525 results match your criteria hba1c estimation

Combining serum 1,5-anhydroglucitol with fasting plasma glucose to detect diabetes mellitus in a community-based population with hypertension.

Ann Palliat Med 2021 Aug;10(8):8746-8752

Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Nanjing, China.

Background: The early diagnosis and treatment of diabetes mellitus has significant clinical benefits. However, the current diagnostic tools available for community-based populations are limited. This study sought to evaluate the clinical benefits of combining serum 1,5-anhydroglucitol (1,5-AG) with fasting plasma glucose (FPG) to detect diabetes in a community-based population with hypertension. Read More

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Effect of Conventional Periodontal Treatment (Scaling and Root Planing) on Type-2 Diabetic Patient with Moderate Generalized Chronic Periodontitis: A Clinical Study.

J Pharm Bioallied Sci 2021 Jun 5;13(Suppl 1):S706-S710. Epub 2021 Jun 5.

Department of Periodontics, Private Practitioner, Patna, Bihar, India.

Background: The aim is to assess the effect of periodontal therapy and scaling and root planing (SRP) on the metabolic control in Type 2 diabetes mellitus (DM) patients with chronic periodontitis based on the estimation of glycated hemoglobin (HbA1c).

Materials And Methods: A prospective, comparative, clinical study was performed on 50 patients suffering from Type 2 DM with moderate, generalized chronic periodontitis. Type 2 moderately controlled diabetic patients with HbA1c values within the range of 6%-8% were selected. Read More

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Non-dipping pattern in early-stage diabetes: association with glycemic profile and hemodynamic parameters.

J Hum Hypertens 2021 Aug 16. Epub 2021 Aug 16.

3rd Department of Internal Medicine, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Patients with longstanding diabetes exhibit diminished nocturnal blood pressure (BP) drop, yet this phenomenon remains understudied in the early stages of the disease. Eighty patients with newly diagnosed (<6 months) Diabetes Mellitus type 2 (T2DM) and 80 non-T2DM individuals underwent office and 24-h ambulatory BP measurements, estimation of hemodynamic parameters using impedance cardiography and blood tests. Ten-year atherosclerotic cardiovascular disease (ASCVD) risk score was calculated. Read More

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Estimation of inter-laboratory reference change values from external quality assessment data.

Biochem Med (Zagreb) 2021 Oct 5;31(3):030902. Epub 2021 Aug 5.

Institute of Laboratory Medicine, University Hospital, LMU Munich, Germany.

Introduction: It is common for patients to switch between several healthcare providers. In this context, the long-term follow-up of medical conditions based on laboratory test results obtained from different laboratories is a challenge. The measurement uncertainty in an inter-laboratory context should also be considered in data mining research based on routine results from randomly selected laboratories. Read More

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October 2021

Antenatal prediction of fetal macrosomia in pregnancies affected by maternal pre-gestational diabetes.

J Matern Fetal Neonatal Med 2021 Jul 6:1-5. Epub 2021 Jul 6.

Obstetrics and Gynecology, National Maternity Hospital, Dublin, Ireland.

Aims: Higher rates of fetal macrosomia may occur in infants of women with pre-gestational diabetes compared with non-diabetic controls. Antenatal predication of fetal macrosomia remains challenging. Ultrasound over-estimated fetal weight could result in over-classification of fetuses as macrosomic with corresponding inappropriate clinical interventions. Read More

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Serum netrin and VCAM-1 as biomarker for Egyptian patients with type IΙ diabetes mellitus.

Biochem Biophys Rep 2021 Sep 11;27:101045. Epub 2021 Jun 11.

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Egypt.

Objective: This study aimed to evaluate the serum level of netrin and soluble vascular cell adhesion molecule 1 (VCAM-I) in patients with type IΙ diabetes mellitus (T2DM) and evaluate the association of their levels with the development of a diabetic complication.

Patients And Methods: This study was carried out on type II diabetic patients with and without complications and healthy individuals served as controls. All subjects were submitted to the estimation of serum lipid profile, serum creatinine, urinary albumin/creatinine ratio (ACR), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), visceral adiposity index (VAI), atherogenic index of plasma (AIP), lipid accumulation product (LAP) and detection of serum level of netrin1 and VCAM1. Read More

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September 2021

Gray Matter Abnormalities in Type 1 and Type 2 Diabetes: A Dual Disorder ALE Quantification.

