270,308 results match your criteria heart failure


Autophagy in the Diabetic Heart: A Potential Pharmacotherapeutic Target in Diabetic Cardiomyopathy.

Ageing Res Rev 2021 Apr 7:101338. Epub 2021 Apr 7.

Department of Biochemistry, Kakatiya Medical College, Warangal, 506007, Telangana, India; Applied Biology, CSIR-Indian Institute of Technology, Uppal Road, Tarnaka, Hyderabad, 50000, Telangana, India. Electronic address:

Association of diabetes with an elevated risk of cardiac failure has been clinically evident. Diabetes potentiates diastolic and systolic cardiac failure following the myocardial infarction that produces the cardiac muscle-specific microvascular complication, clinically termed as diabetic cardiomyopathy. Elevated susceptibility of diabetic cardiomyopathy is primarily caused by the generation of free radicals in the hyperglycemic milieu, compromising the myocardial contractility and normal cardiac functions with increasing redox insult, impaired mitochondria, damaged organelles, apoptosis, and cardiomyocytes fibrosis. Read More

View Article and Full-Text PDF

Iron deficiency is associated with impaired biventricular reserve and reduced exercise capacity in patients with unexplained dyspnea.

J Card Fail 2021 Apr 7. Epub 2021 Apr 7.

Department of Cardiology, Hartcentrum, Jessa Hospital, Hasselt, Belgium; Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.

Background: Iron deficiency (ID) is frequent and associated with diminished exercise capacity in heart failure (HF), but its contribution to unexplained dyspnea without a HF diagnosis at rest remains unclear.

Methods: Consecutive patients with unexplained dyspnea and normal echocardiography and pulmonary function tests at rest underwent prospective standardized cardiopulmonary exercise testing with echocardiography (CPETecho) in a tertiary care dyspnea clinic. ID was defined as ferritin <300µg/l and transferrin saturation (TSAT)<20% and its impact on peak oxygen uptake (peakVO), biventricular response to exercise, and peripheral oxygen extraction was assessed. Read More

View Article and Full-Text PDF

A novel role of claudin-5 in prevention of mitochondrial fission against ischemic/hypoxic stress in cardiomyocytes.

Can J Cardiol 2021 Apr 7. Epub 2021 Apr 7.

Division of Cardiology, Department of Medicine, School of Medicine, University of California Irvine, Irvine, CA 92697, USA. Electronic address:

Background: Downregulation of claudin-5 in the heart is associated with the end-stage heart failure. However, the underlying mechanism of claudin-5 is unclear. Here we investigated the molecular actions of claudin-5 in perspective of mitochondria in cardiomyocytes to better understand the role of claudin-5 in cardioprotection during ischemia. Read More

View Article and Full-Text PDF

Effects of SGLT2 inhibitors on cardiovascular, renal, and major safety outcomes in heart failure: A meta-analysis of randomized controlled trials.

Int J Cardiol 2021 Apr 7. Epub 2021 Apr 7.

Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Electronic address:

Aims: Sodium-glucose co-transporter 2 inhibitor (SGLT2i), initially introduced for the treatment of diabetes mellitus (DM), demonstrates cardiovascular and renal benefits in patients with heart failure (HF). We aimed to conduct a meta-analysis of its effects on cardiovascular, renal, and major safety outcomes in HF.

Methods And Results: PubMed, Embase, Cochrane Library, and Web of Science were searched using the terms of "SGLT2i and HF" or "SGLT2i *". Read More

View Article and Full-Text PDF

Serum LRG1 as a novel biomarker for cardioembolic stroke.

Clin Chim Acta 2021 Apr 7. Epub 2021 Apr 7.

Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao266000, China. Electronic address:

Background: In recent years, LRG1 was found to be closely related to atrial fibrillation, heart failure, and myocardial remodeling after myocardial infarction. While its role in cerebral infarction was still controversial. We aimed to explore the value of LRG1 to identify the cardioembolic stroke. Read More

View Article and Full-Text PDF

The Timed Up and Go test and the ageing heart: Findings from a national health screening of 1,084,875 community-dwelling older adults.

Eur J Prev Cardiol 2021 Apr;28(2):213-219

Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.

Aim: This study aimed to evaluate the relationship between Timed Up and Go test performance and the incidence of older adult heart diseases and mortality.

