1,237,128 results match your criteria health condition


Effects of aerobic exercise on obese children with metabolic syndrome: a systematic review and meta-analysis.

J Pediatr Endocrinol Metab 2021 Jul 21. Epub 2021 Jul 21.

Research Center for Physical Fitness and Health Promotion of Adolescent, Guangzhou Sport University, Guangzhou, China.

Objectives: Metabolic syndrome (MetS) is systemic metabolic disease that results from insulin resistance or obesity. Numerous meta-analyses have investigated the effect of exercise on different populations, but none were aimed at the effect of aerobic exercise alone on obese children. This review systematically assessed and performed a meta-analysis on the effect of aerobic exercise on obese children with MetS. Read More

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Polycystic ovary syndrome and infertility: an update.

Int J Adolesc Med Health 2021 Jul 22. Epub 2021 Jul 22.

Regional Research Institute of Unani Medicine, Srinagar, Jammu and Kashmir, India.

Polycystic ovarian syndrome is the most well-known endocrine condition among women of this generation (PCOS). Symptoms of hyperandrogenism, irregular menstrual periods, and insulin resistance are all traits associated with PCOS. In women with PCOS, the chance of having problems including infertility, insulin resistance, and type 2 diabetes increases. Read More

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Menstrual distress in females of reproductive age: a literature review.

Int J Adolesc Med Health 2021 Jul 22. Epub 2021 Jul 22.

Regional Research Institute of Unani Medicine, Srinagar, Jammu and Kashmir, India.

Menstrual-related issues have significant public-health ramifications. Women who are having menstruation troubles should get their mental health checked by healthcare specialists. In young women, a menstrual-related condition has serious health implications. Read More

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Increase in SARS-CoV-2 infected biomedical waste among low middle-income countries: environmental sustainability and impact with health implications.

J Basic Clin Physiol Pharmacol 2021 Jul 22. Epub 2021 Jul 22.

Department of Anatomical Sciences, School of Medicine and Allied Health Sciences, University of the Gambia, Serekunda, The Gambia.

Studies have shown that severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) is a highly infectious disease, with global deaths rising to about 360,438 as of 28 May 2020. Different countries have used various approaches such as lockdown, social distancing, maintenance of personal hygiene, and increased establishment of testing and isolation centers to manage the pandemic. Poor biomedical waste (BMW) management, treatment, and disposal techniques, especially SARS-CoV-2 infected BMW, may threaten the environmental and public health in most developing countries and, by extension, impact the economic status of individuals and the nation at large. Read More

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Nail changes in diabetes.

Clin Exp Dermatol 2021 Jul 22. Epub 2021 Jul 22.

Department of Dermatology, Bristol Royal Infirmary, Bristol, UK.

Diabetes is a common condition that is increasing in incidence all over the world. Even though the skin manifestations of this condition are well described, there is scant literature of its nail changes. In this review, we allude to the various clinical features of nail changes in those with diabetes. Read More

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The food, the bug, and the ugly: A recipe for food-induced gut pain.

Allergy 2021 Jul 22. Epub 2021 Jul 22.

Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University Medical Center, Hamilton Health Sciences, Hamilton, L8S 4K1, ON, Canada.

It is estimated that one-fifth of the general population experiences adverse reactions to food. There is evidence of an increase in the prevalence of well-defined food sensitivities such as celiac disease, food allergy, and food intolerance, suggesting a critical role of yet unknown environmental factors as modifiers of disease expression. The role of microorganisms in inciting sensitivity to foods has garnered significant attention. Read More

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Metabolic Disorders/Obesity Is a Primary Risk Factor in Hidradenitis Suppurativa: An Immunohistochemical Real-World Approach.

Dermatology 2021 Jul 22:1-9. Epub 2021 Jul 22.

Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany.

Background: Hidradenitis suppurativa (HS) is an inflammatory, potentially scarring disease of the hair follicle, affecting the apocrine gland-bearing skin areas. The major comorbid disorders associated with the occurrence or the aggravation of the disease are obesity and smoking. Numerous efforts to dissociate these factors led to controversial results. Read More

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Impacts of internal migration experience on health among middle-aged and older adults-Evidence from China.

