patients with a history of diabetes, obesity, hypertension or coronary heart disease (CHD). Read More

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Left Pulmonary Artery Patch Augmentation for Lung Transplant in a Patient With Situs Inversus.

Tex Heart Inst J 2021 Jan;48(1)

Division of Cardiothoracic Surgery, Department of Surgery, Baylor College of Medicine, Houston, Texas.

Kartagener syndrome is characterized by situs inversus and defective cilia motion, the latter of which can lead to chronic infections and respiratory failure. If lung transplant is indicated, dextrocardia can pose surgical challenges. We report a rare case of sequential bilateral lung transplant in a 58-year-old man with Kartagener syndrome whose left pulmonary artery was abnormal in length, location, and direction. Read More

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January 2021

Off-Pump Continuous-Flow Left Ventricular Assist Device Implantation.

Tex Heart Inst J 2021 Jan;48(1)

Department of Advanced Cardiopulmonary Therapies and Transplantation, University of Texas Health Science Center at Houston, Houston, Texas.

Continuous-flow left ventricular assist device implantation is the typical treatment for end-stage heart failure. Improvements in device engineering and technology, surgical experience and technique, and perioperative management have advanced the field, and short-term results approach those of heart transplantation. Further improvements may be achieved by minimizing adverse physiologic effects associated with cardiopulmonary bypass. Read More

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January 2021

Urgent-start dialysis in patients referred early to a nephrologist-the CKD-REIN prospective cohort study.

Nephrol Dial Transplant 2021 May 4. Epub 2021 May 4.

Université Paris-Saclay, UVSQ, Inserm, Clinical Epidemiology Team, CESP (Centre de recherche en Epidémiologie et Santé des Populations), Villejuif, France.

Background: The lack of a well-designed prospective study of the determinants of urgent dialysis start led us to investigate its individual- and provider-related factors in patients seeing nephrologists.

Methods: CKD-REIN is a prospective cohort study that included 3033 patients with CKD (mean age, 67 years; 65% men; mean estimated glomerular filtration rate (eGFR), 32 mL/min/1.73 m2) from 40 nationally representative nephrology clinics from 2013-16, who were followed annually through 2020. Read More

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Challenges, experiences, and postoperative outcomes in setting up first successful lung transplant unit in India.

Lung India 2021 May-Jun;38(3):216-222

Institute of Heart and Lung Transplant, Gleneagles Global Health City, Chennai, Tamil Nadu, India.

Background: Lung transplantation (LT) has emerged as a definitive cure for a plethora of end-stage lung diseases (ESLDs). With improvements in immune-suppression protocols, the posttransplantation survival rates have gone up.

Aim: The study reported the initial experience of the India's single largest lung transplant program on clinicopathological profile, procedures, challenges encountered, and outcomes. Read More

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Transplantation for Congenital Heart Disease: Focus on the Impact of Functionally Univentricular Versus Biventricular Circulation.

World J Pediatr Congenit Heart Surg 2021 May;12(3):352-359

Heart Institute, 2518Cincinnati Children's Hospital, Cincinnati, OH, USA.

Background: Varying single center data exist regarding the posttransplant outcomes of patients with single ventricle circulation, particularly following the Fontan operation. We sought to better elucidate these results in patients with congenital heart disease (CHD) through combining two national databases.

Methods: The United Network for Organ Sharing (UNOS) transplantation database was merged with the Pediatric Health Information System (PHIS), an administrative database with 71% of UNOS patients matched. Read More

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Sex-specific temporal evolution of circulating biomarkers in patients with chronic heart failure with reduced ejection fraction.

Int J Cardiol 2021 Apr 30. Epub 2021 Apr 30.

Department of Cardiology, Erasmus Medical Centre, Rotterdam, the Netherlands. Electronic address:

Background: We aimed to assess differences in clinical characteristics, prognosis, and the temporal evolution of circulating biomarkers in male and female patients with HFrEF.

Methods: We included 250 patients (66 women) with chronic heart failure (CHF) between 2011 and 2013 and performed trimonthly blood sampling during a median follow-up of 2.2 years [median (IQR) of 8 (5-10) urine and 9 (5-10) plasma samples per patient]. Read More

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Cardiovascular Issues in Hematopoietic Stem Cell Transplantation (HSCT).

Curr Treat Options Oncol 2021 Apr 30;22(6):51. Epub 2021 Apr 30.

Cardio-Oncology Unit, Hematology Department, La Paz University Hospital, IdiPAZ, Madrid, Spain.

Opinion Statement: Hematopoietic stem cell transplantation (HSCT) is considered, since 1957, a potentially curative therapeutic option for many hemopathies. Although it is an aggressive procedure, improvements in transplantation techniques and supportive strategies have markedly decreased treatment-related mortality, and the prevalence of HSCT survivors is expected to exceed half a million by 2030. At the same time, there is a growing awareness of the potentially negative effects of HSCT-related therapies on the cardiovascular (CV) system, and HSCT survivors constitute a population at high cardiovascular (CV) risk. Read More

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Anaesthetic challenges in pulmonary alveolar microlithiasis - a rare disease treated with bilateral lung transplantation, first case from India.

Ann Card Anaesth 2021 Jan-Mar;24(1):79-82

Institute of Heart, Lung and Transplantation, Gleneagles Global Health City, Chennai, Tamil Nadu, India.

Pulmonary Alveolar Microlithiasis (PAM) is a rare autosomal recessive end stage lung condition characterized by widespread alveolar deposition of calcium microliths. It is worth emphasis india has reported 80 cases out of 1022 cases worldwide but there is no report on lung transplant and and anaesthetic management in this category of patient. This report present the anaesthetic challenge in management of first indian patient with the diagnosis of PAM, who underwent bilateral lung transplantation. Read More

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Pilot Study of Endovascular Delivery of Mesenchymal Stromal Cells in the Aortic Wall in a Pig Model.

Cell Transplant 2021 Jan-Dec;30:9636897211010652

Stem Cell Center, 14644Texas Heart Institute, Houston, Texas, USA.

Abdominal aortic aneurysms (AAAs) have a high mortality. In small-animal models, multipotent mesenchymal stromal cells (MSCs) have shown benefits in attenuating aneurysm formation. However, an optimal cell delivery strategy is lacking. Read More

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