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Anatomy of a Business Case.

Nurs Adm Q 2021 Sep 20. Epub 2021 Sep 20.

Capstone College of Nursing, The University of Alabama, Tuscaloosa.

A business case plan (BCP) provides a structured framework for evidence-based, transparent business decisions. It is an essential tool that when written well will provide you with the means to translate the cost and benefits of nursing practice proposals, often related in anecdotal terms, into quantifiable, evidence-based terms outlining return on investment and business advantages of investing in nursing initiatives. The BCP should include an analysis of the problem and associated needs, the proposed solutions with options, goals for success, implementation, and evaluation plans, as well as a risk-adjusted cost-benefit analysis. Read More

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September 2021

NCCN Guidelines® Insights: Older Adult Oncology, Version 1.2021.

J Natl Compr Canc Netw 2021 Sep 20;19(9):1006-1019. Epub 2021 Sep 20.

29National Comprehensive Cancer Network.

The NCCN Guidelines for Older Adult Oncology address specific issues related to the management of cancer in older adults, including screening and comprehensive geriatric assessment (CGA), assessing the risks and benefits of treatment, preventing or decreasing complications from therapy, and managing patients deemed to be at high risk for treatment-related toxicity. CGA is a multidisciplinary, in-depth evaluation that assesses the objective health of the older adult while evaluating multiple domains, which may affect cancer prognosis and treatment choices. These NCCN Guidelines Insights focus on recent updates to the NCCN Guidelines providing specific practical framework for the use of CGA when evaluating older adults with cancer. Read More

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September 2021

Acute Lymphoblastic Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2021 Sep 20;19(9):1079-1109. Epub 2021 Sep 20.

29National Comprehensive Cancer Network.

The NCCN Guidelines for Acute Lymphoblastic Leukemia (ALL) focus on the classification of ALL subtypes based on immunophenotype and cytogenetic/molecular markers; risk assessment and stratification for risk-adapted therapy; treatment strategies for Philadelphia chromosome (Ph)-positive and Ph-negative ALL for both adolescent and young adult and adult patients; and supportive care considerations. Given the complexity of ALL treatment regimens and the required supportive care measures, the NCCN ALL Panel recommends that patients be treated at a specialized cancer center with expertise in the management of ALL This portion of the Guidelines focuses on the management of Ph-positive and Ph-negative ALL in adolescents and young adults, and management in relapsed settings. Read More

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September 2021

The effect of thyroid function on the risk of psychiatric readmission after hospitalization for major depressive disorder.

Psychiatry Res 2021 Sep 6;305:114205. Epub 2021 Sep 6.

Clinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai 200031, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai 201108, China; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangzhou 510515, China. Electronic address:

The relationship between thyroid function and depression has long been recognized, but little is known about the effect of thyroid function on the risk of readmission after hospitalization for major depressive disorder (MDD). This retrospective cohort study was aimed to explore the effect of thyroid function on psychiatric readmission after hospitalization for MDD. Data was derived from electronic medical records (EMR) of the Shanghai Mental Health Center (SMHC), Shanghai, China. Read More

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September 2021

Relationship of APOE, age at onset, amyloid and clinical phenotype in Alzheimer disease.

Neurobiol Aging 2021 Aug 25;108:90-98. Epub 2021 Aug 25.

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

The apolipoprotein E (APOE) ε4 allele is the most well-established risk factor for Alzheimer's disease (AD), although its relationship to age at onset and clinical phenotype is unclear. We aimed to assess relationships between APOE genotype and age at onset, amyloid-beta (Aβ) deposition and typical versus atypical clinical presentations in AD. Frequency of APOE ε4 carriers by age at onset was assessed in 447 AD patients, 138 atypical AD patients recruited by the Neurodegenerative Research Group at Mayo Clinic, and 309 with typical AD from ADNI. Read More

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Hypomethylating agents and FLT3 inhibitors as maintenance treatment for acute myeloid leukemia and myelodysplastic syndrome following allogeneic hematopoietic stem cell transplant - a systematic review and meta-analysis.

