292,123 results match your criteria heart failure

Cardiovascular Outcomes in Aortopathy: GenTAC Registry of Genetically Triggered Aortic Aneurysms and Related Conditions.

J Am Coll Cardiol 2022 May;79(21):2069-2081

Division of Cardiology, Weill Cornell Medicine, New York, New York, USA.

Background: The GenTAC (Genetically Triggered Thoracic Aortic Aneurysm and Cardiovascular Conditions) Registry enrolled patients with genetic aortopathies between 2007 and 2016.

Objectives: The purpose of this study was to compare age distribution and probability of elective surgery for proximal aortic aneurysm, any dissection surgery, and cardiovascular mortality among aortopathy etiologies.

Methods: The GenTAC study had a retrospective/prospective design. Read More

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Excess ventilation and exertional dyspnoea in heart failure and pulmonary hypertension.

Eur Respir J 2022 May 26. Epub 2022 May 26.

Professor Emeritus, John Rankin Laboratory of Pulmonary Medicine, Dept of Population Health Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Increased ventilation relative to metabolic secondary to alveolar hyperventilation and/or increased physiological dead space (excess ventilation) is a key cause of exertional dyspnoea. Excess ventilation has assumed a prominent role in the functional assessment of patients with heart failure (HF) with reduced (r) or preserved (p) ejection fraction, pulmonary arterial hypertension (PAH), and chronic thromboembolic PH (CTEPH). We herein provide the key pieces of information to the caring physician to a) gain unique insights into the seeds of patients' shortness of breath, and b) develop a rationale for therapeutically lessening excess ventilation to mitigate this distressing symptom. Read More

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Tuberc Respir Dis (Seoul) 2022 May 27. Epub 2022 May 27.

State University of Bahia (UNEB), Brazil.

Objectives: To describe the frequency of comorbidities associated with COPD and their relation with relevant outcomes.

Methods: A systematic review based on the PRISMA methodology was performed. The systematic search was carried until July 2021, using the MEDLINE, Lilacs and Scielo databases to identify studies related to COPD and its comorbidities. Read More

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Short Term Left Ventricular Reverse Remodeling after Transcatheter Aortic Valve Replacement in Children.

J Am Soc Echocardiogr 2022 May 23. Epub 2022 May 23.

Department of Pediatrics, Division of Cardiology, University of Utah and Primary Children's Hospital, Salt Lake City, UT, USA.

Background: There are no published data on left ventricular (LV) reverse remodeling after transcatheter aortic valve replacement (TAVR) in children. We sought to assess changes in LV echocardiographic parameters 6 months post-TAVR in children.

Methods: This single center, retrospective study included all 22 patients (age <21 yrs. Read More

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CA125 a cause or an effect in heart failure?

Int J Cardiol 2022 May 23. Epub 2022 May 23.

Department of cardiovascular department, Dongguan, Kanghua Hospital, 523000, Guangdong, China.. Electronic address:

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Nonalcoholic fatty liver disease and cardiovascular diseases: A Mendelian randomization study.

Metabolism 2022 May 23:155220. Epub 2022 May 23.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. Electronic address:

Background: Evidence suggests that nonalcoholic fatty liver disease (NAFLD) is associated with cardiovascular diseases (CVDs). However, the results are inconsistent, and the causality remains to be established.

Objective: We aimed to investigate the potential causal relationship between NAFLD and CVDs, including arterial stiffness, coronary artery disease, heart failure, stroke, ischemic stroke and its subtypes using two-sample Mendelian randomization (MR). Read More

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Implications of enigmatic transglutaminase 2 (TG2) in cardiac diseases and therapeutic developments.

Biochem Pharmacol 2022 May 23:115104. Epub 2022 May 23.

Department of Biological Sciences, Al al-bayt University, Al-Mafraq, Jordan.

Cardiac diseases are the leading cause of mortality and morbidity worldwide. Mounting evidence suggests that transglutaminases (TGs), tissue TG (TG2) in particular, are involved in numerous molecular responses underlying the pathogenesis of cardiac diseases. The TG family has several intra- and extracellular functions in the human body, including collagen cross-linking, angiogenesis, cell growth, differentiation, migration, adhesion as well as survival. Read More

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Diabetes mellitus and diabetic foot ulcer: Etiology, biochemical and molecular based treatment strategies via gene and nanotherapy.