Front Neurosci 2021 7;15:638861. Epub 2021 Jun 7.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong.

Diabetes mellitus (DM) is associated with comorbid brain disorders. Neuroimaging studies in DM revealed neuronal degeneration in several cortical and subcortical brain regions. Previous studies indicate more pronounced brain alterations in type 2 diabetes mellitus (T2DM) than in type 1 diabetes mellitus (T1DM). Read More

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Performance of early risk assessment tools to predict the later development of gestational diabetes.

Eur J Clin Invest 2021 Jun 18:e13630. Epub 2021 Jun 18.

Department of Obstetrics and Gynaecology, Medical University of Vienna, Vienna, Austria.

Background: Several prognostic models for gestational diabetes mellitus (GDM) are provided in the literature; however, their clinical significance has not been thoroughly evaluated, especially with regard to application at early gestation and in accordance with the most recent diagnostic criteria. This external validation study aimed to assess the predictive accuracy of published risk estimation models for the later development of GDM at early pregnancy.

Methods: In this cohort study, we prospectively included 1132 pregnant women. Read More

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Improved individual and population-level HbA1c estimation using CGM data and patient characteristics.

J Diabetes Complications 2021 08 17;35(8):107950. Epub 2021 May 17.

Department of Management Science and Engineering, Stanford School of Engineering, Stanford, CA, USA; Division of Pediatric Endocrinology, Stanford School of Medicine, Stanford, CA, USA; Lucile Packard Children's Hospital, Stanford, CA, USA; Stanford Diabetes Research Center, Stanford School of Medicine, Stanford, CA, USA; Clinical Excellence Research Center, Stanford School of Medicine, Stanford, CA, USA. Electronic address:

Machine learning and linear regression models using CGM and participant data reduced HbA1c estimation error by up to 26% compared to the GMI formula, and exhibit superior performance in estimating the median of HbA1c at the cohort level, potentially of value for remote clinical trials interrupted by COVID-19. Read More

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Derivation and validation of gray-box models to estimate noninvasive in-vivo percentage glycated hemoglobin using digital volume pulse waveform.

Sci Rep 2021 Jun 9;11(1):12169. Epub 2021 Jun 9.

Department of Electronics Engineering, Kookmin University, Seoul, South Korea.

Glycated hemoglobin and blood oxygenation are the two most important factors for monitoring a patient's average blood glucose and blood oxygen levels. Digital volume pulse acquisition is a convenient method, even for a person with no previous training or experience, can be utilized to estimate the two abovementioned physiological parameters. The physiological basis assumptions are utilized to develop two-finger models for estimating the percent glycated hemoglobin and blood oxygenation levels. Read More

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Glycated Hemoglobin and Subclinical Atherosclerosis in People Without Diabetes.

J Am Coll Cardiol 2021 Jun;77(22):2777-2791

Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain; Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

Background: The metabolic injury caused by protein glycation, monitored as the level of glycated hemoglobin (HbA1c), is not represented in most risk scores (i.e., Systematic Coronary Risk Estimation or atherosclerotic cardiovascular disease risk scale). Read More

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Prevalence of Prediabetes and Undiagnosed Diabetes Among Kuwaiti Adults: A Cross-Sectional Study.

Diabetes Metab Syndr Obes 2021 17;14:2167-2176. Epub 2021 May 17.

St. Antony's College, University of Oxford, Oxford, UK.

Purpose: This study aimed to estimate the prevalence of prediabetes and undiagnosed type 2 diabetes mellitus (T2DM) according to fasting plasma glucose (FPG), 2-h plasma glucose (PG) during oral glucose tolerance test (OGTT), and glycated hemoglobin (HbA1c) among a sample of Kuwaiti adults. In addition, associations of prediabetes and undiagnosed T2DM with sex, age, and body mass index (BMI) were assessed.

Methods: A cross-sectional study enrolled 1238 subjects aged 18-65 years who reported no prior history of DM. Read More

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Economic evaluation of home medication review by community pharmacists (HMR-CP) for patients with type 2 diabetes mellitus (T2DM).

J Med Econ 2021 Jan-Dec;24(1):730-740

Department of Pharmacy Practice, Faculty of Pharmacy, Universiti Teknologi MARA, Cawangan Selangor, Kampus Puncak Alam, Selangor, Malaysia.

