9,687 results match your criteria hdl dysfunction


Spirulina liquid extract prevents metabolic disturbances and improves liver sphingolipids profile in hamster fed a high-fat diet.

Eur J Nutr 2021 Jun 10. Epub 2021 Jun 10.

INRAe UMR1280 PhAN, Physiopathology of Nutritional Adaptations, CHU Hôtel Dieu, IMAD, CRNH Ouest, University of Nantes, 1, Place Alexis Ricordeau, 44093, Nantes Cedex 01, France.

Purpose: Metabolic syndrome is characterized by hyperglycemia, hyperlipemia and exacerbated oxidative stress. The aim of the study was to determine whether Spirulysat, a Spirulina liquid extract (SLE) enriched in phycocyanin, would prevent metabolic abnormalities induced by high-fat diet.

Methods: The effect of acute SLE supplementation on postprandial lipemia and on triton-induced hyperlipidemia was studied in hamster fed control diet (C). Read More

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1-trifluoromethoxyphenyl-3(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor attenuates high fat diet-induced cardiovascular and metabolic disorders in rats.

Eur Rev Med Pharmacol Sci 2021 Jan;25(10):3835-3847

Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Objective: Obesity was induced in rats by feeding on a high fat diet (HFD), 60% w/w cholesterol, 20% w/w carbohydrates, and 20% w/w proteins for two months.

Materials And Methods: Animals were fed on a HFD and treated concurrently with a single daily dose of vehicle or TPPU (2 mg/kg p.o) for two months. Read More

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January 2021

Association of lipoproteins and thyroid hormones with cognitive dysfunction in patients with systemic lupus erythematosus.

BMC Rheumatol 2021 Jun 9;5(1):18. Epub 2021 Jun 9.

Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, PR China.

Background: Neuropsychiatric manifestations occur in up to 75% of adult systemic lupus erythematosus (SLE) patients and are one of the major causes of death in SLE patients. Cognitive dysfunction is a typical clinical feature of neuropsychiatric SLE (NPSLE), which seriously affects the quality of life of patients. Dyslipidaemia and thyroid symptoms, which are prevalent in SLE patients, have both been related to neuropsychiatric disturbances, including significant psychiatric and cognitive disturbances. Read More

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Reduced global longitudinal strain at rest and inadequate blood pressure response during exercise treadmill testing in male heterozygous familial hypercholesterolemia patients.

Int J Cardiol Hypertens 2021 Jun 20;9:100083. Epub 2021 Apr 20.

National and Kapodistrian University of Athens, Division of Experimental Surgery, Greece.

Background: Heterozygous familial hypercholesterolemia (heFH) is a genetic disorder leading to premature coronary artery disease (CAD). We hypothesized that the subclinical pathophysiologic consequences of hypercholesterolemia may be detected before the occurrence of clinically overt CAD by stress testing and myocardial strain imaging.

Patients-methods: We evaluated the treadmill tests (ETTs) of 46 heFH men without known arterial hypertension/diabetes mellitus/vasculopathy like CAD and of 39 healthy men matched for age, baseline systolic/diastolic blood pressure (BP) and heart rate (HR), using Bruce protocol. Read More

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Protects Against Oxidative Cardiotoxicity by Suppressing Lipid Dysmetabolism and Modulating Cardiometabolic Activities Linked to Cardiac Dysfunctions.

Front Pharmacol 2021 20;12:610835. Epub 2021 May 20.

Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa.

Cardiotoxicity leading to cardiovascular dysfunction and ultimately cardiac failure remains a major global health issue irrespective of race, age and country. Several factors including lipotoxicity, oxidative imbalance, exacerbated angiotensin-converting enzyme (ACE) activity and altered bioenergetics have been implicated in the pathophysiology of cardiovascular diseases. (E. Read More

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Influence of seasonal variation on post-farrowing dysgalactia syndrome (PFDS) and serum biochemistry profiles in the periparturient sow.

Trop Anim Health Prod 2021 Jun 6;53(3):346. Epub 2021 Jun 6.

ICAR Research Complex for North Eastern Hill Region, Nagaland Centre, Medziphema, Nagaland, 797 106, India.

