1,276 results match your criteria healthy normals


Vision Impairment Provides New Insight Into Self-Motion Perception.

Invest Ophthalmol Vis Sci 2021 Feb;62(2)

School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.

Purpose: Leading causes of irreversible blindness such as age-related macular degeneration (AMD) and glaucoma can, respectively, lead to central or peripheral vision loss. The ability of sufferers to process visual motion information can be impacted even during early stages of eye disease. We used head-mounted display virtual reality as a tool to better understand how vision changes caused by eye diseases directly affect the processing of visual information critical for self-motion perception. Read More

View Article and Full-Text PDF
February 2021

Isolated diastolic high blood pressure: a distinct clinical phenotype in US children.

Pediatr Res 2021 Jan 27. Epub 2021 Jan 27.

Department of Pediatrics and Child Health, Children's Hospital Research Institute, University of Manitoba, Winnipeg, MB, Canada.

Background: Screening studies have shown that 0.7-4.5% of generally healthy children have isolated diastolic high BP. Read More

View Article and Full-Text PDF
January 2021

Right atrial volume is a major determinant of tricuspid annulus area in functional tricuspid regurgitation: a three-dimensional echocardiographic study.

Eur Heart J Cardiovasc Imaging 2020 Dec 2. Epub 2020 Dec 2.

Department of Medicine, Section of Cardiology, University of Chicago, 5801 S Ellis Ave, Chicago 60637, IL, USA.

Aims: The aim of this study is to explore the relationships of tricuspid annulus area (TAA) with right atrial maximal volume (RAVmax) and right ventricular end-diastolic volume (RVEDV) in healthy subjects and patients with functional tricuspid regurgitation (FTR) of different aetiologies and severities.

Methods And Results: We enrolled 280 patients (median age 66 years, 59% women) with FTR due to left heart disease (LHD), pulmonary hypertension (PH), corrected tetralogy of Fallot (TOF), chronic atrial fibrillation (AF), and 210 healthy volunteers (45 years, 53% women). We measured TAA at mid-systole and end-diastole, tenting volume of tricuspid leaflets, RAVmax, and RVEDV by 3D echocardiography. Read More

View Article and Full-Text PDF
December 2020

Methacholine-Induced Cough in the Absence of Asthma: Insights From Impulse Oscillometry.

Front Physiol 2020 6;11:554679. Epub 2020 Oct 6.

Department of Medicine, School of Medicine, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.

Introduction: The pathophysiologic differences between methacholine-induced cough but normal airway sensitivity (COUGH) and healthy individuals (CONTROL) are incompletely understood and may be due to differences in the bronchodilating effect of deep inspirations (DIs). The purpose of this study is to compare the bronchodilating effect of DIs in individuals with classic asthma (CA), cough variant asthma (CVA), and COUGH with CONTROL and to assess impulse oscillometry (IOS) measures as predictors of the bronchodilating effect of DIs.

Methods: A total of 43 adults [18 female; 44. Read More

View Article and Full-Text PDF
October 2020

Adduction-Induced Strain on the Optic Nerve in Primary Open Angle Glaucoma at Normal Intraocular Pressure.

Curr Eye Res 2021 Apr 11;46(4):568-578. Epub 2020 Sep 11.

Department of Ophthalmology, University of California, Los Angeles, USA.

Purpose/aim: The optic nerve (ON) becomes taut during adduction beyond ~26° in healthy people and patients with primary open angle glaucoma (POAG), but only retracts the globe in POAG. We used magnetic resonance imaging (MRI) to investigate this difference.

Materials And Methods: MRI was obtained in 2-mm quasi-coronal planes in central gaze, and smaller (~23-25°) and larger (~30-31°) adduction and abduction in 21 controls and 12 POAG subjects whose intraocular pressure never exceeded 21 mmHg. Read More

View Article and Full-Text PDF

Effects of new PLM scoring rules on PLM rate in relation to sleep and resting wake for RLS and healthy controls.

Sleep Breath 2021 Mar 25;25(1):381-386. Epub 2020 Jun 25.

Christopher J Earley. Richard P Allen. Department of Neurology, School of Med., Johns Hopkins University, Baltimore, MD, USA.

Purpose: This study evaluates the differences in periodic leg movement (PLM) rates for Restless Legs Syndrome (RLS) and healthy controls when using the updated PLM scoring criteria developed by IRLSSG in 2016 versus the prior PLM scoring criteria developed by IRLSSG in 2006. Four major problems with the prior standards had been objectively identified, i.e. Read More

View Article and Full-Text PDF

Reduced pulmonary vascular reserve during stress echocardiography in confirmed pulmonary hypertension and patients at risk of overt pulmonary hypertension.

