4,780 results match your criteria healthy saudi

Expression and prognostic relevance of long noncoding RNAs CRNDE and AOX2P in adult acute myeloid leukemia.

Int J Lab Hematol 2021 Jun 15. Epub 2021 Jun 15.

Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.

Introduction: Several long noncoding RNAs (lncRNAs) have been demonstrated to play a critical role in the tumorigenesis of acute myeloid leukemia (AML), and altered expression of certain lncRNAs has been recognized as a potential prognostic marker in AML patients. Here, we sought to determine whether the expression of the lncRNA colorectal neoplasia differentially expressed (CRNDE) and aldehyde oxidase 2 pseudogene (AOX2P) is associated with clinicopathological features and clinical outcome of patients with AML.

Methods: CRNDE and AOX2P expression levels were measured in diagnostic blood samples from 200 adult patients with de novo AML, along with 50 healthy control blood samples, using quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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Effects of extended abstinence on cognitive functions in tramadol-dependent patients: A cohort study.

Neuropsychopharmacol Rep 2021 Jun 15. Epub 2021 Jun 15.

Department of Psychiatry, Assiut University, Assiut, Egypt.

Background: Some pieces of the literature report impaired cognitive functioning in tramadol dependence. Whether extended abstinence improves cognitive functioning or not is not well studied.

Aim: We aimed to measure the change in cognitive functioning following complete abstinence among individuals with tramadol dependence. Read More

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Gut microbiome skin axis in the development of atopic dermatitis.

J Pak Med Assoc 2021 Apr;71(4):1221-1227

Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Atopic dermatitis mostly starts with children in early life. Besides the aetiological factors, like environmental, dietary or medical exposures, gut-skin axis microbiome studies have an impact to investigate and to understand the relation between the gut microbiome and changes to the skin microbiom as well as resulting skin diseases like atopic dermatitis. Infants start forming their microbiome in early life and some studies suggest that this phase has a crucial role in AD development. Read More

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A Drug Repositioning Approach Identifies a Combination of Compounds as a Potential Regimen for Chronic Lymphocytic Leukemia Treatment.

Front Oncol 2021 28;11:579488. Epub 2021 May 28.

Medical Research Core Facility and Platforms, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.

Drug repositioning is a promising and powerful innovative strategy in the field of drug discovery. In this study, we screened a compound-library containing 800 Food and Drug Administration approved drugs for their anti-leukemic effect. All screening activities made use of human peripheral blood mononuclear cells (PBMCs), isolated from healthy or leukemic donors. Read More

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Protective role of TIRAP functional variant against development of coronary artery disease.

Saudi J Biol Sci 2021 Jun 18;28(6):3548-3552. Epub 2021 Mar 18.

Atta ur Rehman School of Applied Biosciences (ASAB), National University of Sciences & Technology (NUST), H-12 sector, Islamabad, Pakistan.

Coronary artery disease (CAD) is the leading cause of sudden death worldwide. Inflammation is proved to be an important player in development of the CAD. Inflammation is directly regulated by the Toll like receptors (TLRs). Read More

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Relationship between high CRP and cytokines in Saudi old people with dental caries in alkharj Region, Saudi Arabia.

Saudi J Biol Sci 2021 Jun 18;28(6):3523-3525. Epub 2021 Mar 18.

Dept of Med Lab Sci, College of Appl Med Sci, Prince Sattam University, Alkharj, Saudi Arabia.

Objective: Dental caries is one of the most common problems of the oral cavity which is frequently observed in older people. The aim of this study is to evaluate serum C-reactive proteins (CRP) levels and to identify the correlation between dental caries and CRP levels.

Methodology: The study included 12 aged patients with an average age of 65-years; the patients were diagnosed with dental caries and did not have clinical history of heart diseases, rheumatoid arthritis or any other infection. Read More

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Effect of supplementing fava bean (.) on ulcerative colitis and colonic mucosal DNA content in rats fed a high-sucrose diet.

Saudi J Biol Sci 2021 Jun 19;28(6):3497-3504. Epub 2021 Mar 19.