The objective of this study was to investigate the effect of seasonal variation on the frequency of post-farrowing dysgalactia syndrome (PFDS), sow body condition score (BCS), piglet survival, and weaning to estrus interval under intensive management systems. In addition, the effects of PFDS on litter characteristics and serum biochemistry, oxidative stress indices, thyroid, and cortisol profile were examined in order to identify potential biomarkers in the pre-farrowing stage. The study was conducted in summer and winter seasons in Nagaland, India, on 50 sows from 30 days before farrowing until weaning at 45 days. Read More

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High-sensitivity CRP may be a marker of HDL dysfunction and remodeling in patients with acute coronary syndrome.

Sci Rep 2021 Jun 1;11(1):11444. Epub 2021 Jun 1.

Department of Cardiovascular Medicine, Research Institute of Blood Lipids and Atherosclerosis, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, 410011, Hunan, China.

In patients with coronary artery disease (CAD), further increasing the level of high-density lipoprotein (HDL) cholesterol (HDL-C) as an add-on to statins cannot reduce cardiovascular risk. And it has been reported that HDL functional metric-cholesterol efflux capacity (CEC) may be a better predictor of CAD risk than HDL-C. CEC measurement is time-consuming and not applicable in clinical settings. Read More

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Comparison of Resveratrol Supplementation and Energy Restriction Effects on Sympathetic Nervous System Activity and Vascular Reactivity: A Randomized Clinical Trial.

Molecules 2021 May 26;26(11). Epub 2021 May 26.

Chronic Coronariopathies Clinical Unit, Heart Institute, School of Medicine, University of São Paulo, São Paulo 05403-000, SP, Brazil.

Chronic sympathetic nervous system activation is associated with endothelial dysfunction and cardiometabolic disease, which may be modulated by resveratrol (RSV) and energy restriction (ER). This study aimed to examine the effects of RSV and ER on plasma noradrenaline (NA), flow-mediated vasodilation (ed-FMD), and endothelium-independent nitrate-mediated vasodilation (ei-NMD). : The study included 48 healthy adults randomized to 30-days intervention of RSV or ER. Read More

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Association between the Use of Health Services, Cardiovascular Risk Factors and Metabolic Syndrome in Mexican Adults.

Int J Environ Res Public Health 2021 May 17;18(10). Epub 2021 May 17.

Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS & IDISBA, 07122 Palma de Mallorca, Spain.

: The use of health services is a complex behavioral phenomenon affected by multiple factors (availability, distance, cost, quality, attitudes, cultural beliefs, socioeconomic characteristics, and individuals' self-perception of health). Mexico has a segmented health system, and the access to it depends on the labor insertion and the population's ability to pay. : To assess association between use of health services and cardiovascular and metabolic syndrome risk factors among Mexican adults. Read More

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Association of Early Renal Dysfunction with Lipid Profile Parameters among Hypertensives in Kazakhstan.

Diagnostics (Basel) 2021 May 12;11(5). Epub 2021 May 12.

Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 2C4, Canada.

Dyslipidemia plays an essential role in chronic kidney disease (CKD). The role of lipids and lipoproteins in the early pre-disease state of CKD in hypertensive patients is still unclear. The study aimed to evaluate the relationship between early renal dysfunction and lipid profile parameters among hypertensive patients in Kazakhstan. Read More

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Peripheral Blood Mononuclear Cells Oxidative Stress and Plasma Inflammatory Biomarkers in Adults with Normal Weight, Overweight and Obesity.

Antioxidants (Basel) 2021 May 20;10(5). Epub 2021 May 20.

Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, Health Research Institute of Balearic Islands (IdISBa), and CIBEROBN (Physiopathology of Obesity and Nutrition), E-07122 Palma, Balearic Islands, Spain.

Obesity is an important pathology in public health worldwide. Obese patients are characterized by higher cardiovascular risk and a pro-inflammatory profile. To assess the oxidative stress in peripheral blood mononuclear cells (PBMCs) and inflammatory biomarkers in plasma in adults with normal weight, overweight and obesity. Read More

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Physiological Fitness and the Pathophysiology of Chronic Lymphocytic Leukemia (CLL).

