417,666 results match your criteria health mental


Patterns of mental health problems before and after easing COVID-19 restrictions: Evidence from a 105248-subject survey in general population in China.

PLoS One 2021 3;16(8):e0255251. Epub 2021 Aug 3.

Shantou Longhu People's Hospital, Shantou, Guangdong, China.

Background: The COVID-19 pandemic has alarming implications for individual and population level mental health. Although the future of COVID-19 is unknown at present, more countries or regions start to ease restrictions. The findings from this study have provided the empirical evidence of prevalence and patterns of mental disorders in Chinese general population before and after easing most COVID-19 restrictions, and information of the factors associated with these patterns. Read More

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Assessing the Care Modality Preferences and Predictors for Digital Mental Health Treatment Seekers in a Technology-enabled Stepped Care Delivery System: Cross-sectional Study.

JMIR Form Res 2021 Aug 1. Epub 2021 Aug 1.

Modern Life, Inc., 450 Sansome St, 12th Floor, San Francisco, US.

Background: Access to mental health services continues to be a systemic problem in the United States and around the world due to a variety of barriers including limited availability of skilled providers and lack of mental health literacy among patients. Individuals seeking mental health treatment may not be aware of the multiple modalities of digital mental health care available to address their presenting problem (e.g. Read More

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Machine learning directed interventions associate with decreased hospitalization rates in hemodialysis patients.

Int J Med Inform 2021 Jul 24;153:104541. Epub 2021 Jul 24.

Fresenius Medical Care, Global Medical Office, Waltham, United States. Electronic address:

Background: An integrated kidney disease company uses machine learning (ML) models that predict the 12-month risk of an outpatient hemodialysis (HD) patient having multiple hospitalizations to assist with directing personalized interdisciplinary interventions in a Dialysis Hospitalization Reduction Program (DHRP). We investigated the impact of risk directed interventions in the DHRP on clinic-wide hospitalization rates.

Methods: We compared the hospital admission and day rates per-patient-year (ppy) from all hemodialysis patients in 54 DHRP and 54 control clinics identified by propensity score matching at baseline in 2015 and at the end of the pilot in 2018. Read More

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Living Under Coronavirus and Injecting Drugs in Bristol (LUCID-B): A qualitative study of experiences of COVID-19 among people who inject drugs.

Int J Drug Policy 2021 Jul 20;98:103391. Epub 2021 Jul 20.

Centre for Academic Mental Health, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom; Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom. Electronic address:

Background: People who inject drugs (PWID) are a high-risk group for COVID-19 transmission and serious health consequences. Restrictions imposed in the UK in response to the pandemic led to rapid health and housing service alterations. We aimed to examine PWID experiences of: 1) challenges relating to the COVID-19 public health measures; 2) changes to opioid substitution therapy (OST) and harm reduction services; and 3) perceived effects of COVID-19 on drug use patterns and risk behaviour. Read More

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Reliability and validity of the Chinese version of the CUDOS-M in patients with mood disorders: A multicenter study across China.

J Affect Disord 2021 Jul 18;294:723-729. Epub 2021 Jul 18.

Division of Mood Disorders, Hongkou District Mental Health Center, Shanghai, China; School of Medicine, Shanghai University, Shanghai, China. Electronic address:

Background: A useful scale for identification of mixed features in major depressive episodes (MDE) patients is urgent in China. This study aimed to evaluate the reliability and validity of the Chinese version of the Clinically Useful Depression Outcome Scale supplemented with questions for the DSM-5 mixed features specifier (Chinese-CUDOS-M) in MDE patients.

Methods: A total of 152 MDE patients were recruited and assessed using Chinese-CUDOS-M, Patient Health Questionnaire-9 (PHQ-9) and 32-item Hypomania Checklist (HCL-32). Read More

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Network analysis of physical and psychiatric symptoms of hospital discharged patients infected with COVID-19.

J Affect Disord 2021 Jul 16;294:707-713. Epub 2021 Jul 16.