Transplant Cell Ther 2021 Sep 19. Epub 2021 Sep 19.

Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medical Oncology, Adult Leukemia Program, Dana-Farber Cancer Institute, Boston, MA.

Background: Disease relapse remains the major cause of death among patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) who receive an allogeneic hematopoietic cell transplant (allo-HCT). Maintenance treatment with FLT3 inhibitors and hypomethylating agents (HMA) has been studied in various clinical trials with mixed results.

Objective: To synthesize the current evidence on the efficacy and safety of FLT3 inhibitors and HMA for maintenance therapy following allo-HCT in AML and MDS. Read More

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September 2021

The ethnogeographic variability of genetic factors underlying G6PD deficiency.

Pharmacol Res 2021 Sep 19:105904. Epub 2021 Sep 19.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany. Electronic address:

Glucose-6-phosphate dehydrogenase (G6PD) deficiency caused by genetic variants in the G6PD gene, constitutes the most common enzymopathy worldwide affecting approximately 5% of the global population. While carriers are mostly asymptomatic, they are at substantial risk of acute hemolytic anemia upon certain infections or exposure to various medications. As such, information about G6PD activity status in a given patient can constitute an important parameter to guide clinical decision-making. Read More

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September 2021

SARS-CoV-2 positivity rates in asymptomatic workers at a cancer referral center in Mexico City: a prospective observational study in the context of adapting hospitals back to regular practice.

Am J Infect Control 2021 Sep 19. Epub 2021 Sep 19.

Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.

Background: Healthcare workers are at increased risk of SARS-CoV-2 infection. The positivity rates in hospitals that do not receive patients with COVID-19, such as the National Cancer Institute (INCan) in Mexico, and the associated factors are unknown.

Objective: To assess the incidence and factors associated with SARS-CoV-2 infection in health workers at INCan. Read More

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September 2021

Stem cells immortalized by hTERT perform differently from those immortalized by SV40LT in proliferation, differentiation, and reconstruction of matrix microenvironment.

Acta Biomater 2021 Sep 19. Epub 2021 Sep 19.

Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, USA; WVU Cancer Institute, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA. Electronic address:

Although matrix microenvironment has the potential to improve expanded stem cell proliferation and differentiation capacity, decellularized extracellular matrix (dECM) deposited by senescent cells does not contribute to the rejuvenation of adult stem cells, which has become a barrier to personalized stem cell therapy. Genetic modification is an effective strategy to protect cells from senescence but it carries the increased risk of malignant transformation and genetic instability. In this study, lentivirus carrying either human telomerase reverse transcriptase (hTERT) or simian virus 40 large T antigen (SV40LT) was used to transduce human infrapatellar fat pad-derived stem cells (IPFSCs). Read More

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September 2021

Satisfaction of the Use of Telehealth and Access to Care for Veterans During the COVID-19 Pandemic.

Telemed J E Health 2021 Sep 22. Epub 2021 Sep 22.

Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, California, USA.

While many health care providers have shifted toward telehealth services in response to the COVID-19 pandemic, little is known about the perception and acceptance of such services, particularly among vulnerable populations. Veterans, who are at increased risk of physical and mental health needs, may benefit from the use and availability of telehealth services. Cross sectional survey data related to telehealth use, satisfaction, and access were collected through an online survey. Read More

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September 2021

A Robust Prognostic Signature of Tumor Microenvironment in Colorectal Cancer.

Cancer Biother Radiopharm 2021 Sep 22. Epub 2021 Sep 22.

Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, P.R. China.

Colorectal cancer (CRC) has been a major public health problem. Tumor microenvironment (TME) greatly contributes to the heterogeneity of CRC and is crucial for the regulation of CRC progression. The authors' study wanted to develop a robust prognostic signature for CRC patients based on TME-related genes. Read More

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September 2021

Effects of a Health Promotion Intervention on Physical Activity in African American Men Living with HIV: Randomized Controlled Trial.

