86,018 results match your criteria hdl

SARS-CoV-2 spike protein removes lipids from model membranes and interferes with the capacity of high density lipoprotein to exchange lipids.

J Colloid Interface Sci 2021 Jun 12;602:732-739. Epub 2021 Jun 12.

Biofilms - Research Center for Biointerfaces and Department of Biomedical Science, Faculty of Health and Society, Malmö University, 20506 Malmö, Sweden. Electronic address:

Cholesterol has been shown to affect the extent of coronavirus binding and fusion to cellular membranes. The severity of Covid-19 infection is also known to be correlated with lipid disorders. Furthermore, the levels of both serum cholesterol and high-density lipoprotein (HDL) decrease with Covid-19 severity, with normal levels resuming once the infection has passed. Read More

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Cancer-elicited inflammation attenuates response and outcome in tyrosine kinase inhibitor naive patients with advanced NSCLC.

Pharmacol Res 2021 Jun 19:105734. Epub 2021 Jun 19.

Biological Resource Center, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China; Jiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang 330006, China. Electronic address:

Objective: Cancer elicited inflammation is the main environmental cause leading to carcinogenesis and metastasis of non-small cell lung cancer (NSCLC). Roles of the inflammatory biomarker in predicting the clinical efficacy of tyrosine kinase inhibitor (TKI) and prognosis of naive patients with advanced NSCLC need to be determined, and the best inflammatory predicted biomarker remains unknown.

Methods: A total of 178 eligible advanced NSCLC patients (124 and 54 cases within discovery and validation cohorts, respectively) who received first-line EGFR-TKI between July of 2014 and October of 2020 were enrolled in the present study. Read More

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Influence of Crescentia cujete and Launaea taraxacifolia leaves on growth, immune indices, gut microbiota, blood chemistry, carcass, and meat quality in broiler chickens.

Trop Anim Health Prod 2021 Jun 22;53(3):365. Epub 2021 Jun 22.

Department of Animal Production, Faculty of Agriculture, University of Ilorin, Ilorin, PMB 1515, Nigeria.

The rising concerns pertaining to the safety of synthetic supplements in livestock production have encouraged the exploration of potential alternatives. This study investigated the growth, gut microbiota, blood chemistry, immune indices, meat quality, and antioxidant status in broiler chickens supplemented with Crescentia cujete leaf (CCL), Launaea taraxacifolia leaf (LTL), and a combination of antibiotic (70% oxytetracycline + 30% neomycin) and tert-Butylhydroxyanisole. One-day-old Ross 308 chicks (n = 420) were randomly assigned to either T-1, basal diet (BD) only; T-2, BD + 0. Read More

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Neck circumference and the burden of metabolic syndrome disease: a population-based sample.

J Public Health (Oxf) 2021 Jun 22. Epub 2021 Jun 22.

Department of Nutrition, Universidade Federal de Santa Catarina, Santa Catarina 88040-900, Brazil.

Background: This study aims to verify the association between neck circumference (NC) and metabolic syndrome and establish NC cut-off points to predict metabolic syndrome.

Methods: Weight, height, NC, waist circumference, body mass index, fasting plasma glucose, HDL cholesterol, triglycerides and blood pressure were measured in a cross-sectional and population-based study with 966 adults. The association between NC and the burden of metabolic syndrome disease was evaluated by multinomial logistic regression. Read More

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Household and Child Food Insecurity and Cardiovascular Disease Risk Factors in Lower-Income Adolescents Aged 12 - 17 Years from the National Health and Nutrition Examination Survey (NHANES) 2007 - 2016.

Public Health Nutr 2021 Jun 21:1-21. Epub 2021 Jun 21.

Department of Nutritional Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109.

Objective: Household food insecurity is associated with cardiovascular disease (CVD) risk factors in low-income adults, but research on these associations among adolescents is inconsistent. This study investigates whether household and child food insecurity is associated with CVD risk factors in lower-income adolescents.

Design: Cross-sectional. Read More

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Caveolin-1 Genetic Polymorphism Interact with Polyunsaturated Fatty Acids to Modulate Metabolic Syndrome Risk.

Br J Nutr 2021 Jun 21:1-23. Epub 2021 Jun 21.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Several studies have reported a significant association between metabolic syndrome (MetS) and mortality around the world. Caveolin-1 (CAV-1) has been widely studied in dyslipidemia, and several studies have indicated that CAV-1 genetic variations may correlate with dietary intake of fatty acids. This study aimed to investigate the interaction of CAV-1 rs3807992 with types of dietary fatty acid in MetS risk. Read More

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Can existing electronic medical records be used to quantify cardiovascular risk at point of care?

