2,248 results match your criteria head progressively

[Varicocele and reproductive function: epidemiology and infertility risk (the eamination of 3632 patients)].

Urologiia 2021 Jun(3):122-128

Department of Urology and Andrology, Faculty of Fundamental Medicine, and Head of the Clinic for Mens Health, Lomonosov Moscow State University.

Varicocele does not always lead to infertility; varicocelectomy does not always improve sperm.

The Study Objective: to evaluate the quantitative correlation between varicocele and reproductive function with a large sample.

Design: a cross-sectional and case control study. Read More

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Molecular Characterization of Superficial Layers of the Presubiculum During Development.

Front Neuroanat 2021 24;15:662724. Epub 2021 May 24.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

The presubiculum, a subarea of the parahippocampal region, plays a critical role in spatial navigation and spatial representation. An outstanding aspect of presubicular spatial codes is head-direction selectivity of the firing of excitatory neurons, called head-direction cells. Head-direction selectivity emerges before eye-opening in rodents and is maintained in adulthood through neurophysiological interactions between excitatory and inhibitory neurons. Read More

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Physiologic and molecular characterization of a novel murine model of metastatic head and neck cancer cachexia.

J Cachexia Sarcopenia Muscle 2021 Jul 6. Epub 2021 Jul 6.

Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR, USA.

Background: Cancer cachexia is a metabolic disorder characterized by the progressive loss of fat and lean mass that results in significant wasting, ultimately leading to reduced quality of life and increased mortality. Effective therapies for cachexia are lacking, potentially owing to the mismatch in clinically relevant models of cachexia. Specifically, cachexia observed in a clinical setting is commonly associated with advanced or late-stage cancers that are metastatic, yet pre-clinical metastatic models of cachexia are limited. Read More

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Long-term efficacy of weekly paclitaxel therapy in unresectable primary squamous cell carcinoma of the thyroid.

Auris Nasus Larynx 2021 Jul 3. Epub 2021 Jul 3.

Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.

Primary squamous cell carcinoma of the thyroid (PSCCT) is a rare disease with a poor prognosis. Because of its rarity, there is no established therapeutic regimen in unresectable cases. We report a case of PSCCT treated with weekly paclitaxel (wPTX) for more than 2 years. Read More

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Clinical manifestations of hereditary angioedema and a systematic review of treatment options.

Laryngoscope Investig Otolaryngol 2021 Jun 3;6(3):394-403. Epub 2021 Apr 3.

Department of Otolaryngology-Head and Neck Surgery Penn State College of Medicine, Penn State University 500 University Drive Hershey Pennsylvania MC H091 USA.

Objective: This study systematically reviews the existing literature on the management of hereditary angioedema (HAE) and provides an update on the clinical presentation and specific therapies.

Methods: A literature search of PubMed and Embase databases was conducted from start of the database to February 2021. Inclusion criteria included relevant systematic reviews, randomized control clinical trials, prospective and retrospective cohort studies, and outcomes research published in English and available in full-text. Read More

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Could the oral cavity be a target organ in SARS-CoV-2 infection?

Satish Kumar

Evid Based Dent 2021 01;22(2):78-79

Arizona School of Dentistry and Oral Health, A. T. Still University, Arizona, USA.

Data sources A series of eight patients with active COVID-19 who also presented with associated oral lesions seen at a hospital in Sao Paulo, Brazil provided the information in this report.Study selection The authors reported a case series with eight COVID-19 patients.Data extraction and synthesis Demographic information, hospitalisation details including signs, symptoms and severity of COVID-19, along with presence of anosmia, dysgeusia, ageusia and oral lesions from all eight patients were documented and reported by the authors. Read More

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January 2021

Reference Intervals of Fetal Cardiac Volume Between 14 and 40 Weeks of Gestation.

J Ultrasound Med 2021 Jun 25. Epub 2021 Jun 25.

Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Objectives: To construct the reference intervals for the cardiac volume (CV) of normal fetuses between 14 and 40 weeks of pregnancy.

Methods: Low risk singleton pregnancies with normal fetuses were prospectively recruited to acquire 4D-cardio-spatiotemporal image correlation volume datasets (VDS). Subsequent off-line analyses of VDS were anonymously performed to calculate CV using the Virtual Organ Computer-aided AnaLysis technique. Read More

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Missed Diagnosis of Subarachnoid Haemorrhage.

Eur J Case Rep Intern Med 2021 31;8(5):002616. Epub 2021 May 31.

Department of Surgery, Tokyo Nishi Tokushukai Hospital, Tokyo, Japan.

A 79-year-old woman presented with left retro-orbital pain, headache and blurred vision. Based on negative radiological tests, life-threatening conditions like subarachnoid haemorrhage (SAH) were ruled out and outpatient follow-up was planned. However, the patient returned to the hospital that night because of progressively declining consciousness and was diagnosed with SAH by head computed tomography. Read More

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Tree-based exploration of the optimization objectives for automatic cervical cancer IMRT treatment planning.

Br J Radiol 2021 Jul 16;94(1123):20210214. Epub 2021 Jun 16.

Department of Radiation Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital &Institute, Beijing, China.

Objective: To develop and evaluate a practical automatic treatment planning method for intensity-modulated radiation therapy (IMRT) in cervical cancer cases.

Methods: A novel algorithm named as Optimization Objectives Tree Search Algorithm (OOTSA) was proposed to emulate the planning optimization process and achieve a progressively improving IMRT plan, based on the Eclipse Scripting Application Programming Interface (ESAPI). 30 previously treated cervical cancer cases were selected from the clinical database and comparison was made between the OOTSA-generated plans and clinical treated plans and RapidPlan-based (RP) plans. Read More

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Transvenous Pressure Monitoring Guides Endovascular Treatment of Vein of Galen Malformation: A Technical Note.

Pediatr Neurosurg 2021 9;56(4):401-406. Epub 2021 Jun 9.

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Introduction: Vein of Galen malformations (VGMs) are complex congenital arteriovenous malformations that generally require serial endovascular treatment sessions to slowly correct the high-flow fistulous connections that cause increased venous pressures and ultimately lead to the classic presentations of heart failure, hydrocephalus, and intracranial hemorrhages. Despite the advances in endovascular technology and embolic materials, the resolution of embolization is often limited to the subjective view of diminished flow on angiograms.

Case Report: An 8-month-old patient with a VGM developed clinical signs of heart failure and growing head circumference with ventriculomegaly. Read More

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Using neural networks to extend cropped medical images for deformable registration among images with differing scan extents.

Med Phys 2021 Jun 8. Epub 2021 Jun 8.

Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Purpose: Missing or discrepant imaging volume is a common challenge in deformable image registration (DIR). To minimize the adverse impact, we train a neural network to synthesize cropped portions of head and neck CT's and then test its use in DIR.

Methods: Using a training dataset of 409 head and neck CT's, we trained a generative adversarial network to take in a cropped 3D image and output an image with synthesized anatomy in the cropped region. Read More

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Persistent polyamorphism in the chiton tooth: From a new biomineral to inks for additive manufacturing.

Proc Natl Acad Sci U S A 2021 Jun;118(23)

Materials Science and Engineering, Northwestern University, Evanston, IL 60208;

Engineering structures that bridge between elements with disparate mechanical properties are a significant challenge. Organisms reap synergy by creating complex shapes that are intricately graded. For instance, the wear-resistant cusp of the chiton radula tooth works in concert with progressively softer microarchitectural units as the mollusk grazes on and erodes rock. Read More

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Endoscopic Subtemporal Epidural Key-Hole Approach: Quantitative Anatomic Analysis of Three Surgical Corridors.

World Neurosurg 2021 May 24. Epub 2021 May 24.