AIDS Patient Care STDS 2021 Sep 22. Epub 2021 Sep 22.

Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania, USA.

HIV and its treatment with antiretroviral therapy increase the risk of noncommunicable diseases (NCDs) tied to physical inactivity. Older African American men are also at high risk for NCDs. We tested the efficacy of a theory-based intervention to increase adherence to federal aerobic and muscle-strengthening physical activity (PA) guidelines among African American men aged 40 years and older living with HIV. Read More

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September 2021

Translation and cross-cultural adaptation to Brazilian Portuguese of two brief screening tools for at-risk psychosis youth: the Prodromal Questionnaire (PQ-16) and the PRIME-Screen.

Trends Psychiatry Psychother 2021 Aug 20. Epub 2021 Aug 20.

Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; Instituto #amesuamente.

Introduction: Prodromal characteristics of psychosis have been described for more than a century. Over the last three decades, a variety of studies have proposed methods to prospectively identify individuals (and youth in particular) who are at a high risk of developing a psychotic disorder. These studies have validated various screening instruments and made them available in several languages. Read More

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Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase.

N Engl J Med 2021 Sep 22. Epub 2021 Sep 22.

From Baylor College of Medicine, Houston (H.M.E.S.), and Javara, The Woodlands (C.K.) - both in Texas; Brigham and Women's Hospital, Boston (L.R.B.), and Moderna, Cambridge (A.A., H.C., W.D., S.H., B.L., D.M., R.P., F.S., J.E.T., H.Z., J.M.) - both in Massachusetts; Meridian Clinical Research, Baton Rouge, LA (B.E., F.E.); University of Miami, Miami (S.D.-L.), and DeLand Clinical Research Unit, DeLand (B.R.) - both in Florida; University of Pittsburgh School of Medicine, Pittsburgh (J.M.M.); Emory University School of Medicine, Atlanta (E.J.A.); University of Colorado School of Medicine, Aurora (T.B.C.); University of California, Los Angeles (J.C.), and Wake Research-Medical Center for Clinical Research, San Diego (L.H.-C.) - both in California; Kaiser Permanente Washington Health Research Institute (L.A.J.), and Fred Hutchinson Cancer Research Center (L.C., P.G., H.J.) - both in Seattle; University of Cincinnati, Cincinnati (C.J.F.); Henry Ford Health System, Detroit (M.Z.); Vitalink Research, Greenville, SC (G.F.); Clinical Research Center of Nevada, Wake Research, Las Vegas (M.L.); and the University of Maryland, College Park (K.M.N.), and the Vaccine Research Center (J.R.M., J.E.L., B.S.G.), National Institute of Allergy and Infectious Diseases (D.F., M.M., L.P.), National Institutes of Health, Bethesda - both in Maryland.

Background: At interim analysis in a phase 3, observer-blinded, placebo-controlled clinical trial, the mRNA-1273 vaccine showed 94.1% efficacy in preventing coronavirus disease 2019 (Covid-19). After emergency use of the vaccine was authorized, the protocol was amended to include an open-label phase. Read More

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September 2021

Effectiveness of mRNA Covid-19 Vaccine among U.S. Health Care Personnel.

N Engl J Med 2021 Sep 22. Epub 2021 Sep 22.