Int J Cardiovasc Imaging 2020 Oct 27;36(10):1831-1843. Epub 2020 May 27.

Institute of Clinical Physiology - C.N.R., Pisa, Italy.

Noninvasive estimation of systolic pulmonary artery pressure (SPAP) during exercise stress echocardiography (ESE) is recommended for pulmonary hemodynamics evaluation but remains flow-dependent. Our aim was to assess the feasibility of pulmonary vascular reserve index (PVRI) estimation during ESE combining SPAP with cardiac output (CO) or exercise-time and compare its value in three group of patients: with invasively confirmed pulmonary hypertension (PH), at risk of PH development (PH risk) mainly with systemic sclerosis and in controls (C) without clinical risk factors for PH, age-matched with PH risk patients. We performed semisupine ESE in 171 subjects: 31 PH, 61 PH at risk and 50 controls as well as in 29 young, healthy normals. Read More

View Article and Full-Text PDF
October 2020

Optimization and validation of patient-based real-time quality control procedure using moving average and average of normals with multi-rules for TT3, TT4, FT3, FT3, and TSH on three analyzers.

J Clin Lab Anal 2020 Aug 3;34(8):e23314. Epub 2020 May 3.

Zhejiang Center for Clinical Laboratories, Zhejiang Provincial People's Hospital, Hangzhou, China.

Background: We have designed a patient-based real-time quality control (PBRTQC) procedure to detect analytical shifts and review analytical trends of measurement procedures.

Methods: All the nine months' patient results of total thyroxine (TT4), total triiodothyronine (TT3), free thyroxine (FT4), free triiodothyronine (FT3), and thyrotropin (TSH) measured by three identical analyzers were divided into three groups according to the source of inpatient patients, outpatient patients, and healthy people. The data in each group were truncated by optimized Box-Plot method and normalized by Box-Cox method if necessary. Read More

View Article and Full-Text PDF

Interchangeability of retinal perfusion indices in different-sized angiocubes: An optical coherence tomography angiography study in diabetic retinopathy.

Indian J Ophthalmol 2020 03;68(3):484-489

Department of Vitreoretinal Diseases, Medical Research Foundation, Sankara Nethralaya, Visakhapatnam, India.

Purpose: To evaluate the differences in vascular indices in different scan sizes of optical coherence tomography angiography (OCTA) images in normal persons versus persons with diabetic retinopathy.

Methods: OCTA scans of diabetic patients and age-matched controls were performed by a single operator. Automated quantification of vascular indices of the superficial plexus was analyzed in two angiocubes of 3 × 3 mm and 6 × 6 mm, respectively. Read More

View Article and Full-Text PDF

Relationship between left ventricular isovolumic relaxation flow patterns and mitral inflow patterns studied by using vector flow mapping.

Sci Rep 2019 11 7;9(1):16264. Epub 2019 Nov 7.

Department of Ultrasound, PLA 967th Hospital, Dalian, China.

The purpose of this study was to investigate the relationship between isovolumic relaxation flow (IRF) patterns in left ventricle (LV) and mitral inflow patterns. Color Doppler loops were acquired for vector flow mapping in apical long-axis view in 57 patients with coronary artery disease, 31 patients with dilated cardiomyopathy, and 58 healthy controls. IRF patterns were classified into three categories: pattern A, apically directed flow; pattern B, bidirectional flow with small scattered vortices; and pattern C, a large vortex. Read More

View Article and Full-Text PDF
November 2019

The Correlation between Phospholipase C Epsilon (PLCE1) Gene Polymorphisms and Risk of Gastric Adenocarcinoma in Iranian Population.

Int J Hematol Oncol Stem Cell Res 2019 Jul;13(3):108-115

Immunogenetic Research Center, Cell and Molecular Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

() gene harbors different single nucleotide polymorphisms (SNPs), which can be correlated with the risk of different types of cancers. In this case-control study, the relationship between rs2274223 (A>G), a single nucleotide polymorphism in gene, () and gastric cancer was evaluated among Iranian patients. The rs2274223 polymorphism was genotyped in 60 patients with gastric cancer and 69 control subjects using polymerase chain reaction and restriction fragment length polymorphisms (PCR-RFLP) methods. Read More

View Article and Full-Text PDF

Threshold Automated Perimetry of the Full Visual Field in Patients With Glaucoma With Mild Visual Loss.

J Glaucoma 2019 11;28(11):997-1005

Computational Optometry, Atarfe, Granada, Spain.