Chemistry Department, College of Science, Taibah University, Medina 30002, Saudi Arabia.

Ulcerative colitis (UC) is an inflammatory bowel disease with high morbidity. Acetic acid-induced damage of colonic mucosa in rats is a commonly used experimental animal model of UC. This research aimed to explore for the first time the ameliorative effect of dietary supplementation with fava bean on the incidence of UC in rats fed with sucrose containing diet. Read More

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leaf extracts produce anti-obesity, hypoglycemic, anti-hyperlipidemic, and hepatoprotective effects on high-fat diet fed rats.

Saudi J Biol Sci 2021 Jun 3;28(6):3333-3342. Epub 2021 Mar 3.

Department of Food Science and Nutrition, College of Food and Agricultural Science, King Saud University, Riyadh, Saudi Arabia.

This present research investigated the anti-obesity and hepatoprotective effects of ethanolic leaf (MPLE) and bark extracts (MPBE), in the rats fed with a high-fat diet (HFD). Healthy male rats (n = 48) were randomly distributed to six groups (n = 8): control AIN-93 diet; HFD; HFD + MPBE bark extracts ((300 mg/kg); HFD + MPBE (600 mg/kg); HFD + MPLE (300 mg/kg); HFD + MPLE (600 mg/kg). HFD-fed rats in the (MP) treatment groups received orally administered MP leaf or bark extract daily for eight weeks. Read More

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Nationwide Seroprevalence of SARS-CoV-2 in Saudi Arabia.

J Infect Public Health 2021 Apr 24;14(7):832-838. Epub 2021 Apr 24.

King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background: Estimated seroprevalence of Coronavirus Infectious Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is a critical evidence for a better evaluation of the virus spread and monitoring the progress of COVID-19 pandemic in a population. In the Kingdom of Saudi Arabia (KSA), SARS-CoV-2 seroprevalence has been reported in specific regions, but an extensive nationwide study has not been reported. Here, we report a nationwide study to determine the prevalence of SARS-CoV-2 in the population of KSA during the pandemic, using serum samples from healthy blood donors, non-COVID patients and healthcare workers (HCWs) in six different regions of the kingdom, with addition samples from COVID-19 patients. Read More

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Olive Leaf Powder Modulate Insulin Production and Circulating Adipokines in Streptozotocin Induced Diabetic Rats.

J Diet Suppl 2021 Jun 11:1-16. Epub 2021 Jun 11.

National Research Center, Cairo, Egypt.

Olives () have natural phytochemical compounds that are of great importance for their potential beneficially health effects. This study aimed to evaluate the effects of olive leaf powder (OLP) on insulin production and circulating adipokines in streptozotocin-induced diabetic rats. Forty Wistar-albino male rats, weighing 200-225 g were divided into four groups ( = 10); group I: Normal healthy rats received balanced diet; group II: Diabetic control rats receiving balanced diet; group III: Diabetic rats receiving balanced diet + standard antidiabetic drugs (metformin, 600 mg/bw) and group four: Diabetic rats received diet supplemented with 2. Read More

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Evaluation of dry eye subtypes and characteristics using conventional assessments and dynamic tear interferometry.

Br J Ophthalmol 2021 Jun 9. Epub 2021 Jun 9.

Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, South Korea

Background/aims: To evaluate subtypes and characteristics of dry eye (DE) using conventional tests and dynamic tear interferometry, and to investigate determinants of disease severity in each DE subtype.

Methods: 309 patients diagnosed with DE and 69 healthy controls were prospectively enrolled. All eyes were evaluated using Ocular Surface Disease Index (OSDI), Schirmer's test I (ST1) and Meibomian gland dysfunction (MGD) grade were analysed. Read More

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Pharmacogenetic determinants of warfarin in the Indian population.

Pharmacol Rep 2021 Jun 9. Epub 2021 Jun 9.

Research Chair for Biomedical Applications of Nanomaterials, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.

