4,933 results match your criteria healthy wistar


Curcumin nano-micelle induced testicular toxicity in healthy rats; evidence for oxidative stress and failed homeostatic response by heat shock proteins 70-2a and 90.

Biomed Pharmacother 2021 Jul 23;142:111945. Epub 2021 Jul 23.

Department of Basic Sciences, Division of Comparative Histology & Embryology, Faculty of Veterinary Medicine, Urmia University, P.O.BOX: 1177, Urmia, Iran. Electronic address:

This study explores the effect of curcumin nano-micelle (NCMN) on the testicular anti-oxidant status and heat shock proteins (Hsp) 70-2a and Hsp 90 expression. Therefore, 24 male Wistar rats were divided into control, 7.50 mg/kg, 15 mg/kg, and 30 mg/kg of NCMN-received groups. Read More

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The protective effects of capsaicin on oxidative damage-induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats.

Drug Chem Toxicol 2021 Jul 26:1-8. Epub 2021 Jul 26.

Department of Pharmacology, Faculty of Medicine, University of Pamukkale, Denizli, Turkey.

The present study aimed to investigate the protective role of capsaicin in a rat model of 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD)-induced toxicity. Exposure to TCDD which is an environmental toxicant causes severe toxic effects in the animal and human tissues. Therefore, the potential protective effect of capsaicin in TCDD-induced organ damage was investigated in rats by measuring thiobarbituric acid reactive substances (TBARS) level, superoxide dismutase (SOD) activity, and glutathione (GSH) level in the heart, liver, and kidney tissues for oxidant/antioxidant balance. Read More

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Plumbagin induces testicular damage via mitochondrial-dependent cell death.

Chem Biol Interact 2021 Jul 21:109582. Epub 2021 Jul 21.

Laboratories for Biomembrane Research and Biotechnology, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Different aspects of reproductive functions are regulated by mitochondrial-controlled events. This study investigated the effect of plumbagin (PL) on testicular mitochondria with a view to unravelling the mechanism of the antifertility potential of plumbagin in testis of healthy rats. Thirty-two male Wistar strain albino rats were randomly allocated into four groups of eight animals each. Read More

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induced sperm DNA damage on the experimentally infected rats.

J Parasit Dis 2021 Jun 10;45(2):351-358. Epub 2020 Nov 10.

Department of Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, P.O. Box: 65157838736, Hamadan, Iran.

, as an obligate protozoan parasite, can infect a wide variety of animals as well as human. As some studies have shown, toxoplasmosis decreases the fertility potency in different hosts, so there is a necessity for studies to determine the effects of on reproductive system. Therefore, this project was aimed to investigate the effect of toxoplasmosis on the male reproductive system and sperm DNA integrity. Read More

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Early postnatal overnutrition impairs VO gains with moderate exercise and increase post-exercise muscle damage in adult male rats.

J Dev Orig Health Dis 2021 Jul 21:1-5. Epub 2021 Jul 21.

Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringá, Paraná, Brazil.

Exercise counteracts obesity effects, but information on how early-life obesity may affect long-term adaptation to exercise is lacking. This study investigates the impact of early-life postnatal overfeeding (PO) on animals' adaptation to exercise. Only male Wistar rats were used. Read More

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KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia.

Elife 2021 Jul 19;10. Epub 2021 Jul 19.

Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

The cellular adaptive response to hypoxia, mediated by high HIF1α levels includes metabolic reprogramming, restricted DNA replication and cell division. In contrast to healthy cells, the genome of cancer cells, and Kaposi's sarcoma associated herpesvirus (KSHV) infected cells maintains replication in hypoxia. We show that KSHV infection, despite promoting expression of HIF1α in normoxia, can also restrict transcriptional activity, and promoted its degradation in hypoxia. Read More

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Can remote ischemic preconditioning counteract the renal functional deterioration attributable to partial nephrectomy under warm ischemia? Results of an animal study.

BMC Nephrol 2021 Jul 16;22(1):266. Epub 2021 Jul 16.

Department of Urology, Koc University School of Medicine, Istanbul, Turkey.

