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Indian Pediatr 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. Correspondence to: Dr Rakesh Lodha, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110 029, India.

Diagnostic tests are evolving with betterment of technology, quest for patient safety with less invasive medicine, and evolution of new diseases. It is important to assess diagnostic accuracy of a new test, and clinical impact of introduction of new test on outcomes and cost. A diagnostic study is planned for the index test based on place of new test in diagnostic pathway (screening, triage, diagnostic or add-on test) and established information of the test. Read More

J Med Case Rep 2021 Apr 20;15(1):180. Epub 2021 Apr 20.

Unit of Reconstructive and Plastic Surgery, Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia, 71122, Foggia, Italy.

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare skin fibroblastic tumor, with a high rate of recurrence. The treatment of DFSP is generally surgical, and wide local excision is the mainstay of surgical treatment. Therefore, complete assessment of all surgical margins is fundamental before definitive reconstruction. Read More

J Dairy Sci 2021 Apr 14. Epub 2021 Apr 14.

Department of Animal Science, McGill University, Ste-Anne-de-Bellevue, QC H9X 3V9, Canada.

Mastitis is a highly prevalent disease, which negatively affects cow performance, profitability, welfare, and longevity. The objectives of this study were (1) to quantify the impact of the first instance of mastitis, at different stages of lactation, on production and economic performance, and (2) to further quantify the impact of the first instance of mastitis when only cows that remain in the herd for at least 100 d in milk (DIM) and those that remain for 305 DIM are included in the analysis. A retrospective longitudinal study was conducted using data from existing animal health record files and Dairy Herd Improvement records. Read More

J Dairy Sci 2021 Apr 14. Epub 2021 Apr 14.

Department of Animal Science, McGill University, Ste-Anne-de-Bellevue, QC H9X 3V9, Canada.

Lameness is a persistent and underreported health and welfare problem in the dairy industry, resulting in reduced cow performance and profitability as well as early culling. The study objectives were (1) to quantify the impact of the first instance of lameness, at different stages of lactation, on production and economic performance, and (2) to further quantify the impacts of the first instance of lameness when only cows that remain in the herd for at least 100 d in milk (DIM) and those that remain for 305 DIM are included in the analysis. A retrospective longitudinal study was conducted using pre-existing data from animal health records and Dairy Herd Improvement Association records. Read More

Plant Dis 2021 Apr 15. Epub 2021 Apr 15.

Universiti Putra Malaysia, 37449, Department of Plant Protection, Faculty of Agriculture, Serdang, Selangor, Malaysia;

Plumeria alba L. is a flowering plant in the family Apocynaceae and widely cultivated in Malaysia as a cosmopolitan ornamental plant. In January 2020, anthracnose lesions were observed on leaves of Plumeria alba planted in Agricultural Farm, Universiti Putra Malaysia, in Selangor state, Malaysia. Read More

Plant Dis 2021 Apr 14. Epub 2021 Apr 14.

Universiti Putra Malaysia, 37449, Department of Plant Protection, Faculty of Agriculture, Serdang, Selangor, Malaysia;

Guava (Psidium guajava L.) is an economically important tropical fruit crop and is cultivated extensively in Malaysia. In September and October 2019, postharvest fruit rot symptoms were observed on 30% to 40% of guava fruit cv. Read More

Plant Dis 2021 Apr 14. Epub 2021 Apr 14.

Guangxi University for Nationalities, 47874, Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Nanning 530006, P.R. China, Nanning, China, 530006;

(Thunb.) Rchb. f. Read More

Hum Mov Sci 2021 Apr 9;77:102793. Epub 2021 Apr 9.

Institute of Physical Activity and Sports Sciences and Interdisciplinary Graduate Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil. Electronic address:

The study aimed to investigate the control and coordination of grip force (normal component) and load force (tangential component) in three different manipulation tasks in individuals with diabetes with and with no diagnosis of diabetic peripheral neuropathy (DPN) and healthy controls. Twenty-four individuals with type 2 diabetes mellitus, 12 with no (nDPN) and 12 with DPN (wDPN), and 12 healthy controls performed three manipulation tasks (static holding, lifting and holding, and oscillation) with the dominant hand, using an instrumented handle. Relative safety margin (% of GF exerted above the minimum GF needed to hold the object) was measured in all tasks. Read More

Eur J Ophthalmol 2021 Apr 10:11206721211008789. Epub 2021 Apr 10.