Unit of Neurosurgery, Department of Medical and Surgical Specialties, Radiologic Sciences, and Public Health, University of Brescia, Brescia, Italy.

Background: The endoscope-assisted subtemporal key-hole epidural approach (ESKEA) has been recently described. The aim of this study was to measure working volumes and exposure of key areas of the middle cranial fossa provided by this approach.

Methods: Four fresh frozen cadaver heads were dissected to analyze 3 modular corridors (1A, 1B, and 2) harvested through ESKEA. Read More

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Screw-blade fixation systems for implant anchorage in the femoral head: Horizontal blade orientation provides superior stability.

Injury 2021 Jul 1;52(7):1861-1867. Epub 2021 May 1.

Department of Orthopaedics and Trauma Surgery, Lucerne Cantonal Hospital, Switzerland.

Objectives: Despite continual improvement in the methods and devices used for treatment of proximal femoral fractures, unacceptably high failure rates remain. Novel screw-blade implant systems, combining a lag screw with a blade - the latter adding rotational stability to the femoral head - offer improvement of osseous purchase, especially in osteoporotic bone. The aim of this study was to compare biomechanically the head element (HE) anchorage of two screw-blade implant systems differing in blade orientation in the femoral head - vertical versus horizontal. Read More

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Spatiotemporal contribution of neuromesodermal progenitor-derived neural cells in the elongation of developing mouse spinal cord.

Life Sci 2021 May 15:119393. Epub 2021 May 15.

Department of Anatomy and Division of Brain, Korea 21 Plus Program for Biomedical Science, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul 02841, Republic of Korea. Electronic address:

Aims: During vertebrate development, the posterior end of the embryo progressively elongates in a head-to-tail direction to form the body plan. Recent lineage tracing experiments revealed that bi-potent progenitors, called neuromesodermal progenitors (NMPs), produce caudal neural and mesodermal tissues during axial elongation. However, their precise location and contribution to spinal cord development remain elusive. Read More

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Transplantation of adipose-derived stromal cells protects functional and morphological auditory nerve integrity in a model of cochlear implantation.

Neuroreport 2021 Jun;32(9):776-782

Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Würzburg, Germany.

Cochlear implants are considered the gold standard therapy for subjects with severe hearing loss and deafness. Cochlear implants bypass the damaged hair cells and directly stimulate spiral ganglion neurons (SGNs) of the auditory nerve. Hence, the presence of functional SGNs is crucial for speech perception in electric hearing with a cochlear implant. Read More

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Interhemispheric Auditory Cortical Synchronization in Asymmetric Hearing Loss.

Ear Hear 2021 Mar 26. Epub 2021 Mar 26.

1Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, California, USA 2Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.

Objectives: Auditory cortical activation of the two hemispheres to monaurally presented tonal stimuli has been shown to be asynchronous in normal hearing (NH) but synchronous in the extreme case of adult-onset asymmetric hearing loss (AHL) with single-sided deafness. We addressed the wide knowledge gap between these two anchoring states of interhemispheric temporal organization. The objectives of this study were as follows: (1) to map the trajectory of interhemispheric temporal reorganization from asynchrony to synchrony using magnitude of interaural threshold difference as the independent variable in a cross-sectional study and (2) to evaluate reversibility of interhemispheric synchrony in association with hearing in noise performance by amplifying the aidable poorer ear in a repeated measures, longitudinal study. Read More

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[Effect of FVIII doses on joint structure and function in adolescents with severe hemophilia A: mid-term results of a prospective cohort study].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Apr;41(4):536-542

Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To explore the clinical phenotype and changes in joint structure and function in adolescent patients with severe hemophilia A under different doses of FVIII.

