243,875 results match your criteria head neck


Functional laryngectomy for the dysfunctional larynx: indications and outcomes in setting of prior chemoradiotherapy.

Curr Opin Otolaryngol Head Neck Surg 2021 Sep 15. Epub 2021 Sep 15.

Department of Otolaryngology-Head and Neck Surgery, University of California Davis Medical Center, Sacramento, California, USA.

Purpose Of Review: To review the recent literature on indications for and functional outcomes following laryngectomy for severe laryngeal dysfunction.

Recent Findings: The use of functional laryngectomy as a definitive treatment for severe laryngeal dysfunction is increasing as more patients with head and neck cancer are treated with definitive chemoradiotherapy. Data are emerging on the efficacy of this technique as measured by aspiration, recurrent pneumonias, enteral tube feeding dependence, and surgical complication rates. Read More

View Article and Full-Text PDF
September 2021

A convolutional neural network for estimating cone-beam CT intensity deviations from virtual CT projections.

Phys Med Biol 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, AUSTRALIA.

Extending cone-beam CT (CBCT) use toward dose accumulation and adaptive radiotherapy necessitates more accurate HU reproduction since cone-beam geometries are heavily degraded by photon scatter. This study proposes a novel method that aims to demonstrate how deep learning based on phantom data can be used effectively for CBCT intensity correction in patient images. Four anthropomorphic phantoms were scanned on a CBCT and conventional fan-beam CT system. Read More

View Article and Full-Text PDF
September 2021

Maturation of the anterior petrous apex: surgical relevance for performance of the middle fossa transpetrosal approach in pediatric patients.

J Neurosurg 2021 Sep 17:1-7. Epub 2021 Sep 17.

2Department of Neurosciences and Pediatrics, University of California, San Diego, San Diego.

Objective: The middle fossa transpetrosal approach to the petroclival and posterior cavernous sinus regions includes removal of the anterior petrous apex (APA), an area well studied in adults but not in children. To this end, the authors performed a morphometric analysis of the APA region during pediatric maturation.

Methods: Measurements of the distance from the clivus to the internal auditory canal (IAC; C-IAC), the distance of the petrous segment of the internal carotid artery (petrous carotid; PC) to the mesial petrous bone (MPB; PC-MPB), the distance of the PC to the mesial petrous apex (MPA; PC-MPA), and the IAC depth from the middle fossa floor (IAC-D) were made on thin-cut CT scans from 60 patients (distributed across ages 0-3, 4-7, 8-11, 12-15, 16-18, and > 18 years). Read More

View Article and Full-Text PDF
September 2021

The effect of face mask usage on the allergic rhinitis symptoms in patients with pollen allergy during the covid-19 pandemic.

Am J Otolaryngol 2021 Sep 10;43(1):103206. Epub 2021 Sep 10.

Department of Otorhinolaryngology-Head and Neck Surgery, Pamukkale University School of Medicine, Denizli, Turkey.

Purpose: The study aims to evaluate the use of face masks on allergic rhinitis symptoms in pollen allergy patients who were compulsorily using face masks due to the covid-19 pandemic.

Materials And Methods: A 15-item questionnaire was developed following the study goals by a team experienced in allergic rhinitis. Then the records of patients who underwent allergy tests in our hospital between 2013 and 2019 were retrospectively analyzed. Read More

View Article and Full-Text PDF
September 2021

SARS-CoV-2 vaccine-induced subacute thyroiditis.

Am J Otolaryngol 2021 Sep 9;43(1):103211. Epub 2021 Sep 9.

Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.

View Article and Full-Text PDF
September 2021

Can the mean linear energy transfer of organs be directly related to patient toxicities for current head and neck cancer intensity-modulated proton therapy practice?

Radiother Oncol 2021 Sep 14. Epub 2021 Sep 14.

Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Background And Purpose: The relative biological effectiveness (RBE) of proton therapy is predicted to vary with the dose-weighted average linear energy transfer (LET). However, RBE values may substantially vary for different clinical endpoints. Therefore, the aim of this study was to assess the feasibility of relating mean D⋅LET parameters to patient toxicity for HNC patients treated with proton therapy. Read More

View Article and Full-Text PDF
September 2021

Upper Respiratory Tract Bacterial-Immune Interactions during Respiratory Syncytial Virus Infection in Infancy.

J Allergy Clin Immunol 2021 Sep 14. Epub 2021 Sep 14.

Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN. Electronic address:

Background: The risk factors determining short- and long-term morbidity following acute respiratory infection (ARI) due to respiratory syncytial virus (RSV) in infancy remain poorly understood.

Objectives: To examine the associations of the upper respiratory tract (URT) microbiome during RSV ARI in infancy with the acute local immune response and short- and long-term clinical outcomes.

Methods: We characterized the URT microbiome by 16S ribosomal RNA sequencing and assessed the acute local immune response by measuring 53 immune mediators with high-throughput immunoassays in 357 RSV-infected infants. Read More

View Article and Full-Text PDF
September 2021

5-aza-2'-deoxycytidine induces apoptosis and inhibits tumour growth in vivo of FaDu cells, a specific HPVnegative HNSCC cell line.

PLoS One 2021 17;16(9):e0253756. Epub 2021 Sep 17.

Department of Human Biology, Faculty of Natural Science, University of Haifa, Haifa, Israel.

Head and neck cancer squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, resulting in over 600,000 new diagnoses annually. Traditionally, HNCC has been related to tobacco and alcohol exposure; however, over the past decade, a growing number of head and neck cancers are attributed to human papillomavirus (HPV) infection. 5-Aza-2'-deoxycytidine (5-AzaD) was demonstrated as an effective chemotherapeutic agent for acute myelogenous leukaemia. Read More

View Article and Full-Text PDF
September 2021

Vestibular Perceptual Thresholds in Older Adults With and Without Age-related Hearing Loss.

Ear Hear 2021 Sep 15. Epub 2021 Sep 15.

KITE-Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada Department of Psychology, University of Toronto, Toronto, ON, Canada Department of Psychology and Centre for Vision Research, York University, Toronto, ON, Canada Department of Otolaryngology-Head & Neck Surgery Hospital for Sick Children, Toronto, ON, Canada Department of Otolaryngology-Head & Neck Surgery, University of Toronto, Toronto, ON, Canada Archie's Cochlear Implant Laboratory, Hospital for Sick Children, Toronto, ON, Canada University of Toronto Institute for Aerospace Studies, Toronto, ON, Canada.

Objectives: Older adults with age-related hearing loss (ARHL) are at greater risk of falling and have greater mobility problems than older adults with normal hearing (NH). The underlying cause of these associations remains unclear. One possible reason is that age-related declines in the vestibular system could parallel those observed in the auditory system within the same individuals. Read More

View Article and Full-Text PDF
September 2021

Impact of RBE variations on risk estimates of temporal lobe necrosis in patients treated with intensity-modulated proton therapy for head and neck cancer.

Acta Oncol 2021 Sep 17:1-8. Epub 2021 Sep 17.

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Temporal lobe necrosis (TLN) is a potential late effect after radiotherapy for skull base head and neck cancer (HNC). Several photon-derived dose constraints and normal tissue complication probability (NTCP) models have been proposed, however variation in relative biological effectiveness (RBE) may challenge the applicability of these dose constraints and models in proton therapy. The purpose of this study was therefore to investigate the influence of RBE variations on risk estimates of TLN after Intensity-Modulated Proton Therapy for HNC. Read More

View Article and Full-Text PDF
September 2021

Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L-formate axis.

J Pineal Res 2021 Sep 17:e12767. Epub 2021 Sep 17.

School of Dentistry, University of California, Los Angeles, California, 90095, United States.