Methods: This was a retrospective cohort study of 1,084,875 older adults who participated in a national health screening program between 2009-2014 (all aged 66 years old). Participants free of myocardial infarction, congestive heart failure, and atrial fibrillation at baseline were included and were divided into Group 1 (<10 s), Group 2 (10-20 s) and Group 3 (≥20 s) using the Timed Up and Go test scores. Read More

View Article and Full-Text PDF

Prognostic impact of hospital-acquired disability in elderly patients with heart failure.

ESC Heart Fail 2021 Apr 10. Epub 2021 Apr 10.

Department of Physical Therapy, Faculty of Health Science, Juntendo University Tokyo, 3-2-12, Hongo, Bunkyo-ku, Ochanomizu Centre Building 503, Tokyo, 113-0033, Japan.

Aims: Functional decline is associated with worse outcomes in patients with elderly heart failure (HF), but little is known about the prognostic impact of hospital-acquired disability (HAD) during hospital stay after acute HF. The present study examines the prognostic significance of HAD in the prediction of all-cause mortality in elderly patients who admitted for acute HF.

Methods And Results: This retrospective study was performed in 1941 elderly patients aged ≥65 years or older from the cardiovascular physiotherapy for acute HF patients in the Tokyo metropolitan area registry and excluded those who died in hospital. Read More

View Article and Full-Text PDF

Association of anaemia and all-cause mortality in patients with ischaemic heart failure varies by renal function status.

ESC Heart Fail 2021 Apr 10. Epub 2021 Apr 10.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.

Aims: The aims of the current study were to evaluate the association between anaemia and all-cause mortality according to chronic kidney disease (CKD) status and to explore at what level of haemoglobin concentration would the all-cause mortality risk increase prominently among CKD and non-CKD patients, respectively.

Methods And Results: This is a prospective cohort study, and 1559 patients with ischaemic heart failure (IHF) were included (mean age of 63.5 ± 11. Read More

View Article and Full-Text PDF

Relationship of physical function with quality of life in older patients with acute heart failure.

J Am Geriatr Soc 2021 Apr 10. Epub 2021 Apr 10.

Section of Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States.

Background: Older patients with acute decompensated heart failure (ADHF) have severely impaired physical function (PF) and quality of life (QOL). However, relationships between impairments in PF and QOL are unknown but are relevant to clinical practice and trial design.

Methods: We assessed 202 consecutive patients hospitalized with ADHF in the multicenter Rehabilitation Therapy in Older Acute HF Patients (REHAB-HF) Trial. Read More

View Article and Full-Text PDF

Inferior mesenteric arteriovenous fistula with colonic ischemia: a case report and review of the literature.

Clin J Gastroenterol 2021 Apr 10. Epub 2021 Apr 10.

Department of Radiology, Saint-Eloi University Hospital, 80 Av. Augustin Fliche, 34000, Montpellier, France.

Inferior mesenteric arteriovenous fistula is a rare abnormal high flow communication with only 40 primary and secondary cases reported in literature. Shunting of arterial flow through the inferior mesenteric vein to the portal system can cause a variety of nonspecific clinical signs and symptoms usually associated with the diagnosis of arteriovenous malformation. Symptom intensities are flow-dependent and can range from minimal abdominal symptoms to severe heart failure due to left to right shunt. Read More

View Article and Full-Text PDF

Home sleep apnea testing: an accuracy study.

Sleep Breath 2021 Apr 10. Epub 2021 Apr 10.

Neuro-Sono Sleep Center, Neurology Department, Unifesp, São Paulo, Brazil.

Aim: There are no studies comparing tests performed at home with those carried out in the laboratory, using the same device. The only studies that have been performed have compared the device used at home with the standard polygraph used in the laboratory. The purpose of this study was therefore to verify the accuracy of the home diagnosis of obstructive sleep apnea syndrome (OSAS) via unassisted type 2 portable polysomnography, compared with polysomnography using the same equipment in a sleep laboratory. Read More

View Article and Full-Text PDF

LA reservoir strain: a sensitive parameter for estimating LV filling pressure in patients with preserved EF.

Int J Cardiovasc Imaging 2021 Apr 10. Epub 2021 Apr 10.