Background: To investigate if remote ischemic preconditioning (RIPC) can offer any renoprotective value by counteracting the deleterious effect of partial nephrectomy (PN) under warm ischemia on renal function.

Methods: Four groups, each with 5 Wistar albino rats, were constructed; RIPC + PN, PN, RIPC and sham. Right nephrectomy was performed to constitute a solitary kidney model. Read More

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The Combination of Stromal Vascular Fraction Cells and Platelet-Rich Plasma Reduces Malondialdehyde and Nitric Oxide Levels in Deep Dermal Burn Injury.

J Inflamm Res 2021 8;14:3049-3061. Epub 2021 Jul 8.

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.

Introduction: Thermal burns release reactive oxygen species, which cause profound systemic and local changes. Stromal vascular fraction cells (SVFs) combined with platelet-rich plasma accelerate burn wound healing. This study investigated the effect of a combination of locally injected SVFs and PRP on malondialdehyde (MDA) and nitric oxide (NO) serum and tissue levels in a deep dermal burn model in Wistar rats. Read More

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Protective effect of taxifolin against prooxidant and proinflammatory kidney damage associated with acrylamide in rats.

Biomed Pharmacother 2021 Jul 11;139:111660. Epub 2021 May 11.

Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey. Electronic address:

The current study investigates the biochemical and histopathological effects of taxifolin on acrylamide-induced kidney damage. A 50 mg/kg dose of taxifolin was administered via oral gavage to the taxifolin + acrylamide (TACR) group (n-6) consisting of male albino Wistar rats. The same volume of distilled water used as solvent was orally administered to the acrylamide (ACR) (n-6) and healthy (HG) (n-6) groups. Read More

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Hyperpolarized pyruvate to measure the influence of PKM2 activation on glucose metabolism in the healthy kidney.

NMR Biomed 2021 Jul 8:e4583. Epub 2021 Jul 8.

MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

The purpose of the current study was to investigate if hyperpolarized [1- C]pyruvate can inform us on the metabolic consequences for the kidney glucose metabolism upon treatment with the pyruvate kinase M2 (PKM2) activator TEPP-46, which has shown promise as a novel therapeutic target for diabetic nephropathy. A healthy male Wistar rat model was employed to study the conversion of [1- C]pyruvate to [1- C]lactate in the kidney 2 and 4 h after treatment with TEPP-46. All rats were scanned with hyperpolarized [1- C]pyruvate kidney MR and vital parameters and blood samples were taken after scanning. Read More

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Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with hydroalcoholic extract of Securigera Securidaca seeds, and Glibenclamide.

Reprod Biol Endocrinol 2021 Jul 7;19(1):104. Epub 2021 Jul 7.

Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Structural and physiological changes in sperm and semen parameters reduce fertility in diabetic patients. Securigera Securidaca (S. Securidaca) seed is a herbal medicine with hypoglycemic, antioxidant, and anti-hypertensive effects. Read More

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Canonical Wnt signaling in the kidney in different hypertension models.

Hypertens Res 2021 Jul 5. Epub 2021 Jul 5.

Department of Histology and Cytophysiology, Medical University of Białystok, Białystok, Poland.

There is a close relationship between the kidney and blood pressure. On the one hand, kidney dysfunction causes an increase in blood pressure; on the other hand, high blood pressure causes kidney dysfunction. Wnt/β-catenin signaling is a key pathway that regulates various cellular processes and tissue homeostasis and is also involved in damage and repair processes. Read More

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Effect of spirulina and chlorella alone and combined on the healing process of diabetic wounds: an experimental model of diabetic rats.

J Diabetes Metab Disord 2021 Jun 19;20(1):161-169. Epub 2021 Jan 19.

Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Using chemical agents to cure diabetes mellitus and its complications may be accompanied by complications. New natural agents, such as spirulina and chlorella, could be used as alternative choices in this case.

Methods: 65 male Wistar rats were allocated to 5 groups: A (healthy control), B (diabetic rats with a normal diet), C (diabetic rats supplemented with 50 g/kg/day spirulina), D (diabetic rats supplemented with 50 g/kg/day chlorella) and E (diabetic rats supplemented with 25 g/kg/day chlorella and 25 g/kg/day spirulina). Read More

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Benfotiamine reduced collagen IV contents of sciatic nerve in hyperglycemic rats.