Biomed Pharmacother 2022 May 23;151:113134. Epub 2022 May 23.

Department of Orthopaedic Surgery, Dongtan Sacred Heart Hospital, Hallym University, College of Medicine, Hwaseong, Republic of Korea. Electronic address:

Diabetes mellitus (DM) is a collection of metabolic and pathophysiological disorders manifested with high glucose levels in the blood due to the inability of β-pancreatic cells to secrete an adequate amount of insulin or insensitivity of insulin towards receptor to oxidize blood glucose. Nevertheless, the preceding definition is only applicable to people who do not have inherited or metabolic disorders. Suppose a person who has been diagnosed with Type 1 or Type 2DM sustains an injury and the treatment of the damage is complicated and prolonged. Read More

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An Investigation of Physiological System Impairments in Individuals 4 Weeks to 6 Months Following Mild Traumatic Brain Injury.

J Head Trauma Rehabil 2022 May 26. Epub 2022 May 26.

Neck and Head Research Unit, School of Health and Rehabilitation Sciences, University of Queensland, Brisbane, Australia (Drs Galea, O'Leary, and Treleaven); and Physiotherapy Department, Royal Brisbane and Women's Hospital, Brisbane, Australia (Dr O'Leary).

Objective: The Buffalo Concussion Treadmill Test (BCTT) was developed to identify potential physiological system impairment (PSI) underlying persistent symptoms post-mild traumatic brain injury (mTBI). This study evaluates PSI in individuals 4 weeks to 6 months post-mTBI using the BCTT "failure" criteria, and additional exploratory measures of test duration and heart rate (HR) response.

Setting: Tertiary hospital and university. Read More

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Diabetes Drug Now Approved for Heart Failure.

Am J Nurs 2022 Jun;122(6):22

Diane S. Aschenbrenner is a former member of the faculty at Notre Dame of Maryland University and the Johns Hopkins University School of Nursing. She coordinates Drug Watch:

The diabetes drug empagliflozin (Jardiance) is now approved to reduce the risk of cardiovascular death and hospitalization in adults with heart failure, even if they do not have diabetes.Nurses and NPs should monitor patients for adverse effects, especially fluid deficits. Read More

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Erratum: Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model.


J Vis Exp 2022 May 26(183). Epub 2022 May 26.

An erratum was issued for: Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model. The Protocol and Discussion sections were updated. Step 3. Read More

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Arrhythmias as Presentation of Genetic Cardiomyopathy.

Circ Res 2022 May 26;130(11):1698-1722. Epub 2022 May 26.

Division of Cardiovascular Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN.

There is increasing evidence regarding the prevalence of genetic cardiomyopathies, for which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias presenting in the absence of known myocardial disease are often labelled as idiopathic, or lone. While ventricular arrhythmias are well-recognized as presentation for arrhythmogenic cardiomyopathy in the right ventricle, the scope of arrhythmogenic cardiomyopathy has broadened to include those with dominant left ventricular involvement, usually with a phenotype of dilated cardiomyopathy. Read More

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Multi-system trajectories and the incidence of heart failure in the Framingham Offspring Study.

PLoS One 2022 26;17(5):e0268576. Epub 2022 May 26.

Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.

Background: Heart failure is a multi-system disease, with non-cardiac systems playing a key role in disease pathogenesis.

Objective: Investigate whether longitudinal multi-system trajectories incrementally predict heart failure risk compared to single-occasion traits.

Methods: We evaluated 3,412 participants from the Framingham Heart Study Offspring cohort, free of heart failure, who attended examination cycle 5 and at least one examination between 1995-2008 (mean age 67 years, 54% women). Read More

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The impact of medical therapy on left ventricular strain: Current state and future perspectives.

J Clin Ultrasound 2022 May 26. Epub 2022 May 26.

Limited Liability Company "International Heart Center", 6 Tverskaya street, Saint-Petersburg, 191015, Russia.

The speckle tracking strain is becoming a frequently used marker of subclinical left ventricular systolic dysfunction. Despite the wide range of data concerning left ventricular strain variability in the general population and its changes in various pathologic conditions, the information about the impact of medical therapy on left ventricle strain is limited. This article provides an analysis of published studies of left ventricle strain changes in response to different agents and combinations of medical therapies used for hypertension and congestive heart failure. Read More

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Cardiogenic Shock and Temporary Mechanical Circulatory Support.

