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Genome-wide Association and Meta-analysis of Age-at-Onset in Parkinson Disease: Evidence From COURAGE-PD Consortium.

Neurology 2022 May 26. Epub 2022 May 26.

Sorbonne Université (SU) Unité Mixte de Recherche (UMR) 1127, INSERM U1127, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.

Background And Objectives: Considerable heterogeneity exists in the literature concerning genetic determinants of the age of onset (AAO) of Parkinson's disease (PD), which could be attributed to lack of well-powered replication cohorts. The previous largest GWAS identified nd loci on chromosome (Chr) 4 with a significant influence on AAO of PD, these have not been independently replicated. The present study aims to conduct a meta-analysis of GWAS of PD AAO and validate previously observed findings in worldwide populations. Read More

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Association of Nonalcoholic Fatty Liver Disease and Fibrosis With Incident Dementia and Cognition: The Rotterdam Study.

Neurology 2022 May 26. Epub 2022 May 26.

Department of Epidemiology Erasmus MC university medical center, Rotterdam, The Netherlands

Background: & Objectives: Non-alcoholic fatty liver disease (NAFLD) might affect brain health, via the so-called liver-brain axis. Whether this results in increased risk for dementia remains unclear. Therefore, we investigated the association of NAFLD and fibrosis with incident dementia and cognition among the elderly. Read More

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Pragmatic, Data-Driven Method to Determine Cutoffs for CSF Biomarkers of Alzheimer Disease Based on Validation Against PET Imaging.

Neurology 2022 May 26. Epub 2022 May 26.

Cognitive Neurology Center, Lariboisiere - Fernand Widal Hospital, AP-HP, Université de Paris, Paris, France.

Objective: To elaborate a new algorithm to establish a standardized method to define cuff-offs for CSF biomarkers of Alzheimer's disease (AD) by validating the algorithm against CSF classification derived from PET imaging.

Methods: Low and high levels of CSF phosphorylated tau were first identified to establish optimal cut-offs for CSF amyloid-β peptide (Aβ) biomarkers. These Aβ cut-offs were then used to determine cut-offs for CSF tau and phosphorylated tau markers. Read More

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Comprehensive evolutionary analysis and nomenclature of plant G3BPs.

Life Sci Alliance 2022 Sep 26;5(9). Epub 2022 May 26.

Center for Desert Agriculture (CDA), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia

Stress induces extensive reprogramming of mRNA metabolism, which includes the transcription and translation of stress-related genes and the formation of stress granules. RasGAP SH3 domain-binding proteins (G3BPs, also called Rasputins) form a highly conserved family of proteins found throughout eukaryotic evolution, which coordinate signal transduction and posttranscriptional gene regulation and play a key role in the formation of stress granules. G3BPs play a role in osmotic, oxidative, and biotic stress in mammals, and recent results revealed that they play similar functions in higher plants. Read More

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September 2022

Microinfarcts in the Deep Gray Matter on 7T MRI: Risk Factors, MRI Correlates, and Relation to Cognitive Functioning-The SMART-MR Study.

AJNR Am J Neuroradiol 2022 May 26. Epub 2022 May 26.

Julius Center for Health Sciences and Primary Care (R.G., I.R., M.I.G.)

Background And Purpose: The clinical relevance of cortical microinfarcts has recently been established; however, studies on microinfarcts in the deep gray matter are lacking. We examined the risk factors and MR imaging correlates of microinfarcts in the deep gray matter on 7T MR imaging and their relation to cognitive functioning.

Materials And Methods: Within the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study, 213 patients (mean age, 68 [SD, 8] years) had a risk-factor assessment, 7T and 1. Read More

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Application of 7T MRS to High-Grade Gliomas.

AJNR Am J Neuroradiol 2022 May 26. Epub 2022 May 26.

From the Department of Neurosurgery (L.M., C.G.H.), Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, New York.

MRS, including single-voxel spectroscopy and MR spectroscopic imaging, captures metabolites in high-grade gliomas. Emerging evidence indicates that 7T MRS may be more sensitive to aberrant metabolic activity than lower-field strength MRS. However, the literature on the use of 7T MRS to visualize high-grade gliomas has not been summarized. Read More

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Usefulness of Wave-CAIPI for Postcontrast 3D T1-SPACE in the Evaluation of Brain Metastases.

AJNR Am J Neuroradiol 2022 May 26. Epub 2022 May 26.

Neurology (S.-I.O.), Inje University Busan Paik Hospital, Busan, Republic of Korea.

Background And Purpose: High-resolution postcontrast 3D T1WI is a widely used sequence for evaluating brain metastasis, despite the long scan time. This study aimed to compare highly accelerated postcontrast 3D T1-weighted sampling perfection with application-optimized contrasts by using different flip angle evolution by using wave-controlled aliasing in parallel imaging (wave-T1-SPACE) with the commonly used standard high-resolution postcontrast 3D T1-SPACE for the evaluation of brain metastases.