Department of Cardiovascular Medicine, Ankara University School of Medicine, Cebeci Kalp Merkezi, Mamak, Ankara, Turkey.

An elevated left ventricular (LV) filling pressure is the main finding in patients with heart failure with preserved ejection fraction (HFpEF), and LV filling pressure is estimated with an algorithm in the recent American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI) guideline. In this study, we sought to determine the efficacy of LA global longitudinal strain to estimate elevated LV filling pressure. Seventy-one consecutive patients (mean age of 63. Read More

View Article and Full-Text PDF

Deciphering Genetic Variants of Warfarin Metabolism in Children With Ventricular Assist Devices.

Pediatr Cardiol 2021 Apr 10. Epub 2021 Apr 10.

Heart Failure, Transplant and Mechanical Assistance Program Unit, Bambino Gesù Children Hospital, Rome, Italy.

Warfarin is prescribed in patients with ventricular assist devices (VADs). Dosage depends on several factors including the underlying genotype. These include polymorphisms of genes encoding cytochrome P450 enzymes, the main ones being CYP2C9, VKORC1, and CYP4F2. Read More

View Article and Full-Text PDF

Impact of chronic total occlusion lesions on clinical outcomes in patients receiving rotational atherectomy: results from the ROCK registry.

Heart Vessels 2021 Apr 10. Epub 2021 Apr 10.

Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Korea.

The aim of this study was to investigate the impact of chronic total occlusion (CTO) on clinical outcomes in patients with calcified coronary lesions receiving rotational atherectomy (RA). This multi-center registry enrolled consecutive patients with calcified coronary artery disease who underwent RA during percutaneous coronary intervention (PCI) from 9 tertiary centers in Korea between January 2010 and October 2019. The primary outcome was target-vessel failure (TVF) which included the composite of cardiac death, target-vessel myocardial infarction (TVMI), and target-vessel revascularization (TVR). Read More

View Article and Full-Text PDF

New horizons in cardiogeriatrics: geriatricians and heart failure care-the custard in the tart, not the icing on the cake.

Age Ageing 2021 Apr 9. Epub 2021 Apr 9.

Department of Cardiology, Imperial College Healthcare NHS Trust, London, UK.

Heart failure (HF) can be considered a disease of older people. It is a leading cause of hospitalisation and is associated with high rates of morbidity and mortality in the over-65s. In 2012, an editorial in this journal detailed the latest HF research and guidelines, calling for greater integration of geriatricians in HF care. Read More

View Article and Full-Text PDF

The bidirectional interaction between atrial fibrillation and heart failure: consequences for the management of both diseases.

Europace 2021 Apr;23(Supplement_2):ii40-ii45

Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.

Atrial fibrillation (AF) and heart failure (HF) are both highly prevalent diseases and are accompanied by a significant disease burden and increased mortality. Although the conditions may exist independently, they often go hand in hand as each is able to provoke, sustain, and aggravate the other. In addition, the diseases share a risk profile with several coinciding cardiovascular risk factors, promoting the odds of developing both AF and HF separately from each other. Read More

View Article and Full-Text PDF

Epidemiology of cardiogenic shock and cardiac arrest complicating non-ST-segment elevation myocardial infarction: 18-year US study.

ESC Heart Fail 2021 Apr 9. Epub 2021 Apr 9.

Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Aims: This study aims to evaluate the impact of the combination of cardiogenic shock (CS) and cardiac arrest (CA) complicating non-ST-segment elevation myocardial infarction (NSTEMI).

Methods And Results: Adult (>18 years) NSTEMI admissions using the National Inpatient Sample database (2000 to 2017) were stratified by the presence of CA and/or CS. Outcomes of interest included in-hospital mortality, early coronary angiography, hospitalization costs, and length of stay. Read More

View Article and Full-Text PDF

Clinical and demographic correlates of accelerometer-measured physical activity in participants enrolled in the OPTIMISE HFpEF study.

Eur J Cardiovasc Nurs 2021 Apr 9. Epub 2021 Apr 9.

Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, Forvie Site, Cambridge Biomedical Campus, Cambridge CB22 5DT, UK.

Aims: This study aimed to measure physical activity (PA) in participants with suspected heart failure with preserved ejection fraction (HFpEF) and assess associations between PA and participant characteristics.

