74,268 results match your criteria health priority

Patient-reported outcomes for monitoring symptomatic toxicities in cancer patients treated with immune-checkpoint inhibitors: A Delphi study.

Eur J Cancer 2021 Sep 15;157:225-237. Epub 2021 Sep 15.

Department of Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland; Institute of Higher Education and Research in Healthcare, Faculty of Biology and Medicine, University of Lausanne and Lausanne University Hospital, Lausanne, Switzerland. Electronic address:

Background: Immune-related adverse events (IrAEs) associated with the use of immune checkpoint inhibitors (ICIs) may not be fully covered by existing measures like the PRO-CTCAE™. Selecting PRO-CTCAE™ items for monitoring symptomatic adverse events is hindered by the heterogeneity and complexity of IrAEs, and no standardised selection process exists. We aimed to reach expert consensus on the PRO-CTCAE™ symptom terms relevant for cancer patients receiving ICIs and to gather preliminary expert opinions about additional symptom terms reflecting ICI symptomatic toxicities. Read More

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September 2021

Concentrations, spatial distribution, sources and environmental health risks of potentially toxic elements in urban road dust across China.

Sci Total Environ 2021 Sep 10;805:150266. Epub 2021 Sep 10.

Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Potentially toxic element (PTE) pollution is widespread in road dust across China, and the effects of PTEs in road dust on health cannot be ignored. In this study, the concentrations of six PTEs (Pb, Cd, Cr, Cu, Zn and Ni) in 4336 road dust samples from 58 cities in 31 provincial regions of China taken after 2000 were obtained from the literatures. Based on these data, the spatial distribution, pollution sources, and ecological and human health risks of PTEs in road dust were comprehensively assessed and the main pollution factors and areas of high risk were identified. Read More

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September 2021

Noncancerous Genitourinary Conditions as a Public Health Priority: Conceptualizing the Hidden Burden.

Urology 2021 Sep 15. Epub 2021 Sep 15.

Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, Wisconsin.

Objective: To provide a conceptual framework to guide investigations into burdens of noncancerous genitourinary conditions (NCGUCs), which are extensive and poorly understood.

Methods: The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) convened a workshop of diverse, interdisciplinary researchers and health professionals to identify known and hidden burdens of NCGUCs that must be measured to estimate the comprehensive burden. Following the meeting, a subgroup of attendees (authors of this article) continued to meet to conceptualize burden. Read More

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September 2021

The fairness of ventilator allocation during the COVID-19 pandemic.

Xueshi Wang

Bioethics 2021 Sep 18. Epub 2021 Sep 18.

Department of Philosophy, Harvard University, Cambridge, Massachusetts, USA.

There is ongoing debate on how to fairly allocate scarce critical care resources to patients with COVID-19. The debate revolves around two views: those who believe that priority for scarce resources should primarily aim at saving the most lives (SML) or at saving the most life-years, and those who believe that public health should focus on health equity to address health disparities and social determinants of health. I argue that maximizing medical outcomes by saving the greatest number of patients is not a plausible strategy for combating COVID-19. Read More

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September 2021

Does weight management after Gestational Diabetes Mellitus diagnosis improve pregnancy outcomes? A multi-ethnic cohort study.

Diabet Med 2021 Sep 18:e14692. Epub 2021 Sep 18.

School of Health Sciences, College of Health, Medicine and Wellbeing, The University of Newcastle University Drive, Callaghan, NSW, 2308, Australia.

Aims: To assess the impact of achieving an Institute of Medicine based personalised weight target in addition to conventional glycaemic management after gestational diabetes mellitus diagnosis on maternal and neonatal outcomes.

Methods: A retrospective audit of clinical data (2016 to 2019) for singleton gestational diabetes pregnancies was conducted in a multi-ethnic cohort. Logistic regression analyses assessed relationships between achieving, exceeding, and gaining less than a personalised weight target provided after gestational diabetes diagnosis and rates of large for gestational age, small for gestational age infants, insulin therapy initiation, and neonatal outcomes. Read More

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September 2021

The sexual health, orientation, and activity of autistic adolescents and adults.

Autism Res 2021 Sep 18. Epub 2021 Sep 18.

Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.