Intern Med J 2021 Jun 22. Epub 2021 Jun 22.

Westmead Applied Research Centre and Faculty of Medicine and Health, University of Sydney.

Background: Using electronic data for cardiovascular risk stratification could help in prioritising healthcare access and optimise cardiovascular prevention.

Aims: To determine whether assessment of absolute cardiovascular risk (Australian Absolute Cardiovascular Disease Risk, ACVDR) and short-term ischaemic risk (HEART Score) are possible from available data in Electronic Medical Record (EMR) and My Health Record (MHR) of patients presenting with acute cardiac symptoms to a Rapid Access Cardiology Clinic (RACC).

Methods: Audit of EMR and MHR on 200 randomly selected adults who presented to RACC between 1st of March 2017 and 4th February 2020. Read More

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[Effectiveness of the TG/HDL-C ratio to improve GLP-1 prescription in patients with type 2 diabetes in primary care].

Semergen 2021 Jun 19. Epub 2021 Jun 19.

Servicio de Investigación en Cuidados, Colegio de Enfermeros, Santa Cruz de Tenerife, España.

Aims: Check the usefulness of ratio TG/HDL-C≥2.5 to improve the effectiveness of GLP-1 prescribing in patients with type 2 diabetes (DM2) in primary care, and determine whether any patient profile would higher benefit.

Design: Descriptive cross-sectional study. Read More

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Effects of weight loss medications on mortality and cardiovascular events: A systematic review of randomized controlled trials in adults with overweight and obesity.

Nutr Metab Cardiovasc Dis 2021 May 28. Epub 2021 May 28.

Center for Outcomes Research and Clinical Epidemiology - CORESEARCH, Pescara, Italy. Electronic address:

Aims: Adults affected by obesity are at higher risk of premature mortality. Medications can help to lose weight and to maintain weight loss. Aim of this meta-analysis was to assess whether anti-obesity medications affect all-cause mortality, mortality due to cardiovascular events, cardiovascular risk factors and body weight. Read More

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Effect of Beetroot Consumption on Serum Lipid Profile: A Systematic Review and Meta-Analysis.

Curr Probl Cardiol 2021 May 8:100887. Epub 2021 May 8.

Cardiac Rehabilitation Research Centre, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Beetroot has recently become very popular among people as a medicinal superfood that decreases blood pressure and improves athletes' performance. The present meta-analysis aimed to investigate the effect of beetroot consumption on serum lipid profile. A literature search was conducted covering PubMed, ISI Web of Science, Scopus, and Google scholar of English human subject randomized clinical trials (RCT) up to December 2020. Read More

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Healthy eating index patterns in adults by sex and age predict cardiometabolic risk factors in a cross-sectional study.

BMC Nutr 2021 Jun 22;7(1):30. Epub 2021 Jun 22.

Obesity and Metabolism Research Unit, United States Department of Agriculture-Agricultural Research Services-Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA, 95616, USA.

Background: Associations between diet and cardiometabolic disease (CMD) risk may vary in men and women owing to sex differences in eating habits and physiology. The current secondary analysis sought to determine the ability of sex differences in dietary patterns to discriminate groups with or without CMD risk factors (CMDrf) in the adult population and if this was influenced by age.

Methods: Diet patterns and quality were evaluated using 24 h recall-based Healthy Eating Index (HEI-2015) in free-living apparently healthy men (n = 184) and women (n = 209) 18-65 y of age with BMIs of 18-44 kg/m. Read More

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The Impact of Subclinical Hypothyroidism on Patients with Polycystic Ovary Syndrome: A Meta-Analysis.

Horm Metab Res 2021 Jun 21;53(6):382-390. Epub 2021 Jun 21.

Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China.

The association between subclinical hypothyroidism (SCH) and polycystic ovary syndrome (PCOS) has been shown in many studies. These findings are still controversial, however. It is unclear whether the co-incidence of subclinical hypothyroidism and polycystic ovary syndrome will affect the severity of metabolism. Read More

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Beneficial effects of dietary supplementation with olive oil, oleic acid, or hydroxytyrosol in metabolic syndrome: systematic review and meta-analysis.

Free Radic Biol Med 2021 Jun 18. Epub 2021 Jun 18.

Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS & IDISBA, E-07122 Palma de Mallorca, Spain; CIBEROBN (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain. Electronic address:

Background And Aims: Olive oil and components might have a beneficial effect on Metabolic Syndrome (MetS). The aim of this review and meta-analysis was to assess whether those effects are related to hydroxytyrosol or oleic acid contents, or the combination of them as olive oil, and how powerful is this effect.

Methods: A systematic literature search was performed in MEDLINE via Pubmed, Web of Science (WOS) core collection, and Virtual Health Library (VHL) via LILACS and IBECS (Spain). Read More

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Carboxylesterase 1d (Ces1d) does not contribute to cholesteryl ester hydrolysis in the liver.

J Lipid Res 2021 Jun 18:100093. Epub 2021 Jun 18.

Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Mouse carboxylesterase 1d (Ces1d) and its human ortholog CES1 have been described to possess lipase activity and play a role in hepatic triacylglycerol (TG) metabolism and very-low density lipoprotein (VLDL) assembly. Liver is a central organ regulating cholesterol synthesis, storage, transport, and elimination. It has been proposed that Ces1d/CES1 might also catalyze cholesteryl ester (CE) hydrolysis in the liver and be responsible for the hydrolysis of high-density lipoprotein (HDL)-derived CE, thus contributing to the final step in the reverse cholesterol transport (RCT) pathway, where cholesterol is secreted from the liver into bile and feces, either directly or after conversion to water-soluble bile salts. Read More

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Magnitude, components and predictors of metabolic syndrome in Northern Ethiopia: Evidences from regional NCDs STEPS survey, 2016.

PLoS One 2021 21;16(6):e0253317. Epub 2021 Jun 21.

Tigray Health Research Institute, Mekelle, Tigray, Ethiopia.

Background: Individuals with metabolic syndrome are five times more susceptible to chronic diseases. Assessment of its magnitude, components, and risk factors is essentials to deploy visible interventions needed to avoid further complications. The study aimed to assess magnitude, components, and predictors of metabolic syndrome in Tigray region northern Ethiopia, 2016. Read More

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Effect of thymoquinone on high fat diet and STZ-induced experimental type 2 diabetes: A mechanistic insight by in vivo and in silico studies.

J Food Biochem 2021 Jun 21:e13807. Epub 2021 Jun 21.

Pharmaceutical Chemistry & Pharmacognosy Department, Unaizah College of Pharmacy, Qassim University, Unaizah, Saudi Arabia.

The aim was to investigate whether thymoquinone (TQ) attenuates hyperglycemia-induced insulin resistance in experimental type 2 diabetes. Type 2 diabetes mellitus (T2DM) was induced by injection of streptozotocin (STZ, 40 mg/kg) in high fat diet (HFD) rats. The levels of glucose, insulin, area under curve (AUC) of glucose, lipid profile parameters, homeostasis model assessment of insulin resistance (HOMA-IR), peroxisome proliferator-activated receptor-γ (PPARγ), and dipeptidyl peptidase peptidase-IV (DPP-IV) were evaluated in HFD + STZ-induced type 2 diabetic rats. Read More

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The causal effects of serum lipids and apolipoproteins on kidney function: multivariable and bidirectional Mendelian-randomization analyses.

Int J Epidemiol 2021 Jun 21. Epub 2021 Jun 21.

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Background: The causal nature of the observed associations between serum lipids and apolipoproteins and kidney function are unclear.

Methods: Using two-sample and multivariable Mendelian randomization (MR), we examined the causal effects of serum lipids and apolipoproteins on kidney function, indicated by the glomerular-filtration rate estimated using creatinine (eGFRcrea) or cystatin C (eGFRcys) and the urinary albumin-to-creatinine ratio (UACR). We obtained lipid- and apolipoprotein-associated genetic variants from the Global Lipids Genetics Consortium (n = 331 368) and UK Biobank (n = 441 016), respectively, and kidney-function markers from the Trøndelag Health Study (HUNT; n = 69 736) and UK Biobank (n = 464 207). Read More

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Oncogenic human papillomavirus in breast cancer: molecular prevalence in a group of Congolese patients.

Access Microbiol 2021 Mar 23;3(3):000216. Epub 2021 Mar 23.

Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, Republic of the Congo.

Background: Since the work of Band . in 1990 ( 87:463-467), several studies have suggested a possible link between the pathogenesis of breast cancer and viral infection. Infection with oncogenic HPV has been one of the viruses implicated in breast cancer cases worldwide. Read More

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Comparative effects of insulin glulisine and lispro on postprandial plasma glucose and lipid profile in Japanese patients with type 2 diabetes mellitus.