Metabolic remodeling is now widely recognized as a hallmark of cancer, yet its role in head and neck squamous cell carcinoma (HNSCC) remains largely unknown. In this study, metabolomic analysis of melatonin-treated HNSCC cell lines revealed that exogenous melatonin inhibited many important metabolic pathways including folate cycle in HNSCC cells. Methylenetetrahydrofolate dehydrogenase 1 like (MTHFD1L), a metabolic enzyme of the folate cycle regulating the production of formate, was identified as a downstream target of melatonin. Read More

View Article and Full-Text PDF
September 2021

Stigma, depression, and anxiety among patients with head and neck cancer.

Support Care Cancer 2021 Sep 17. Epub 2021 Sep 17.

Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Dapi Road, Niaosung District, Kaohsiung City, Taiwan.

Purpose: Patients with head and neck cancer (HNC) are vulnerable to psychiatric comorbidities, particularly anxiety and depression, and also suffer from cancer stigma. This study aimed to comprehensively compare HNC patients' stigma, depression, and anxiety, and elucidate the underlying relationships among them.

Methods: This cross-sectional study recruited inpatients with HNC from a medical center. Read More

View Article and Full-Text PDF
September 2021

Three-dimensional printing in otolaryngology education: a systematic review.

Eur Arch Otorhinolaryngol 2021 Sep 17. Epub 2021 Sep 17.

Radiology Department, Radiology at DAPI, Catholic Ladies League of Curitiba, Curitiba, Brazil.

Purpose: The progressive expansion of the technology that facilitates the development of three-dimensional (3D) printing within the field of otorhinolaryngology has opened up a new study front in medicine. The objective of this study is to systematically review scientific publications describing the development of 3D models having applications in otorhinolaryngology, with emphasis on subareas with a large number of publications, as well as the countries in which the publications are concentrated.

Methods: In this literature review, specific criteria were used to search for publications on 3D models. Read More

View Article and Full-Text PDF
September 2021

HPV Vaccination Is Safe-You Don't Have to Whisper It.

JAMA Netw Open 2021 Sep 1;4(9):e2125124. Epub 2021 Sep 1.

Department of Population Science and Policy, Southern Illinois University School of Medicine, Springfield.

View Article and Full-Text PDF
September 2021

COVID-19 vaccination and allergen immunotherapy (AIT) - A position paper of the German Society for Applied Allergology (AeDA) and the German Society for Allergology and Clinical Immunology (DGAKI).

Allergol Select 2021 24;5:251-259. Epub 2021 Aug 24.

Allergology and Immunology, Clinic for Dermatotology, Venerology and Allergology, Charité Universitätsmedizin Berlin, Germany.

Background: Vaccinations against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are intended to induce an immune response to protect against infection/disease. Allergen immunotherapy (AIT) is thought to induce a (different) immune response, e.g. Read More

View Article and Full-Text PDF

The safety of povidone-iodine solution in tympanoplasty: a randomised, triple-blind, placebo-controlled study.

Acta Otorhinolaryngol Ital 2021 Aug;41(4):377-382

Otolaryngology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: Nowadays, povidone-iodine is commonly used as a disinfectant in head and neck procedures. The present study investigated the effect of povidone-iodine, which is used as a disinfectant solution in tympanoplasty, on patients' hearing.

Methods: A povidone-iodine solution was used as disinfection in chronic otitis media patients undergoing tympanoplasty. Read More

View Article and Full-Text PDF

Sound frequency spectra of snore in relation to the site of obstruction among snorers.

Acta Otorhinolaryngol Ital 2021 Aug;41(4):348-355

Department of Otorhinolaryngology, Head and Neck Surgery, Pusat Perubatan Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Objective: This study aimed to describe the sound frequency of snoring in relation to the site of upper airway vibration among snorers.

Methods: 383 snores from 40 participants who complained of snoring were digitally recorded during natural and induced sleep using a level III polysomnography monitor with a built-in microphone. During drug-induced sleep endoscopy (DISE), the real-time site of upper airway obstruction was assessed, and the sound frequency of snoring was recorded synchronously. Read More

View Article and Full-Text PDF

How to predict the outcome of septorhinoplasty? A normative study of ROE and FROI-17 scores.