Small studies suggest significant differences between autistic and nonautistic individuals regarding sexual orientation and behavior. We administered an anonymized, online survey to n = 2386 adults (n = 1183 autistic) aged 16-90 years to describe sexual activity, risk of sexually transmitted infections (STIs), and sexual orientation. Autistic individuals are less likely to report sexually activity or heterosexuality compared to nonautistic individuals, but more likely to self-report asexuality or an 'other' sexuality. Read More

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September 2021

French General Practitioners Frequently See Patients with Long-COVID.

J Am Board Fam Med 2021 Sep-Oct;34(5):1010-1013

From the Observatoire Régional de la Santé (ORS) Provence-Alpes-Côte d'Azur, 27 boulevard Jean Moulin, 13005 Marseille, France (BD-C, RL, DS, VG, PV).

A second epidemic has appeared among some patients infected with COVID-19 persistent disorders, commonly called "long COVID syndrome." Our study sought to identify the proportion of French GPs dealing with patients with potential long COVID syndrome and their symptoms in an online cross-sectional questionnaire-based survey among a representative national panel of GPs. The majority (53. Read More

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Using systems science to advance health equity in tobacco control: a causal loop diagram of smoking.

Tob Control 2021 Sep 17. Epub 2021 Sep 17.

Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Objectives: Develop and use a causal loop diagram (CLD) of smoking among racial/ethnic minority and lower-income groups to anticipate the intended and unintended effects of tobacco control policies.

Methods: We developed a CLD to elucidate connections between individual, environmental and structural causes of racial/ethnic and socioeconomic disparities in smoking. The CLD was informed by a review of conceptual and empirical models of smoking, fundamental cause and social stress theories and 19 qualitative interviews with tobacco control stakeholders. Read More

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September 2021

Prehabilitation services for people diagnosed with cancer in Scotland - Current practice, barriers and challenges to implementation.

Surgeon 2021 Sep 14. Epub 2021 Sep 14.

Professor of Public Health Nutrition, Centre for Research Into Cancer Prevention and Screening, Level 7, Mailbox 7, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK. Electronic address:

Background: Prehabilitation is the practice of enhancing a patient's functional and psychological capacity before treatment commences. It is of interest in the cancer context because of the impact of treatments on quality of life and cancer survivorship. This work aims to document current practice, barriers and challenges to implementing prehabilitation to inform the development of a national framework. Read More

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September 2021

Implementing welfare technology in palliative homecare for patients with cancer: a qualitative study of health-care professionals' experiences.

BMC Palliat Care 2021 Sep 17;20(1):146. Epub 2021 Sep 17.

Lovisenberg Diaconal University College, Lovisenberggata 15B, 0456, Oslo, Norway.

Background: Introducing welfare technology in home-based palliative care has been suggested to be beneficial for improving access to health care at home and enhancing patients' feelings of security and safety. However, little is known about the experiences of municipal health-care professionals using welfare technology in palliative home care. The aim of this study was to explore municipal health-care professionals' experiences regarding the significant challenges, facilitators, and assessments associated with implementing a technological solution named "remote home care" in palliative home care for patients with cancer. Read More

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September 2021

Evaluating satisfaction with the quality and provision of end-of-life care for patients from diverse ethnocultural backgrounds.

BMC Palliat Care 2021 Sep 17;20(1):145. Epub 2021 Sep 17.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.

Background: Recently immigrated and ethnic minority patients in Ontario, Canada are more likely to receive aggressive life-prolonging treatment at the end of life in comparison to other patients. To explore this finding further, this survey-based observational study aimed to evaluate satisfaction with the quality of end-of-life care for patients from diverse ethnocultural backgrounds.

Methods: The End-of-Life Satisfaction Survey was used to measure satisfaction with the quality of inpatient end-of-life care from the perspective of next-of-kin of recently deceased patients at Sunnybrook Health Sciences Centre in Toronto, Ontario (between March 2012 to May 2019). Read More

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September 2021

Exploring women's experiences of participation in shared decision-making during childbirth: a qualitative study at a reference hospital in Spain.

BMC Pregnancy Childbirth 2021 Sep 17;21(1):631. Epub 2021 Sep 17.

Preventive Medicine and Epidemiology Department, Hospital Clínic, Barcelona, Spain.