Department of Communication, Renmin University of China, China.

In the current study, we aimed to investigate the network structure of COVID-19 symptoms and its related psychiatric symptoms, using a network approach. Specifically, we examined how COVID-19 symptoms relate to psychiatric symptoms and highlighted potential pathways between COVID-19 severity and psychiatric symptoms. With a sample of six hundred seventy-five recovered COVID-19 patients recruited 1 month after hospital discharge, we respectively integrated COVID-19 symptoms with PTSD, depression, and anxiety symptoms and analyzed the three network structures. Read More

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Delirium-related distress in the ICU: A qualitative meta-synthesis of patient and family perspectives and experiences.

Int J Nurs Stud 2021 Jul 3;122:104030. Epub 2021 Jul 3.

School of Nursing Sydney, The University of Notre Dame Australia, Darlinghurst, NSW, Australia; The Cunningham Centre for Palliative Care, St Vincent's Health Network Sydney, Darlinghurst, NSW, Australia; University of Technology Sydney, IMPACCT - Improving Palliative, Aged and Chronic Care through Research and Translation, Faculty of Health, Ultimo, NSW, Australia. Electronic address:

Background: Better understanding of patient and family member experiences of delirium and related distress during critical care is required to inform the development of targeted nonpharmacologic interventions.

Objective: To examine and synthesize qualitative data on patient and family member delirium experiences and relieving factors in the Intensive Care Unit (ICU).

Design: We conducted a systematic review and qualitative meta-synthesis. Read More

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Therapeutic inertia in relapsing-remitting multiple sclerosis.

Mult Scler Relat Disord 2021 Jul 27;55:103176. Epub 2021 Jul 27.

Neurology Department, Centro Hospitalar Universitário de São João, Porto 4200-319, Portugal; Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of Porto University, Porto 4200-319, Portugal. Electronic address:

Background: Therapeutic inertia (TI) is defined as a failure to initiate or intensify treatments despite evidence of disease activity. Its prevalence and determining factors in Relapsing-Remitting Multiple Sclerosis (RRMS) patients in Portugal are not known. The main objective of this work was to ascertain the prevalence of TI in RRMS and its determining factors. Read More

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Title: Functional seizures across the adult lifespan: female sex, delay to diagnosis and disability.

Seizure 2021 Jul 26;91:476-483. Epub 2021 Jul 26.

Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Objective: The clinical characteristics of functional seizures may vary based on age-of-onset or age-of-presentation. Description of age-related differences has focused on three categories: pediatric, young-adult, and older-adult. We evaluated how factors continuously varied based on age-of-presentation across the adult lifespan. Read More

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Effects of long-term unilateral cochlear implant use on large-scale network synchronization in adolescents.

Hear Res 2021 Jul 8;409:108308. Epub 2021 Jul 8.

Archie's Cochlear Implant Laboratory, Department of Otolaryngology, The Hospital for Sick Children, ON, Canada; Program in Neuroscience and Mental Health, Hospital for Sick Children Research Institute, ON, Canada; Institute of Medical Sciences, Faculty of Medicine, University of Toronto, ON, Canada; Department of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, University of Toronto, ON, Canada. Electronic address:

Unilateral cochlear implantation (CI) limits deafness-related changes in the auditory pathways but promotes abnormal cortical preference for the stimulated ear and leaves the opposite ear with little protection from auditory deprivation. In the present study, time-frequency analyses of event-related potentials elicited from stimuli presented to each ear were used to determine effects of unilateral CI use on cortical synchrony. CI-elicited activity in 34 adolescents (15. Read More

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Burden of Disease for Psoriasis in Argentina, Brazil, Colombia, and Mexico.

Value Health Reg Issues 2021 Jul 31;26:126-134. Epub 2021 Jul 31.

Eli Lilly and Company, Indianapolis, IN, USA; Division of Pharmaceutical Sciences, University of Cincinnati, Cincinnati, OH, USA.

