192,373 results match your criteria health include

Impact of the COVID-19 pandemic on acute inpatient psychiatric units in Spain.

Psychiatry Res 2021 Jul 24;304:114136. Epub 2021 Jul 24.

Department of Psychiatry, University Hospital Ramón y Cajal, Madrid, Spain.

Patients with more severe mental health symptoms are treated in acute inpatient psychiatric units (AIPUs), but the functioning of these units throughout Spain has been challenged by the COVID-19 pandemic. We therefore conducted a descriptive, cross-sectional study to assess the situation. An online survey was distributed to all hospitals with AIPUs in Spain and made accessible for 28 days. Read More

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Stress management versus cognitive restructuring in trauma-affected refugees - A follow-up study on a pragmatic randomised trial.

J Affect Disord 2021 Jul 16;294:628-637. Epub 2021 Jul 16.

Competence Centre for Transcultural Psychiatry, Mental Health Centre Ballerup, Mental Health Services of the Capital Region, Ballerup, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Background: There is a lack of research and consensus with respect to long-term effective treatments for trauma-affected refugees. The purpose of this follow-up study of a randomised clinical trial was to investigate the effectiveness of Stress Management (SM) versus Cognitive Restructuring (CR) in treating trauma-affected refugees, six and 18 months post-treatment, respectively.

Methods: From a total of 126 refugees with PTSD, the intention-to-treat sample in the original trial, 74 patients were present at the six-month follow-up (SM; n = 37, CR; n = 37) and 34 patients at the 18-month follow-up (SM; n = 14, CR; n = 20). Read More

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The meaningful change threshold as measured by the 16-item quick inventory of depressive symptomatology in adults with treatment-resistant major depressive and bipolar disorder receiving intravenous ketamine.

J Affect Disord 2021 Jul 20;294:592-596. Epub 2021 Jul 20.

Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, ON, Canada; Canadian Rapid Treatment Center of Excellence, Mississauga, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Objective: .To identify a meaningful change threshold (MCT) in depression outcomes in adults with treatment-resistant major depressive disorder (MDD) or bipolar disorder (BD) receiving intravenous ketamine treatment at a community-based mood disorders center.

Method: . Read More

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Impact of a computerized physician order entry (CPOE)-based antibiotic stewardship intervention on the treatment duration for pneumonia and COPD exacerbations.

Respir Med 2021 Jul 24;186:106546. Epub 2021 Jul 24.

Department of Respiratory Medicine, Evangelische Lungenklinik, Berlin, Germany.

Background: In hospitalized patients, the duration of antibiotic therapy for uncomplicated pneumonia is often longer than recommended in clinical guidelines. Consequences include increased risk of Clostridioides difficile infection and the emergence of antibiotic resistance. Reducing the duration of antibiotic therapy is an important goal of antibiotic stewardship (ABS) programs. Read More

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Airway hyperresponsiveness to inhaled mannitol identifies a cluster of non-eosinophilic asthma patients with high symptom burden.

J Allergy Clin Immunol Pract 2021 Jul 28. Epub 2021 Jul 28.

Department of Respiratory Medicine, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark; Institute of Clinical medicine, University of Copenhagen, Denmark; Copenhagen Center for Translational Research, Copenhagen, Denmark.

Background: Patients with asthma are heterogeneous in clinical presentation and in response to treatment. Despite this, tools to guide treatment are limited and include mainly measures of eosinophilic inflammation and symptoms. Airway hyperresponsiveness (AHR) to mannitol is present in patients across inflammatory phenotypes and improve with inhaled cortico-steroids. Read More

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A randomized crossover trial of HEPA air filtration to reduce cardiovascular risk for near highway residents: Methods and approach.

Contemp Clin Trials 2021 Jul 28:106520. Epub 2021 Jul 28.

Department of Public Health and Community Medicine, Tufts University, Boston, MA 02111, United States of America.

Background: Near highway residents are exposed to elevated levels of traffic-related air pollution (TRAP), including ultrafine particles, which are associated with adverse health effects. The efficacy of using in-home air filtration units that reduce exposure and potentially yield health benefits has not been tested in a randomized controlled trial.