Diabetol Int 2021 Jul 17;12(3):330-335. Epub 2020 Nov 17.

Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, 910-1193 Japan.

Objective: The control of postprandial plasma glucose (PPG) excursions is critical in the prevention of diabetic complications. Controversy remains on the differences in postprandial actions of insulin glulisine and lispro. The aim of this study was to define the differences in the efficacy of these two insulin analogues on PPG. Read More

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The correlation study on homocysteine, blood lipids and blood glucose levels in patients with cerebral infarction.

Am J Transl Res 2021 15;13(5):5659-5664. Epub 2021 May 15.

Department of Pharmacy, Affiliated RICH Hospital of Nantong University Nantong 226010, Jiangsu, China.

Purpose: To explore the correlation of changes in homocysteine (HCY) l, blood lipids and blood glucose levels in patients with cerebral infarction.

Methods: 120 patients with cerebral infarction admitted to our hospital from February 2018 to February 2020 were selected as the experimental group, and 120 healthy volunteers in the same period were selected as the control group. The blood pressure and the homocysteine, blood lipids, blood glucose levels were compared; the experimental group was subdivided into single cerebral infarction group, combined diabetes group and combined hypertension group, and their blood lipid levels were compared with the control group; Spearman method was used to analyze the relationship between HCY, blood lipid, blood sugar levels and cerebral infarction. Read More

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Effects of yeast hydrolysate on growth performance, serum parameters, carcass traits, meat quality and antioxidant status of broiler chickens.

J Sci Food Agric 2021 Jun 19. Epub 2021 Jun 19.

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, P.R. China.

Backgroud: Yeast hydrolysate (YH) has multiple salutary biological activities. Nevertheless, the application of YH in broiler production is limited. This study was conducted to evaluate the protective effects of YH derived from Saccharomyces cerevisiae by exploring growth performance, serum parameters, organs relative weight, carcass traits, meat quality and antioxidant status of broilers. Read More

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Association of SIRT6 circulating levels with urinary and glycometabolic markers in pre-diabetes and diabetes.

Acta Diabetol 2021 Jun 20. Epub 2021 Jun 20.

Advanced Institute for Medical Sciences, Dalian Medical University, Lvshun South Road west 9, Dalian, 116044, Liaoning, China.

Aim: The study is aimed to detect the expression of serum Sirtuin 6 (SIRT6) with different severities and urinary albumin creatinine ratios (UACR) in type 2 diabetes mellitus (T2DM) patients, thus exploring the association of SIRT6 together with glycolipid metabolism and urinary protein in the cross-sectional study.

Methods: T2DM patients (313 cases), pre-diabetic patients (102 cases), and healthy volunteers (100 cases) were selected. T2DM patients were divided into the normal albuminuria (103 cases, UACR < 30 mg/g), micro-albuminuria (106 cases, UACR 30-300 mg/g), and large amount of albuminuria group (104 cases, UACR > 300 mg/g) based on different UACR levels. Read More

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Evaluation of antidiabetic activity of dietary phenolic compound chlorogenic acid in streptozotocin induced diabetic rats: Molecular docking, molecular dynamics, in silico toxicity, in vitro and in vivo studies.

Comput Biol Med 2021 May 2;134:104462. Epub 2021 May 2.

Department of Biochemistry, University of Allahabad, Prayagraj, 211002, India. Electronic address:

Background: Chlorogenic acid is amongst the well-known polyphenolic compounds being used in human food and beverages. Its presence has been reported in tea leaves, roasted green beans, coffee, cocoa, berry fruits, apples, citrus fruits, and pears.

Objective: The present study aims to elucidate the effectiveness of chlorogenic acid on in silico and in vitro inhibition of glucose metabolising enzymes (α-amylase and α-glucosidase) and on blood-based markers associated with diabetic complications in vivo. Read More

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Direction of association between Cardiovascular risk and depressive symptoms during the first 18 years of life: A prospective birth cohort study.

J Affect Disord 2021 Jun 9;292:508-516. Epub 2021 Jun 9.

Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Avon and Wiltshire Mental Health Partnership NHS Trust, Bristol, United Kingdom.

Background: Cardiovascular disease (CVD) and depression are bidirectionally associated in adults. However, the direction of association between CVD risk and depressive symptoms in young people and potential mechanisms are poorly understood.