From the Covid-19 Response Team, Centers for Disease Control and Prevention (T.P., R.G., K.E.F.-D., J.L.F., M.F., N.C., S.S.M., J.R.V., S.J.S.), and the Georgia Emerging Infections Program and Emory University School of Medicine (S.K.F.) - both in Atlanta; the University of Iowa, Iowa City (N.M.M., D.A.T., K.K.H., B.F.); Olive View and University of California Los Angeles Ronald Reagan Medical Centers, Los Angeles (D.A.T., A.K., G.J.M.), the University of California San Francisco, Fresno (B.C.), and the California Emerging Infections Program, Oakland (J.L.); Baystate Medical Center, Springfield (H.A.S.), Brigham and Women's Hospital, Boston (P.C.H.), and the University of Massachusetts Medical Center, Worcester (J.P.H.) - all in Massachusetts; Jackson Memorial Hospital, Miami (L.C.L.); University Medical Center, Louisiana State University, New Orleans (S.C.L.); Thomas Jefferson University Hospital, Philadelphia (E.K.); Truman Medical Center, University of Missouri-Kansas City School of Medicine, Kansas City (M.T.S.); the University of Chicago (D.G.B.) and the Department of Medicine, Rush University Medical Center (M.Y.L.) - both in Chicago; the University of Mississippi Medical Center, Jackson (U.N.); the University of Alabama at Birmingham, Birmingham (W.A.S.); the University of Washington, Seattle (D.J.H.); Valleywise Health Medical Center, Arizona State University, Phoenix (F.L.); the Colorado Department of Public Health and Environment, Denver (D.B.); the Connecticut Emerging Infections Program and Yale School of Public Health, New Haven (M.B.); the Maryland Department of Health (K.M.-G.) and Johns Hopkins University School of Medicine (A.K.D.) - both in Baltimore; the Minnesota Emerging Infections Program, Minnesota Department of Health, St. Paul (S.L.); the University of New Mexico, Albuquerque (E.C.P.), and the New Mexico Emerging Infections Program, Santa Fe (E.C.P.); the University of Rochester Medical Center and the New York State-Rochester Emerging Infections Program, Rochester (G.D.); the Public Health Division, Oregon Health Authority, Portland (R.P.); Vanderbilt University Medical Center, Nashville (T.M.M.); the Duke Center for Antimicrobial Stewardship and Infection Prevention, Duke University School of Medicine, Durham, NC (D.J.A.); the University of Utah Veterans Affairs Salt Lake City Health Care System, Salt Lake City (J.M.); Washington University School of Medicine, Division of Infectious Diseases, St. Louis (J.H.K.); the University of Wisconsin-Madison and the William S. Middleton Memorial Veterans Hospital, Madison (N.S.); and the Alaska Native Tribal Health Consortium, Anchorage (R.S.).

Background: The prioritization of U.S. health care personnel for early receipt of messenger RNA (mRNA) vaccines against severe acute respiratory disease coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19), allowed for the evaluation of the effectiveness of these new vaccines in a real-world setting. Read More

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September 2021

Prevalence, determinants, and outcomes of SARS-COV-2 infection among cancer patients. A population-based study in northern Italy.

Cancer Med 2021 Sep 22. Epub 2021 Sep 22.

Friuli Venezia Giulia Regional Health Coordination Agency, Udine, Italy.

Background: It is well established that cancer patients infected with SARS-CoV-2 are at particularly elevated risk of adverse outcomes, but the comparison of SARS-CoV-2 infection risk between cancer patients and cancer-free individuals has been poorly investigated on a population-basis.

Methods: A population-based study was thus conducted in Friuli Venezia Giulia region, northeastern Italy, to estimate prevalence and determinants of SARS-CoV-2 infection among cancer patients, as compared to cancer-free individuals, and to evaluate adverse outcomes of SARS-CoV-2 infection. The study included 263,042 individuals tested for SARS-CoV-2 in February-December 2020 with cancer history retrieved through the regional cancer registry. Read More

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September 2021

rs41291957 controls miR-143 and miR-145 expression and impacts coronary artery disease risk.

EMBO Mol Med 2021 Sep 22:e14060. Epub 2021 Sep 22.

Humanitas Research Hospital-IRCCS, Rozzano, Italy.

The role of single nucleotide polymorphisms (SNPs) in the etiopathogenesis of cardiovascular diseases is well known. The effect of SNPs on disease predisposition has been established not only for protein coding genes but also for genes encoding microRNAs (miRNAs). The miR-143/145 cluster is smooth muscle cell-specific and implicated in the pathogenesis of atherosclerosis. Read More

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September 2021

Right ventricular dysfunction and tricuspid regurgitation in functional mitral regurgitation.