Methods: We will conduct a randomized double-blind crossover trial of portable air filtration units for 200 adults 30 years and older who live in near-highway homes in Somerville, MA, USA. Read More

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Peripheral Levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: a meta-analysis of mean differences and variability.

Brain Behav Immun 2021 Jul 28. Epub 2021 Jul 28.

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, 75 Pigdon's Road, Waurn Ponds, Geelong, VIC, 3216, Australia. Electronic address:

Importance: It is unclear whether differences exist in the magnitude and variability of pro-inflammatory mediators in the different phases of bipolar disorder (BD) and among subjects with BD, as compared to healthy controls.

Objective: To run a comparative meta-analysis of C-Reactive Protein (CRP), IL-1, IL-6, TNF-α in BD vs healthy controls, measuring mean and variability effects on all subjects. Sensitivity analyses include disease activity. Read More

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Hypoxia-Inducible Factor Stabilization as an Emerging Therapy for CKD-Related Anemia: Report From a Scientific Workshop Sponsored by the National Kidney Foundation.

Am J Kidney Dis 2021 Jul 28. Epub 2021 Jul 28.

Department of Medicine, Perelman School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

The National Kidney Foundation convened an interdisciplinary international workshop in March 2019 to discuss the potential role of a new class of agents for the treatment of anemia in patients with chronic kidney disease (CKD): the hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs). International experts with expertise in physiology, biochemistry, structural chemistry, translational medicine and clinical management of anemia participated. Participants reviewed the unmet needs of current anemia treatment, the biology of hypoxia-inducible factor, the pharmacology of prolyl hydroxylase inhibitors, and the results of phase 2 clinical trials of HIF-PHIs among patients with both non-dialysis dependent and dialysis-dependent CKD. Read More

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The presence of Toxoplasma gondii in the terrestrial and marine environments and its importance for public health.

Ann Parasitol 2021 ;67(2):137-149

Institute of Health Sciences, Pomeranian University in Słupsk, ul. Bohaterów Westerplatte 64, Słupsk 76-200, Poland.

Toxoplasma gondii occurred in terrestrial and marine environments. Many people still do not realize that how important are the role of prevention, especially hygiene and proper food processing as well as diagnostics for pregnant women. Humans become infected with T. Read More

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January 2021

Peripheral Nerve Stimulation: A Review of Techniques and Clinical Efficacy.

Pain Ther 2021 Jul 31. Epub 2021 Jul 31.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Chronic pain is a common source of morbidity in many patient populations worldwide. There are growing concerns about the potential side effects of currently prescribed medications and a continued need for effective treatment. Related to these concerns, peripheral nerve stimulation has been regaining popularity as a potential treatment modality. Read More

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Holistic health risk assessment in an artisanal mercury mining region in Mexico.

Environ Monit Assess 2021 Jul 31;193(8):541. Epub 2021 Jul 31.

Facultad de Medicina-Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología, Universidad Autónoma de San Luis Potosí, Avenida Sierra Leona No. 550, Colonia Lomas Segunda Sección, C.P. 78210, San Luis Potosí, S.L.P., México.

Mexico is one of the world's leading mercury producers and exporters. However, mercury mining is carried out using artisanal procedures, which highly impact ecosystems. In the municipality of Pinal de Amoles, Queretaro, Mexico, artisanal mercury mining (AMM) is practiced in a region that has been categorized as a Biosphere Reserve. Read More

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Healthy Aging Data Reports: Measures of Community Health to Identify Disparities and Spur Age-Friendly Progress.

Gerontologist 2021 Jul 31. Epub 2021 Jul 31.

Department of Gerontology, John W. McCormack Graduate School of Policy & Global Studies, University of Massachusetts Boston, Boston, Massachusetts, USA.

Background And Objectives: This translational research had two aims. First, to analyze and translate data from multiple original data sources to provide accurate, unbiased local community and statewide information about healthy aging. Second, to work with stakeholders to use the tools to identify disparities in healthy aging and to support their efforts to advance healthy aging. Read More

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COVID-19 Preparedness and Response Plans from 106 countries: a review from a health systems resilience perspective.