Department of Pathology, Faculty of Medicine, Van Yüzüncüyıl University, Van, Turkey.

Purpose: To evaluate the tear parameters, meibomian glands and lid margin and tarsal conjunctival impression cytology in patients with conjunctivochalasis (CCH).

Methods: The study included 57 patients diagnosed with CCH and 35 healthy volunteers. Tear break-up time (TBUT) was measured and Schirmer test was performed. Read More

Gait Posture 2021 Apr 3;86:303-310. Epub 2021 Apr 3.

Department of Informatics, Graduate School of Informatics and Engineering, The University of Electro-communications, 1-5-1 Chofugaoka, Chofu, Tokyo, 182-8585, Japan. Electronic address:

Background: Rocker sole (RS) shoes have been linked to impaired postural control. However, which features of RS design affect balance is unclear.

Research Question: Which RS design features affect standing balance and gait stability?

Methods: This study utilized an intervention and cross-over design. Read More

Plant Dis 2021 Apr 6. Epub 2021 Apr 6.

Instituto de Investigaciones Agropecuarias, Producción Vegetal, Av. Vicente Méndez 515, Chillán, Ñuble, Chile;

Sweet cherry () is one the most important fruit crops in Chile. Its production has significantly grown in recent years, reaching 228,448 tons exported in 2019/2020, to 47 countries. One of the main threats for this expanding crop are fungal pathogens, especially those that cause wood diseases. Read More

PLoS One 2021 6;16(4):e0249303. Epub 2021 Apr 6.

School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.

The arm elevation strategy assists in recovering stability during slips in healthy young and elderly individuals. However, in people with Parkinson's Disease, one of the main motor symptoms affecting the upper limbs is reduced arm swing which intensifies throughout the course of the disease before becoming absent. This holds direct implications for these individuals when encountering slips as the arm elevation strategy is an integral component in the interlimb slip response to restore stability. Read More

Plant Dis 2021 Apr 6. Epub 2021 Apr 6.

Kyungpook National University, 34986, School of Applied Biosciences, Daegu, Daegu, Korea (the Republic of);

The Chinese quince ( (Thouin) CK Schneid.) is a tree that is commonly distributed in all regions of South Korea and other Asian countries. The ripened yellow fruit contains medically active compounds (Hamauzu et al. Read More

Br J Clin Pharmacol 2021 Apr 6. Epub 2021 Apr 6.

University of California, Los Angeles, California, USA.

Aim: To evaluate pharmacokinetic equivalence and preliminary safety of the adalimumab biosimilar CT-P17 administered via autoinjector (CT-P17 AI) or prefilled syringe (CT-P17 PFS) in healthy subjects.

Methods: This phase I, open-label study (ClinicalTrials.gov: NCT04295356) randomised subjects (1:1) to receive a single 40 mg (100 mg/mL) dose of CT-P17 AI or CT-P17 PFS. Read More

JFMS Open Rep 2021 Jan-Jun;7(1):2055116921999595. Epub 2021 Mar 22.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas A&M University, College Station, TX, USA.

Case Summary: This case report documents the clinical appearance, diagnosis and novel treatment of a central Texas cat with cutaneous leishmaniosis. The cat presented with a linear erosion on the right pinnal margin, an ulcerated exophytic nodule on the right hock and a swelling in the right nostril. Cytological and histopathological findings were consistent with leishmaniosis. Read More

J Clin Pharmacol 2021 Apr 2. Epub 2021 Apr 2.

Walter Reed Army Institute of Research, Experimental Therapeutics, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.