Methods: Using longitudinal birth cohort data, we created a CVD risk score age at 15 using age, ethnicity, physical activity, maternal social status, maternal smoking, own smoking, BMI, systolic blood pressure, LDL, HDL and triglycerides. Read More

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The Role of RNA-Targeted Therapeutics to Reduce ASCVD Risk: What Have We Learned Recently?

Curr Atheroscler Rep 2021 Jun 19;23(8):40. Epub 2021 Jun 19.

Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Av. Dr. Enéas C. Aguiar 44 CEP, São Paulo, SP, -05403-900, Brazil.

Purpose Of Review: To discuss advances on the RNA-targeted therapies to treat dyslipidemia with the aim of reducing atherosclerotic cardiovascular disease (ASCVD).

Recent Findings: Genetic studies have paved the way for therapies that reduce translation of proteins that play causal roles in dyslipidemia and atherosclerosis like proprotein convertase subtilisin/kexin type 9 (PCSK9), apolipoprotein B-100 (apoB), apolipoprotein(a) [apo(a)], apolipoprotein C3 (apoC3), and angiopoietin-like 3 (ANGPTL3). Either antisense oligonucleotide (ASO) therapies and small interfering RNA (siRNA) molecules inhibit protein synthesis and consequently improve dyslipidemia. Read More

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Specific Dietary Protein Sources Are Associated with Cardiometabolic Risk Factors in the Boston Puerto Rican Health Study.

J Acad Nutr Diet 2021 Jun 15. Epub 2021 Jun 15.

Background: Puerto Rican adults residing in the US mainland experience a high prevalence of metabolic syndrome (MetS). A diet containing healthy protein-rich sources may help control risk factors for MetS.

Objective: This study aimed to evaluate 2-year longitudinal associations between intake of various protein-rich foods and changes in the six MetS components. Read More

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Vitamin D status and vitamin D deficiency risk factors among pregnancy of Shanghai in China.

BMC Pregnancy Childbirth 2021 Jun 18;21(1):431. Epub 2021 Jun 18.

School of Medicine, The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: There is increasing awareness that vitamin D deficiency in pregnant women may be associated with several adverse effects for the mother and newborn. The risks for vitamin D deficiency are unclear. This study was to assess vitamin D nutritional status and vitamin D deficiency risk factors among pregnant women in Shanghai in China. Read More

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Trends of Dyslipidemia in Korean Youth According to Sex and Body Mass Index: Based on the Korea National Health and Nutrition Examination Survey (2007- 2018).

J Pediatr 2021 Jun 15. Epub 2021 Jun 15.

From the Department of Pediatrics, Severance Children's Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea. Electronic address:

Objective: To assess trends of dyslipidemia among youth, we investigated secular trends in serum lipid levels from 2007 to 2018 and the current prevalence of dyslipidemia in Korean children and adolescents.

Study Design: This cross-sectional study investigated lipid profiles of 10,734 youths aged 10-18 years using data from phases Ⅳ-Ⅶ of the Korea National Health and Nutritional Examination Survey. We assessed age-, sex-, and body mass index (BMI)-adjusted mean levels of lipids at each survey. Read More

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Hashimoto's thyroiditis is associated with elevated serum uric acid to High Density Lipoprotein-Cholesterol ratio.

Rom J Intern Med 2021 Jun 17. Epub 2021 Jun 17.

Abant Izzet Baysal University Hospital, Department of Internal Medicine, Bolu, Turkey.

. Hashimoto's thyroiditis (HT) is an auto-immune condition characterized with lymphocytic and fibroblastic infiltration of the thyroid gland. The rate of uric acid and HDL cholesterol; so called as uric acid to HDL ratio (UHR) has been shown to be elevated in inflammatory conditions diseases. Read More

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Evaluation of clinical, endocrine and metabolic findings in obese children with and without hepatosteatosis.

J Pediatr Endocrinol Metab 2021 Jun 16. Epub 2021 Jun 16.

Department of Pediatrics,Zeynep Kamil Women and Children's Diseases Training and Research Hospital, Üsküdar, Istanbul, Turkey.

Objectives: Non-alcoholic fatty liver disease (NAFLD) is a common obesity-related comorbidity in childhood. In this study, we aimed to evaluate predictors of NAFLD by comparing clinical, endocrine and metabolic findings in obese children with and without hepatosteatosis.

Methods: Two hundred and eight obese children aged 6-18 years were included. Read More

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