Acta Otorhinolaryngol Ital 2021 Aug;41(4):327-335

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Objective: Normative values of patient-reported outcome instruments are needed to identify good candidates for rhinoplasty. Rhinoplasty Outcome Evaluation (ROE) and Functional Rhinoplasty Outcome Inventory-17 (FROI-17) are disease-specific questionnaires that evaluate quality of life in patients undergoing rhinoplasty.

Methods: The reference cohort contained 1,000 participants, selected from a non-probability panel. Read More

View Article and Full-Text PDF

Organ preservation and oncological outcomes in early laryngeal cancer: a propensity score-based study.

Acta Otorhinolaryngol Ital 2021 Aug;41(4):317-326

Head and Neck Surgery and Otorhinolaryngology Department, A. C. Camargo Cancer Center, São Paulo, Brazil.

Background: The rates of laryngeal preservation according to therapeutic modality in patients with initial laryngeal squamous cell carcinoma (LSCC) are still controversial. This study evaluated the rates of laryngeal preservation in patients who underwent treatment with surgery or radiotherapy.

Methods: This retrospective cohort study evaluated 151 patients with stage I or II LSCC. Read More

View Article and Full-Text PDF

Surgical treatment for squamous cell carcinoma of the temporal bone: predictors of survival.

Acta Otorhinolaryngol Ital 2021 Aug;41(4):308-316

Department of Otolaryngology & Head and Neck Surgery, Amsterdam University Medical Centre, location VU University Medical Centre, Amsterdam, The Netherlands.

Objective: Evaluation of the management and survival in patients treated for temporal bone squamous cell carcinoma (TBSCC) in a tertiary referral centre.

Methods: Forty-nine patients underwent primary treatment for TBSCC. Thirty-six patients underwent a lateral temporal bone resection (LTBR) or subtotal temporal bone resection (STBR). Read More

View Article and Full-Text PDF

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.

Authors:
Giulio Cantù

Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307

Former Director of Otorhinolaryngology and Cranio-Maxillo-Facial Unit, Fondazione I.R.C.C.S. Istituto Nazionale dei Tumori, Milano, Italy.

View Article and Full-Text PDF

Development, assessment, and monitoring of audiologic treatment fidelity in the aging and cognitive health evaluation in elders (ACHIEVE) randomised controlled trial.

Int J Audiol 2021 Sep 17:1-11. Epub 2021 Sep 17.

Department of Communication Sciences & Disorders, University of South Florida, Florida, FL, USA.

Objective: Studies investigating hearing interventions under-utilise and under-report treatment fidelity planning, implementation, and assessment. This represents a critical gap in the field that has the potential to impede advancements in the successful dissemination and implementation of interventions. Thus, our objective was to describe treatment fidelity planning and implementation for hearing intervention in the multi-site Ageing and Cognitive Health Evaluation in Elders (ACHIEVE) randomised controlled trial. Read More

View Article and Full-Text PDF
September 2021

Perceptions of older adults? Measuring positive, negative, and physical descriptors using the stereotype content and strength survey.

J Gerontol Soc Work 2021 Sep 17:1-13. Epub 2021 Sep 17.

Department of Mathematics and Statistics, Utah State University, Logan, UT, USA.

The COVID-19 pandemic has disproportionately impacted the health of older adults. In addition to a higher risk for serious illness and death, the societal value of senescent adults was challenged. There have been conflicting results reported in the research literature regarding positive and negative stereotypes of older adults, and areliable and valid assessment tool to measure content (existence of astereotype) and strength (intensity of astereotype) is unavailable. Read More

View Article and Full-Text PDF
September 2021

Risk of thyroid as a first or second primary cancer. A population-based study in Italy, 1998-2012.

Cancer Med 2021 Sep 17. Epub 2021 Sep 17.

Mantova Cancer Registry, Epidemilogy Unit, Agenzia di Tutela della Salute (ATS) della Val Padana, Mantova, Italy.

Background: The number of patients living after a cancer diagnosis is increasing, especially after thyroid cancer (TC). This study aims at evaluating both the risk of a second primary cancer (SPC) in TC patients and the risk of TC as a SPC.