ESC Heart Fail 2021 Sep 22. Epub 2021 Sep 22.

The Christ Hospital Health Network, 2139 Auburn Ave, Cincinnati, OH, 45219, USA.

Aim: The objective of this study was to investigate the prognostic importance of right ventricular dysfunction (RVD) and tricuspid regurgitation (TR) in patients with moderate-severe functional mitral regurgitation (FMR) receiving MitraClip procedure. RVD and TR grade are associated with cardiovascular mortality in the general population and other cardiovascular diseases. However, there are limited data from observational studies on the prognostic significance of RVD and TR in FMR receiving MitraClip procedure. Read More

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September 2021

Second- or third-generation tyrosine kinase inhibitors in first-line treatment of chronic myeloid leukemia in general population: Is there a real benefit?

Cancer Med 2021 Sep 22. Epub 2021 Sep 22.

Bordeaux Population Health Research Center, Inserm UMR1219-EPICENE, University of Bordeaux, Bordeaux, France.

Introduction: Since 2009, multiple randomized trials have shown faster and deeper responses in CML patients treated with new-generation TKI (NG-TKI) compared to those treated with imatinib (IM). Are the same results observed in the general population?

Materials And Methods: Patients were identified from the three French hematological malignancies population-based registries. All CML patients (ICD-O-3: 9875/3) diagnosed between 2006 and 2016 and resided in registries areas were included. Read More

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September 2021

Association between visceral adipose tissue and major depressive disorder across the lifespan: a Scoping Review.

Bipolar Disord 2021 Sep 22. Epub 2021 Sep 22.

Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Objectives: Increasing evidence supports a bidirectional relationship between major depressive disorder (MDD) and obesity, but the role of visceral adipose tissue (VAT) as a measure of obesity in relation to MDD is not well understood. Here we review literature investigating the link between MDD and VAT in terms of biomarkers, sex differences, and aging.

Methods: PubMed, EMBASE, PsycINFO, and CINAHL searches were conducted on December 11, 2020. Read More

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September 2021

Focused Microbiome Shifts in Reconstructed Wetlands Correlated with Elevated Cu Concentrations Originating from Micronized Copper Azole Treated Wood.

Environ Toxicol Chem 2021 Sep 22. Epub 2021 Sep 22.

U.S. Environmental Protection Agency, Office of Research and Development, Center for Public Health and Environmental Assessment, Pacific Ecological Systems Division, Corvallis, OR, USA.

Micronized copper azole (MCA) wood preservative formulations include Cu in nano form, and relatively little is known about longer-term effects of Cu leached from MCA into wetland ecosystems. Here we tested the hypothesis that changes in soil microbiomes within reconstructed freshwater wetlands will be associated with exposure to elevated Cu concentrations originating from immersed MCA treated wood stakes. Eight replicate communities were assembled with Willamette Valley flood plain soil, and clonally propagated wetland plants within mesocosms. Read More

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September 2021

Growth After Adenotonsillectomy for Obstructive Sleep Apnea: Revisited.

Laryngoscope 2021 Sep 22. Epub 2021 Sep 22.

Department of Otolaryngology, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado, U.S.A.

Objectives/hypothesis: To reanalyze the growth trajectory and assess longitudinal changes of children undergoing adenotonsillectomy (AT) versus watchful waiting (WW) enrolled in the Childhood Adenotonsillectomy Trial (CHAT) study and to determine if an AT increases the risk of obesity in children.

Study Design: Reanalysis of prospective cohort investigation.

Methods: The study analyzed publicly available data from CHAT, including 3 months visit data not previously included in a prior publication. Read More

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September 2021

Impact of era of diagnosis on cause-specific late mortality among 77 423 five-year European survivors of childhood and adolescent cancer: the PanCareSurFup consortium.

Int J Cancer 2021 Sep 22. Epub 2021 Sep 22.