Objectives: Psoriasis (PsO) is a chronic, inflammatory, multisystem disease with predominantly skin and joint manifestations. The disease is also associated with lower quality of life, lower work productivity, and higher healthcare costs. The objective of this study was to conduct a systematic literature review of the disease burden for PsO in Argentina, Brazil, Colombia, and Mexico. Read More

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Volition in prospective Memory: Evidence against differences between free and fixed target events.

Conscious Cogn 2021 Jul 31;94:103175. Epub 2021 Jul 31.

CNRU, CFIN, Health, Aarhus University, Aarhus, Denmark; Centre for Cognitive Neuroscience, Department of Communication and Psychology, Aalborg University, Aalborg, Denmark; Sino-Danish Center for Education and Research, Aarhus, Denmark & Beijing, China.

Volition is the extent to which actions are generated as a result of internal states in contrast to responses to external conditions or dictated by external events. Delayed intentions about future action are stored in prospective memory until the intended action has to be formed at a later point in time. It is unknown how voluntary choice affects prospective memory. Read More

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No evidence for association between human body odor quality and immune system functioning.

Psychoneuroendocrinology 2021 Jul 20;132:105363. Epub 2021 Jul 20.

Department of Zoology, Faculty of Science, Charles University, Viničná 7, 128 44 Prague, Czech Republic; National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic.

Previous studies have shown that women perceive male faces with a more reactive immune system as more attractive, but whether body odor might likewise provide cues to immune function has not been investigated yet. These two studies tested a possible relationship between body odor quality and immunoreactivity (Study 1) and immune system function (Study 2). In Study 1, we collected body odor samples from 21 men just before and two weeks after vaccination against hepatitis A/B and meningococcus. Read More

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Aberrant modulation of brain activity underlies impaired working memory following traumatic brain injury.

Neuroimage Clin 2021 Jul 28;31:102777. Epub 2021 Jul 28.

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, Victoria 3800, Australia; Monash Epworth Rehabilitation Research Centre, Epworth Healthcare, Melbourne, Australia.

Impaired working memory is a common and disabling consequence of traumatic brain injury (TBI) that is caused by aberrant brain processing. However, little is known about the extent to which deficits are perpetuated by specific working memory subprocesses. Using a combined functional magnetic resonance imaging (fMRI) and working memory paradigm, we tested the hypothesis that the pattern of brain activation subserving working memory following TBI would interact with both task demands and specific working memory subcomponents: encoding, maintenance, and retrieval. Read More

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Treatment of Parkinson's disease in Zebrafish model with a berberine derivative capable of crossing blood brain barrier, targeting mitochondria, and convenient for bioimaging experiments.

Comp Biochem Physiol C Toxicol Pharmacol 2021 Jul 31:109151. Epub 2021 Jul 31.

Biology Institute, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250103, Shandong Province, China; Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Jinan 250103, Shandong Province, China. Electronic address:

Berberine is a famous alkaloid extracted from Berberis plants and has been widely used as medications and functional food additives. Recent studies reveal that berberine exhibits neuroprotective activity in animal models of Parkinson's disease (PD), the second most prevalent neurodegenerative disorders all over the world. However, the actual site of anti-PD action of berberine remains largely unknown. Read More

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Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice.

Brain Behav Immun 2021 Jul 31. Epub 2021 Jul 31.

Axe neurosciences, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada; Molecular Medicine Department, Université Laval, Québec City, QC, Canada; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada; The Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, BC, Canada. Electronic address:

Chronic psychological stress is one of the most important triggers and environmental risk factors for neuropsychiatric disorders. Chronic stress can influence all organs via the secretion of stress hormones, including glucocorticoids by the adrenal glands, which coordinate the stress response across the body. In the brain, glucocorticoid receptors (GR) are expressed by various cell types including microglia, which are its resident immune cells regulating stress-induced inflammatory processes. Read More

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Healthcare lobbying on upstream social determinants of health in the US.

Prev Med 2021 Jul 31:106751. Epub 2021 Jul 31.