Precis: The authors used the Open Perimetry Interface to design a static automated perimetry test of the full field. Abnormal test locations in the nasal midperiphery and temporal inferior sector area best separated glaucomas from normals.

Purpose: The peripheral visual field in glaucoma outside 30 degrees is largely unexplored with static perimetry. Read More

View Article and Full-Text PDF
November 2019

Factors influencing the end-diastolic vortex assessed by using vector flow mapping.

Echocardiography 2019 09 8;36(9):1639-1645. Epub 2019 Aug 8.

Department of Ultrasound, PLA 967th Hospital, Dalian, China.

Objectives: The purpose of this study was to assess the factors influencing the late diastolic vortex in normal and abnormal ventricles.

Methods: Color Doppler data in left ventricle (LV) were acquired from apical long-axis view and analyzed using vector flow mapping in 57 patients with coronary artery disease, 57 patients with dilated cardiomyopathy, and 53 healthy volunteers.

Results: In normals, corrected area and flux of the end-diastolic vortex were positively correlated with transmitral A velocity and heart rate. Read More

View Article and Full-Text PDF
September 2019

Layer-specific longitudinal strain in Anderson-Fabry disease at diagnosis: A speckle tracking echocardiography analysis.

Echocardiography 2019 07 27;36(7):1273-1281. Epub 2019 Jun 27.

Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy.

Background: Speckle tracking advancements make now available the analysis of layer-specific myocardial deformation. This study investigated multilayer longitudinal strain in Anderson-Fabry disease (AFD) patients at diagnosis.

Methods: In a case-control study, 33 newly diagnosed, untreated AFD patients and 33 healthy age- and sex-matched healthy controls underwent a complete echocardiogram, including assessment of left ventricular (LV) transmural global longitudinal strain (GLS), subendocardial longitudinal strain (LSsubendo), subepicardial longitudinal strain (LSsubepi), and strain gradient (LSsubendo-LSsubpepi). Read More

View Article and Full-Text PDF

The association between temporal measures of swallowing with penetration and aspiration in patients with dysphagia: A meta-analysis.

NeuroRehabilitation 2019 ;44(1):111-129

Swallowing Lab, University of Toronto, University Health Network, Canada.

Introduction: Temporal features of swallowing physiology vary with age in healthy normals and have the potential to impact swallow safety and efficiency in patients with dysphagia. We conducted a meta-analysis to assess the relation between temporal features of swallowing with penetration, aspiration and residue in adult patients with dysphagia regardless of etiology.

Methods: Operational definitions of relevant terms were defined a priori. Read More

View Article and Full-Text PDF

Relationship between left ventricular vortex and preejectional flow velocity during isovolumic contraction studied by using vector flow mapping.

Echocardiography 2019 03 6;36(3):558-566. Epub 2019 Feb 6.

Department of Ultrasound, PLA 967th Hospital, Dalian, China.

Objectives: The purpose of this study was to investigate the relationship between the vortex in left ventricle (LV) during the isovolumic contraction (IVC) period and the preejectional flow velocity in LV outflow tract (V ).

Methods: Color Doppler loops were acquired for vector flow mapping in apical long-axis view in 76 patients with dilated cardiomyopathy, 61 patients with coronary artery disease and 36 healthy controls.

Results: All normals exhibited an IVC vortex reaching the LV base. Read More

View Article and Full-Text PDF

[Functioning features of the mirror neuron system in patients with affective disorders].

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(9):48-52

Solovyov Research and Practical Psychoneurological Center, Moscow, Russia.

Aim: To reveal EEG patterns and activation of neural network changes during perception and realization of a simple motor act in healthy subjects and patients with affective disorders.

Material And Methods: The patient group consisted of 15 people with affective disorders, the control group included 11 normals. As task subjects were asked to observe the movement of the experimenter hand (clenching of the hand), then submit this motion and then repeat it by themselves. Read More

View Article and Full-Text PDF

Immunopathological Features of Severe Chronic Atopic Keratoconjunctivitis and Effects of Topical Cyclosporine Treatment.

Ocul Immunol Inflamm 2019 6;27(7):1184-1193. Epub 2018 Sep 6.

Ocular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, Johns Hopkins University School of Medicine , Baltimore , Maryland , USA.

Purpose: To assess differential roles of inflammatory cells in pathophysiology of severe atopic keratoconjunctivitis (AKC) and evaluate immunomodulatory effects of topical cyclosporine A (CsA).