J Diabetes Metab Disord 2021 Jun 20;20(1):21-30. Epub 2021 Feb 20.

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Azadi Square, Mashhad, Iran.

Background: Neuropathy as a common complication of hyperglycemia in diabetic patients is probably caused by metabolic and structural changes in extracellular matrix (ECM) of peripheral nerves. This study was designed to evaluate the effects of benfotiamine (BT) on the structural, biological and mechanical characteristics of rat sciatic nerve in hyperglycemic condition.

Materials And Methods: Forty eight adult male Wistar rats were assigned to 6 groups (n = 8): control (healthy rats with no treatment; C), positive control (healthy rats received BT treatment; B), negative control groups 1&2 (hyperglycemic rats kept for 4 and/or 8 weeks; 4WD and 8WD, respectively) and experimental groups 1&2 (hyperglycemic rats treated by daily oral gavage of 100 mg kg body weight BT for 4 and/or 8 weeks; 4WD + BT and 8WD + BT, respectively). Read More

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The differences in the number of fibroblasts and blood vessels after the topical and systemic administration of Shirota probiotics for the treatment of traumatic ulcers in Wistar rats ().

Vet World 2021 May 23;14(5):1279-1283. Epub 2021 May 23.

Undergraduate Program of Dental Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.

Background And Aim: The use of drugs as a therapy for traumatic ulcers may lead to drug resistance and other side effects. Shirota can affect the number of fibroblasts and blood vessels in wound healing. The aim of this study was to investigate the difference in the number of fibroblast cells and blood vessels after the topical and systemic administration of Shirota probiotics in Wistar rats with traumatic ulcer. Read More

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Doxorubicin and doxorubicin-loaded nanoliposome induce senescence by enhancing oxidative stress, hepatotoxicity, and in vivo genotoxicity in male Wistar rats.

Naunyn Schmiedebergs Arch Pharmacol 2021 Aug 5;394(8):1803-1813. Epub 2021 Jul 5.

Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

The senescence phenomenon is historically considered as a tumor-suppressing mechanism that can permanently arrest the proliferation of damaged cells, and prevent tumor eradication by activating cell cycle regulatory pathways. Doxorubicin (DX) as an antineoplastic agent has been used for the treatment of solid and hematological malignancies for a long time, but its clinical use is limited due to irreversible toxicity on off-target tissues. Thereby, the encapsulation of plain drugs in a vehicle may decrease the side effects while increasing their permeability and availability in target cells. Read More

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Protective effects of olive leaf extract against reproductive toxicity of the lead acetate in rats.

Environ Sci Pollut Res Int 2021 Jul 3. Epub 2021 Jul 3.

Department of Medical Laboratory Techniques, Al-maarif University College, Al-Anbar, Ramadi, Iraq.

Lead acetate (PbAc) is one of the toxic metals in the environment which causes many effects on different organs of the body. And due to the importance of the olive tree, with its healthy and protective elements against many diseases, the leaf extract of this tree was chosen in our study. Therefore, the aim of this study was to investigate the role of olive leaf (Olea europea L. Read More

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Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing.

J Ethnopharmacol 2021 Jun 25;279:114374. Epub 2021 Jun 25.

Department of Animal Biology & Physiology, Faculty of Sciences, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

Ethnopharmacological Relevance: Information collected from local traditional healers reported that Eremomastax speciosa (Hochst.) Cufod. has for a long time been used to manage gastric ulcers in many regions of Cameroon and beyond. Read More

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Static Magnetic Stimulation Induces Changes in the Oxidative Status and Cell Viability Parameters in a Primary Culture Model of Astrocytes.

Cell Biochem Biophys 2021 Jun 27. Epub 2021 Jun 27.

Coordinator of NeuroCell Laboratory, Laboratory of Histology, Department of Morphology, Post-Graduate Program in Biochemistry and Bioprospection, Universidade Federal de Pelotas Avenida Duque de Caxias, 250, 96030-000, Pelotas, Rio Grande do Sul, Brasil.