Authors:
Nan Sun Fan Yang

Soc Sci Med 2021 Jul 16;284:114236. Epub 2021 Jul 16.

Research Institute of Social Development, Southwestern University of Finance and Economics, Chengdu, China. Electronic address:

As a life course factor, internal migration plays a role in shaping health condition in middle age and later life. Using data from the 2014 and 2015 China Health and Retirement Longitudinal Study (CHARLS), the present study examined the impacts and mechanism of internal migration experience on the health of middle-aged and older adults in China. Internal migration experience had significant negative impacts on health, whether in relation to self-reported health or number of chronic diseases. Read More

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Prognostic nomogram for progression-free survival in patients with BRCA mutations and platinum-sensitive recurrent ovarian cancer on maintenance olaparib therapy following response to chemotherapy.

Eur J Cancer 2021 Jul 19;154:190-200. Epub 2021 Jul 19.

National Health and Medical Research Council Clinical Trials Centre, The University of Sydney, Sydney, NSW 2050, Australia; Department of Medical Oncology, St George Hospital, Kogarah, NSW 2217, Australia; Australia New Zealand Gynecological Oncology Group, Camperdown, New South Wales, Australia.

Background: The impact of maintenance therapy with PARP inhibitors (PARPi) on progression-free survival (PFS) in patients with BRCA mutations and platinum-sensitive recurrent ovarian cancer (PSROC) varies widely. Individual prognostic factors do not reliably distinguish patients who progress early from those who have durable benefit. We developed and validated a prognostic nomogram to predict PFS in these patients. Read More

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Diagnostic potential of trace metals concentration in expressed prostatic secretion and serum of patients with category IV prostatitis.

J Trace Elem Med Biol 2021 Jul 8;68:126819. Epub 2021 Jul 8.

Scientific Research Center, Guilin Medical University, Guilin, Guangxi, China; Guangxi Health Commission Key Laboratory of Disease Proteomics Research, China. Electronic address:

Background: The National Institutes of Health (NIH) category IV prostatitis is a painless prostate gland inflammation, just as its name implies, this type of prostatitis is related with inflammation of the prostate, but most men are not conscious of it. However, category IV prostatitis is fairly common in general populations and reported having indirect relationships with prostate cancer.

Method: We analyzed the concentration of zinc (Zn), copper (Cu), calcium (Ca) and magnesium (Mg) in expressed prostatic secretion (EPS) and serum of patients with category IV prostatitis and healthy controls, investigating the diagnostic potential of different metals in category IV prostatitis using a flame atomic absorption spectrometer (FAAS). Read More

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Maternal urinary cadmium concentrations in early pregnancy in relation to prenatal and postpartum size of offspring.

J Trace Elem Med Biol 2021 Jul 16;68:126823. Epub 2021 Jul 16.

National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China. Electronic address:

Background: The impacts of environmental cadmium (Cd) exposure on birth size parameters including weight, length and head circumference (HC) have been reported in multiple studies. However, little remains known of the impacts of maternal Cd exposure during pregnancy on size during in utero development and during early childhood. The aim of this study was to comprehensively investigate impacts of maternal Cd exposure during pregnancy on the size of offspring in utero (from 24 weeks pregnancy) until six months of age. Read More

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Leishmania infantum strains from cats are similar in biological properties to canine and human strains.

Vet Parasitol 2021 Jul 15;298:109531. Epub 2021 Jul 15.

Global Health and Tropical Medicine (GHMT), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (NOVA), 1349-008, Lisbon, Portugal; Medical Parasitology Unit, IHMT/NOVA, 1349-008, Lisbon, Portugal. Electronic address:

Zoonotic visceral leishmaniosis is a worldwide severe disease caused by Leishmania infantum, a protozoan that has phlebotomine sand flies as vectors and dogs as primary reservoir hosts. Over the last few decades, cats have been regarded as an indisputable piece within the ecological system in which L. infantum is maintained indefinitely. Read More

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Review: The development of the gastrointestinal tract microbiota and intervention in neonatal ruminants.