Methods: A total of 10 patients with severe, steroid-dependent/resistant chronic active AKC were treated using frequent topical CsA 0.05% as monotherapy for 2 months. Read More

View Article and Full-Text PDF

[The interaction effect of ANKK1/DRD2 TaqIA and HTR2C Cys23Ser on approach motivation in schizophrenic patients and normals].

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(7):67-72

Mental Health Research Center, Moscow, Russia.

Aim: To evaluate the association of the DRD2 gene and DRD2 x HTR2C interaction with hedonic and activational aspects of approach motivation in schizophrenia.

Material And Methods: Genotypes at polymorphic loci DRD2 rs1800497 and HTR2C rs6318 (Cys23Ser) were identified in a sample that included 174 patients with schizophrenic spectrum disorders and 268 healthy subjects without a family history of psychoses. The participants completed the BIS/BAS and Temporal Experience of Pleasure Scale (TEPS). Read More

View Article and Full-Text PDF

Sleep assessment in a randomized trial of hyperbaric oxygen in U.S. service members with post concussive mild traumatic brain injury compared to normal controls.

Sleep Med 2018 11 30;51:66-79. Epub 2018 Jun 30.

Division of Hyperbaric Medicine, Intermountain Medical Center, Murray, UT, USA; Division of Hyperbaric Medicine, Intermountain LDS Hospital, Salt Lake City, USA; Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address:

Study Objective: In this exploratory, double-blind, longitudinal sham-controlled trial of hyperbaric oxygen (HBO) for military personnel with post concussive mild traumatic brain injury (mTBI), self-reports and objective measures of sleep-wake disturbances were assessed and compared to normals.

Methods: Self-reports consisting of Pittsburg Sleep Quality Index (PSQI), sleep diary, screening for obstructive sleep apnea (OSA) risk, restless legs syndrome (RLS), cataplexy, and objective actigraphic measures of sleep-wake were obtained on 71 military personnel with mTBI [baseline, 13 weeks and six months post-randomization (post-intervention)], of which 35 met post-traumatic stress disorder (PTSD) criteria, and 75 healthy volunteers (baseline). Baseline between-group and follow-up changes from baseline overall and within subgroups were evaluated. Read More

View Article and Full-Text PDF
November 2018

Blink Reflex in Episodic and Chronic Migraine.

Noro Psikiyatr Ars 2018 4;55(2):146-151. Epub 2018 May 4.

Bakırköy Psychiatric and Neurological Diseases Hospital, 2. Neurology Clinic, Istanbul, Turkey.

Introduction: Activation of the trigeminovascular system and sensitization of brainstem trigeminal nuclei play a significant role in the physiopathology of migraine. Our aim was to investigate blink reflex (BR) and its recovery in episodic and chronic migraine patients.

Methods: Twenty-eight chronic migraine patients, thirty-two episodic migraine without aura patients and thirty healthy controls were included in the study. Read More

View Article and Full-Text PDF

Leukocyte Distribution in the Open Eye Tears of Normal and Dry Eye Subjects.

Curr Eye Res 2018 10 9;43(10):1253-1259. Epub 2018 Aug 9.

a School of Optometry , University of Alabama at Birmingham , Birmingham , Alabama , USA.

Purpose: Leukocytes accumulate in the eye with sleep, but little is known about the presence or absence of leukocytes in awake, open eye tears. This study sought to compare normal and dry eye subjects for daily variation in open eye leukocyte composition.

Materials And Methods: Ten normal subjects and nine dry eye subjects were enrolled. Read More

View Article and Full-Text PDF
October 2018

Sustained Impairment of Lurasidone Clearance After Discontinuation of Posaconazole: Impact of Obesity, and Implications for Patient Safety.

J Clin Psychopharmacol 2018 Aug;38(4):289-295

Emerald Lake Safety, Newport Beach, CA.

Purpose/background: The antipsychotic agent lurasidone (Latuda®) is metabolized by Cytochrome P450-3A (CYP3A) enzymes. Coadministration with strong CYP3A inhibitors (such as ketoconazole, posaconazole, and ritonavir) is contraindicated due to the risk of sedation and movement disorders from high levels of lurasidone. This study evaluated the time-course of recovery from the posaconazole drug interaction, and the effect of obesity on the recovery process. Read More

View Article and Full-Text PDF

Persistence of a Posaconazole-Mediated Drug-Drug Interaction With Ranolazine After Cessation of Posaconazole Administration: Impact of Obesity and Implications for Patient Safety.

J Clin Pharmacol 2018 11 11;58(11):1436-1442. Epub 2018 May 11.

Tufts University School of Medicine, Boston, MA, USA.