Background: Several studies optimized the warfarin dose based on CYP2C9*2, CYP2C9*3, VKORC1 -1639 G > A, CYP4F2 V433M. But, the information on the rare variants is lacking. In this study, we have explored the prevalence of common and rare pharmacogenetic determinants of warfarin and determined their damaging nature. Read More

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Primary Adrenal Malignant Rhabdoid Tumor in a 14-Year-Old Female: A Case Report and Literature Review.

Int J Surg Pathol 2021 Jun 9:10668969211024331. Epub 2021 Jun 9.

Children's Hospital Los Angeles, Los Angeles, CA, USA.

Malignant rhabdoid tumor (MRT) is a rare, SWItch/sucrose nonfermentable-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 ()-deficient, aggressive tumor, occurring predominantly in children below 3 years of age. Primary adrenal MRT is extremely rare, with only 3 cases reported in the literature. A previously healthy 14-year-old female presented with left upper quadrant/epigastric abdominal pain. Read More

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Determination of serum tumor necrosis factor-alpha (TNF-α) levels in metabolic syndrome patients from Saudi population.

Pak J Med Sci 2021 May-Jun;37(3):700-705

Hasan Ejaz, PhD.. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al Jouf, Saudi Arabia.

Objectives: To detect the relationship between serum tumor necrosis factor-alpha (TNF-α) and metabolic syndrome (MetS) components in patients of the Saudi population.

Methods: This cross-sectional study was carried out at Jouf University Saudi Arabia from September 2019 to August 2020 and comprised of 183 individuals (91 cases and 92 controls). The blood samples were drawn from the patients visiting two tertiary care settings of Al Jouf province. Read More

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Family Functioning and Dental Behaviours of Pre-school Children.

Community Dent Health 2021 May 24. Epub 2021 May 24.

Faculty of Dentistry, Oral & Craniofacial Sciences, Kings College London, London, UK.

Objectives: To examine the association of family functioning with child dental behaviours and to identify family functioning domains associated with those behaviours.

Methods: Cross-sectional data from the East London Oral Health Inequalities (ELOHI) study were analysed in a subsample of 733 parent-child (3-4-years-olds) dyads. Family functioning was measured with the 60-item Family Assessment Device that yielded a general functioning score and six domain scores (roles, communication, problem solving, affective involvement, affective responsiveness, and behaviour control). Read More

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Is sputum cytology reliable for detection of atypical lung epithelial proliferative changes triggered by cigarette smoking?

Int J Clin Exp Pathol 2021 15;14(5):618-626. Epub 2021 May 15.

Department of Histopathology and cytology, CMLS, SUST Sudan.

Background: In recent years, Saudi Arabia has witnessed major tobacco smoking-related disease, such as cardiovascular disease and cancer, particularly among the younger population.

Methodology: The present study aimed at evaluating the effect of cigarette smoke on lung epithelial cells.

Results: This was a cross-sectional case-control study involving 300 apparently healthy volunteers living in Ha'il, Northern Saudi Arabia. Read More

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Ischemic Heart Disease Related Sudden Cardiac Death in Autopsied Cases: An Egyptian perspective.

Am J Forensic Med Pathol 2021 Jun 5. Epub 2021 Jun 5.

From the Forensic Pathology Department, Forensic Medicine Authority, Ministry of Justice, Cairo, Egypt Forensic Medicine and Clinical Toxicology, College of Medicine, Jouf University, Aljouf, Saudi Arabia Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Suez Canal University (SCU), Ismailia, Egypt.

Abstract: Diagnosis of the underlying cause of sudden unexpected death in a previously healthy individual remains one of the important challenges in forensic practice. Ischemic heart disease is the most common cause of sudden death. The current study aims to investigate the incidence and pathology of sudden ischemic cardiac death in Egypt. Read More

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Treatment of gingival recession defects using non-invasive pinhole technique with propolis application, a case report.

Int J Surg Case Rep 2021 May 26;83:106042. Epub 2021 May 26.

Preventive Dental Sciences, Vision Colleges, Riyadh, Saudi Arabia.