Animal 2021 Jul 19;15(8):100316. Epub 2021 Jul 19.

Department of Animal Science, College of Animal Sciences, Jilin University, Changchun 130062, China. Electronic address:

The complex microbiome colonizing the gastrointestinal tract (GIT) of ruminants plays an important role in the development of the immune system, nutrient absorption and metabolism. Hence, understanding GIT microbiota colonization in neonatal ruminants has positive impacts on host health and productivity. Microbes rapidly colonize the GIT after birth and gradually develop into a complex microbial community, which allows the possibility of GIT microbiome manipulation to enhance newborn health and growth and perhaps induce lasting effects in adult ruminants. Read More

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The relationship between urinary phthalate metabolites and polycystic ovary syndrome in women undergoing in vitro fertilization: Nested case-control study.

Authors:
Iman Al-Saleh

Chemosphere 2021 Jul 14;286(Pt 1):131495. Epub 2021 Jul 14.

Environmental Health Program, Research Centre, King Faisal Specialist Hospital and Research Centre, PO Box: 3354, Riyadh, 11211, Saudi Arabia. Electronic address:

Certain endocrine disruptor chemicals are involved in the pathogenesis of polycystic ovary syndrome (PCOS), a hormonal disease related to infertility in women. Phthalates are the most common plasticizers found in several consumer products. Experimental and epidemiologic evidence suggests that some phthalates disrupt endocrine functions in reproductive mechanisms and development. Read More

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Blood volatile organic aromatic compounds concentrations across adulthood in relation to total and cause specific mortality: A prospective cohort study.

Chemosphere 2021 Jul 16;286(Pt 1):131590. Epub 2021 Jul 16.

Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic address:

Objective: We aimed to evaluate the relationship between blood volatile organic aromatic compounds (VOACs) across adulthood and mortality.

Methods: A total of 16,968 participants from the National health and Nutrition Examination Surveys (NHANES 1988-1994 and 1999-2014) were included in the present study. Cox proportional hazards models were used to explore the associations between VOACs and total or cause-specific mortality. Read More

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Hematopoietic Stem Cell Transplantation For Patients With Autosomal Recessive Complete Interferon Gamma Receptor 2 Deficiency: Experience In Oman.

Transplant Cell Ther 2021 Jul 19. Epub 2021 Jul 19.

Department of, Hematology, Sultan Qaboos University Hospital, Muscat, Oman; Apollo Hospital, Muscat, Oman. Electronic address:

Autosomal recessive complete interferon- gamma receptor-2 (IFN-γR2) deficiency is a rare potentially fatal primary immune deficiency that predisposes to disseminated mycobacterial disease.Hematopoietic stem cell transplantation (HSCT) is currently the only curative treatment. Few patients had been reported so far. Read More

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The Effects of Chronic Lymphocytic Thyroiditis on Clinicopathological Factors In Papillary Thyroid Cancer.

Endocr Pract 2021 Jul 19. Epub 2021 Jul 19.

Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

Introduction: This study evaluated the impact of chronic lymphocytic thyroiditis (CLT) on clinicopathological parameters, prognostic outcome and initial treatment responses in patients with papillary thyroid cancer (PTC).

Methods: A retrospective review was made of 1409 patients with PTC, comprising 443 pathology proven PTC patients with CLT and 447 PTC patients without CLT.

Results: The median follow-up time was 58 (8-380) months and the median age at the time of diagnosis was 43 years. Read More

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Ciclesonide Impacts Clinicopathological Features of Eosinophilic Esophagitis.

J Allergy Clin Immunol Pract 2021 Jul 19. Epub 2021 Jul 19.

Department of Pediatrics, Gastrointestinal Eosinophilic Diseases Program, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine; Digestive Health Institute, Children's Hospital Colorado; Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Background: - Eosinophilic Esophagitis (EoE) is a chronic allergen-mediated disease of the esophagus. Pharmacologic treatment has largely relied on repurposing corticosteroids. Ciclesonide (CIC) is a corticosteroid for the treatment of asthma with biochemical properties that improve topical potency. Read More

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Population seroprevalence of SARS-CoV-2 antibodies in Anambra state, South-East, Nigeria.

