9,616 results match your criteria healthcare pathway

The role of Mobile phones as a possible pathway for pathogen movement A CROSS-SECTIONAL, MICROBIAL ANALYSIS.

Travel Med Infect Dis 2021 Jun 8:102095. Epub 2021 Jun 8.

Faculty of Health Sciences and Medicine, Bond University, Robina, QLD, Australia (AU); Harry Butler Institute, Murdoch University, Murdoch, WA, 6150, Australia (AU); General Department of Forensic Science and Criminology, Dubai Police, Dubai, United Arab Emirates (UAE); Dubai Future Council on Community Security, Dubai, United Arab Emirates (UAE); Dubai Police Scientists Council, Dubai Police, Dubai, United Arab Emirates (UAE).

Introduction: Mobile phones are used the world over, including in healthcare settings. This study aimed to investigate the viable microbial colonisation of mobile phones used by healthcare personnel.

Methods: Swabs collected on the same day from 30 mobile phones belonging to healthcare workers from three separate paediatric wards of an Australian hospital were cultured on five types of agar plate, then colonies from each phone were pooled, extracted and sequenced by shotgun metagenomics. Read More

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Diabetes and susceptibility to infections: implication for COVID-19.

Immunology 2021 Jun 11. Epub 2021 Jun 11.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.

A number of mechanisms have been proposed to explain the well-established link between diabetic status and an increase susceptibility to infection. Notably, diabetes has been shown to be one of the strongest factors influencing healthcare outcome in COVID-19 infections. Though it has long been noted that lymphocytes upregulate insulin receptors following immune activation, until recently, this observation has received little attention. Read More

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Early life adversity predicts brain-gut alterations associated with increased stress and mood.

Neurobiol Stress 2021 Nov 25;15:100348. Epub 2021 May 25.

G. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, USA.

Alterations in the brain-gut system have been implicated in various disease states, but little is known about how early-life adversity (ELA) impacts development and adult health as mediated by brain-gut interactions. We hypothesize that ELA disrupts components of the brain-gut system, thereby increasing susceptibility to disordered mood. In a sample of 128 healthy adult participants, a history of ELA and current stress, depression, and anxiety were assessed using validated questionnaires. Read More

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November 2021

Differential methylation of G-protein coupled receptor signaling genes in gastrointestinal neuroendocrine tumors.

Sci Rep 2021 Jun 10;11(1):12303. Epub 2021 Jun 10.

Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, 84112-5550, USA.

Neuroendocrine tumors (NETs) of the small intestine undergo large chromosomal and methylation changes. The objective of this study was to identify methylation differences in NETs and consider how the differentially methylated genes may impact patient survival. Genome-wide methylation and chromosomal copy number variation (CNV) of NETs from the small intestine and appendix were measured. Read More

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How can we improve our practices in obstetric anal sphincter injury prevention, diagnosis, and management of symptomatic women?

J Gynecol Obstet Hum Reprod 2021 Jun 7:102183. Epub 2021 Jun 7.

Poitiers University Hospital, Department of Obstetrics and Gynecology, Poitiers, France; INSERM CIC-P 1402, Poitiers University Hospital, Poitiers, France.

Obstetric anal sphincter injury (OASI) is strongly associated with a major negative impact on women's health. Due to the consequences of an undiagnosed and therefore unrepaired OASI, it is essential to prevent or at least diagnose OASI at childbirth. We need to promote training of professionals to improve OASI screening at childbirth. Read More

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Implementing organicity investigations in early psychosis: Spreading expertise.

PLoS One 2021 10;16(6):e0252610. Epub 2021 Jun 10.

Child and Adolescent Department-Maison de Solenn, Hospital Cochin, Paris, France.

Background: Many medical disorders may contribute to adolescent psychoses. Although guidelines for thorough organicity investigations (OI) exist, their dissemination appears scarce in nonacademic healthcare facilities and some rare disorders remain undiagnosed, many of them presenting without easily recognized phenotypes. This study aims to understand the challenges underlying the implementation of OI in non-academic facilities by practitioners trained in expert centers. Read More

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The pan-cancer analysis of the two types of uterine cancer uncovered clinical and prognostic associations with m6A RNA methylation regulators.

Mol Omics 2021 Mar 24. Epub 2021 Mar 24.

Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China. and The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China.

The role of m6A RNA methylation modification in uterine cancer has not been studied until now. We explored the relationship between m6A regulators and clinical characteristics and prognosis in uterine corpus endometrial carcinoma (UCEC) and uterine carcinosarcoma (UCS) with the data from the Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx). We found that several regulators were up-regulated or down-regulated in the two types of cancer, and identified two cluster subgroups with statistically significant differences in pathological grade, age and survival rate. Read More

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Acute lymphoblastic leukemia-derived exosome inhibits cytotoxicity of natural killer cells by TGF-β signaling pathway.