Introduction And Importance: Despite the considerable surgical techniques that have been done for the root coverage, surgical difficulties, time, and patients' discomfort are still the main obstacles. However, the morbidity associated with the secondary graft sites has generated interest in new modalities to achieve the esthetic and functional requirements without complications, to reach patient comfort and satisfaction. In our study, we used a recent novel surgical technique which is called the pinhole surgical technique as it is a minimally invasive treatment that reverses gingival recession without using donor graft, flap elevation, or sutures. Read More

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Test-retest assessment of non-contrast MRI sequences to characterise and quantify the small bowel wall in healthy participants.

MAGMA 2021 Jun 5. Epub 2021 Jun 5.

Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK.

Objective: Quantitative Magnetic Resonance Imaging sequences have been investigated as objective imaging biomarkers of fibrosis and inflammation in Crohn's disease.

Aim: To determine the repeatability and inter- and intra-observer agreement of these measures in the prepared small bowel wall.

Methods: Ten healthy participants were scanned at 3 T on 2 separate occasions using T1 and T2 relaxometry, IVIM-DWI and MT sequences. Read More

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Optical coherence tomography angiography microvascular changes in diabetics without diabetic retinopathy.

Saudi J Ophthalmol 2020 Jul-Sep;34(3):156-159. Epub 2021 Feb 27.

Department of Ophthalmology, FSI Hospital, Tunis, Tunisie.

Purpose: The purpose of this study was to analyze the retinal vasculature of diabetic eyes without clinical retinopathy in order to detect microvascular abnormalities, comparing them to that of healthy nondiabetic control eyes.

Methods: This is a prospective, cross-sectional study including 40 patients (76 eyes). Twenty patients (40 eyes) were diabetics with no diabetic retinopathy group (NDRG). Read More

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February 2021

A novel multi-class imbalanced EEG signals classification based on the adaptive synthetic sampling (ADASYN) approach.

Adi Alhudhaif

PeerJ Comput Sci 2021 14;7:e523. Epub 2021 May 14.

Department of Computer Science, College of Computer Engineering and Sciences in Al-kharj, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.

Background: Brain signals (EEG-Electroencephalography) are a gold standard frequently used in epilepsy prediction. It is crucial to predict epilepsy, which is common in the community. Early diagnosis is essential to reduce the treatment process of the disease and to keep the process healthier. Read More

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Incidental finding of a needle in the root of the mesentery of an 11-month-old boy: A case report.

Int J Pediatr Adolesc Med 2021 Jun 7;8(2):117-120. Epub 2020 Apr 7.

Pediatric Gastroenterology & Hepatology, KFSH&RC, Riyadh, Saudi Arabia.

Foreign body (FB) ingestion is very common in the pediatric population. Children will have different presentations based on their age, size, type, and site of the ingested FB. Some children can present with serious complications, others can be completely asymptomatic. Read More

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The Impact of Khat () on Hemodynamics of the Common Carotid Arteries in Regular Khat Chewers: A Case-control Study Using Doppler Ultrasound.

J Med Ultrasound 2021 Jan-Mar;29(1):46-49. Epub 2021 Mar 20.

Faculty of Medicine, University of Hargeisa, Hargeisa, Somaliland.

Background: To evaluate the effect of chewing khat on the hemodynamics of the common carotid arteries (CCAs) using Doppler ultrasound imaging.

Methods: This is a cross-sectional case-control study. Fifty volunteers who were chronic regular khat chewers were selected and compared with healthy nonkhat chewers. Read More

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Standing and Walking Balance in Patients with Chronic Shoulder Pain: A Case-control Study.

Saudi J Med Med Sci 2021 May-Aug;9(2):152-158. Epub 2021 Apr 29.

Rehabilitation Centre (Building 2), Dammam Medical Complex, Dammam, Saudi Arabia.

Background: Patients with shoulder pain may have proprioceptive and balance deficits. However, studies on balance in patients with shoulder pain are scarce.