Astrocytes play an important role in the central nervous system function and may contribute to brain plasticity response during static magnetic fields (SMF) brain therapy. However, most studies evaluate SMF stimulation in brain plasticity while few studies evaluate the consequences of SMF at the cellular level. Thus, we here evaluate the effects of SMF at 305 mT (medium-intensity) in a primary culture of healthy/normal cortical astrocytes obtained from neonatal (1 to 2-day-old) Wistar rats. Read More

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Development and Validation of a Semi-Automated, Preclinical, MRI-Template Based PET Image Data Analysis Tool for Rodents.

Front Neuroinform 2021 8;15:639643. Epub 2021 Jun 8.

Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.

Aim: In PET imaging, the different types of radiotracers and accumulations, as well as the diversity of disease patterns, make the analysis of molecular imaging data acquired challenging. Here, we evaluate and validate a semi-automated MRI template-based data analysis tool that allows preclinical PET images to be aligned to a self-created PET template. Based on the user-defined volume-of-interest (VOI), image data can then be evaluated using three different semi-quantitative parameters: normalized activity, standardized uptake value, and uptake ratio. Read More

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Contribution of fasting and postprandial glucose-lowering mechanisms to the acute hypoglycemic effect of traditionally used Eryngium cymosum F.Delaroche.

J Ethnopharmacol 2021 Jun 21;279:114339. Epub 2021 Jun 21.

Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Av. Universidad 3000, Circuito Exterior S/N, Delegación Coyoacán, C.P, 04510, Ciudad Universitaria, Ciudad de México, Mexico. Electronic address:

Ethnopharmacological Relevance: Eryngium cymosum F. Delaroche was detected as a traditional remedy against type 2 diabetes consumed by patients of Tlanchinol in the state of Hidalgo, Mexico.

Aim Of The Study: Assessing the hypoglycemic effect and safety of the traditional extract of E. Read More

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The investigation of the protective effect of water extract and vitamin E on malathion-induced oxidative damage in rats.

Toxicol Res (Camb) 2021 May 1;10(3):627-630. Epub 2021 Jun 1.

Faculty of Healthy Science, Department of Nursing, Giresun University, 28100, Giresun, Turkey.

Pesticides and other agricultural protective chemical products are widely used almost all over the world. It poses a serious threat, especially for public health. Many studies have reported that pesticide poisoning is a major problem in morbidity and mortality. Read More

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Orange Juice and Yogurt Carrying Probiotic GBI-30 6086: Impact of Intake on Wistar Male Rats Health Parameters and Gut Bacterial Diversity.

Front Microbiol 2021 1;12:623951. Epub 2021 Apr 1.

Department of Food Science and Nutrition, Faculty of Food Engineering, University of Campinas, Campinas, Brazil.

This study aimed to investigate the impact of the food matrix (orange juice and yogurt) on the effects of the spore-forming probiotic microorganism GBI-30 6086 in health parameters and gastrointestinal tract (gut) bacterial diversity in male rats. Rats ( = 48) were randomly distributed into six groups. The groups were the Control (which received sterile distilled water), Juice (which received orange juice), Yogurt (which received yogurt), Probiotic (which received GBI-30 6086 in distilled water), Probiotic Juice (which received orange juice with GBI-30 6086), and Probiotic Yogurt (which received yogurt with GBI-30 6086). Read More

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Antibacterial, antioxidant, and sun protection potential of selected ethno medicinal plants used for skin infections in Uganda.

Trop Med Health 2021 Jun 15;49(1):49. Epub 2021 Jun 15.

Department of Plant Sciences, Microbiology & Biotechnology, Makerere University, P.O Box 7062, Kampala, Uganda.

Background: Rural populations in Uganda rely heavily on medicinal plants for the treatment of bacterial skin infections. However, the efficacy of these medicinal plants for their pharmacological action is not known. The study aimed at evaluating the antibacterial, antioxidant, and sun protection potential of Spermacoce princeae, Psorospermum febrifugum, Plectranthus caespitosus, and Erlangea tomentosa extracts. Read More

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Cancer-induced muscle atrophy is determined by intrinsic muscle oxidative capacity.

FASEB J 2021 07;35(7):e21714

School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.

