289,238 results match your criteria heart tissues


Chikungunya Virus Infects the Heart and Induces Heart-Specific Transcriptional Changes in an Immunodeficient Mouse Model of Infection.

Am J Trop Med Hyg 2021 Nov 29. Epub 2021 Nov 29.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas.

Chikungunya virus (CHIKV) is a mosquito-transmitted pathogen in family Togaviridae, genus Alphavirus. Although CHIKV is well known for its ability to cause debilitating rheumatoid-like arthritis, it has been also been observed to cause cardiovascular symptoms such as arrhythmias. Here, using samples from a previous study, we sequenced RNA from serum, kidney, skeletal muscle, and cardiac muscle from CHIKV- and mock-infected IFN-αR-/- mice using two sequencing techniques to investigate heart-specific changes in virus mutational profiles and host gene expression. Read More

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November 2021

Identifying the heat resistant genes by multi-tissue transcriptome sequencing analysis in Turpan Black sheep.

Theriogenology 2021 Nov 16;179:78-86. Epub 2021 Nov 16.

Department of Animal Science, College of Animal Science, Xinjiang Agricultural University, Urumqi, 830052, China. Electronic address:

Heat stress not only affects the physical condition but also affects reproductive performance in sheep. A thorough understanding of the molecular and physiological mechanisms underlying heat stress would certainly improve livestock productivity and provide genetic evaluation ways for heat resistant breeds selection. In this study, 85 Turpan Black sheep, a breed exhibited excellent heat resistance from long-term artificial selection, and 85 heat sensitive Kazakh sheep in Turpan basin were tested for physiological and reproductive performance from July to August in summer. Read More

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November 2021

Design and characterization of an in vivo injectable hydrogel with effervescently generated porosity for regenerative medicine applications.

Acta Biomater 2021 Nov 26. Epub 2021 Nov 26.

Laboratory for tissue biology and therapeutic engineering (LBTI), CNRS, Université de Lyon, UMR 5305, 7 Passage du Vercors, 69367, Lyon cedex 7, France. Electronic address:

Injectable hydrogels that polymerize directly in vivo hold significant promises in clinical settings to support the repair of damaged or failing tissues. Existing systems that allow cellular and tissue ingrowth after injection are limited because of deficient porosity and lack of oxygen and nutrient diffusion inside the hydrogels. Here is reported for the first time an in vivo injectable hydrogel in which the porosity does not pre-exist but is formed concomitantly with its in situ injection by a controlled effervescent reaction. Read More

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November 2021

Use of Coronary Intravascular Lithotripsy: A Comprehensive Review of Literature.

Curr Probl Cardiol 2021 Nov 26:101076. Epub 2021 Nov 26.

University of Texas Medical Branch, Department of Internal Medicine, Division of Cardiovascular Diseases, Galveston, TX, USA.

Severe coronary artery calcification (CAC) is associated with high rate of procedural complications. The current techniques that facilitate PCI in moderate to severe CAC have significant risk of complications, including periprocedural myocardial infarction (MI), dissection, perforation and transient atrioventricular block. Coronary Intravascular lithotripsy (IVL) is a novel technology for the treatment of moderate to severe calcified lesions. Read More

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November 2021

Modern advances regarding interatrial communication in congenital heart defects.

J Card Surg 2021 Nov 29. Epub 2021 Nov 29.

Department of Pediatric and Congenital Heart Surgery, Houston Children's Heart Institute, Memorial Hermann Children's Hospital, University of Texas Health, McGovern Medical School, Houston, Texas, USA.

Background: The interatrial communication, one of the most frequent congenital heart defects, represents an important intracardiac shunt between systemic and pulmonary circulations. Direction and magnitude of the interatrial shunting depends upon several features, including defect size, shape and location, pressure difference between right and left atrium, and difference in right and left ventricular compliance.

Methods: In this review article, the presence or absence of interatrial communication, and its role, have been analyzed, as they can have a critical impact on the cardiovascular physiopathology, and the interatrial communication can prove to be either clinically harmful, useful or indispensable. Read More

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November 2021

Repurposing hyperpolarization-activated cyclic nucleotide-gated channels as a novel therapy for breast cancer.