Objective: Home medication review (HMR) programs could minimise patients' health-related costs and burdens, thereby enhancing the quality of life and well-being. The aim of this economic evaluation is to determine if home medication review by community pharmacists (HMR-CP) for patients with type 2 diabetes mellitus (T2DM) is a cost-effective intervention from the Malaysian healthcare provider perspective.

Methods: The economic evaluation was conducted alongside the randomised controlled trial (RCT) to estimate the intermediate cost-effectiveness of HMR-CP for patients with T2DM. Read More

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Accurate prediction of HbA1c by continuous glucose monitoring using a kinetic model with patient-specific parameters for red blood cell lifespan and glucose uptake.

Diab Vasc Dis Res 2021 May-Jun;18(3):14791641211013734

Abbott Diabetes Care, Alameda, CA, USA.

Background: A recent kinetic model proposed a new individualized glycaemic marker, calculated HbA1c (cHbA1c), based on kinetic parameters and glucose levels that are specific to each person. The aims of the current work were to validate the accuracy of this glucose metric for clinical use and evaluate data requirements for the estimation of personal kinetic factors.

Methods: We retrieved HbA1c and glucose data from a group of 51 Japanese T1D patients under sensor-augmented pump (SAP) therapy. Read More

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Comparison of Equations Estimating Resting Metabolic Rate in Older Adults with Type 2 Diabetes.

J Clin Med 2021 Apr 12;10(8). Epub 2021 Apr 12.

The Academic College at Wingate, Wingate Institute, Netanya 42902, Israel.

Measuring resting metabolic rate (RMR) is time-consuming and expensive, and thus various equations for estimating RMR have been developed. This study's objective was to compare five equations in elderly people with type 2 diabetes (T2DM). RMR was measured in 90 older adults (≥65 years) with T2DM (mean body mass index (BMI) of 31. Read More

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Efficacy and safety of nelfinavir in asymptomatic and mild COVID-19 patients: a structured summary of a study protocol for a multicenter, randomized controlled trial.

Trials 2021 Apr 28;22(1):309. Epub 2021 Apr 28.

Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.

Objectives: The aim of this trial is to evaluate the antiviral efficacy, clinical efficacy, and safety of nelfinavir in patients with asymptomatic and mild COVID-19.

Trial Design: The study is designed as a multicenter, open-label, blinded outcome assessment, parallel group, investigator-initiated, exploratory, randomized (1:1 ratio) controlled clinical trial.

Participants: Asymptomatic and mild COVID-19 patients will be enrolled in 10 university and teaching hospitals in Japan. Read More

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Seasonal variation in estimated cardiovascular risk in patients with type 2 diabetes.

Nutr Metab Cardiovasc Dis 2021 05 6;31(5):1494-1500. Epub 2021 Feb 6.

Department of Medicine and Rehabilitation, Policlinico di Monza, Monza, Italy; School of Medicine and Surgery, University of Milano Bicocca, Milan, Italy. Electronic address:

Background And Aims: Seasonal variations in several risk factors for cardiovascular events (CVD) were described. Here, we evaluate the impact of seasonal variations in blood pressure (BP), lipid profile and glycemic control on estimated CVD risk in patients with type 2 diabetes (T2D).

Methods And Results: Retrospective monocentric study of patients with T2D who were visited at least once in the winter period and once in the summer period, less than 8 months apart, for which data related to systolic (S) BP, diastolic (D) BP, body mass index, glycosylated hemoglobin (HbA1c), total cholesterol, HDL cholesterol and smoking habit were available on both occasions. Read More

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Skin autofluorescence predicts cancer in subjects with type 2 diabetes.

BMJ Open Diabetes Res Care 2021 03;9(1)

Nutrition-Diabetology, CHU de Bordeaux, Hôpital Haut-Lévêque, Pessac, France.

Introduction: Subjects with type 2 diabetes have an excess risk of cancer. The potential role of advanced glycation end products (AGEs) accumulated during long-term hyperglycemia in cancer development has been suggested by biological studies but clinical data are missing. AGEs can be estimated by measuring the skin autofluorescence. Read More

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Exocrine and endocrine functions and pancreatic volume in patients with pancreatic trauma.