We tested the hypothesis that cancer cachexia progression would induce oxidative post-translational modifications (Ox-PTMs) associated with skeletal muscle wasting, with different responses in muscles with the prevalence of glycolytic and oxidative fibers. We used cysteine-specific isotopic coded affinity tags (OxICAT) and gel-free mass spectrometry analysis to investigate the cysteine Ox-PTMs profile in the proteome of both plantaris (glycolytic) and soleus (oxidative) muscles in tumor-bearing and control rats. Histological analysis revealed muscle atrophy in type II fibers in plantaris muscle, with no changes in plantaris type I fibers and no differences in both soleus type I and II fibers in tumor-bearing rats when compared to healthy controls. Read More

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Olive Leaf Powder Modulate Insulin Production and Circulating Adipokines in Streptozotocin Induced Diabetic Rats.

J Diet Suppl 2021 Jun 11:1-16. Epub 2021 Jun 11.

National Research Center, Cairo, Egypt.

Olives () have natural phytochemical compounds that are of great importance for their potential beneficially health effects. This study aimed to evaluate the effects of olive leaf powder (OLP) on insulin production and circulating adipokines in streptozotocin-induced diabetic rats. Forty Wistar-albino male rats, weighing 200-225 g were divided into four groups ( = 10); group I: Normal healthy rats received balanced diet; group II: Diabetic control rats receiving balanced diet; group III: Diabetic rats receiving balanced diet + standard antidiabetic drugs (metformin, 600 mg/bw) and group four: Diabetic rats received diet supplemented with 2. Read More

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Protection against experimental cisplatin-induced optic nerve toxicity using resveratrol: A rat model study.

Cutan Ocul Toxicol 2021 Jun 21:1-5. Epub 2021 Jun 21.

Erzincan Binali, Yildirim University, Faculty of Medicine, Department of Pharmacology, Erzincan, Turkey.

Aim: To investigate the effects of resveratrol on oxidative stress and inflammation parameters and histological alterations in cisplatin-induced optic nerve damage in a mouse model.

Material And Method: Thirty-six albino Wistar male rats were divided into three groups as control, 5 mg/kg cisplatin-administered (Cis) and 5 mg/kg cisplatin + 25 mg/kg resveratrol-administered (Cis + Res) animals. At the end of the experimental period, the rats were sacrificed with high-dose (50 mg/kg) thiopental sodium, and their optic nerves were dissected. Read More

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Swimming exercise improves short- and long-term memories: Time-course changes.

Physiol Rep 2021 Jun;9(11):e14851

Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan.

The beneficial effects of exercise training on memory formation are well documented. However, the memory enhancement profile following the time-course of exercise training remains unknown. In this investigation, changes in the spatial hippocampal memory following a time-course of swimming exercise training were examined. Read More

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Digital image processing: a useful tool in the analysis of lung injuries caused by chronic inhalation of agricultural herbicides.

Environ Sci Pollut Res Int 2021 Jun 7. Epub 2021 Jun 7.

Environmental and Regional Development, Oeste Paulista University, Km 572, SP-270 - Bairro Limoeiro, Pres. Prudente, SP, 19026-310, Brazil.

The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is widely used in agriculture to control various weeds. The objective of this study was to use the digital image processing method to identify alveolar lesions in the lungs of rats submitted to chronic 2,4-dichlorophenoxyacetic acid (2,4-D) inhalation exposure. We used forty adult male Wistar rats. Read More

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Associations Between Betatrophin with Irisin and Metabolic Factors: Effects of Exercise Training in Diabetic Rats.

Am J Med Sci 2021 May 30. Epub 2021 May 30.

Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Bu-Ali Sina University, Hamedan, Iran. Electronic address:

Background: Irisin and betatrophin are involved in insulin resistance. We investigated the effects of aerobic and resistance exercise (AE/RE) and de-training (cessation of the training after the AE/RE) on betatrophin, irisin and some metabolic factors in rats.

Methods: Wistar rats were assigned into six groups: non-diabetic rats (C), non-diabetic rats that performed AE/RE, diabetic rats (Dia), and diabetic rats that performed AE/RE (Dia+AE and Dia+RE). Read More

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