Clin Transl Med 2021 Nov;11(11):e578

Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are members of the voltage-gated cation channel family known to be expressed in the heart and central nervous system. Ivabradine, a small molecule HCN channel-blocker, is FDA-approved for clinical use as a heart rate-reducing agent. We found that HCN2 and HCN3 are overexpressed in breast cancer cells compared with normal breast epithelia, and the high expression of HCN2 and HCN3 is associated with poorer survival in breast cancer patients. Read More

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November 2021

Epicardial and endothelial cell activation concurs with extracellular matrix remodeling in atrial fibrillation.

Clin Transl Med 2021 Nov;11(11):e558

Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Heart Center, Amsterdam, The Netherlands.

Background: Improved understanding of the interconnectedness of structural remodeling processes in atrial fibrillation (AF) in patients could identify targets for future therapies.

Methods: We present transcriptome sequencing of atrial tissues of patients without AF, with paroxysmal AF, and persistent AF (total n = 64). RNA expression levels were validated in the same and an independent cohort with qPCR. Read More

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November 2021

Potential Therapeutic Effect of Citronellal on Diabetic Cardiomyopathy in Experimental Rats.

Evid Based Complement Alternat Med 2021 17;2021:9987531. Epub 2021 Nov 17.

College of Pharmacy, Henan International Joint Laboratory of Cardiovascular Remodeling and Drug Intervention, Xinxiang Key Laboratory of Vascular Remodeling Intervention and Molecular Targeted Therapy Drug Development, Xinxiang Medical University, Xinxiang 453003, China.

Diabetic cardiomyopathy (DCM), a cardiovascular complication of patients with diabetes, is a special cardiomyopathy that is independent of coronary heart disease, hypertension, and valvular disease. Citronellal (CT) is a monoterpene compound generated by the secondary metabolism of plants. In this work, the therapeutic effect and mechanism of CT in DCM were investigated. Read More

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November 2021

Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults.

Mediators Inflamm 2021 18;2021:1796204. Epub 2021 Nov 18.

Institute of Genetics and Biochemistry, Federal University of Uberlândia, 38400-902 Uberlândia, MG, Brazil.

Periodontal disease is an infectious inflammatory disease related to the destruction of supporting tissues of the teeth, leading to a functional loss of the teeth. Inflammatory molecules present in the exudate are catalyzed and form different metabolites that can be identified and quantified. Thus, we evaluated the inflammatory exudate present in crevicular fluid to identify metabolic biological markers for diagnosing chronic periodontal disease in older adults. Read More

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November 2021

Molecular detection of in aborted fetuses of goats in Chattogram, Bangladesh.

Vet World 2021 Sep 14;14(9):2386-2391. Epub 2021 Sep 14.

Department of Surgery and Theriogenology, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet 3100, Bangladesh.

Background And Aim: is a protozoan parasite that is responsible for the major cause of congenital diseases, abortion, and stillbirth in humans and farm animals. Primary infection in pregnant goats due to leads to abortion and significant economic losses in the livestock industry. Moreover, very few studies have been performed for the identification of from aborted fetuses of goats. Read More

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September 2021

Pharmacological inhibition of mTOR attenuates DOCA-salt-induced hypertension and related pathophysiology: regulation of oxidative stress, inflammation and cardiovascular hypertrophy in male rats.

J Cardiovasc Pharmacol 2021 Nov 23. Epub 2021 Nov 23.

Department of Pharmacology, Faculty of Pharmacy, Mersin University, Mersin, Turkey; Department of Cardiovascular Surgery, Mersin State Hospital, Mersin, Turkey; Department of Cardiovascular Surgery, Faculty of Medicine, Mersin University, Mersin, Turkey; Department of Histology and Embryology, Faculty of Medicine, Mersin University, Mersin, Turkey; Department of Pharmacology, College of Medicine, University of Tennessee, Center for Health Sciences, Memphis, TN, USA.