3 Biotech 2021 Jul 4;11(7):313. Epub 2021 Jun 4.

Shenzhen Maternal and Child Healthcare Hospital, The First School of Clinical Medicine, Southern Medical University, 2004 Hongli road, Futian District, Shenzhen, Guangdong China.

This study was conducted to explore whether acute lymphoblastic leukemia (ALL)-derived exosomes affect natural killer (NK) cells. Exosomes were isolated and identified from Jurkat cells and co-cultured with NK cells. Then, the cytotoxicity, viability, and release of perforin and granzyme B in NK92-MI cells were measured. Read More

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The role of polyamines in gastric cancer.

Oncogene 2021 Jun 9. Epub 2021 Jun 9.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Nashville, TN, USA.

Advancements in our understanding of polyamine molecular and cellular functions have led to increased interest in targeting polyamine metabolism for anticancer therapeutic benefits. The polyamines putrescine, spermidine, and spermine are polycationic alkylamines commonly found in all living cells and are essential for cellular growth and survival. This review summarizes the existing research on polyamine metabolism and function, specifically the role of polyamines in gastric immune cell and epithelial cell function. Read More

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Mapping Hospital-Based Lactation Care Provided to Bereaved Mothers: A Basis for Quality Improvement.

Breastfeed Med 2021 Jun 9. Epub 2021 Jun 9.

Research School of Social Sciences, Australian National University, Acton, Australia.

The study aimed to identify and map the factors that shape the delivery of hospital-based lactation care for bereaved mothers to inform quality improvement initiatives targeting hospital-based lactation care. Focus groups and interviews were conducted at three large hospitals in Australia with 113 health professionals including obstetricians, neonatologists, midwives, neonatal nurses, lactation consultants, social workers or pastoral care workers, Human Milk Bank (HMB) staff, and perinatal bereavement nurses. Thematic and interactional data analysis identified the nature, scope, and pattern of bereavement lactation care. Read More

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Patient-centered digital healthcare for patients undergoing breast surgery - A cross-sectional questionnaire study.

Int J Clin Pract 2021 Jun 9:e14446. Epub 2021 Jun 9.

Nottingham Breast Institute, Nottingham University Hospitals NHS Trust, Nottingham.

Introduction: The potential of digital health services have become apparent in recent years, more so now following the coronavirus disease outbreak. However, despite majority of UK population integrating digital based platforms into their everyday life, there is low engagement with NHS digital services, citing lack of patient-centered approaches to the design of such services. As such, this cross-sectional questionnaire aims to understand the patient perspective pertaining the utility of web-based information in aiding their breast cancer pathway at a large volume tertiary breast institute. Read More

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Improving productivity, costs and environmental impact in International Eye Health Services: using the 'Eyefficiency' cataract surgical services auditing tool to assess the value of cataract surgical services.

BMJ Open Ophthalmol 2021 20;6(1):e000642. Epub 2021 May 20.

Population Health, NYU Langone Health, New York, New York, USA.

Objective: Though one of the most common surgeries, there is limited information on variability of practices in cataract surgeries. 'Eyefficiency' is a cataract surgical services auditing tool to help global units improve their surgical productivity and reduce their costs, waste generation and carbon footprint. The aim of the present research is to identify variability and efficiency opportunities in cataract surgical practices globally. Read More

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The contribution of bile acid metabolism to the pathogenesis of infection.

Therap Adv Gastroenterol 2021 28;14:17562848211017725. Epub 2021 May 28.

Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 850 Boylston Street, Suite 201, Chestnut Hill, MA 02467, USA.

infection (CDI) remains a major global cause of gastrointestinal infection, with significant associated morbidity, mortality and impact upon healthcare system resources. Recent antibiotic use is a key risk factor for the condition, with the marked antibiotic-mediated perturbations in gut microbiome diversity and composition that underpin the pathogenesis of CDI being well-recognised. However, only relatively recently has further insight been gained into the specific mechanistic links between these gut microbiome changes and CDI, with alteration of gut microbial metabolites - in particular, bile acid metabolism - being a particular area of focus. Read More

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Post-COVID symptoms reported at asynchronous virtual review and stratified follow-up after COVID-19 pneumonia.

Clin Med (Lond) 2021 Jun 8. Epub 2021 Jun 8.

Barts Health NHS Trust, London, UK, and hon senior lecturer, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK

Background: The COVID-19 pandemic has strained healthcare systems and how best to address post-COVID health needs is uncertain. Here we describe the post-COVID symptoms of 675 patients followed up using a virtual review pathway, stratified by severity of acute COVID infection.