Background: Women's engagement in healthcare decision-making during childbirth has been increasingly emphasised as a priority in maternity care, since it increases satisfaction with the childbirth experience and provides health benefits for women and newborns. The birth plan was developed as a tool to facilitate communication between health professionals and women in Spain, but their value in routine practice has been questioned. Besides, little is known about women's experiences of participation in decision-making in the Spanish context. Read More

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September 2021

Infertility, Infertility Treatment and Cardiovascular Disease: An Overview.

Can J Cardiol 2021 Sep 14. Epub 2021 Sep 14.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Research Institute, McGill University Health Centre, Montreal, Quebec, Canada; Division of General Internal Medicine, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:

The prevalence of maternal cardiovascular disease (CVD) has risen throughout the developed world, reflecting an increase in acquired cardiovascular risk factors, such as hypertension and diabetes, and the improved life expectancy of those living with congenital CVD due to advances in care. Because many cardiovascular risk factors or cardiovascular conditions are associated with infertility, reproductive-aged women with CVD may increasingly seek reproductive assistance. The worldwide use of assisted reproductive technologies (ART), such as in-vitro fertilization (IVF) with or without intracytoplasmic sperm injection, or intrauterine insemination following pharmacological ovulation induction have increased steadily over the last several decades. Read More

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September 2021

Rapid Changes in the Provision of Rehabilitation Care in Post-Acute and Long-Term Care Settings During the COVID-19 Pandemic.

J Am Med Dir Assoc 2021 Aug 27. Epub 2021 Aug 27.

Center for Long-Term Care Quality & Innovation, Brown University School of Public Health, Providence, RI, USA; Department of Health Services, Policy & Practice, Brown University School of Public Health, Providence, RI, USA. Electronic address:

Objectives: Little is known about how the COVID-19 pandemic has affected rehabilitation care in post-acute and long-term care. As part of a process to assess research priorities, we surveyed professionals in these settings to assess the impact of the pandemic and related research needs.

Design: Qualitative analysis of open-ended survey results. Read More

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A meta-synthesis of qualitative studies on stress urinary incontinence in women for the development of a Core Outcome Set: A systematic review.

Int J Gynaecol Obstet 2021 Sep 17. Epub 2021 Sep 17.

American University of the Caribbean, School of Medicine.

Objective: Given the high variation of perceptions of women with stress urinary incontinence (SUI), qualitative meta-synthesis in this field appears warranted. We aimed to synthesize evidence on women's experiences of SUI by analysing qualitative data.

Methods: A literature search of Medline, Embase, Scopus, PsycInfo and CINAHL databases was performed by a CHORUS Working Group, from inception to August 2020. Read More

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September 2021

Reconstruction of the Upper Extremity High-Voltage Electrical Injury: A Pediatric Burn Hospital's 13-Year Experience.

J Burn Care Res 2021 Sep 17. Epub 2021 Sep 17.

Department of Clinical Research, Shriners Hospitals for Children-Boston; Boston MA.

High-voltage electrical injury is a rare yet destructive class of burn injury that persists as a serious public health issue. High-voltage exposure is commonly associated with complex wounds to the upper extremities, which can be a significant challenge for burn and plastic surgeons to reconstruct. This intensive and multistage reconstructive process is especially difficult in the growing child. Read More

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September 2021

The effect of unobserved preferences and race on vaccination hesitancy for COVID-19 vaccines: implications for health disparities.

J Manag Care Spec Pharm 2021 Sep;27(9-a Suppl):S4-S13

Larner College of Medicine, University of Vermont, Burlington.

Reducing the extra burden COVID-19 has on people already facing disparities is among the main national priorities for the COVID-19 vaccine rollout. Early reports from states releasing vaccination data by race show that White residents are being vaccinated at significantly higher rates than Black residents. Public health efforts are being targeted to address vaccine hesitancy among Black and other minority populations. Read More

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September 2021

Daily coordination of orexinergic gating in the rat superior colliculus-Implications for intrinsic clock activities in the visual system.

FASEB J 2021 Oct;35(10):e21930

Department of Neurophysiology and Chronobiology, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, Krakow, Poland.