Methods: We analyzed two population-based cohorts of individuals with TC or other neoplasms diagnosed between 1998 and 2012, in 28 Italian areas covered by population-based cancer registries. Read More

View Article and Full-Text PDF
September 2021

Poor tumor differentiation is an independent adverse prognostic variable in patients with locally advanced oral cavity cancer--Comparison with pathological risk factors according to the NCCN guidelines.

Cancer Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan, Republic of China.

Methods: We sought to compare the prognostic impact of tumor differentiation with respect to adverse risk factors (RFs) identified by the National Comprehensive Cancer Network (NCCN) guidelines--including extranodal extension (ENE), positive/close margins, perineural invasion, lymphatic invasion, and vascular invasion--in patients with locally advanced oral cavity squamous cell carcinoma (OCSCC).

Results: Between 1996 and 2018, 1179 consecutive patients with first primary pT3-4 OCSCC were included. A three-level grading system was adopted--in which the final classification was assigned according to the most prevalent tumor grade. Read More

View Article and Full-Text PDF
September 2021

Surgical Treatment of Type III Laryngotracheoesophageal Clefts: Techniques and Outcomes.

Laryngoscope 2021 Sep 17. Epub 2021 Sep 17.

Division of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, U.S.A.

Objectives/hypothesis: Determine surgical and swallowing outcomes after surgery for type III laryngotracheoesophageal cleft (LTEC).

Study Design: Case series with chart review.

Methods: Chart review was performed on patients with type III LTEC between 2000 and 2019. Read More

View Article and Full-Text PDF
September 2021

Is intraoperative margin sampling necessary in inverted papilloma resection?

Eur Arch Otorhinolaryngol 2021 Sep 16. Epub 2021 Sep 16.

Department of Otolaryngology Head and Neck Surgery, The Sheba Medical Center, Tel Hashomer, Israel.

Purpose: To explore the association between intraoperative surgical margin sampling by the frozen sections and recurrence in inverted papilloma surgery.

Methods: A multicenter, retrospective study of patients who underwent attachment-oriented IP resection in four tertiary care medical centers with a minimal follow-up of 36 months.

Results: The study included 220 surgeries with a mean follow-up period of 49 months (range 36-204). Read More

View Article and Full-Text PDF
September 2021

The methylation modification of m6A regulators contributes to the prognosis of head and neck squamous cell carcinoma.

Ann Transl Med 2021 Aug;9(16):1346

Department of Radiation Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: N6-methyladenosine (m6A) regulation is a common type of messenger ribonucleic acid (mRNA) modification, and has been proven to contribute to the malignant behavior of tumors. However, the expression pattern and the prognostic role of m6A RNA methylation regulators in head and neck squamous cell carcinoma (HNSCC) remains unclear.

Methods: We downloaded the data of 422 patients from The Cancer Genome Atlas (TCGA) database. Read More

View Article and Full-Text PDF

Nomograms-based prediction of overall and cancer-specific survivals for patients diagnosed with major salivary gland carcinoma.

Ann Transl Med 2021 Aug;9(15):1230

Department of Oromaxillofacial-Head & Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Background: Major salivary glands carcinoma (MSGC) is a relatively rare cancer with diverse histological types and biological behavior. The treatment planning and prognosis prediction are challenging for clinicians. The aim of the current study was to establish a reliable and effective nomogram to predict the overall survival (OS) and cancer-specific survival (CSS) for MSGC patients. Read More

View Article and Full-Text PDF

Identification of novel biomarkers of prostate cancer through integrated analysis.

Transl Androl Urol 2021 Aug;10(8):3239-3254

Department of Urology Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: The current methods adopted to screen for prostate cancer (PCa) can sometimes be misleading and inaccurate. Moreover, for advanced stages of PCa, the current effect of treatment is not satisfactory for some patients. Accordingly, we aimed to identify new biomarkers for the diagnosis and prognosis of PCa. Read More

View Article and Full-Text PDF