Methods: COVID-19 survivors completed an online/telephone questionnaire of symptoms after 12+ weeks and a chest radiograph. Read More

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Effect of PIK3CA variants on glioma-related epilepsy and response to treatment.

Epilepsy Res 2021 Jun 2;175:106681. Epub 2021 Jun 2.

Department of Neurology, Brigham and Women's Hospital, Boston, MA, United States.

Upregulation of the PI3K/AKT/mTOR pathway has been implicated in glioma-related epileptogenesis. In this retrospective analysis, epilepsy characteristics and response to treatment were evaluated in patients with gliomas harboring somatic mutation variants in PIK3CA. A cohort of 134 patients with 150 PIK3CA variants was extracted from previously validated databases. Read More

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Mediational Pathways From Genetic Risk to Alcohol Use Disorder in Swedish Men and Women.

J Stud Alcohol Drugs 2021 May;82(3):431-438

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

Objective: The purpose of this study was to clarify the mediational pathways from genetic risk for alcohol use disorder (AUD) to AUD itself.

Method: Using information on AUD status from first- through fourth-degree relatives obtained from national registries, we created a genetic risk score for AUD for the Swedish population. We first tested a simple mediational path model in males and females separately, with early onset externalizing psychopathology (EPP), internalizing psychopathology (IPP), and poor educational attainment (EA). Read More

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Rural health research capacity building: an anchored solution.

Rural Remote Health 2021 Jun 8;21(2):6162. Epub 2021 Jun 8.

Centre for Rural Health Studies, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada

Rural physicians face many challenges with providing rural health care, which often leads to innovative solutions. Despite their creativity with overcoming barriers, there is a lack of support for rural health research - an area of health care where research makes great impacts on small communities. Rural research capacity building (RRCB) is essential to support rural physicians so that they can conduct relevant research, but RRCB programs are sparse. Read More

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Biosynthesis of Soyasapogenol B by Engineered Saccharomyces cerevisiae.

Appl Biochem Biotechnol 2021 Jun 7. Epub 2021 Jun 7.

School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People's Republic of China.

Soyasapogenol B is an oleanane-type pentacyclic triterpene that has various applications in food and healthcare and has a higher biological activity than soyasaponin. Saccharomyces cerevisiae is a potential platform for terpenoid production with mature genetic tools for metabolic pathway manipulation. In this study, we developed a biosynthesis method to produce soyasapogenol B. Read More

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What Happens to Our Neuromuscular Patients in Adulthood: Pathway to Independence and Maximal Function.

J Pediatr Orthop 2021 Jul;41(Suppl 1):S87-S89

Department of Orthopedics, Alfred I. DuPont Hospital for Children, Wilmington, DE.

Background: Children with neuromuscular disorders regularly seek care from pediatric orthopaedic surgeons. These conditions can have a significant impact on the growth and development of children and their function and well-being as adults. Questions exist about the long-term outcomes of musculoskeletal interventions performed during childhood. Read More

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Quantitative Bioreactor Monitoring of Intracellular Bacterial Metabolites in Using Liquid Chromatography-Isotope Dilution Mass Spectrometry.

ACS Omega 2021 Jun 20;6(21):13518-13526. Epub 2021 May 20.

Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, U.K.

We report a liquid chromatography-isotope dilution mass spectrometry method for the simultaneous quantification of 131 intracellular bacterial metabolites of . A comprehensive mixture of uniformly C-labeled internal standards (U-C IS) was biosynthesized from the closely related bacterium using 4% C-glucose as a carbon source. The U-C IS mixture combined with C authentic standards was used to validate the linearity, precision, accuracy, repeatability, limits of detection, and quantification for each metabolite. Read More

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Novel induction of CD40 expression by tumor cells with RAS/RAF/PI3K pathway inhibition augments response to checkpoint blockade.

Mol Cancer 2021 Jun 6;20(1):85. Epub 2021 Jun 6.

Department of Veterans Affairs, Tennessee Valley Healthcare System, 432 PRB, 2220 Pierce Ave, Nashville, TN, 37232, USA.

Background: While immune checkpoint blockade (ICB) is the current first-line treatment for metastatic melanoma, it is effective for ~ 52% of patients and has dangerous side effects. The objective here was to identify the feasibility and mechanism of RAS/RAF/PI3K pathway inhibition in melanoma to sensitize tumors to ICB therapy.

Methods: Rigosertib (RGS) is a non-ATP-competitive small molecule RAS mimetic. Read More

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Recovery of health-related quality of life in patients undergoing robotic radical cystectomy with intracorporeal diversion.

BJU Int 2021 Jun 5. Epub 2021 Jun 5.

Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK.