Int J Infect Dis 2021 Jul 19. Epub 2021 Jul 19.

State Ministry of Health, Jerome Udoji Secretariat Complex, Aroma Awka, Anambra State, Nigeria.

Objective: The objective of this study was to determine the proportion of Anambra State population that had been infected by the SARS-CoV-2 virus and developed antibodies before the second wave.

Methods: The WHO-recommended health facility-based cross-sectional approach was adapted for this survey. Between 8 and 15 December 2020, 3142 participants across the 21 local government areas (LGAs) of the state, aged one year and over, attending randomly selected health facilities were recruited. Read More

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Combining tumor deposits with the number of lymph node metastases to improve the prognostic accuracy in stage III colon cancer: a post hoc analysis of the CALGB/SWOG 80702 phase III study (Alliance).

Ann Oncol 2021 Jul 19. Epub 2021 Jul 19.

Department of Medical Oncology, Dana-Farber/Partners Cancer Care, Boston, MA, USA.

Background: In colon cancer, tumor deposits (TD) are considered in assigning prognosis and staging only in the absence of lymph node metastasis (i.e., stage III pN1c tumors). Read More

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Pembrolizumab for locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma (KEYNOTE-629 Study): an open-label, nonrandomized, multicenter, phase 2 trial.

Ann Oncol 2021 Jul 19. Epub 2021 Jul 19.

Service de Dermatologie et Cancérologie Cutanée, Aix-Marseille University, Marseille, France.

Background: Pembrolizumab demonstrated clinically meaningful and durable antitumor activity with a manageable safety profile in recurrent/metastatic (R/M) cutaneous squamous cell carcinoma (cSCC).

Patients And Methods: KEYNOTE-629 was a global, open-label, nonrandomized, phase 2 trial of patients with locally advanced (LA) or R/M cSCC conducted at 59 centers. Eligible patients received intravenous pembrolizumab 200 mg every three weeks for up to 35 cycles. Read More

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Association of periodontal disease with breed size, breed, weight, and age in pure-bred client-owned dogs in the United States.

Vet J 2021 Jul 19:105717. Epub 2021 Jul 19.

Waltham Petcare Science Institute, Freeby Lane, Waltham-on-the-Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK.

Despite periodontal disease (PD) being amongst the most common diagnoses in primary-care practice, the disease is generally underdiagnosed. However, the millions of clinical records generated by pet hospitals each year provide unique opportunities to generate insights about disease risk across large numbers of dogs. The objective of this study was to undertake a retrospective analysis of medical records to ascertain which sizes and breeds of dog are most frequently diagnosed with PD. Read More

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Does NAFLD Mediate the Relationship Between Obesity and Type 2 Diabetes Risk? Evidence from the Multi-Ethnic Study of Atherosclerosis (MESA).

Ann Epidemiol 2021 Jul 19. Epub 2021 Jul 19.

University of California, Berkeley, School of Public Health, Division of Epidemiology & Biostatistics, Berkeley, CA, USA.

Purpose: To estimate the effect of obesity on type 2 diabetes (T2DM) risk and evaluate to what extent non-alcoholic fatty liver disease (NAFLD) mediates this association.

Methods: Data came from 4,522 adults ages 45-84 participating in the Multi-Ethnic Study of Atherosclerosis cohort. Baseline obesity was defined using established BMI categories. Read More

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American Academy of Ophthalmology recommendations on screening for endogenous Candida endophthalmitis.

Ophthalmology 2021 Jul 19. Epub 2021 Jul 19.

Department of Ophthalmology, Mayo Clinic, Rochester, Minneapolis.