The antianginal agent ranolazine (Ranexa®) is metabolized primarily by cytochrome P450-3A (CYP3A) enzymes. Coadministration with strong CYP3A inhibitors, such as ketoconazole and posaconazole, is contraindicated due to risk of QT prolongation from high levels of ranolazine. This study evaluated the time course of recovery from the posaconazole drug interaction in normal-weight and otherwise healthy obese subjects. Read More

View Article and Full-Text PDF
November 2018

Discriminating ability of Cirrus and RTVue optical coherence tomography in different stages of glaucoma.

Indian J Ophthalmol 2018 05;66(5):675-680

Glaucoma and Cataract Services, Dr. Shroff's Charity Eye Hospital, New Delhi, India.

Purpose: The aim of this study is to determine which parameter of Cirrus and RTVue optical coherence tomography (OCT) has the highest ability to discriminate between early, moderate, and advanced glaucoma. Simultaneously, to compare the performance of the two OCT devices in terms of their ability to differentiate the three stages of glaucoma. Further, to analyze the macular parameters of both devices and compare them with the conventional retinal nerve fiber layer (RNFL) parameters. Read More

View Article and Full-Text PDF

Noisy vestibular stimulation increases gait speed in normals and in bilateral vestibulopathy.

Brain Stimul 2018 Jul - Aug;11(4):709-715. Epub 2018 Mar 10.

Department of Otolaryngology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

Background: Galvanic vestibular stimulation delivered as zero-mean current noise (noisy GVS) has been shown to improve static and dynamic postural stability probably by enhancing vestibular information.

Objective: /Hypothesis: To examine the effect of an imperceptible level of noisy GVS on dynamic locomotion in normal subjects as well as in patients with bilateral vestibulopathy.

Methods: Walking performance of 19 healthy subjects and 12 patients with bilateral vestibulopathy at their preferred speed was examined during application of noisy GVS with an amplitude ranging from 0 to 1000 μA. Read More

View Article and Full-Text PDF
February 2019

Bone histomorphometry in transiliac biopsies from 48 normal, healthy men.

Bone 2018 06 16;111:109-115. Epub 2018 Mar 16.

Creighton University School of Medicine, United States.

Investigators and clinicians use bone histomorphometry data from iliac bone biopsies to study bone abnormalities in diseased patients, and to understand the safety and effectiveness of pharmaceutical interventions. This requires access to a high quality normal data-set to be used for comparisons, a resource that has not been adequate to date. The objective of this work is to present static and dynamic bone histomorphometry data from transilial bone biopsies performed on 48 healthy males, evenly distributed between ages 45 and 75. Read More

View Article and Full-Text PDF

Chest wall strapping increases expiratory airflow and detectable airway segments in computer tomographic scans of normal and obstructed lungs.

J Appl Physiol (1985) 2018 05 4;124(5):1186-1193. Epub 2018 Jan 4.

Department and Internal Medicine, University of Iowa , Iowa City, Iowa.

Chest wall strapping (CWS) induces breathing at low lung volumes but also increases parenchymal elastic recoil. In this study, we tested the hypothesis that CWS dilates airways via airway-parenchymal interdependence. In 11 subjects (6 healthy and 5 with mild to moderate COPD), pulmonary function tests and lung volumes were obtained in control (baseline) and the CWS state. Read More

View Article and Full-Text PDF

Perimenopausal bone histomorphometry before and after menopause.

Bone 2018 03 16;108:55-61. Epub 2017 Dec 16.

Creighton University School of Medicine, 6829 N 72nd St, Ste 7400, Omaha, NE, 68122, United States.

Investigators and clinicians have had few normal bone histomorphometry data available to compare with those found in diseased patients, or in the results of treatments. The Goals and Objectives of this work are two-fold: 1. to present static and dynamic bone histomorphometry data from transilial bone biopsies performed on 76 healthy, premenopausal women. Read More

View Article and Full-Text PDF

Association between quality of life and anxiety, depression, physical activity and physical performance in maintenance hemodialysis patients.

Chronic Dis Transl Med 2016 Jun 3;2(2):110-119. Epub 2016 Nov 3.

Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor - UCLA Medical Center, Torrance, CA 90502, USA.

Objective: Maintenance hemodialysis (MHD) patients often have impaired quality of life (QOL), anxiety, depression, and reduced daily physical activity (DPA) and physical performance. The contributions of these latter factors to reduced QOL in MHD are poorly understood. We examined the association of QOL with anxiety, depression, DPA, and physical performance. Read More

View Article and Full-Text PDF