Cells 2021 May 11;10(5). Epub 2021 May 11.

Division of Medical Oncology, Duke University School of Medicine, Durham, NC 27710, USA.

Chronic lymphocytic leukemia (CLL) is associated with physical dysfunction and low overall fitness that predicts poor survival following the commencement of treatment. However, it remains unknown whether higher fitness provides antioncogenic effects. We identified ten fit (CLL-FIT) and ten less fit (CLL-UNFIT) treatment-naïve CLL patients from 144 patients who completed a set of physical fitness and performance tests. Read More

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Maternal metabolic health drives mesenchymal stem cell metabolism and infant fat mass at birth.

JCI Insight 2021 Jun 1. Epub 2021 Jun 1.

Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, United States of America.

Exposure to maternal obesity may promote metabolic dysfunction in offspring. We use infant mesenchymal stem cells (MSC) to experimentally examine cellular mechanisms of intergenerational health transmission. Our earlier reports show MSCs collected from infants of mothers with obesity had a dichotomous distribution in metabolic efficiency; they were either efficient (Ef-Ob) or inefficient (In-Ob) with respect to fatty acid oxidation (FAO). Read More

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An association between fibrinogen gene polymorphisms and diabetic peripheral neuropathy in young patients with type 1 diabetes.

Mol Biol Rep 2021 Jun 1. Epub 2021 Jun 1.

Department of Pediatrics, Jessenius Faculty of Medicine and University Hospital, Comenius University in Bratislava, Kollárova 2, 036 01, Martin, Slovakia.

In complex etiopathogenesis of diabetic peripheral neuropathy (DPN), hemostatic dysfunction and subclinical inflammation play a possible role. Fibrinogen is involved in both the hemostatic and inflammatory pathways, so we hypothesize that fibrinogen gene polymorphisms might be associated with DPN. A total of 127 young patients with type 1 diabetes (T1D) (average age, 18. Read More

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Association Between Renal Dysfunction and Low HDL Cholesterol Among the Elderly in China.

Front Cardiovasc Med 2021 12;8:644208. Epub 2021 May 12.

Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Chronic kidney disease (CKD) and cardiovascular disease (CVD) have a high morbidity and mortality among the elderly. Low levels of high-density lipoprotein cholesterol (HDL-C), a traditional risk marker for CVD, are common in CKD patients. Little is known about the association of low HDL-C with renal dysfunction in the community dwelling population. Read More

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High-density lipoprotein cholesterol and brain aging among rural-dwelling older adults: a population-based MRI study.

Eur J Neurol 2021 May 25. Epub 2021 May 25.

Department of Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P. R. China.

Background: Current evidence supports the involvement of lipids in brain aging. We explore a range of serum lipids in association with brain structure and cognitive function among rural-dwelling older adults.

Methods: This population-based cross-sectional study included 184 rural-dwelling adults (age ≥65 years, 39. Read More

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Association of Serum Melatonin Level with Mild Cognitive Impairment in Type 2 Diabetic Patients: A Cross-Sectional Study.

Int J Endocrinol 2021 28;2021:5566019. Epub 2021 Apr 28.

Department of Endocrinology, Shanghai Pudong New District Gongli Hospital, Second Military Medical University, Shanghai 200135, China.

Objectives: Melatonin is an essential neuroendocrine hormone that participates in the regulation of sleep rhythm and cognitive function. This study aimed to determine serum melatonin levels with mild cognitive impairment (MCI) in patients with type 2 diabetes (T2DM).

Methods: A total of 247 T2DM patients were recruited in this retrospective study and divided into 75 subjects with MCI and 172 with normal cognition. Read More

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Adipose Tissue Insulin Resistance Is Longitudinally Associated With Adipose Tissue Dysfunction, Circulating Lipids, and Dysglycemia: The PROMISE Cohort.

Diabetes Care 2021 May 17. Epub 2021 May 17.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Objective: To determine the association of adipose tissue insulin resistance with longitudinal changes in biomarkers of adipose tissue function, circulating lipids, and dysglycemia.