Objective: Forty- three adolescents with severe hemophilia A aged 4-18 years were divided into on-demand group (=7), low-dose group (FVIII dose of 10-15 U/kg, 2-3 times a week, and ≤30 U/kg a week; =17), and intermediate-dose group (FVIII dose of 15-20 U/kg, 2-3 times a week, and 45-60 U/kg a week (=19). The 3 groups were compared for their clinical bleeding phenotype, annual bleeding rate (ABR), annual joint bleeding rate (AJBR), annual the most severe joint bleeding rate, joint imaging scores (ultrasound HEAD-US score and IPSG MRI score), Hemophilia Joint Health Score (HJHS) and Functional Independence Score in Hemophilia (FISH) within 24 months. Read More

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[Varicocele and reproductive function: pathozoospermia treatment (a prospective comparative study)].

Urologiia 2021 May(2):62-68

Department of Urology and Andrology, Faculty of Fundamental Medicine, and Head of the Clinic for Mens Health, Lomonosov Moscow State University, Moscow, Russia.

Varicocele does not always lead to infertility; varicocelectomy does not always improve sperm.

Objective: to evaluate the standardized effect (Es) of nutrient therapy, microsurgical and laparoscopic varicocelectomy for pathozoospermia.

Study Design: a multicenter case-control study with stratified randomization. Read More

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Middle Meningeal Artery Embolization of a Pediatric Patient With Progressive Chronic Subdural Hematoma.

Oper Neurosurg (Hagerstown) 2021 May 6. Epub 2021 May 6.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Background And Importance: Evidence suggests middle meningeal artery (MMA) embolization benefits adult patients with chronic subdural hematoma (CSDH) at high risk for recurrence or hemorrhagic complications. Yet, there has not been any report discussing MMA embolization in the pediatric population. Thus, we present a case of an infant with CSDH successfully managed with MMA embolization without surgical management. Read More

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Review of recent treatment trends of laryngeal cancer in Poland: a population-based study.

BMJ Open 2021 04 30;11(4):e045308. Epub 2021 Apr 30.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Warszawa, Poland.

Objectives: To investigate the utilisation of different treatment modalities for patients with laryngeal cancer (LC) during last decade in Poland.

Setting: Retrospective population-based study.

Participants: Patients with LC treated between January 2009 and December 2018. Read More

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Diode laser for the treatment of a high flow lip vascular malformation: a case report with four years follow up.

Minerva Dent Oral Sci 2021 Apr 30. Epub 2021 Apr 30.

Radiology Institute, Department of Medicine - DIMED, University of Padua, Padua, Italy.

Background: About 50% of vascular malformations are located at the head and neck region where they can usually be associated with functional and/or aesthetic limitations. Laser treatment has proven to be effective in treatment of small low-flow vascular malformations but little is known about the use of this therapy for high-flow larger arteriovenous malformations (AVMs).

Methods: a congenital high-flow vascular malformation of the upper lip had to be treated because it was causing functional impairment and deformity which were affecting the quality of life. Read More

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Impact of K-Ras Over-expression in Laryngeal Squamous Cell Carcinoma.

In Vivo 2021 May-Jun;35(3):1611-1615

1 ENT Department, Hippocration Hospital, University of Athens, Athens, Greece.

Background/aim: Oncogene up-regulation combined with suppressor gene down-regulation is a crucial genetic combination that promotes cell neoplastic phenotype and progressively malignant transformation in solid malignancies, including laryngeal squamous cell carcinoma (LSCC). Among oncogenes, the Kirsten ras oncogene homolog (K-Ras) is involved in LSCC onset and progression.

Patients And Methods: Sixty (n=60) primary LSCC tissue sections were analyzed by immunohistochemistry (IHC). Read More

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Redefining the tail of pancreas based on the islets microarchitecture and inter-islet distance: An immunohistochemical study.

Medicine (Baltimore) 2021 Apr;100(17):e25642

Department of Anatomy, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Abstract: Researchers divided the pancreas distal to the neck into 2 equal parts as the body and tail region by an arbitrary line. Surgeons considered the part of the pancreas, left to the aorta as the tail region. We performed this study to identify the transition zone of low-density to high-density islet cells for redefining the tail region. Read More

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Biomechanical assessment of different fixation methods in mandibular high sagittal oblique osteotomy using a three-dimensional finite element analysis model.