Continuous veno-venous hemofiltration (CVVH) is a life-sustaining procedure in patients with severe burns and acute kidney injury (AKI). Physiologic changes due to burn injury and use of CVVH may alter imipenem pharmacokinetics (PK). We aimed to compare imipenem clearance (CL) in burn patients with and without CVVH, determine the effect of burn on imipenem volume of distribution (Vd), and evaluate the adequacy of imipenem dosing in this population. Read More

Dent J (Basel) 2021 Mar 6;9(3). Epub 2021 Mar 6.

Section of Periodontics, Department of Oral and Maxillofacial Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.

The purpose of this study was to histologically examine the clinically healthy gingiva of patients with altered passive eruption (APE). Five patients with type 1 APE were enrolled. They underwent scaling and polishing and received oral hygiene instructions. Read More

Int J Environ Res Public Health 2021 Mar 28;18(7). Epub 2021 Mar 28.

Department of Social and Economic Sciences, Sapienza University, 00185 Rome, Italy.

Background: Postural tone alterations are expressions of myofascial and, therefore, of structural, visceral, and emotional disorders. To prevent these disorders, this study proposes a quantitative investigation method which administers a postural evaluation questionnaire and a postural biomechanical evaluation to 100 healthy subjects.

Methods: The reliability of the method is studied by comparing both assessments with digitized biometrics. Read More

Res Vet Sci 2021 Jan 23;136:396-407. Epub 2021 Jan 23.

WALTHAM Petcare Science Institute, Melton Mowbray, Leicestershire, LE14 4RT, United Kingdom.

The purpose of the investigation was to determine whether canine gingival margin (GM) plaque is a reliable surrogate for subgingival (SG) plaque from a microbial community (microbiota) perspective. SG and GM plaque samples were collected from 381 dogs visiting pet hospitals in the USA, China and Thailand. Dogs with clinically healthy gingivae through to early periodontitis were included in the study. Read More

Plant Dis 2021 Apr 2. Epub 2021 Apr 2.

Guangdong Ocean University, 74780, Zhanjiang, Guangdong, China;

Wild rice (Oryza rufipogon), a species only recently cultivated in China, is an invaluable resource for rice breeding and basic research. In June 2019, a leaf spot disease on wild rice (O. rufipogon cv. Read More

Laryngoscope 2021 Apr 1. Epub 2021 Apr 1.

Department of Otolaryngology-Head and Neck Surgery, The Pennsylvania State University, Hershey, Pennsylvania, USA.

Objectives/hypothesis: The goal of head and neck cancer surgery is the complete resection of tumor with a cuff of healthy tissue. A 5-mm margin is optimal but not always achievable in the oropharynx. We aimed to identify a consensus of definition and management of close margins for human papilloma virus (HPV)-associated oropharyngeal cancer without other risk factors. Read More

Biomed Opt Express 2021 Mar 25;12(3):1621-1634. Epub 2021 Feb 25.

School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

Brain tumor surgery involves a delicate balance between maximizing the extent of tumor resection while minimizing damage to healthy brain tissue that is vital for neurological function. However, differentiating between tumor, particularly infiltrative disease, and healthy brain in-vivo remains a significant clinical challenge. Here we demonstrate that quantitative oblique back illumination microscopy (qOBM)-a novel label-free optical imaging technique that achieves tomographic quantitative phase imaging in thick scattering samples-clearly differentiates between healthy brain tissue and tumor, including infiltrative disease. Read More

J Ultrason 2021 8;21(84):41-47. Epub 2021 Mar 8.

Department of Radiology, Selçuk University School of Medicine, Konya, Turkey.

Aim Of The Study: To determine the parenchymal vascularity of the thyroid gland with color superb microvascular imaging in patients with Graves' disease, and compare the vascularization index values with healthy subjects.

Materials And Methods: The thyroid glands of 37 patients whose laboratory and clinical findings were consistent with Graves' disease, and 40 asymptomatic subjects with normal laboratory values, were examined using color superb microvascular imaging. Measurements of the vascularization index were performed with a free region of interest which was drawn along the outer margin of the gland on the color superb microvascular imaging mode. Read More

Rev Med Suisse 2021 Mar;17(732):630-634

Unité de dermatochirurgie, Service de dermatologie et vénéréologie, Département des spécialités de médecine, HUG, 1211 Genève 14.