Research Design And Methods: Adults at risk for type 2 diabetes in the Prospective Metabolism and Islet Cell Evaluation (PROMISE) cohort had up to four assessments over 9 years ( = 468). Adipose tissue insulin resistance was determined using a novel validated index, Adipo-IR, calculated as the product of fasting insulin and nonesterified fatty acids measured at baseline. Read More

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Abnormal levels of apolipoprotein A-I in chronic thromboembolic pulmonary hypertension.

Pulm Circ 2021 Apr-Jun;11(2):20458940211010371. Epub 2021 Apr 22.

Department of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.

Recent studies have shown low high-density lipoprotein cholesterol (HDL-C) and dysregulated lipid metabolism in chronic thromboembolic pulmonary hypertension (CTEPH). Apolipoprotein A-I (ApoA-I) is the major protein component of HDL-C and mediates most of its functions. We hypothesize that ApoA-1 and its oxidative state might be more sensitive biomarkers in CTEPH. Read More

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Association of lipid profile with decompensation, liver dysfunction, and mortality in patients with liver cirrhosis.

Postgrad Med 2021 May 17. Epub 2021 May 17.

Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), Shenyang, Liaoning 110840, P.R. China.

Background And Aims: Lipid metabolism is often disrupted in liver cirrhosis. The present study aimed to evaluate the impact of lipid profile on decompensation events, severity of liver dysfunction, and death in patients with liver cirrhosis.

Methods: In a cross-sectional study, 778 patients with lipid profile data were enrolled, and then were divided into 240 and 538 patients with and without liver cirrhosis, respectively. Read More

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Association of Lipid Profile with Severity of Meibomian Gland Dysfunction.

Nepal J Ophthalmol 2020 Jul;12(24):216-235

All India Institute of Medical Sciences, Rishikesh, India.

Introduction: The impact of Meibomian gland dysfunction (MGD) on the overall health of the patient is not known. Efforts are being made to understand the association of dyslipidemia with MGD. The objective of the study was to determine the association of dyslipidemia with the severity of MGD, a contributor to dry eye syndrome. Read More

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Effect of high-intensity interval training on cardiometabolic risk factors in childhood obesity: a meta-analysis.

J Sports Med Phys Fitness 2021 May;61(5):743-752

Department of Sports and Health, Guangzhou Sport University, Guangzhou, China.

Introduction: This systematic review with meta-analysis aimed to quantify the effectiveness of high-intensity interval training (HIIT) on the cardiometabolic health of obese children and adolescents.

Evidence Acquisition: Relevant articles were sourced from PubMed, Embase, the Web of Science, EBSCO, the Cochrane Library and China National Knowledge Infrastructure (CNKI). Randomized controlled trials were included if they employed participants aged 7-19 years. Read More

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Lipoproteins and fatty acids in chronic kidney disease: molecular and metabolic alterations.

Nat Rev Nephrol 2021 May 10. Epub 2021 May 10.

Institute for Molecular Cardiovascular Research, RWTH Aachen University, University Hospital, Aachen, Germany.

Chronic kidney disease (CKD) induces modifications in lipid and lipoprotein metabolism and homeostasis. These modifications can promote, modulate and/or accelerate CKD and secondary cardiovascular disease (CVD). Lipid and lipoprotein abnormalities - involving triglyceride-rich lipoproteins, LDL and/or HDL - not only involve changes in concentration but also changes in molecular structure, including protein composition, incorporation of small molecules and post-translational modifications. Read More

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Endovascular treatment of hemodialysis-induced lower limb artery ischemia: retrospective analysis from a single center.

Ann Palliat Med 2021 Apr;10(4):4661-4669

Department of Nephrology, Wuxi Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Wuxi, China.

Background: Critical limb artery ischemia is one of common complications after hemodialysis, with endovascular therapy (EVT) having become its first-line treatment. There is no relevant study investigating the relationship between EVT and the prognosis of hemodialysis patients with critical lower limb ischemia, the most common site of vascular dysfunction.

Methods: This was a retrospective, nonrandomized, single-center study. Read More

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Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease.

J Lipid Res 2021 May 5;62:100085. Epub 2021 May 5.