Health Policy Plan 2021 Jul 31. Epub 2021 Jul 31.

Universal Health Coverage and Life Course, World Health Organization, Geneva, Switzerland.

Coronavirus disease (COVID-19) has exposed long-standing fragmentation in health systems strengthening efforts for health security and universal health coverage while these objectives are largely interdependent and complementary. In this prevailing background, we reviewed countries' COVID-19 Preparedness and Response Plans (CPRPs) to assess the extent of integration of non-COVID-19 essential health service continuity considerations alongside emergency response activities. We searched for COVID-19 planning documents from governments and ministries of health, World Health Organization (WHO) country offices and United Nations (UN) country teams. Read More

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Health systems, population and patient challenges for achieving universal health coverage for hypertension in Ghana.

Health Policy Plan 2021 Jul 31. Epub 2021 Jul 31.

Department of Management Science, Strathclyde Business School, University of Strathclyde, 199 Cathedral Street, Glasgow G4 0QU, UK.

Ghana has signed on to the United Nations Sustainable Development Goal to achieve universal health coverage (UHC), ensuring that all individuals receive the health care they require without financial hardship. Achieving that goal is a difficult task in any setting. The challenges are further exacerbated by a changing disease landscape, as the burden of non-communicable diseases (NCDs) is increasing and creating a dual burden along with infectious diseases. Read More

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Dysautonomia in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders is associated with exercise intolerance and cardiac atrophy.

Am J Med Genet A 2021 Jul 30. Epub 2021 Jul 30.

Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Dysautonomia is a recognized manifestation in patients with joint hypermobility (JH) disorders. Symptoms can be highly debilitating and commonly include physical deconditioning and poor aerobic fitness. In this study, the prevalence of dysautonomia, range of associated symptoms, patient-reported physical activity levels, and echocardiographic features were assessed retrospectively in a cohort of 144 patients (94% female) with hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobility spectrum disorder (HSD). Read More

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Optimizing the Differentiation of Cardiomyocytes from Human Induced Pluripotent-Derived Stem Cells.

Methods Mol Biol 2021 ;2319:51-60

Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.

Cardiovascular disease is a worldwide health issue that affects millions of lives every year, and thus, researchers are in need of high-throughput model systems with which to investigate mechanisms of disease and to develop and test potential therapies. The use of human-derived induced pluripotent stem cells (iPSCs) differentiated into cardiomyocytes aims to address this need. While cardiac differentiation protocols have been established previously in iPSCs, optimization of cardiac differentiation remains crucial to obtaining high quality cardiomyocytes for future experimental analyses. Read More

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January 2021

Days alive and at home after hip fracture: a cross-sectional validation of a patient-centred outcome measure using routinely collected data.

BMJ Qual Saf 2021 Jul 30. Epub 2021 Jul 30.

Anesthesia, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada.

Background: Days alive and at home (DAH) is a patient centered outcome measureable in routinely collected health data. The validity and minimally important difference (MID) in hip fracture have not been evaluated.

Objective: We assessed construct and predictive validity and estimated a MID for the patient-centred outcome of DAH after hip fracture admission. Read More

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Self-management challenges following hospital discharge for patients with multimorbidity: a longitudinal qualitative study of a motivational interviewing intervention.

BMJ Open 2021 Jul 30;11(7):e046896. Epub 2021 Jul 30.

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Objectives: The aim of this study was to describe challenges in self-management activities among people with multimorbidity during a 4-week post-discharge period.

Design: This is a longitudinal qualitative study using data from a randomised controlled trial (RCT) of motivational interviewing (MI) sessions.

Setting: The RCT was conducted at six wards in two hospitals-one university hospital and one general hospital in Stockholm, Sweden, during 2016-2018. Read More

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Using electronic health records to develop and validate a machine-learning tool to predict type 2 diabetes outcomes: a study protocol.

BMJ Open 2021 Jul 30;11(7):e046716. Epub 2021 Jul 30.