Background: To report the health-related quality of life (HRQoL) after robotic assisted radical cystectomy and intracorporeal urinary diversion (iRARC) and to identify factors impacting on return to baseline.

Patients And Methods: Consecutive patients undergoing iRARC between January 2016 - December 2017 completed the EORTC-QLQ-C30 and EORTC-QLQ-BLM30 questionnaires before surgery and had a minimum of 12 months follow-up postoperatively.

Results: A total of 76 patients met the inclusion criteria at 12 months. Read More

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Integrative review about somatic care improvement tools for people with autistic syndrome disorder.

Frederic Perrel

Perspect Psychiatr Care 2021 Jun 6. Epub 2021 Jun 6.

Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.

Purpose: Perform an integrative literature review on ways to improve somatic care access for people with autistic spectrum disorders (PASD).

Design And Methods: Integrative review as described by Whittemore and Kanfl methodology has been chosen by the author to concatenate knowledge about somatic care situation and existing processes that could improve its access for PASD. The PRISMA diagram was applied for its synthetic and visual modeling of the research process. Read More

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Meta-analysis of epigenome-wide association studies of carotid intima-media thickness.

Eur J Epidemiol 2021 Jun 6. Epub 2021 Jun 6.

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

Common carotid intima-media thickness (cIMT) is an index of subclinical atherosclerosis that is associated with ischemic stroke and coronary artery disease (CAD). We undertook a cross-sectional epigenome-wide association study (EWAS) of measures of cIMT in 6400 individuals. Mendelian randomization analysis was applied to investigate the potential causal role of DNA methylation in the link between atherosclerotic cardiovascular risk factors and cIMT or clinical cardiovascular disease. Read More

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Pilot and feasibility studies in rehabilitation research: a review and educational primer for the physiatrist researcher.

Am J Phys Med Rehabil 2021 May 28. Epub 2021 May 28.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON Canada Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom Institute of Population Health Sciences, Queen Mary University of London, London, United Kingdom Department of Medicine, McMaster University, Hamilton, ON Canada Biostatistics Unit, Father Sean O'Sullivan Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON Canada.

Abstract: Pilot and feasibility studies are conducted early in the clinical research pathway to evaluate whether a future, definitive study can or should be done, and if so, how. Poor planning and reporting of pilot and feasibility studies can compromise subsequent research efforts. Inappropriate labelling of studies as pilots also compromises education. Read More

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Prevalence of patients with lysosomal storage disorders and peroxisomal disorders: A nationwide survey in Japan.

Mol Genet Metab 2021 May 12. Epub 2021 May 12.

Advanced Clinical Research Center, Southern Tohoku Research Center for Neuroscience, Kanagawa, Japan.

Introduction: Lysosomal storage disorders and peroxisomal disorders are rare diseases caused by the accumulation of substrates of the metabolic pathway within lysosomes and peroxisomes, respectively. Owing to the rarity of these diseases, the prevalence of lysosomal storage disorders and peroxisomal disorders in Japan is unknown. Therefore, we conducted a nationwide survey to estimate the number of patients with lysosomal storage disorders and peroxisomal disorders in Japan. Read More

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Ventralis intermedius nucleus anatomical variability assessment by MRI structural connectivity.

Neuroimage 2021 Jun 2:118231. Epub 2021 Jun 2.

Wellcome Centre for Human Neuroimaging, 12 Queen Square, London WC1N 3AR, United Kingdom.

The ventralis intermedius nucleus (Vim) is centrally placed in the dentato-thalamo-cortical pathway (DTCp) and is a key surgical target in the treatment of severe medically refractory tremor. It is not visible on conventional MRI sequences; consequently, stereotactic targeting currently relies on atlas-based coordinates. This fails to capture individual anatomical variability, which may lead to poor long-term clinical efficacy. Read More

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A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation.

Br J Pharmacol 2021 Jun 5. Epub 2021 Jun 5.

Research Unit Lung Repair and Regeneration, Helmholtz Zentrum München, German Research Center for Environmental Health, Ludwig-Maximilians-University, University Hospital Grosshadern, Member of the German Center of Lung Research (DZL), Munich, Germany.

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Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1.

Cell Death Dis 2021 Jun 4;12(6):576. Epub 2021 Jun 4.

Department of Pathology, Dongguan People's Hospital affiliated to Southern Medical University, Dongguan, China.

Cancer-secreted exosomes are critical mediators of cancer-host crosstalk. In the present study, we showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to endothelial cells via exosomes increased the amount of miR-21-5p in recipient cells. MiR-21-5p suppressed Krev interaction trapped protein 1 (KRIT1) in recipient HUVECs and subsequently activated β-catenin signaling pathway and increased their downstream targets VEGFa and Ccnd1, which consequently promoted angiogenesis and vascular permeability in CRC. Read More

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