Eur J Trauma Emerg Surg 2021 Mar 14. Epub 2021 Mar 14.

Division of Trauma Surgery and Critical Care, Department of Surgical Disciplines, JPN Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, 29, India.

Introduction: Injury to the pancreas may lead to significant morbidity and mortality. We aim to assess pancreatic endocrine and exocrine functions and evaluated morphological regenerations of pancreas following partial pancreatectomy in patients with pancreatic trauma.

Methods: The study was performed between June 2016 and December 2017. Read More

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Personalized diabetes management: what do patients with diabetes mellitus prefer? A discrete choice experiment.

Eur J Health Econ 2021 Apr 15;22(3):425-443. Epub 2021 Feb 15.

Gesundheitsökonomie und Medizinmanagement, Hochschule Neubrandenburg, Brodaer Straße 2, 17033, Neubrandenburg, Germany.

Background: There are unresolved procedural and medical problems in the care of diabetes, which cause high costs for health systems. These include the inadequate glycemic adjustment, care gaps, therapeutic inertia, and a lack of motivation. Personalized diabetes management can be seen as a kind of "standard process" that provides both physicians and patients with a framework. Read More

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Relationship between diabetic retinopathy microalbuminuria and other modifiable risk factors.

Prim Care Diabetes 2021 06 4;15(3):567-570. Epub 2021 Feb 4.

Eye Q Vision Pvt Limited, Gurugram, Haryana, India.

Background: Diabetic Retinopathy (DR) is an important microvascular complication of diabetes that can lead to irreversible blindness. Microalbuminuria is strongly associated with diabetic retinopathy and can be used as a reliable marker of diabetic retinopathy.

Aim: To assess the association between DR, microalbuminuria, and other modifiable risk factors in patients with type 2 diabetes. Read More

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Deintensification of basal-bolus insulin after initiation of GLP-1RA in patients with type 2 diabetes under routine care.

Diabetes Res Clin Pract 2021 Mar 3;173:108686. Epub 2021 Feb 3.

Department of Medicine, University of Padova, 35128 Padova, Italy. Electronic address:

Aims: We evaluated de-intensification of basal-bolus insulin (BBI) after initiation of a GLP-1 receptor agonist (GLP-1RA) under routine care.

Research Design And Methods: This retrospective, multicenter study conducted at outpatient clinics in North-East Italy collected data on patients with T2D on BBI who initiated a GLP-1RA. Patients were divided according to whether they de-intensified BBI at the end of observation by stopping prandial insulin. Read More

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The poor quality of diabetes care in a cluster randomized community survey from Delhi (DEDICOM-II): A crisis, an opportunity.

Diabet Med 2021 Sep 5;38(9):e14530. Epub 2021 Feb 5.

Sitaram Bhartia Institute of Science and Research, New Delhi, India.

Aims: To evaluate the quality of care in known diabetes patients of Delhi.

Methods: A cross-sectional survey was conducted using a two-stage cluster design. In all, 30 of 150 wards were chosen in Stage 1 (using a random computer-generated seed value and then selecting wards at a predefined sampling interval; Probability Proportionate to Size-Systematic) and one colony from each ward was selected randomly in Stage 2. Read More

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September 2021

Assessment of serum and salivary adiponectin levels in newly diagnosed Type II diabetes mellitus patients.

J Oral Maxillofac Pathol 2020 May-Aug;24(2):245-250. Epub 2020 Sep 9.

Department of Oral Pathology, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India.

Background: Adiponectin, an adipocytokine, plays an important role in the development of Type 2 Diabetes Mellitus (T2DM) in obese and cardiovascular disease patients, with few studies having observed low plasma concentrations. Persistent low-grade inflammation, an important feature in T2DM and obesity, bears an indirect influence on insulin resistance and insulin secretion and is reflected by increased plasma levels of C-reactive protein (CRP). Thus, low levels of anti-inflammatory cytokine, adiponectin, depicts that inflammation could be the link between T2DM, obesity and adiponectin. Read More

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September 2020

Role of antimicrobial photodynamic therapy in reducing whole salivary oral yeasts colonization in type-2 diabetic and non-diabetic patients with and without dental implants.

Photodiagnosis Photodyn Ther 2021 Mar 14;33:102183. Epub 2021 Jan 14.

Department of Prosthodontics, Riyadh Elm University, Riyadh, Saudi Arabia.