NIHR Imperial Patient Safety Translational Research Centre, Imperial College London, London, UK.

Introduction: Type 2 diabetes mellitus (T2DM) is a major cause of blindness, kidney failure, myocardial infarction, stroke and lower limb amputation. We are still unable, however, to accurately predict or identify which patients are at a higher risk of deterioration. Most risk stratification tools do not account for novel factors such as sociodemographic determinants, self-management ability or access to healthcare. Read More

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Hands-Up program: protocol for a feasibility randomised controlled trial of a combined 6-week exercise and education intervention in adults aged 50-65 with a distal radius fracture.

BMJ Open 2021 Jul 30;11(7):e046122. Epub 2021 Jul 30.

St Joseph's Health Centre, London, Ontario, Canada.

Introduction: This pilot study will determine the feasibility of recruitment, retention and adherence for the online combined exercise and education programme (Hands-Up) compared with usual care.

Methods And Analysis: The proposed randomised controlled trial will be a pilot feasibility study with a 1:1 randomisation to the Hands-Up programme or usual physical therapy. The programme setting is an online home exercise and education program. Read More

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Consideration of antimicrobial resistance and contextual factors in infectious disease guidelines: a systematic survey.

BMJ Open 2021 Jul 30;11(7):e046097. Epub 2021 Jul 30.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada

Objectives: Guidelines that include antimicrobial recommendations should explicitly consider contextual factors that influence antimicrobial resistance and their downstream effects on resistance selection. The objectives were to analyse (1) how, and to what extent, tuberculosis, gonorrhoea and respiratory tract infection guidelines are considering antimicrobial resistance; (2) are of acceptable quality and (3) if they can be easily contextualised to fit the needs of specific populations and health systems.

Methods: We conducted a systematic review and searched Ovid MEDLINE and Embase from 1 January 2007 to 7 June 2019 for tuberculosis, gonorrhoea and respiratory tract infection guidelines published in English. Read More

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Predicting non-state terrorism worldwide.

Sci Adv 2021 Jul 30;7(31). Epub 2021 Jul 30.

School of Public Health, Imperial College London, London, UK.

Several thousand people die every year worldwide because of terrorist attacks perpetrated by non-state actors. In this context, reliable and accurate short-term predictions of non-state terrorism at the local level are key for policy makers to target preventative measures. Using only publicly available data, we show that predictive models that include structural and procedural predictors can accurately predict the occurrence of non-state terrorism locally and a week ahead in regions affected by a relatively high prevalence of terrorism. Read More

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Development and validation of explicit criteria to identify potentially inappropriate prescribing for adults with type 2 diabetes mellitus.

Res Social Adm Pharm 2021 Jul 16. Epub 2021 Jul 16.

Pharmacy, School of Rural Medicine, University of New England, Armidale, 2351, Australia. Electronic address:

Background: Early detection and timely resolution of potentially inappropriate prescribing (PIP) prevents adverse outcomes and improves patient care. An explicit tool specifically designed to detect PIP among people with Type 2 Diabetes Mellitus (T2DM) has not been published.

Objectives: This study aims to develop and validate the Inappropriate Medication Prescribing Assessment Criteria for Type 2 Diabetes Mellitus (IMPACT2DM); an explicit tool that can be used to identify PIP for adults with T2DM. Read More

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Improvement in student-led debriefing analysis after simulation-based team training using a revised teamwork assessment tool.

Surgery 2021 Jul 27. Epub 2021 Jul 27.

LSU Health New Orleans School of Nursing, New Orleans, LA.

Background: Team debriefing is an important teamwork development intervention for improving team outputs in healthcare. Debriefing is a key component of experiential team training teamwork development interventions such as simulation-based training. Improving the quality of debriefing of healthcare teams, therefore, has multiple benefits. Read More

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A Roadmap for Innovation to Advance Transplant Access and Outcomes: A Position Statement From the National Kidney Foundation.

Am J Kidney Dis 2021 Jul 21. Epub 2021 Jul 21.