Abstract: The present study aimed to explore the contribution of mTOR in deoxycorticosterone acetate (DOCA)-salt-induced hypertension and related pathophysiological changes in cardiovascular and renal tissues. DOCA-salt loading resulted in an increase in systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) along with the activity of ribosomal protein S6 (rpS6), the effector protein of mTOR. Treatment with rapamycin, the selective inhibitor of mTOR, initiated at the 4th week of DOCA-salt administration normalized the SBP and attenuated rpS6 activity in the heart, aorta, and kidney. Read More

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November 2021

Protective role of emodin in rats with post-myocardial infarction heart failure and influence on extracellular signal-regulated kinase pathway.

Bioengineered 2021 Dec;12(2):10246-10253

Department of Cardiovascular Medicine, Avic 363 Hospital, Chengdu, Sichuan Province, China.

We aimed to explore the effects of emodin on the energy metabolism of myocardial cells in rats with post-myocardial infarction (MI) heart failure (HF) and the extracellular signal-regulated kinase (ERK) pathway. The model of MI was established by ligation of the left anterior descending branch. After 4 weeks, the rats with left ventricular ejection fraction (LVEF) of ≤45% were used aspost-MI HF model animals and randomly divided into model, low-dose, middle-dose, high-dose and control groups (n=10). Read More

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December 2021

Metabolic design in a mammalian model of extreme metabolism, the North American least shrew (Cryptotis parva).

J Physiol 2021 Nov 27. Epub 2021 Nov 27.

National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Key Points: Least shrews were studied to explore the relationship between metabolic function, mitochondrial morphology and protein content in different tissues. Liver and kidney mitochondrial content and enzymatic activity approaches the heart indicating similar metabolic demand among tissues that contribute to basal and maximum metabolism. This allows examination of mitochondrial structure and composition in tissues with similar maximum metabolic demands. Read More

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November 2021

Multiview confocal super-resolution microscopy.

Nature 2021 Nov 26. Epub 2021 Nov 26.

Laboratory of High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.

Confocal microscopy remains a major workhorse in biomedical optical microscopy owing to its reliability and flexibility in imaging various samples, but suffers from substantial point spread function anisotropy, diffraction-limited resolution, depth-dependent degradation in scattering samples and volumetric bleaching. Here we address these problems, enhancing confocal microscopy performance from the sub-micrometre to millimetre spatial scale and the millisecond to hour temporal scale, improving both lateral and axial resolution more than twofold while simultaneously reducing phototoxicity. We achieve these gains using an integrated, four-pronged approach: (1) developing compact line scanners that enable sensitive, rapid, diffraction-limited imaging over large areas; (2) combining line-scanning with multiview imaging, developing reconstruction algorithms that improve resolution isotropy and recover signal otherwise lost to scattering; (3) adapting techniques from structured illumination microscopy, achieving super-resolution imaging in densely labelled, thick samples; (4) synergizing deep learning with these advances, further improving imaging speed, resolution and duration. Read More

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November 2021

High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes.

Nutrients 2021 Nov 17;13(11). Epub 2021 Nov 17.

Institute of Life Sciences, College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China.

Salt, commonly known as sodium chloride, is an important ingredient that the body requires in relatively minute quantities. However, consuming too much salt can lead to high blood pressure, heart disease and even disruption of circadian rhythms. The biological process of the circadian rhythm was first studied in and is well understood. Read More

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November 2021

Morphology of the Myocardium after Experimental Bone Tissue Trauma and the Use of Extracellular Vesicles Derived from Mesenchymal Multipotent Stromal Cells.

J Pers Med 2021 Nov 15;11(11). Epub 2021 Nov 15.

Institute of Molecular Pathology and Pathomorphology, Federal State Budget Scientific Institution "Federal Research Center of Fundamental and Translational Medicine" of the Ministry of Science and Higher Education of the Russian Federation, Timakova St., 2, 630117 Novosibirsk, Russia.

The effect of extracellular vesicles (EVs) of various origins on the heart structures in the time of health and disease has been well studied. At the same time, data on the distribution of EVs throughout the body after introduction into the tissues and the possibility of the influence of these EVs on organs distant from the injection site are practically absent. It is also necessary to note a certain inconsistency in the results of various researchers: from articles on the direct absorption of EVs derived from mesenchymal multipotent stromal cells (MSC EVs) by cardiomyocytes to the data that the heart is inherently immune to drug delivery mediated by nanoparticles. Read More

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November 2021

Targeting the Gut Mucosal Immune System Using Nanomaterials.