Objective: This study aims to investigate if patients with chronic shoulder pain demonstrate deficits in standing and walking balance and to study the relationship between outcome measures of balance and age and body mass index (BMI). Read More

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Epidemic dropsy toxin, sanguinarine chloride, stimulates sucrose-sensitive hemolysis and breakdown of membrane phospholipid asymmetry in human erythrocytes.

Toxicon 2021 May 31;199:41-48. Epub 2021 May 31.

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.

Sanguinarine (SGN) is a benzophenathridine alkaloid extracted from Sanguinaria canadensis plant. SGN is incriminated in epidemic dropsy (ED) characterized by multiple-organ failure and anemia. Nevertheless, how SGN leads to anemia of ED remains poorly understood. Read More

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Sex Differences in Oral Health and the Consumption of Sugary Diets in a Saudi Arabian Population.

Patient Prefer Adherence 2021 26;15:1121-1131. Epub 2021 May 26.

Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi Arabia.

Background And Purpose: Adolescence is a crucial period for developing healthy lifestyle and dietary habits. The growing consumption of high-sugar foods and beverages constitutes a serious public health concern. The aim of this study was to evaluate sex differences in the consumption of a sugary diet and oral health among Saudi adolescents. Read More

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Validation and clinical application of the Arabic rhinoplasty outcomes evaluation questionnaire.

Saudi Med J 2021 Jun;42(6):655-659

From the Department of Otolaryngology-Head and Neck Surgery (Mulafikh, Alharethy, Alqabbani), College of Medicine and from the Research Chair of Voice, Communications, and Swallowing Disorders, Otolaryngology Department (Mesallam), King Saud University, Riyadh, Kingdom of Saudi Arabia.

Objectives: To carry out translation, cross-cultural adaptation, and validation of the rhinoplasty outcome evaluation (ROE) into Arabic.

Methods: This non-randomized, prospective study included 50 patients from the Otorhinolaryngology Department, King Saud University, Riyadh, Saudi Arabia who underwent primary rhinoplasty from January to October 2020 and a control group of 89 healthy individuals. The reliability of the Arabic (ROE) was tested using Cronbach's alpha. Read More

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Vascular cell adhesion molecule-1 in rheumatoid arthritis patients: Relation to disease activity, oxidative stress, and systemic inflammation.

Saudi Med J 2021 Jun;42(6):620-628

From the Medical Physiology Department (Salem), and from Internal Medicine Department (Zahran), Immunology & Rheumatology Unit, Faculty of Medicine, Menoufia University, Egypt.

Objectives: To evaluate the potential role of vascular cell adhesion molecule-1 (VCAM-1), an endothelial factor, in endothelial dysfunction in rheumatoid arthritis (RA) patients, and to determine its relation to disease activity, oxidative stress, and inflammatory markers.

Methods: This study was designed as a cross-sectional case-control study. One-hundred patients with RA were selected from out-patient clinics of Menoufia University Hospital, Menoufia, Egypt from May 2019 to May 2020. Read More

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Deep learning and evolutionary intelligence with fusion-based feature extraction for detection of COVID-19 from chest X-ray images.

Multimed Syst 2021 May 27:1-13. Epub 2021 May 27.

Department of Computer Science and Engineering, Maharaja Agrasen Institute of Technology, Delhi, India.

In recent times, COVID-19 infection gets increased exponentially with the existence of a restricted number of rapid testing kits. Several studies have reported the COVID-19 diagnosis model from chest X-ray images. But the diagnosis of COVID-19 patients from chest X-ray images is a tedious process as the bilateral modifications are considered an ill-posed problem. Read More

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Improved Transfer-Learning-Based Facial Recognition Framework to Detect Autistic Children at an Early Stage.

Brain Sci 2021 May 31;11(6). Epub 2021 May 31.

WHO Collaborating Centre on eHealth, UNSW Digital Health, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.

Autism spectrum disorder (ASD) is a complex neuro-developmental disorder that affects social skills, language, speech and communication. Early detection of ASD individuals, especially children, could help to devise and strategize right therapeutic plan at right time. Human faces encode important markers that can be used to identify ASD by analyzing facial features, eye contact, and so on. Read More

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