Crit Care Nurs Q 2022 Jul-Sep 01;45(3):218-224

Department of Interventional Cardiology, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, Pennsylvania (Drs Khalif and Ranganathan) and Division of Pulmonary Critical Care Medicine, School of Nursing, Ryerson University, Toronto, Ontario, Canada (Dr DuMont).

Cardiogenic shock is a state of circulatory collapse due to low cardiac output resulting from heart failure. Heart failure in this setting may be due to left, right, or biventricular dysfunction. Acute myocardial infarctions remain the most common cause of cardiogenic shock, although in contemporary patient populations, the increasing prevalence of end-stage heart failure has resulted in a growing population of heart failure cardiogenic shock presentations. Read More

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Diaphragm plication using a subcostal approach as an alternative to a thoracotomy.

Carine Pavy

Multimed Man Cardiothorac Surg 2022 Mar 31;2022. Epub 2022 Mar 31.

Diaphragm paralysis is a rare complication in pediatric heart surgery (0.28%-5.6%, depending on the procedure). Read More

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Periplocin Alleviates Cardiac Remodeling in DOCA-Salt-Induced Heart Failure Rats.

J Cardiovasc Transl Res 2022 May 26. Epub 2022 May 26.

Hebei Medical University, Shijiazhuang, 050017, Hebei, China.

Heart failure with preserved ejection fraction (HFpEF) is a common public health problem associated with increased morbidity and long-term mortality. However, effective treatment for HFpEF was not discovered yet. In the present study, we aimed to decipher the effects of Periplocin on DOCA-induced heart failure rats and explore the possible underlying mechanisms. Read More

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The effect of cognitive-behavioral therapy on death anxiety and depression in patients with heart failure: A quasi-experimental study.

Perspect Psychiatr Care 2022 May 26. Epub 2022 May 26.

Department of Psychiatric Nursing, Faculty of Nursing & Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.

Purpose: In this study, the effect of cognitive-behavioral therapy (CBT) on death anxiety and depression was investigated in patients with heart failure.

Design And Methods: In this quasi-experimental study, 66 patients with heart failure were randomly assigned to intervention (n = 33) and control (n = 33) groups. Data collection was done using a demographic questionnaire, Templer death anxiety scale, and Beck depression inventory. Read More

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Cardiorenal Nexus: A Review With Focus on Combined Chronic Heart and Kidney Failure, and Insights From Recent Clinical Trials.

J Am Heart Assoc 2022 May 26:e024139. Epub 2022 May 26.

International Renal Research Institute of Vicenza Italy.

The cardiorenal nexus encompasses a bidirectional relationship between the heart and the kidneys. Chronic abnormalities in cardiac function can lead to progressive kidney disease, and chronic kidney disease can lead to progressively decreasing cardiac function and increasing risk of cardiovascular disease, including heart failure. About 15% of US adults have chronic kidney disease, 2% have heart failure, and 9% have cardiovascular disease. Read More

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Overcoming perioperative inflammation as a hurdle for successful preclinical orthotopic cardiac xenogeneic transplantations - particular in regard of the mandatory use of heart-lung machines.

Xenotransplantation 2022 May 26:e12749. Epub 2022 May 26.

Department of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany.

Introduction: After orthotopic cardiac xenotransplantation, the combination of both the inflammatory responses to the exposure of a recipient to the xenogeneic organ and the use of cardiopulmonary bypass has been assumed to cause detrimental side effects. These have been described not only to affect the transplanted organ (heart) itself, but also the recipient's lungs. In this article, we summarize how these possible detrimental processes can be minimized or even avoided. Read More

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Fine-Tuning Cardiac Insulin/Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity.

Circulation 2022 May 26:101161CIRCULATIONAHA122059863. Epub 2022 May 26.

Department of Cardiology, Medical University of Graz, Austria. (M.A., V.T.-H., A.H., J.V., A.S., P.P.R., D.S., D.v.L. E.B., S.S.).

Background: The insulin/insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular metabolism and aging. Although its inhibition promotes longevity across species, the effect of attenuated IGF1 signaling on cardiac aging remains controversial.

Methods: We performed a lifelong study to assess cardiac health and lifespan in 2 cardiomyocyte-specific transgenic mouse models with enhanced versus reduced IGF1 receptor (IGF1R) signaling. Read More

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BMP7-based peptide agonists of BMPR1A protect the left ventricle against pathological remodeling induced by pressure overload.