Boston University School of Public Health, Boston, MA, United States of America.

Healthcare stakeholders are increasingly investing to address social determinants of health (SDOH) as they seek to improve health outcomes and reduce total healthcare costs in their communities. Policy heavily shapes SDOH, and healthcare lobbying on SDOH issues may offer large impacts through positive policy change. Federal lobbying disclosures from the ten highest spending health insurance and healthcare provider organizations and related associations between 2015 and 2019 were reviewed to identify lobbying reported on the salient SDOH issues, defined based on the Accountable Health Communities Model health-related social needs screening tool. Read More

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Apelin receptor homodimer inhibits apoptosis in vascular dementia.

Exp Cell Res 2021 Jul 31:112739. Epub 2021 Jul 31.

School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, China. Electronic address:

Apelin receptor (APJ), a member of family A of the G protein-coupled receptors (GPCRs), is a potential pharmaceutical target for diseases of the nervous system. Our previous work revealed that human APJ can form a homodimer that has different functional characteristics than the monomer. To investigate the effects of APJ homodimers on neuroprotection in vascular dementia (VD), we established VD model in rats and treated the animals by injecting apelin-13 into the lateral ventricle. Read More

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Effects of tree canopy on psychological distress: A repeated cross-sectional study before and during the COVID-19 epidemic.

Environ Res 2021 Jul 31:111795. Epub 2021 Jul 31.

Research Institute of Forestry, Chinese Academy of Forestry, Beijing, 100091, China; Key Laboratory of Tree Breeding and Cultivation and Urban Forest Research Centre, National Forestry and Grassland Administration, Beijing, 10091, China. Electronic address:

Background: During the COVID-19 epidemic period, people showed a stronger connection to the environment within their communities. Although tree canopy in residential areas has been shown to positively affect psychological distress, it is not clear whether the COVID-19 epidemic played a role in this process. Elucidation of the relationship between tree canopy and the impact on psychological distress during the COVID-19 epidemic could provide valuable information as to the best methods to help individuals cope with urban mental stress events. Read More

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Accommodating Vaccine Preferences Among Women of Childbearing Age.

Am J Obstet Gynecol 2021 Jul 31. Epub 2021 Jul 31.

Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States.

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Spatiotemporal patterns of pain distribution and recall accuracy: a dose-response study.

Scand J Pain 2021 Aug 2. Epub 2021 Aug 2.

Department of Health Science and Technology, Faculty of Medicine, Center for Neuroplasticity and Pain (CNAP), Center for Sensory Motor Interaction (SMI©), Aalborg University, Aalborg, Denmark.

Objectives: Clinical decisions rely on a patient's ability to recall and report their pain experience. Monitoring pain in real-time (momentary pain) may reduce recall errors and optimize the clinical decision-making process. Tracking momentary pain can provide insights into detailed changes in pain intensity and distribution (area and location) over time. Read More

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Glycated Haemoglobin (HbA1c), Diabetes and Neuropsychological Performance in Community-Dwelling Older Adults.

Diabet Med 2021 Aug 3:e14668. Epub 2021 Aug 3.

Mercer's Institute for Successful Ageing, St James's Hospital, Dublin, Ireland.

Aims: Given that diabetes is associated with cognitive impairment and dementia in later life, we aimed to investigate the relationship between glycated haemoglobin (HbA1c), diabetes and domain-specific neuropsychological performance in older adults.

Methods: Cross-sectional cohort study using data from the Trinity-Ulster-Department of Agriculture (TUDA) study. Participants underwent detailed cognitive and neuropsychological assessment using the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB) and Repeatable Assessment for Neuropsychological Status (RBANS). Read More

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COVID-19, Telehealth, and Pediatric Integrated Primary Care: Disparities in Service Use.

J Pediatr Psychol 2021 Aug 3. Epub 2021 Aug 3.

University of Missouri Kansas City School of Medicine, Kansas City, MO, USA.