Sci Rep 2021 Apr 22;11(1):8755. Epub 2021 Apr 22.

Department of Computational Mechanics Physics CEMEF, MINES ParisTech, PSL Research University, Centre de Mise en Forme Des Matériaux (CEMEF), French National Centre for Scientific Research, Sophia Antipolis, France.

With modern-day technical advances, high sagittal oblique osteotomy (HSOO) of the mandible was recently described as an alternative to bilateral sagittal split osteotomy for the correction of mandibular skeletal deformities. However, neither in vitro nor numerical biomechanical assessments have evaluated the performance of fixation methods in HSOO. The aim of this study was to compare the biomechanical characteristics and stress distribution in bone and osteosynthesis fixations when using different designs and placing configurations, in order to determine a favourable plating method. Read More

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Standardized artificially created stable pertrochanteric femur fractures present more homogenous results compared to osteotomies for orthopaedic implant testing.

BMC Musculoskelet Disord 2021 Apr 20;22(1):371. Epub 2021 Apr 20.

University of Basel, Basel, Switzerland.

Background: With regard to biomechanical testing of orthopaedic implants, there is no consensus on whether artificial creation of standardized bone fractures or their simulation by means of osteotomies result in more realistic outcomes. Therefore, the aim of this study was to artificially create and analyze in an appropriate setting the biomechanical behavior of standardized stable pertrochanteric fractures versus their simulation via osteotomizing.

Methods: Eight pairs of fresh-frozen human cadaveric femora aged 72. Read More

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Sustained Hippocampal Synaptic Pathophysiology Following Single and Repeated Closed-Head Concussive Impacts.

Front Cell Neurosci 2021 31;15:652721. Epub 2021 Mar 31.

Center for Neurodegenerative Disease and Therapeutics, Rosalind Franklin University of Medicine and Science, North Chicago, IL, United States.

Traumatic brain injury (TBI), and related diseases such as chronic traumatic encephalopathy (CTE) and Alzheimer's (AD), are of increasing concern in part due to enhanced awareness of their long-term neurological effects on memory and behavior. Repeated concussions, vs. single concussions, have been shown to result in worsened and sustained symptoms including impaired cognition and histopathology. Read More

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Integrating hydraulic tomography, electrical resistivity tomography, and partitioning interwell tracer test datasets to improve identification of pool-dominated DNAPL source zone architecture.

J Contam Hydrol 2021 Apr 7;241:103809. Epub 2021 Apr 7.

Key Laboratory of Surficial Geochemistry of Ministry of Education, School of Earth Sciences and Engineering, Nanjing University, Nanjing 210023, China. Electronic address:

High-resolution characterization of complex dense non-aqueous phase liquid (DNAPL) contaminated sites is crucial for developing effective remediation strategies. The DNAPL source zone is usually characterized by hydraulic/partitioning tracer tomography (HPTT). However, the HPTT method may fail to capture the highly saturated pool-dominated DNAPL source zone architecture (SZA), because partitioning tracers tend to bypass the low-permeability zones where the pool DNAPL accumulates, resulting in a low-resolution DNAPL estimation. Read More

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Anthropometric, biochemical and hormonal profiles of the partially admixed pygmoid group in Rampasasa (Flores, Indonesia).

J Pediatr Endocrinol Metab 2021 May 13;34(5):547-557. Epub 2021 Apr 13.

Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.

Objectives: We performed a cross-sectional study on anthropometric and laboratory characteristics of inhabitants of Rampasasa (Flores, Indonesia). Adults were categorised according to ancestry into three groups: pygmoid (P/P, offspring of pygmoid parents, n=8), mixed pygmoid (P/N, offspring of pygmoid and non-pygmoid parents, n=12) and non-pygmoid (N/N, n=10). Children (n=28) were P/N. Read More

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