Department of Surgery, University of Iowa Transplant Institute, Iowa City, IA.

Over the past 65 years, kidney transplantation has evolved into the optimal treatment for patients with kidney failure, dramatically reducing suffering through improved survival and quality of life. However, access to transplant is still limited by organ supply, opportunities for transplant are inequitably distributed, and lifelong transplant survival remains elusive. To address these persistent needs, the National Kidney Foundation convened an expert panel to define an agenda for future research. Read More

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Long-term changes in nutritional status and body composition in patients with malignant pancreatic disease - A systematic review.

Clin Nutr ESPEN 2021 Aug 10;44:85-95. Epub 2021 Jun 10.

Royal Surrey Hospital NHS Foundation Trust, Egerton Road, Guildford, UK.

Background And Aims: Patients with pancreatic cancer often experience significant deterioration in nutritional status over time. Malnutrition is complex and multifactorial, with malabsorption, pain, toxic dependencies, co-morbidities and malignant processes all playing a role. The aims of this systematic review were to assess nutritional changes over time and identify tolerance of nutritional intervention, thus identifying potential areas for further research to improve patient outcomes. Read More

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Feasibility of dietary folic acid reduction intervention for men on active surveillance for prostate cancer.

Clin Nutr ESPEN 2021 Aug 3;44:270-275. Epub 2021 Jul 3.

Department of Urology, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78249, United States; College of Pharmacy, University of Texas at Austin, 110 Inner Campus Drive, Austin, TX 78705, United States. Electronic address:

Background & Aims: Fortification of the US food supply has increased folic acid intake and resulted in a concomitant decrease in neural tube defects in women. However, a body evidence supports the hypothesis that increased circulating folate levels due to excessive dietary or supplemental folic acid may be harmful for men with prostate cancer. Therefore, this pilot study aimed to investigate the feasibility of a reduced folic acid dietary intervention in men on an active surveillance monitoring program for prostate cancer. Read More

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Returning Cardiac Rhythm Data to Patients: Opportunities and Challenges.

Card Electrophysiol Clin 2021 Sep 2;13(3):555-567. Epub 2021 Jul 2.

Division of Health Informatics, Weill Cornell Medicine, 425 E 61st St, Floor 3, New York, NY 10065, USA.

Spurred by federal legislation, professional organizations, and patients themselves, patient access to data from electronic cardiac devices is increasingly transparent. Patients can collect data through consumer devices and access data traditionally shared only with health care providers. These data may improve screening, self-management, and shared decision-making for cardiac arrhythmias, but challenges remain, including patient comprehension, communication with providers, and sustained engagement. Read More

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September 2021

Organizational Models for Cardiac Implantable Electronic Device Remote Monitoring: Current and Future Directions.

Card Electrophysiol Clin 2021 Sep;13(3):483-497

Health Services and Informatics Research Department, Parkview Mirro Center for Research and Innovation, 10622 Parkview Plaza Dr., Fort Wayne, IN 46845, USA; Department of BioHealth Informatics, IUPUI School of Informatics and Computing, 535 W. Michigan St., Indianapolis, IN 46202, USA; Department of Medicine, Indiana University School of Medicine, 340 West 10th St., Indianapolis, IN 46202, USA.

This review provides an overview of the literature on the organization, staffing, and structure of remote monitoring (RM) clinics, primarily from countries in Western Europe and United States, as well as the challenges, considerations, and future directions for RM clinic models of care. Using a current case example of an RM clinic in the Midwestern United States, this document provides key information from the viewpoint of a clinic undergoing a shift in workflow. Finally, this review distills key considerations for RM management for electrophysiology clinics, vendors and industry, and policy makers. Read More

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September 2021

Ethics in Research: Relevance for Nephrology.

Semin Nephrol 2021 May;41(3):272-281

Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Pediatrics and Child Health, University of Cape Town, Cape Town, South Africa. Electronic address:

Research is crucial to progress in nephrology. It is important that studies are conducted rigorously from the scientific perspective, as well as in adherence to ethical standards. Traditional clinical research places a high value on individual research subject autonomy. Read More

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