Materials And Methods: Among the 387 patients who underwent postcontrast wave-T1-SPACE and standard SPACE, 56 patients with suspected brain metastases were retrospectively included. Read More

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Nonlesional Sources of Contrast Enhancement on Postgadolinium "Black-Blood" 3D T1-SPACE Images in Patients with Multiple Sclerosis.

AJNR Am J Neuroradiol 2022 May 26. Epub 2022 May 26.

Form the Departments of Neuroradiology (L.D., D.D., E. Prodi, A.C., E. Pravatà)

Background And Purpose: We hypothesized that 3D T1-TSE "black-blood" images may carry an increased risk of contrast-enhancing lesion misdiagnosis in patients with MS because of the misinterpretation of intraparenchymal vein enhancement. Thus, the occurrence of true-positive and false-positive findings was compared between standard MPRAGE and volumetric interpolated brain examination techniques.

Materials And Methods: Sampling perfection with application-optimized contrasts by using different flip-angle evolution (SPACE) images obtained from 232 patients with MS, clinically isolated syndrome, or radiologically isolated syndrome were compared with standard MPRAGE and volumetric interpolated brain examination images. Read More

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Anal and oral detection of in men who have sex with men with early syphilis infection.

Sex Transm Infect 2022 May 26. Epub 2022 May 26.

Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.

Objectives: We aimed to characterise patterns of anal and oral detection of among men who have sex with men (MSM) with early syphilis.

Methods: 200 MSM with serologically confirmed primary, secondary and early latent syphilis were tested with PCR using an anal canal swab, oral rinse, plus swabs from any anal and oral lesions in a prospective, cross-sectional study. Anal and oral cycle threshold values were compared between subsets of men and according to rapid plasma reagin (RPR) titre. Read More

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Single-capture ultra-widefield guided swept-source optical coherence tomography in the management of rhegmatogenous retinal detachment and associated peripheral vitreoretinal pathology.

Br J Ophthalmol 2022 May 26. Epub 2022 May 26.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada

Background/aim: To assess the utility of single-capture ultra-widefield confocal scanning laser ophthalmoscope with integrated swept-source optical coherence tomography (UWF-SS-OCT) in the management of rhegmatogenous retinal detachment (RRD) and associated peripheral pathology.

Methods: 138 eyes of 101 consecutive patients with RRD and/or associated peripheral pathology at a vitreoretinal practice in Toronto, Canada between December 2020 and February 2021 that had UWF-SS-OCT with interpretable scans were included. A 200 degree fundus photograph was used to navigate a built-in 100 kHz UWF-SS-OCT to image pathology with a high-density 23 mm line scan and/or volume scan. Read More

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Views about Primary Care health checks for autistic adults: UK survey findings.

BJGP Open 2022 May 26. Epub 2022 May 26.

Cumbria Northumberland Tyne and Wear NHS Foundation Trust, Morpeth, UK.

Background: Compared to the general population, autistic adults experience higher rates of physical and mental health conditions, premature morbidity and mortality, and barriers to healthcare. A health check for autistic people may improve their health outcomes.

Aim: To establish the views of autistic people toward a primary care health check for autistic people. Read More

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What's New in the Management of Neonatal Early-Onset Sepsis?

Arch Dis Child Fetal Neonatal Ed 2022 May 26. Epub 2022 May 26.

Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA

The expert guidelines highlighted in this review provide an evidence-based framework for approaching at-risk infants and allow for a more limited and standardised approach to antibiotic use. While these guidelines have significantly reduced antibiotic utilisation worldwide, optimally each unit would individualise their approach to early onset sepsis (EOS) based on the neonatal population they serve and available resources. As advancements in EOS research continue and limitations with sepsis prediction tools are addressed, it is inevitable that our risk stratification and management guidelines will become more precise. Read More

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Current Landscape of Produce Prescription Programs in the US.

J Nutr Educ Behav 2022 Jun;54(6):575-581

Department of Health Policy and Management, College of Public Health, University of Georgia, Athens, GA.

Objective: To understand the design and implementation models of US produce prescription programs.

Methods: In a mixed-methods study, program providers completed an online survey and an individual phone interview regarding their 2019 programming.

Results: Twenty-three programs completed surveys; 20 completed interviews. Read More

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Determinants of High Fat Mass Index in Preschoolers Living in Brazilian Urban Areas.

J Nutr Educ Behav 2022 Jun;54(6):532-539

Faculty of Physiotherapy, Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina, Minas Gerais, Brazil.

Objective: Determine the social, environmental, and personal factors associated with high fat mass index in preschoolers.

Design: A quantitative, exploratory, and cross-sectional study.

Setting And Participants: Fifty-one Brazilian preschoolers from public schools living in urban areas. Read More

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Food Access, Dietary Intake, and Nutrition Knowledge of Adults on Probation.

J Nutr Educ Behav 2022 Jun;54(6):510-520

Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA.