German Childhood Cancer Registry (GCCR), Division of Childhood Cancer Epidemiology, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), Johannes Gutenberg University Mainz, Germany.

Late mortality of European five-year survivors of childhood or adolescent cancer has dropped over the last 60 years, but excess mortality persists. There is little information concerning secular trends in cause-specific mortality among older European survivors. PanCareSurFup pooled data from 12 cancer registries and clinics in 11 European countries from 77 423 five-year survivors of cancer diagnosed before age 21 between 1940 to 2008 followed for an average age of 21 years and a total of 1. Read More

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September 2021

Between a rock and a hard place: Ethics, nurses' safety, and the right to protest during the COVID-19 pandemic.

Int Nurs Rev 2021 Sep;68(3):270-278

Department of Nursing, Walter Sisulu University, Mthatha, South Africa.

Aim: In this paper, we critically discuss the ethics of nurses' choice to strike during the COVID-19 pandemic, considering legal and ethical arguments, overlaying the Ubuntu philosophy, an African ethic.

Background: The recent unprecedented coronavirus disease pandemic and the increased reports on the absence of personal protective equipment in South Africa places many health workers' lives at risk. Nurses spend most of their time with patients, which exposes them to fatal risks as they work in unsafe environments. Read More

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September 2021

Examining socio-economic factors to understand the hospital case fatality rates of COVID-19 in the city of São Paulo, Brazil.

Trans R Soc Trop Med Hyg 2021 Sep 22. Epub 2021 Sep 22.

Departamento de Geografia, Faculdade de Filosofia, Letras e Ciências Humanas e Instituto de Estudos Avançados da Universidade de São Paulo, São Paulo, SP, Brazil.

Background: Understanding differences in hospital case fatality rates (HCFRs) of coronavirus disease 2019 (COVID-19) may help evaluate its severity and the capacity of the healthcare system to reduce mortality.

Methods: We examined the variability in HCFRs of COVID-19 in relation to spatial inequalities in socio-economic factors, hospital health sector and patient medical condition across the city of São Paulo, Brazil. We obtained the standardized hospital case fatality ratio adjusted indirectly by age and sex, which is the ratio between the HCFR of a specific spatial unit and the HCFR for the entire study area. Read More

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September 2021

Acute exposure to diesel affects inflammation and vascular function.

Eur J Prev Cardiol 2021 Sep;28(11):1192-1200

Molecular and Clinical Sciences Research Institute, St George's University of London, UK.

Background: Diesel exhaust fumes represent one of the most common toxic pollutants. The prolonged effects of acute exposure to this pollutant on inflammatory status and vascular properties are unknown.

Methods: During a 2-h session, 40 healthy subjects were exposed to diesel exhaust fumes and/or filtered air. Read More

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September 2021

The effects of transitions in metabolic health and obesity status on incident cardiovascular disease: Insights from a general Chinese population.

Eur J Prev Cardiol 2021 Sep;28(11):1250-1258

Department of Cardiology, The First Hospital of China Medical University, China.

Background: Recent studies have investigated the association of transitions in metabolic health and obesity status over time with the risk of cardiovascular disease, focusing on the subgroup demonstrating metabolically healthy obesity. However, these studies have produced inconsistent results. This study evaluates the relation in a general Chinese population. Read More

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September 2021

Early cardiovascular structural and functional abnormalities as a guide to future morbid events.

Eur J Prev Cardiol 2021 Sep;28(11):1214-1221

Department of Medicine, Cardiovascular Division, University of Minnesota Medical School, Minneapolis, MN, USA.

Aims: Our aim was to evaluate the predictive value of a battery of 10 non-invasive tests of cardiovascular structural and functional health on the future risk of cardiovascular morbid events.

Methods And Results: A total of 1900 asymptomatic adults concerned about their risk for cardiovascular disease underwent non-invasive assessment with 10 tests of vascular and cardiac structure and function. A disease score (DS) was calculated for each individual based on these 10 tests. Read More

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September 2021