Research Center, CHU Ste-Justine, Université de Montréal, Montreal, Quebec, Canada; Department of Pharmacology & Physiology, Université de Montréal, Montreal, Quebec, Canada; Department of Nutrition, Université de Montréal, Montreal, Quebec, Canada. Electronic address:

Chylomicron retention disease (CRD) is an autosomal recessive disorder associated with biallelic Sar1b mutations leading to defects in intracellular chylomicron (CM) trafficking and secretion. To date, a direct cause-effect relationship between CRD and Sar1b mutation has not been established, but genetically modified animal models provide an opportunity to elucidate unrecognized aspects of these mutations. To examine the physiological role and molecular mechanisms of Sar1b function, we generated mice expressing either a targeted deletion or mutation of human Sar1b using the CRISPR-Cas9 system. Read More

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Total flavonoids of Ameliorated Bile Acid Metabolism Dysfunction in Diabetes Mellitus.

Evid Based Complement Alternat Med 2021 12;2021:6675567. Epub 2021 Apr 12.

Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China.

is one of the common traditional Chinese medicines used to treat diabetes. However, the underlying mechanism is not fully understood. Flavones are a class of active components that have been reported to exert various activities. Read More

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Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model.

Microbiome 2021 05 5;9(1):100. Epub 2021 May 5.

Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.

Background: The objective of this study was to increase understanding of the complex interactions between diet, obesity, and the gut microbiome of adult female non-human primates (NHPs). Subjects consumed either a Western (n=15) or Mediterranean (n=14) diet designed to represent human dietary patterns for 31 months. Body composition was determined using CT, fecal samples were collected, and shotgun metagenomic sequencing was performed. Read More

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Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population.

Oxid Med Cell Longev 2021 27;2021:6661940. Epub 2021 Jan 27.

Department for Medical Biochemistry, University of Belgrade-Faculty of Pharmacy, Belgrade, Serbia.

Different byproducts of oxidative stress do not always lead to the same conclusion regarding its relationship with cardiometabolic risk, since controversial results are reported so far. The aim of the current study was to examine prooxidant determinant ((prooxidant-antioxidant balance (PAB)) and the marker of antioxidant defence capacity (total sulphydryl groups (tSHG)), as well as their ratio (PAB/tSHG) in relation to different cardiometabolic risk factors in the cohort of adult population. Additionally, we aimed to examine the joint effect of various cardiometabolic parameters on these markers, since to our knowledge, there are no studies that investigated that issue. Read More

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The role of high-density lipoprotein in the regulation of the immune response: implications for atherosclerosis and autoimmunity.

Immunology 2021 May 2. Epub 2021 May 2.

Center of the Study of Chronic Diseases, New University of Lisbon, Lisbon, Portugal.

Inflammation and immune dysfunction have been increasingly recognized as crucial mechanisms in atherogenesis. Modifications in cell lipid metabolism, plasma dyslipidaemia and particularly low high-density lipoprotein (HDL) levels occur both in atherosclerosis and in autoimmune rheumatic diseases (which are strongly associated with an increased risk of atherosclerosis), suggesting the presence of a crucial link. HDL, the plasma lipoprotein responsible for reverse cholesterol transport, is known for its several protective effects in the context of atherosclerosis. Read More

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Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study.

Clin Nutr 2021 May 18;40(5):2825-2836. Epub 2021 Mar 18.

Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Unit of Cardiovascular Risk and Nutrition, Institut Hospital del Mar de Investigaciones Médicas Municipal d`Investigació Médica (IMIM), Barcelona, Spain.

Background & Aims: The Portfolio and Dietary Approaches to Stop Hypertension (DASH) diets have been shown to lower cardiometabolic risk factors in randomized controlled trials (RCTs). However, the Portfolio diet has only been assessed in RCTs of hyperlipidemic patients. Therefore, to assess the Portfolio diet in a population with metabolic syndrome (MetS), we conducted a longitudinal analysis of one-year data of changes in the Portfolio and DASH diet scores and their association with cardiometabolic risk factors in Prevención con Dieta Mediterránea (PREDIMED)-Plus trial. Read More

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