Methods And Results: Adults with presumed HFpEF were recruited and received diagnostic evaluation and clinical assessment. Physical activity was objectively measured using accelerometers over 7 days. Read More

View Article and Full-Text PDF

Chronic breathlessness in advanced cardiorespiratory disease: patient perceptions of opioid use.

BMJ Support Palliat Care 2021 Apr 9. Epub 2021 Apr 9.

The University of Melbourne Faculty of Medicine, Dentistry and Health Sciences, Melbourne, Victoria, Australia

Objective: Low-dose oral opioids may improve severe chronic breathlessness in advanced cardiorespiratory diseases. Prescription of opioids for breathlessness occurs infrequently however, with little known about patients' attitudes towards their use in this setting. The aim of this qualitative study was to explore patients' perceptions regarding opioids for the management of severe chronic breathlessness in people with advanced cardiorespiratory disease. Read More

View Article and Full-Text PDF

Donor Left Ventricular Function Assessed by Echocardiographic Strain is a Novel Predictor of Primary Graft Failure After Orthotopic Heart Transplantation.

J Cardiothorac Vasc Anesth 2021 Mar 17. Epub 2021 Mar 17.

Thoracic Organ Transplants, Institute of Heart and Lung Transplantation, Gleneagles Global Health City, Chennai, India.

Objectives: This study sought to determine the utility of donor left ventricular function assessment by echocardiographic left ventricular global longitudinal strain (LV GLS) in predicting primary graft failure (PGF) after orthotopic heart transplantation (HT).

Design: Retrospective, observational study.

Setting: Tertiary referral hospital. Read More

View Article and Full-Text PDF

A BERIBERI UNHEALTHY LATTE: ENCEPHALOPATHY AND SHOCK FROM SEVERE NUTRITIONAL DEFICIENCY.

J Emerg Med 2021 Apr 6. Epub 2021 Apr 6.

Department of Emergency Medicine, University of California, San Diego, San Diego, California; Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, San Diego, California.

Background: Thiamine deficiency is an uncommon cause of severe illness in the United States that can lead to significant morbidity because of high-output cardiac failure, peripheral neuropathy, and permanent neurologic impairment. We report the case of a middle-aged woman with extreme malnutrition caused by complications of Roux-en-Y gastric bypass (RYGB) surgery who presented with signs and symptoms of severe thiamine deficiency and septic shock.

Case Report: A 43-year-old woman who had undergone RYGB surgery and who had multiple complications presented to the emergency department with agitation, confusion, and lethargy. Read More

View Article and Full-Text PDF

Original and minimally invasive approach to a left-lung refractary atelectasis after reparation of an aortic recoarctation in a lactant: Selective endobronchial CPAP.

Rev Esp Anestesiol Reanim 2021 Apr 6. Epub 2021 Apr 6.

Servicio de Cirugía Pediátrica, Hospital Universitario La Paz, Madrid, España.

Atelectasis is one of the most common respiratory complications in pediatric patients after open-heart surgery, and may lead to weaning failure and increased morbidity. We report the use of an original, minimally invasive approach to refractory left lung atelectasis after repair of an aortic coarctation in a 2 month-old infant, in which a CPAP system connected to a flexible endobronchial tube resolved the atelectasis. Read More

View Article and Full-Text PDF

Timing of Gastrografin administration in the management of adhesive small bowel obstruction (ASBO): Does it matter?

Surgery 2021 Apr 6. Epub 2021 Apr 6.

Department of Surgery, Albert Einstein Medical Center, Philadelphia, PA; Department of Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.

Background: Gastrografin challenge is increasingly used as a diagnostic tool to predict patients who may benefit from nonoperative management in adhesive small bowel obstruction. This study explores the optimal timing of Gastrografin in the management of adhesive small bowel obstruction by comparing early versus late Gastrografin challenge.

Methods: A retrospective chart review from January 2016 to January 2018 identified patients with adhesive small bowel obstruction who underwent Gastrografin challenge. Read More

View Article and Full-Text PDF

Targeting necroptosis as therapeutic potential in chronic myocardial infarction.

J Biomed Sci 2021 Apr 9;28(1):25. Epub 2021 Apr 9.

Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Cardiovascular diseases (CVDs) are considered the predominant cause of morbidity and mortality globally. Of these, myocardial infarction (MI) is the most common cause of CVD mortality. MI is a life-threatening condition which occurs when coronary perfusion is interrupted leading to cardiomyocyte death. Read More

View Article and Full-Text PDF

Symptom Status Questionnaire - Heart Failure - Brazilian Version: cross-cultural adaptation and content validation.

Heart Lung 2021 Apr 6;50(4):525-531. Epub 2021 Apr 6.

Escola Paulista de Enfermagem, Universidade Federal de São Paulo, Rua Napoleão de Barros 754, CEP 04024-002, Vila Clementino, São Paulo, SP, Brazil. Electronic address:

Background: In Brazil, there are no instruments available to measure the presence, frequency, severity and distress related to heart failure (HF) symptoms.

Aims: To adapt the Symptom Status Questionnaire - HF (SSQ-HF) into Brazilian Portuguese and to examine the content validity of the adapted version.

Methods: The instrument was translated, back-translated and evaluated by an expert committee for semantic, idiomatic, cultural, and conceptual equivalences. Read More

View Article and Full-Text PDF

Internal-external cross-validation helped to evaluate the generalizability of prediction models in large clustered datasets.

J Clin Epidemiol 2021 Apr 6. Epub 2021 Apr 6.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands; Health Data Research UK and Institute of Health Informatics, University College London, Gibbs Building, 215 Euston Road, London, NW1 2BE, United Kingdom. Electronic address:

Objective: To illustrate how to evaluate the need of complex strategies for developing generalizable prediction models in large clustered datasets.

Study Design And Setting: We developed eight Cox regression models to estimate the risk of heart failure using a large population-level dataset. These models differed in the number of predictors, the functional form of the predictor effects (non-linear effects and interaction) and the estimation method (maximum likelihood and penalization). Read More

View Article and Full-Text PDF

New treatment regimens for Chagas disease: light at the end of the tunnel?

Lancet Infect Dis 2021 Apr 6. Epub 2021 Apr 6.

Heart Failure and Heart Transplant Service, Fundación Cardiovascular de Colombia, Floridablanca, Santander, Colombia.

View Article and Full-Text PDF

Sex and Racial Differences in Autopsy-Defined Causes of Presumed Sudden Cardiac Death.

Circ Arrhythm Electrophysiol 2021 Apr 9. Epub 2021 Apr 9.

Office of the Chief Medical Examiner, City & County of San Francisco, San Francisco, CA.

- Sudden cardiac death (SCD) studies report higher incidence in men and Blacks but presume cardiac cause. We sought to identify sex and race differences in rates and causes of presumed SCDs in a prospective postmortem study in San Francisco County. - All incident presumed SCDs meeting World Health Organization definition ages 18-90 were autopsied via active surveillance of consecutive out-of-hospital deaths in the stmortem ystematic Invesigation of udden ardiac eath (POST SCD) Study (2/1/2011 - 3/1/2014). Read More

View Article and Full-Text PDF

Association between Heart Failure and Clinical Prognosis in Patients with Acute Ischemic Stroke: A Retrospective Cohort Study.

J Clin Neurol 2021 Apr;17(2):200-205

School of Medicine, Universidad de la Sabana, Chía, Colombia.

Background And Purpose: Ischemic stroke is a common cause of death worldwide. In clinical practice it is observed that many individuals who have experienced an ischemic stroke also suffer from simultaneous comorbidities such as heart failure, which could be directly associated with a worse clinical prognosis. Therefore, this study analyzed outcomes in terms of the severity of the event, inhospital mortality, duration of hospital stay, and inhospital recurrence of the episode, in order to determine the implications resulting from the presentation of both pathologies. Read More

View Article and Full-Text PDF

Association between oral contraceptive use and incident heart failure.

ESC Heart Fail 2021 Apr 9. Epub 2021 Apr 9.

Department of Cardiology, Guangdong Provincial People's Hospital, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, 106 Zhongshan 2nd Road, Guangzhou, 510080, China.

Aims: Oral contraceptives (OCs) are widely used in women of reproductive age, but their influences on heart failure (HF) development have yet to be reported. This study was performed to assess HF risk associated with OC use.

Methods And Results: We studied women participating in the Multi-Ethnic Study of Atherosclerosis with available data on OC use. Read More

View Article and Full-Text PDF