Pharmaceutics 2021 Oct 21;13(11). Epub 2021 Oct 21.

Fischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Drive, College Park, MD 20742, USA.

The gastrointestinal (GI) tract is one the biggest mucosal surface in the body and one of the primary targets for the delivery of therapeutics, including immunotherapies. GI diseases, including, e.g. Read More

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October 2021

The Challenges and Opportunities in the Development of MicroRNA Therapeutics: A Multidisciplinary Viewpoint.

Cells 2021 Nov 9;10(11). Epub 2021 Nov 9.

Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.

microRNAs (miRs) are emerging as attractive therapeutic targets because of their small size, specific targetability, and critical role in disease pathogenesis. However, <20 miR targeting molecules have entered clinical trials, and none progressed to phase III. The difficulties in miR target identification, the moderate efficacy of miR inhibitors, cell type-specific delivery, and adverse outcomes have impeded the development of miR therapeutics. Read More

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November 2021

Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance.

Cells 2021 Nov 8;10(11). Epub 2021 Nov 8.

Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.

Diabetes mellitus (DM), one of the metabolic diseases which is characterized by sustained hyperglycemia, is a life-threatening disease. The global prevalence of DM is on the rise, mainly in low- and middle-income countries. Diabetes is a major cause of blindness, heart attacks, kidney failure, stroke, and lower limb amputation. Read More

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November 2021

Mitochondrial Dysfunction in Cardiorenal Syndrome 3: Renocardiac Effect of Vitamin C.

Cells 2021 Nov 5;10(11). Epub 2021 Nov 5.

Laboratory of Cardiovascular Immunology, Center of Natural and Human Sciences (CCNH), Federal University of ABC, Santo André 09210-580, Brazil.

Cardiorenal syndrome (CRS) is a pathological link between the kidneys and heart, in which an insult in a kidney or heart leads the other organ to incur damage. CRS is classified into five subtypes, and type 3 (CRS3) is characterized by acute kidney injury as a precursor to subsequent cardiovascular changes. Mitochondrial dysfunction and oxidative and nitrosative stress have been reported in the pathophysiology of CRS3. Read More

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November 2021

The Role of GDF15 as a Myomitokine.

Cells 2021 Nov 3;10(11). Epub 2021 Nov 3.

Department of Physiology of Energy Metabolism, German Institute of Human Nutrition, Potsdam-Rehbruecke (DIfE), 14558 Nuthetal, Germany.

Growth differentiation factor 15 (GDF15) is a cytokine best known for affecting systemic energy metabolism through its anorectic action. GDF15 expression and secretion from various organs and tissues is induced in different physiological and pathophysiological states, often linked to mitochondrial stress, leading to highly variable circulating GDF15 levels. In skeletal muscle and the heart, the basal expression of GDF15 is very low compared to other organs, but GDF15 expression and secretion can be induced in various stress conditions, such as intense exercise and acute myocardial infarction, respectively. Read More

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November 2021

Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis.

Cells 2021 Oct 28;10(11). Epub 2021 Oct 28.

Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA.

Alterations in the accumulation and composition of the extracellular matrix are part of the normal tissue repair process. During fibrosis, this process becomes dysregulated and excessive extracellular matrix alters the biomechanical properties and function of tissues involved. Historically fibrosis was thought to be progressive and irreversible; however, studies suggest that fibrosis is a dynamic process whose progression can be stopped and even reversed. Read More

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October 2021

Functional Inhibition of Valosin-Containing Protein Induces Cardiac Dilation and Dysfunction in a New Dominant-Negative Transgenic Mouse Model.

Cells 2021 Oct 26;10(11). Epub 2021 Oct 26.

Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA.

Valosin-containing protein (VCP) was found to play a vital protective role against cardiac stresses. Genetic mutations of VCP are associated with human dilated cardiomyopathy. However, the essential role of VCP in the heart during the physiological condition remains unknown since the VCP knockout in mice is embryonically lethal. Read More

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October 2021

Oxidative Stability, Carcass Traits, and Muscle Fatty Acid and Amino Acid Profiles in Heat-Stressed Broiler Chickens.