Objective: To examine food access, dietary intake, and perceptions about diet and associations with health among adults on probation.

Design: Using a mixed-methods approach, interviews were used to understand food access, dietary intake, and diet and associations with health. A survey measured self-assessed diet quality and diet and associations with health. Read More

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Campus Food Pantry Use Is Linked to Better Health Among Public University Students.

J Nutr Educ Behav 2022 Jun;54(6):491-498

Department of Psychiatry, University of Arizona, Tucson, AZ.

Objective: To examine retrospectively whether access to a campus food pantry (CFP) is related to improvements in sleep, mental health, and physical health among college students in a public university system.

Design: Retrospective, cross-sectional study of student CFP users who completed an online survey in the summer of 2019.

Setting: Ten-campus University of California system. Read More

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Message from the Guest Editor.

Authors:
Natalie Rozanec

J Med Imaging Radiat Sci 2022 Jun;53(2S):S3-S5

Southlake Regional Health Centre, Newmarket, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada.

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Increased risk of incident knee osteoarthritis in those with greater work-related physical activity.

Occup Environ Med 2022 May 26. Epub 2022 May 26.

Division of Rheumatology, Allergy, and Immunology, Tufts Medical Center, Boston, Massachusetts, USA.

Objective: Occupations involving greater physical activity may increase risk for knee osteoarthritis (OA). Existing studies have not evaluated work-related physical activity before OA onset. Hence, we aimed to evaluate the association between work-related physical activity and knee OA incidence. Read More

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Prevalence of depression and anxiety and their predictors among patients undergoing maintenance hemodialysis in Northern China: a cross-sectional study.

Ren Fail 2022 Dec;44(1):933-944

Department of Nephrology, the Attached Hospital of Inner Mongolia Medical University, Hohhot, China.

Objective: To investigate the prevalence of depression and anxiety in patients undergoing maintenance hemodialysis (MHD) in Hohhot, a large city on the northern border of China, and to identify independent risk factors for depression and anxiety in these patients.

Methods: Patients receiving MHD for >3 months were enrolled in the four largest hemodialysis centers between September 2020 and December 2020. Depression and anxiety were assessed using the Zung self-rated depression scale (SDS) and Zung self-rated anxiety scale (SAS), respectively, with demographic and other data collected for logistic regression analyses. Read More

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December 2022

Cost analysis and cost-effectiveness of hand-scored and automated approaches to writing screening.

J Sch Psychol 2022 Jun 28;92:80-95. Epub 2022 Mar 28.

Department of Educational and Counselling Psychology, and Special Education, The University of British Columbia, Canada.

Although researchers have investigated technical adequacy and usability of written-expression curriculum-based measures (WE-CBM), the economic implications of different scoring approaches have largely been ignored. The absence of such knowledge can undermine the effective allocation of resources and lead to the adoption of suboptimal measures for the identification of students at risk for poor writing outcomes. Therefore, we used the Ingredients Method to compare implementation costs and cost-effectiveness of hand-calculated and automated scoring approaches. Read More

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Early career Black women in school-based mental health fields: Understanding their experiences of workplace discrimination.

J Sch Psychol 2022 Jun 8;92:49-65. Epub 2022 Mar 8.

William and Mary, United States of America.

This study aimed to understand school mental health providers' experiences with racism and other forms of discrimination (i.e., gendered-based discrimination) at work, with an exclusive focus on early career Black women. Read More

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Is it more effective or efficient to coach teachers in pairs or individually? A comparison of teacher and student outcomes and coaching costs.

J Sch Psychol 2022 Jun 17;92:346-359. Epub 2022 May 17.

University of Virginia, School of Education and Human Development, PO Box 400270, Charlottesville, VA 22904, USA.

A growing body of research documents the positive impacts of teacher coaching, but research contrasting the effectiveness of different coaching approaches is limited. This study contrasted paired coaching - delivered to two teachers simultaneously - with traditional coaching for individual in-service teachers. We examined the effects of these two approaches on observations of teachers' classroom management practices and student behavioral outcomes, relative to non-coached conditions, over the course of a single school year and at a 1-year follow-up. Read More

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Exploring profiles of coaches' fidelity to Double Check's Motivational Interviewing-embedded coaching: Outcomes associated with fidelity.

J Sch Psychol 2022 Jun 30;92:285-298. Epub 2022 Apr 30.

University of Virginia, School of Education and Human Development, United States of America.

Motivational interviewing (MI) is applied in a variety of clinical and coaching models to promote behavior change, with increasing interest in its potential to optimize school-based implementation fidelity. Yet there has been less consideration of fidelity indicators for MI-embedded coaching and their associations with outcomes. We leveraged exisiting data from 151 teachers across 18 schools, who were part of a larger 39 middle school randomized controlled trial of a teacher coaching model, to explore profiles of fidelity and the associations between fidelity and outcomes. Read More

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