Biomed Pharmacother 2022 May 4;149:112910. Epub 2022 Apr 4.

Instituto de Investigación Sanitaria Valdecillla (IDIVAL), Santander, Spain; Departamento de Fisiología y Farmacología, Facultad de Medicina, Universidad de Cantabria, Santander, Spain. Electronic address:

Aortic stenosis (AS) exposes the left ventricle (LV) to pressure overload leading to detrimental LV remodeling and heart failure. In animal models of cardiac injury or hemodynamic stress, bone morphogenetic protein-7 (BMP7) protects LV against remodeling by counteracting TGF-β effects. BMP receptor 1A (BMPR1A) might mediate BMP7 antifibrotic effects. Read More

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Fulminant necrotizing eosinophilic myocarditis after COVID-19 vaccination survived with mechanical circulatory support.

ESC Heart Fail 2022 May 26. Epub 2022 May 26.

Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

A 69-year-old man was hospitalized for heart failure 7 days after coronavirus disease 2019 (COVID-19) mRNA vaccination. Electrocardiography showed ST-segment elevation and echocardiography demonstrated severe left ventricular dysfunction. Venoarterial extracorporeal membrane oxygenation and Impella 5. Read More

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Frailty Status Modifies the Efficacy of Exercise Training Among Patients With Chronic Heart Failure and Reduced Ejection Fraction: An Analysis From the HF-ACTION Trial.

Circulation 2022 May 26:101161CIRCULATIONAHA122059983. Epub 2022 May 26.

Cardiovascular Medicine and Geriatrics Sections, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.K.).

Background: Supervised aerobic exercise training (ET) is recommended for stable outpatients with heart failure (HF) with reduced ejection fraction (HFrEF). Frailty, a syndrome characterized by increased vulnerability and decreased physiologic reserve, is common in patients with HFrEF and associated with a higher risk of adverse outcomes. The effect modification of baseline frailty on the efficacy of aerobic ET in HFrEF is not known. Read More

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Interventional Microbubble Enhanced Sonothrombolysis on Left Ventricular Assist Devices.

Adv Sci (Weinh) 2022 May 26:e2201291. Epub 2022 May 26.

State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.

The left ventricular assist device (LVAD) is often used in the treatment of heart failure. However, 4% to 9% implanted LVAD will have thrombosis problem in one year, which is fatal to the patient's life. In this work, an interventional sonothrombolysis (IST) method is developed to realize the thrombolysis on LVAD. Read More

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Cardiorenal syndrome and the association with fitness: Data from a telerehabilitation randomized clinical trial.

ESC Heart Fail 2022 May 26. Epub 2022 May 26.

Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Aims: To investigate the associations of cardiorespiratory fitness with cardiac, vascular, renal and cardiorenal characteristics in chronic heart failure in a telerehabilitation randomized clinical trial. Secondly, to evaluate the associations of cardiorenal syndrome with the effects of exercise.

Methods And Results: Sixty-nine heart failure patients attended baseline examination, and 61 patients were randomly assigned 1:1 to 3-month telerehabilitation or control. Read More

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Safety and efficacy of transcatheter mitral valve repair in patients with COPD; results from real-world cohort.

Catheter Cardiovasc Interv 2022 May 26. Epub 2022 May 26.

Department of Pneumology and Intensive Care Medicine, University Hospital RWTH, Aachen, Germany.

Objective: To evaluate the safety and efficacy of transcatheter mitral valve repair (TMVR) in patients with chronic obstructive pulmonary disease (COPD).

Background: Heart failure and COPD share many clinical features and commonly coexist. Data about the safety and efficacy of TMVR in patients with COPD is not conclusive. Read More

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Long-term follow-up of a patient undergoing interatrial shunt device implantation for treatment of heart failure with a preserved ejection fraction.

J Int Med Res 2022 May;50(5):3000605221098178

Head of Heart Failure Clinic, Department of Cardiology, Na Homolce Hospital Cardiovascular Center, Roentgenova 2, 150 30, Prague 5, Czech Republic.

We herein present a case study of a patient with heart failure with a preserved ejection fraction and severe symptoms who underwent interatrial shunt device implantation and follow-up at a tertiary care heart failure clinic. The interatrial shunt device implantation was successful. No adverse events occurred, and the device prevented hospitalization for heart failure during long-term follow-up. Read More

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