Objective: The coronavirus disease 2019 pandemic (COVID-19) may increase pediatric mental health needs due to its social, economic, and public health threats, especially among Black, Indigenous, and People of Color and those served within disadvantaged communities. COVID-19 protocols have resulted in increased provision of telehealth in integrated primary care (IPC) but little is known about pediatric telehealth IPC utilization during the pandemic for diverse and traditionally underserved groups.

Methods: A comparative study was conducted to explore variability between in-person (pre-COVID-19; n = 106) and telehealth (mid-COVID-19; n = 120) IPC consultation utilization among children 1-19 years old served through a large, inner-city primary care clinic. Read More

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BEREAVEMENT AMONG ADULT SIBLINGS: AN EXAMINATION OF HEALTH SERVICE UTILIZATION AND MENTAL HEALTH OUTCOMES.

Am J Epidemiol 2021 Aug 3. Epub 2021 Aug 3.

National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.

We aimed to examine the association of young and middle-aged sibling bereavement with use of health services and risk of developing mental health disorders over 24 months before and after sibling's death. All persons aged 18-56 years who died of illness/natural causes between 2009 and 2016 were identified in the Danish Register of Causes of Death. The study sample included 31,842 bereaved siblings and 31,842 age- and sex-matched controls. Read More

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Attention-Deficit/Hyperactivity Disorder and Alcohol and Other Substance Use Disorders in Young Adulthood: Findings from a Canadian Nationally Representative Survey.

Alcohol Alcohol 2021 Aug 3. Epub 2021 Aug 3.

Toronto General Hospital, 200 Elizabeth St, University Health Network, Toronto, ON, Canada.

Aim: (a) To document the prevalence and odds of (i) alcohol use disorders, (ii) cannabis use disorders, (iii) other drug use disorders and (iv) any substance use disorder (SUD), among young adults with and without ADHD, and (b) to investigate the degree to which the association between ADHD and SUDs is attenuated by socio-demographics, early adversities and mental health.

Method: Secondary analysis of the nationally representative Canadian Community Health Survey-Mental Health (CCHS-MH). The sample included 6872 respondents aged 20-39, of whom 270 had ADHD. Read More

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Parent reports of children's emotional and behavioral problems in a low- and middle- income country (LMIC): An epidemiological study of Nepali schoolchildren.

PLoS One 2021 3;16(8):e0255596. Epub 2021 Aug 3.

Regional Centre for Child and Youth Mental Health and Child Welfare -North, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.

Background: As epidemiological data on child mental health in low- and middle-income countries are limited, a large-scale survey was undertaken to estimate the prevalence and amount of child emotional and behavioral problems (EBP) in Nepal as reported by the parents.

Methods: 3820 schoolchildren aged 6-18 years were selected from 16 districts of the three geographical regions of Nepal, including rural, semi-urban and urban areas. We used the Nepali version of the Child Behavior Checklist (CBCL)/6-18 years as screening instrument. Read More

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Impact of Prolonged Duration of Symptoms on Mental Health in Anterior Cervical Disectomy and Fusion Patients.

J Am Acad Orthop Surg 2021 Jul 30. Epub 2021 Jul 30.

From the Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL.

Introduction: Prolonged duration of symptoms is associated with worse pain and disability in patients undergoing anterior cervical discectomy and fusion (ACDF). Our study aims to determine the effect of symptom duration on severity of depression among ACDF patients.

Methods: We retrospectively reviewed a prospective surgical database from 2006 to 2019 for primary, single, or multilevel ACDF. Read More

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Cannabis-Related Perceptions as Mediators of the Association Between Trait Impulsivity and Cannabis Outcomes.

J Stud Alcohol Drugs 2021 Jul;82(4):522-535

Universidad Nacional de Córdoba, Facultad de Psicología, Córdoba, Argentina.

Objective: Normative perceptions have been shown to mediate the effect of personality traits on cannabis outcomes. We examined descriptive norms, injunctive norms, and the role of cannabis in college life as possible mediators of the association between impulsivity-related traits (i.e. Read More

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