The American Academy of Ophthalmology evaluated the practice of routine screening for intraocular infection from Candida septicemia. In the United States, ophthalmologists are consulted in the hospital to screen for intraocular infection routinely for patients with Candida bloodstream infections. This practice was established in the era prior to the utilization of systemic antifungal medication and to the establishment of definitions of ocular disease with candidemia. Read More

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Loss of APP in mice increases thigmotaxis and is associated with elevated brain expression of IL-13 and IP-10/CXCL10.

Physiol Behav 2021 Jul 19:113533. Epub 2021 Jul 19.

Department of Pathology and Human Anatomy, School of Medicine, Loma Linda University, Loma Linda, CA, U.S.A. Electronic address:

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to memory loss and is often accompanied by increased anxiety. Although AD is a heterogeneous disease, dysregulation of inflammatory pathways is a consistent event. Interestingly, the amyloid precursor protein (APP), which is the source of the amyloid peptide Aβ, is also necessary for the efficient regulation of the innate immune response. Read More

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Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD.

Am J Kidney Dis 2021 Jul 19. Epub 2021 Jul 19.

University of Maryland School of Medicine, Department of Medicine.

Rationale & Objective: The utility of conventional upper reference limits (URL) for N-terminal pro brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hsTnT) in chronic kidney disease (CKD) remains debated. We analyzed the distribution of hsTnT and NT-proBNP in people with CKD in ambulatory settings to examine the diagnostic value of conventional URL in this population.

Study Design: Observational study. Read More

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Timing, duration, and differential susceptibility to early life adversities and cardiovascular disease risk across the lifespan: Implications for future research.

Prev Med 2021 Jul 19:106736. Epub 2021 Jul 19.

Department of Psychology, University of Denver, Denver, CO, United States of America.

Early life adversities (ELA), include experiences such as child maltreatment, household dysfunction, bullying, exposure to crime, discrimination, bias, and victimization, and are recognized as social determinants of cardiovascular disease (CVD). Strong evidence shows exposure to ELA directly impacts cardiometabolic risk in adulthood and emerging evidence suggests there may be continuity in ELA's prediction of cardiometabolic risk over the life course. Extant research has primarily relied on a cumulative risk framework to evaluate the relationship between ELA and CVD. Read More

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Differences in pediatric cholesterol screening rates between family physicians and pediatricians correlate with conflicting guidelines.

Prev Med 2021 Jul 19:106732. Epub 2021 Jul 19.

Department of Pediatrics, Division of General Pediatrics and Adolescent Medicine, University of Wisconsin School of Medicine and Public Health, 2870 University Ave. Ste. 200 MC 9010, Madison, WI 53705, USA. Electronic address:

Conflicting guidelines regarding universal pediatric cholesterol screening were released between 2011 and 2019, but the impact on screening rates remains understudied. The purpose of this study was to examine trends in pediatric cholesterol screening rates within a single institution in the United States and their association with release of national guidelines, local educational tools, and electronic health record (EHR) modifications. Order placement was defined as ordering a high-density lipoprotein cholesterol level in a patient aged 9-21 years with ≥1 well visit in prior 3 years. Read More

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Efficient roles of miR-146a in cellular and molecular mechanisms of neuroinflammatory disorders: An effectual review in neuroimmunology.

Immunol Lett 2021 Jul 19;238:1-20. Epub 2021 Jul 19.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Known as one of the most sophisticated systems of the human body, the nervous system consists of neural cells and controls all parts of the body. It is closely related to the immune system. The effects of inflammation and immune reactions have been observed in the pathogenesis of some neurological disorders. Read More

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Socioeconomic Disparities and Risk Factors in Patients Presenting with Ischemic Priapism: A Multi-Institutional Study.

Urology 2021 Jul 19. Epub 2021 Jul 19.

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH. Electronic address:

Objectives: To evaluate contemporary clinical presentations of priapism, their association with socioeconomic characteristics, and the role of prescribing providers in priapism episodes in a large cohort of patients managed at three major academic health systems.

Methods: We identified all consecutive patients presenting with ischemic priapism to the emergency departments of three major academic health systems (2014-2019). Demographic characteristics, priapism etiologies, and clinical management were evaluated. Read More

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