The orexinergic system delivers excitation for multiple brain centers to facilitate behavioral arousal, with its malfunction resulting in narcolepsy, somnolence, and notably, visual hallucinations. Since the circadian clock underlies the daily arousal, a timed coordination is expected between the orexin system and its target subcortical visual system, including the superior colliculus (SC). Here, we use a combination of electrophysiological, immunohistochemical, and molecular approaches across 24 h, together with the neuronal tract-tracing methods to investigate the daily coordination between the orexin system and the rodent SC. Read More

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October 2021

Adults With Autism Should be Considered a Priority in COVID-19 Immunization Programs.

J Autism Dev Disord 2021 Sep 17. Epub 2021 Sep 17.

Faculty of Medicine of Bahia, Federal University of Bahia, Praça XV de Novembro, s/n-Largo do Terreiro de Jesus, Salvador, Brazil.

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September 2021

The rise of deep learning and transformations in bioactivity prediction power of molecular modeling tools.

Chem Biol Drug Des 2021 Sep 16. Epub 2021 Sep 16.

Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.

The search and design for the better use of bioactive compounds are used in many experiments to best mimic compounds' functions in the human body. However, finding a cost-effective and timesaving approach is a top priority in different disciplines. Nowadays, artificial intelligence (AI) and particularly deep learning (DL) methods are widely applied to improve the precision and accuracy of models used in the drug discovery process. Read More

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September 2021

Triage assessment of transitory loss of consciousness in the emergency department-A retrospective observational study.

J Adv Nurs 2021 Sep 17. Epub 2021 Sep 17.

Emergency Department, Hospital of Merano (SABES-ASDAA), Merano, Italy.

Aim: To establish how the Manchester Triage System can correctly prioritize patients admitted to the emergency department for transitory loss of consciousness in relation to their risk of presenting severe acute disease.

Design: A observational retrospective study.

Methods: A total of 2291 patients who required a triage evaluation for a transitory loss of consciousness at the emergency department of Merano Hospital between 1 January 2017 and 30 June 2019 were considered. Read More

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September 2021

"The Continuous Shadow of My Mother's Breast Cancer": exploring the voice of daughters.

Support Care Cancer 2021 Sep 16. Epub 2021 Sep 16.

Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan.

Purpose: Women whose mothers have been diagnosed with breast cancer are concerned about their mothers' illness and fear developing cancer themselves. This study, conducted in Taiwan, aims to understand daughters' lived experiences after their mothers were diagnosed with breast cancer.

Method: In-depth interviews were conducted to understand daughters' emotional reactions to their mothers' diagnoses, their challenges with taking care of their mothers, and their concerns or perceptions regarding their own risks of developing breast cancer. Read More

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September 2021

Gaps in the civil registration and vital statistics systems of low- and middle-income countries and the health sector's role in improving the situation.

Glob Health Med 2021 Aug;3(4):243-245

National Center for Global Health and Medicine, Tokyo, Japan.

Civil Registration and Vital Statistics (CRVS) is an essential administrative system that provides legal identification to all individuals and accurate statistical data of vital events, such as birth and death rates within the population. Globally, CRVS has been considered a priority issue, especially for low- and middle-income countries where the coverage of this system is poor. This may be attributed to factors such as inefficiency of laws, poor inter-ministerial cooperation, and a lack of awareness among people. Read More

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Measuring the Impact of Health on Economic Growth Using Pooling Data in Regions of Asia: Evidence From a Quantile-On-Quantile Analysis.

Front Public Health 2021 31;9:689610. Epub 2021 Aug 31.

Department of Business Administration, National Changhua University of Education, Changhua, Taiwan.

Health improvement has become a significant social priority since a moderately good human capital condition improves the workforce's abilities, efficiency, and quality of life. A rapid increase in healthcare expenditure is a trend in major developing and developed countries; however, healthcare expenditure widely varies among most Asian countries. Asian countries contribute a significant amount of output to economic development worldwide. Read More

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The Study of Cost-Effectiveness of Rivaroxaban versus Warfarin in Patients with Atrial Fibrillation Who Developed Ischemic Stroke.

Stroke Res Treat 2021 7;2021:5534873. Epub 2021 Sep 7.

Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Rivaroxaban is a new anticoagulant providing benefits for the treatment of patients with atrial fibrillation (AF). This study is aimed at evaluating the cost-effectiveness of rivaroxaban compared to warfarin in patients with AF.

Method: This economic evaluation study was conducted among 144 selected nonrandomly patients who were treated with rivaroxaban or warfarin and suffered from AF leading to stroke, in the stroke ward of Shiraz Nemazee Hospital in 2019. Read More

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September 2021

[The European ADVANTAGE experience for management of frailty: keys to its applicability in Latin AmericaA experiência europeia ADVANTAGE para manejo da fragilidade: apontamentos para sua aplicabilidade na América Latina].

Rev Panam Salud Publica 2021 13;45:e107. Epub 2021 Sep 13.

Servicio de Geriatría, Hospital Universitario de Getafe GetafeMadrid España Servicio de Geriatría, Hospital Universitario de Getafe, Getafe, Madrid, España.

The European Commission and 22 of its Member States cofinanced, in 2017-2019, the first joint action to address frailty in older persons, known as ADVANTAGE Joint Action. The initiative developed a common strategy, based on the best scientific evidence, to position healthy aging and frailty as priority public health issues in the participating countries and thus contribute to uniformly addressing frailty across Europe. This article details the methodology and main achievements of ADVANTAGE and includes an analysis of the key factors contributing to its success. Read More

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September 2021

The Burden of Respiratory Viruses and Their Prevalence in Different Geographical Regions of India: 1970-2020.

Front Microbiol 2021 31;12:723850. Epub 2021 Aug 31.

Division of Molecular Biology, ICMR-National AIDS Research Institute, Pune, India.

As per the 2019 report of the National Health Portal of India, 41,996,260 cases and 3,740 deaths from respiratory infections were recorded across India in 2018. India contributes to 18% of the global population, with severe acute respiratory infection (SARI) as one of the prominent causes of mortality in children >5 years of age. Measures in terms of the diagnosis and surveillance of respiratory infections are taken up globally to discover their circulating types, detect outbreaks, and estimate the disease burden. Read More

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Biofilm Formation and Its Role in Disease Pathogenesis: A Review.

Infect Drug Resist 2021 10;14:3711-3719. Epub 2021 Sep 10.

Department of Medical Laboratory Sciences, Debre Birhan Health Science College, Debre Birhan, Ethiopia.

species, particularly , is the first pathogen on the critical priority list of pathogens for novel antibiotics to become a "red-alert" human pathogen. is an emerging global antibiotic-resistant gram-negative bacteria that most typically causes biofilm-associated infections such as ventilator-associated pneumonia and catheter-related infection, both of which are resistant to antibiotic therapy. capacity to develop antibiotic resistance mechanisms allows the organism to thrive in hospital settings, facilitating the global spread of multidrug-resistant strains. Read More

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September 2021

Inequalities in older LGBT people's health and care needs in the United Kingdom: a systematic scoping review.

Ageing Soc 2021 Mar 11;41(3):493-515. Epub 2019 Oct 11.

School of Medicine, Cardiff University, Cardiff, UK.

The hostile environment that older lesbian, gay, bisexual and transgender (LGBT) people faced at younger ages in the United Kingdom (UK) may have a lasting negative impact on their health. This systematic scoping review adds to the current knowledge base through comprehensively synthesising evidence on what is known about the extent and nature of health and care inequalities, as well as highlighting gaps in the evidence which point the way towards future research priorities. We searched four databases, undertook manual searching, and included studies which presented empirical findings on LGBT people aged 50+ in the UK and their physical and mental health or social care status. Read More

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The role of cardiac rehabilitation in improving cardiovascular outcomes.

Nat Rev Cardiol 2021 Sep 16. Epub 2021 Sep 16.

University of Exeter Medical School (Primary Care), Smeall Building, St Luke's Campus, Exeter, UK.

Cardiac rehabilitation is a complex intervention that seeks to improve the functional capacity, wellbeing and health-related quality of life of patients with heart disease. A substantive evidence base supports cardiac rehabilitation as a clinically effective and cost-effective intervention for patients with acute coronary syndrome or heart failure with reduced ejection fraction and after coronary revascularization. In this Review, we discuss the major contemporary challenges that face cardiac rehabilitation. Read More

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September 2021