Objective: The aim was to assess the impact of antimicrobial photodynamic therapy (aPDT) in reducing whole salivary oral yeasts colonization in type-2 diabetic and non-diabetic patients with dental implants.

Methods: Type-2 diabetic and self-reported non-diabetic patients were included. Participants were divided into the following groups: Group-1: Type-2 diabetic patients with dental implants; Group-2: Non-diabetic patients with dental implants; Group-3: Type-2 diabetic patients without dental prostheses; Group-4: Non-diabetic patients without dental prostheses. Read More

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Estimation of the hemoglobin glycation rate constant.

Sci Rep 2021 01 13;11(1):986. Epub 2021 Jan 13.

Department of Internal Medicine, Hakuhokai Central Hospital, Hyogo, 661-0953, Japan.

In a previous study, a method of obtaining mean erythrocyte age ([Formula: see text]) from HbA1c and average plasma glucose (AG) was proposed. However, the true value of the hemoglobin glycation constant ([Formula: see text] dL/mg/day), required for this model has yet to be well characterized. Another study also proposed a method of deriving [Formula: see text] from erythrocyte creatine (EC). Read More

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January 2021

In patients with type 2 diabetes the presence of Hashimoto's thyroiditis reduces the beneficial effect of dipeptidyl peptidase-4 inhibitor on plasma glucose control.

Endocr J 2021 May 7;68(5):599-603. Epub 2021 Jan 7.

Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.

In this study, we compared the efficacy of a dipeptidyl peptidase-4 inhibitor (DPP4i) to improve glucose control in patients with type 2 diabetes mellitus (T2DM) with or without Hashimoto's thyroiditis (HT). First, we compared the change in glycated hemoglobin (HbA1c) between the hypothyroid condition (before levothyroxine sodium hydrate [LT4] treatment) and euthyroid condition (after LT4 treatment when patients had achieved euthyroidism for at least six months) in patients with T2DM and HT. Next, we compared the change in HbA1c levels before and six months of DPP4i treatment in patients with T2DM with and without HT. Read More

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Diabetes mellitus in pheochromocytoma and paraganglioma: Prevalence, dynamics of insulin secretion / sensitivity and predictors of remission.

Diabetes Metab Syndr 2020 Nov-Dec;14(6):2169-2175. Epub 2020 Nov 5.

Department of Endocrinology and Metabolism, All India Institute of Medical Sciences(AIIMS), New Delhi, India.

Background And Aims: Pheochromocytoma and paraganglioma (PPGL) are associated with dysglycemia and diabetes mellitus (DM) much of which improves post operatively. In this study, we set out to ascertain pre and post-operative prevalence of DM in patients with PPGL based on oral glucose tolerance test (OGTT) and HbA1c and to evaluate effect of insulin secretion and sensitivity indices on DM pre-operatively.

Methods: Clinical and anthropometric data collection, HbA1c, 75 g OGTT with serum insulin estimation were done pre-operatively (n = 34) and at follow-up after successful surgery (n = 24) in patients with PPGL. Read More

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November 2020

Early Diabetic Nephropathy and Retinopathy in Patients with Type 1 Diabetes Mellitus Attending Sudan Childhood Diabetes Centre.

J Diabetes Res 2020 24;2020:7181383. Epub 2020 Nov 24.

Department of Paediatric and Child Health, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Objective: Data on microvascular complications in children and adolescents with type 1 diabetes mellitus (T1DM) in Sudan are scarce. This study was aimed at determining the prevalence of diabetic nephropathy (DN) and retinopathy (DR) and their relationship to certain risk factors in children with T1DM attending the Sudan Childhood Diabetes Centre. . Read More

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November 2020

Oral glucose tolerance test does not affect degree of hemoglobin glycation as measured by routine assay.

Ann Endocrinol (Paris) 2020 Dec 2;81(6):545-550. Epub 2020 Dec 2.

Labormedizinisches Zentrum Dr. Risch, Vaduz, Liechtenstein.

Background: Hemoglobin A1c (HbA1c) is an accurate index of fluctuation in glycemia over the 2-3 months prior to quantitative assessment. During this time, hemoglobin (Hb) slowly glycates until it shows the properties of advanced glycation end-products. Glycation kinetics is intensified by prolonged glucose exposure. Read More

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December 2020