Cutaneous tumours can be ill-delineated and subclinical tumour can be missed when using the usual methods of pathology processing because only less than 1 % of the margin is examined. Micrographic surgery was developed to allow for examination of 100 % of the margin. It reduces the recurrence rate and spares healthy tissue thus reducing lesion size and facilitating reconstruction. Read More

Int Ophthalmol 2021 Mar 31. Epub 2021 Mar 31.

Department of Ophthalmology, Faculty of Medicine, University of Malaya Eye Research Centre, University of Malaya, Lembah Pantai, 59100, Kuala Lumpur, Federal Territory of Kuala Lumpur, Malaysia.

Purpose: To evaluate ocular surface changes among patients with psoriasis in Malaysia, a developing country in Southeast Asia.

Methods: An interdisciplinary case-control study (60 psoriasis patients and 40 control subjects) to look at the differences in ocular surface manifestations between patients with psoriasis and a group of age-, gender- and ethnicity-matched healthy controls.

Results: One hundred and twenty eyes of 60 patients with psoriasis and 80 eyes of 40 healthy controls without psoriasis were included in the study. Read More

Plant Dis 2021 Mar 29. Epub 2021 Mar 29.

National Taiwan University, 33561, Department of Plant Pathology and Microbiology, Taipei, Taiwan;

Starting from the May to August 2020 (average humidity 76.6% and temperature 25.2°C in Taipei), Boston ivy (Parthenocissus tricuspidata) plants on the campus of National Taiwan University (25°01'05. Read More

Clin Pharmacol Drug Dev 2021 Mar 25. Epub 2021 Mar 25.

Pfizer Inc, Collegeville, Pennsylvania, USA.

This open-label, single-dose, randomized, parallel-group, 2-arm phase 1 bioequivalence (BE) study assessed the pharmacokinetics (PK), safety, and tolerability of PF-06410293 (ADL-PF), an adalimumab (ADL) biosimilar, following administration by prefilled pen (PFP) or prefilled syringe (PFS). A total of 164 healthy adult subjects were randomized (1:1) to receive ADL-PF (40 mg subcutaneously) in the lower abdomen or upper anterior thigh by PFS or PFP; 163 subjects were included in the primary PK analysis. The concentration-time profiles of the ADL-PF PFS and PFP treatment arms were similar. Read More

Plant Dis 2021 Mar 24. Epub 2021 Mar 24.

Agriculture and Agri-Food Canada, 4902 Victoria Avenue North, Vineland Station, ON L0R 2E0, Canada, Vineland, Ontario, Canada;

Moldy core is a fungal disease of apple fruits that is characterized by mycelial growth in the seed locules and is sometimes accompanied by penetration of the immediate surrounding flesh. The disease can go undetected until the fruit is cut open, as no external symptoms appear on the fruit. Alternaria, Aspergillus, Cladosporium, Coniothyrium, Epicoccum, Phoma and Stemphylium are some of the common pathogens associated with moldy core (Serdani et al. Read More

Transfusion 2021 Mar 24. Epub 2021 Mar 24.

National Institutes of Health (NIH) Clinical Center, Bethesda, Maryland, USA.

Background: Source plasma is essential to support the growing demand for plasma-derived medicinal products. Supply is short, with donor availability further limited by the coronavirus disease 2019 (COVID-19) pandemic. This study examined whether a novel, personalized, technology-based nomogram was noninferior with regard to significant hypotensive adverse events (AEs) in healthy donors. Read More

Plant Dis 2021 Mar 23. Epub 2021 Mar 23.

Northwest A&F University, 12469, College of Horticulture, College of Horticulture, Northwest A&F University, Yangling, Shaanxi 712100, P. R. China, Yangling, China, 712100;

Pepper (Capsicum annuum L.) is an important solanaceous vegetable crop, with high nutritional and economic value. However, it is susceptible to Colletotrichum spp. Read More