Antioxidants (Basel) 2021 Oct 29;10(11). Epub 2021 Oct 29.

Department of Animal Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, New Valley University, El-Kharga P.O. Box 72511, Egypt.

The objective was to elucidate the effects of chronic heat stress on carcass traits, muscle oxidative stability, muscle fatty acids and amino acid profiles in broiler chickens. A total of 100-day-old male Ross broiler chicks were divided into two equal groups of five replicates. The control group (TN) was maintained on a thermoneutral condition, while the experimental group (HS) was subjected to 8 h of heat stress (34 °C). Read More

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October 2021

Automated Quantitative Lung CT Improves Prognostication in Non-ICU COVID-19 Patients beyond Conventional Biomarkers of Disease.

Diagnostics (Basel) 2021 Nov 16;11(11). Epub 2021 Nov 16.

Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, Via Vetoio 1, 67100 L'Aquila, Italy.

(1) Background: COVID-19 continues to represent a worrying pandemic. Despite the high percentage of non-severe illness, a wide clinical variability is often reported in real-world practice. Accurate predictors of disease aggressiveness, however, are still lacking. Read More

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November 2021

Gaining Insight into Mitochondrial Genetic Variation and Downstream Pathophysiology: What Can i(PSCs) Do?

Genes (Basel) 2021 Oct 22;12(11). Epub 2021 Oct 22.

Evans Department of Medicine and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.

Mitochondria are specialized organelles involved in energy production that have retained their own genome throughout evolutionary history. The mitochondrial genome (mtDNA) is maternally inherited and requires coordinated regulation with nuclear genes to produce functional enzyme complexes that drive energy production. Each mitochondrion contains 5-10 copies of mtDNA and consequently, each cell has several hundreds to thousands of mtDNAs. Read More

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October 2021

Fatal Infection in a Juvenile Free-Ranging Short-Beaked Common Dolphin ().

Animals (Basel) 2021 Oct 31;11(11). Epub 2021 Oct 31.

School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA 5371, Australia.

is a significant aquatic pathogen of farmed fish species, important zoonotic pathogen, and reported cause of disease in captive Amazon River dolphins () and a bottlenose dolphin (). Here we report as the cause of subcutaneous abscesses, sepsis and mortality in a juvenile free-ranging short-beaked common dolphin () found deceased on a metropolitan Australian beach. Body surfaces were covered by multifocal, depressed, deep, irregular cutaneous ulcerations, which microscopically were characterised by ruptured subcutaneous abscesses with intralesional cocci. Read More

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October 2021

Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease.

Biomolecules 2021 Nov 12;11(11). Epub 2021 Nov 12.

German Heart Centre Munich, Department of Cardiology, Technical University Munich, 80636 Munich, Germany.

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development and progression. While microRNAs (miRs) have been well studied in blood samples, there is little data on tissue-specific miRs in cardiovascular relevant tissues and their relation to cardiovascular risk factors. Read More

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November 2021

The Emerging Role of Metabolism in Brain-Heart Axis: New Challenge for the Therapy and Prevention of Alzheimer Disease. May Thioredoxin Interacting Protein (TXNIP) Play a Role?

Biomolecules 2021 Nov 8;11(11). Epub 2021 Nov 8.

Department of Medicine, University of Udine, 33100 Udine, Italy.

Alzheimer disease (AD) is the most frequent cause of dementia and up to now there is not an effective therapy to cure AD. In addition, AD onset occurs decades before the diagnosis, affecting the possibility to set up appropriate therapeutic strategies. For this reason, it is necessary to investigate the effects of risk factors, such as cardiovascular diseases, in promoting AD. Read More

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November 2021

A Survey of Computer-Aided Tumor Diagnosis Based on Convolutional Neural Network.

Biology (Basel) 2021 Oct 22;10(11). Epub 2021 Oct 22.

School of Computing and Mathematical Sciences, University of Leicester, University Road, Leicester LE1 7RH, UK.

Tumors are new tissues that are harmful to human health. The malignant tumor is one of the main diseases that seriously affect human health and threaten human life. For cancer treatment, early detection of pathological features is essential to reduce cancer mortality effectively. Read More

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October 2021