Sleep Med 2018 11 30;51:66-79. Epub 2018 Jun 30.
Division of Hyperbaric Medicine, Intermountain Medical Center, Murray, UT, USA; Division of Hyperbaric Medicine, Intermountain LDS Hospital, Salt Lake City, USA; Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address:
Study Objective: In this exploratory, double-blind, longitudinal sham-controlled trial of hyperbaric oxygen (HBO) for military personnel with post concussive mild traumatic brain injury (mTBI), self-reports and objective measures of sleep-wake disturbances were assessed and compared to normals.
Methods: Self-reports consisting of Pittsburg Sleep Quality Index (PSQI), sleep diary, screening for obstructive sleep apnea (OSA) risk, restless legs syndrome (RLS), cataplexy, and objective actigraphic measures of sleep-wake were obtained on 71 military personnel with mTBI [baseline, 13 weeks and six months post-randomization (post-intervention)], of which 35 met post-traumatic stress disorder (PTSD) criteria, and 75 healthy volunteers (baseline). Baseline between-group and follow-up changes from baseline overall and within subgroups were evaluated. Read More