15,572 results match your criteria hba1c cohort


Demographic and clinical characteristics of a population-based paediatric cohort of type 1 and type 2 diabetes in Western Australia (1999-2019).

Pediatr Diabetes 2021 Sep 18. Epub 2021 Sep 18.

Children's Diabetes Centre, Telethon Kids Institute, The University of Western Australia, Perth, Western Australia.

Objectives: To determine demographic and clinical characteristics of youth diagnosed with type 1 (T1D) or type 2 (T2D) diabetes aged ≤15 years from 1999-2019 in Western Australia, and examine time to first diagnosis of diabetes complications.

Methods: A retrospective cohort study was conducted of patients identified from the population-based, prospective Western Australian Children's Diabetes Database and longitudinal data extracted for available demographic and clinical variables. Patients were followed from diagnosis to transition to adult services, death or 31 December 2019. Read More

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September 2021

Associations of Race, Insurance, and Zip Code-Level Income with Nonadherence Diagnoses in Primary and Specialty Diabetes Care.

J Am Board Fam Med 2021 Sep-Oct;34(5):891-897

From the Department of Medicine, Massachusetts General Hospital, Boston, MA (SB); Perelman School of Medicine, University of Pennsylvania Philadelphia, PA (DJA); Department of Medical Ethics and Health Policy, University of Pennsylvania (SB); Pritzker School of Medicine, University of Chicago, Chicago, IL (IJLH); Department of Medicine, Section of General Internal Medicine, University of Chicago (ELT); Chicago Center for Diabetes Translation Research, University of Chicago (ELT); Department of Family Medicine and Community Health, University of Pennsylvania (PFC); Center for Public Health Initiatives, University of Pennsylvania (PFC); Leonard Davis Institute of Health Economics, University of Pennsylvania (PFC).

Introduction: Evidence suggests that clinicians may view or label patients as nonadherent in a biased manner. Therefore, we performed a retrospective cohort analysis exploring associations between patient demographics and zip code-level income with the (ICD-10) diagnoses for nonadherence among type 2 diabetes mellitus (T2DM) patients, comparing primary and specialty care settings. Providers in the primary care group included internal medicine and family medicine physicians. Read More

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December 2020

Questionnaire-based service evaluation of the efficacy and usefulness of SEREN: a structured education programme for children and young people diagnosed with type 1 diabetes mellitus.

BMJ Open Qual 2021 Sep;10(3)

Department of Paediatrics, Princess of Wales Hospital, Bridgend, UK

Objectives: To evaluate the usefulness and effectiveness of a new structured education module for children with type 1 diabetes: S E R E N (SEREN) 'Diabetes at Diagnosis'.

Design: Retrospective questionnaire-based service evaluation.

Setting: 12/14 paediatric diabetes centres across Wales took part. Read More

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September 2021

Development and Progression of Diabetic Retinopathy in Adolescents and Young Adults With Type 2 Diabetes: Results From the TODAY Study.

Authors:

Diabetes Care 2021 Sep 16. Epub 2021 Sep 16.

Objective: The Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study reported a 13.9% prevalence of diabetic retinopathy (DR) in youth with mean ± SD type 2 diabetes duration of 4.9 ± 1. Read More

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September 2021

Effects of Metabolic Factors, Race-Ethnicity, and Sex on the Development of Nephropathy in Adolescents and Young Adults With Type 2 Diabetes: Results From the TODAY Study.

Authors:

Diabetes Care 2021 Sep 16. Epub 2021 Sep 16.

Objective: To describe the longitudinal effects of sex, race-ethnicity, and metabolic factors on the risk of developing diabetic kidney disease (DKD) in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) cohort.

Research Design And Methods: Urine albumin-to-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) by serum creatinine and cystatin C were assessed annually for up to 15 years after study entry. Markers of DKD included micro- and macroalbuminuria (UACR ≥30 mg/g and ≥300 mg/g, respectively), hyperfiltration (eGFR ≥135 mL/min/1. Read More

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September 2021

Plasma glycated CD59 predicts postpartum glucose intolerance after gestational diabetes.

Eur J Endocrinol 2021 Sep 1. Epub 2021 Sep 1.

J Halperin, Divisions of Hematology, Bringham and Women's Hospital, Harvard Medical School, Boston, United States.

Aims: To assess whether in women with gestational diabetes mellitus (GDM), postpartum plasma glycated CD59 (pGCD59) levels predict conversion to glucose intolerance diagnosed with an oral glucose tolerance test (OGTT).

Methods: Blood levels of pGCD59 were measured in a case-control study of 105 women with GDM who underwent a 75g OGTT three months postpartum. The 35 postpartum glucose intolerant cases were individually matched for age, BMI, ethnic origin and parity with 70 women with GDM but normal postpartum OGTT (controls). Read More

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September 2021

A Risk Stratification Approach to Allocating Diabetes Education and Support Services.

Diabetes Technol Ther 2021 Sep 15. Epub 2021 Sep 15.

University of Pittsburgh, 6614, Department of Medicine, Division of Endocrinology and Metabolism; , Pittsburgh, Pennsylvania, United States;

The objective of this study was to describe a predictive modeling approach to risk stratify people with type 2 diabetes for diabetes self-management education and support services (DSMES). With data from a large health system, a predictive model including age, HbA1c, and insulin use among other factors, was developed to assess risk of future high HbA1c. The model was retrospectively applied to a cohort of people who received DSMES over a 2-year period to assess the impact of DSMES on glycemia by risk strata. Read More

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September 2021

Novel continuous glucose monitoring metrics and LGA risk; an exploratory retrospective cohort study in pregnancies with type 1 diabetes.

Diabetes Technol Ther 2021 Sep 15. Epub 2021 Sep 15.

Poznan University of Medical Sciences, 37807, Department of Reproduction, Poznan, Poland;

Background: Continuous glucose monitoring (CGM) improves pregnancy outcomes in patients with type 1 diabetes (T1D). We aimed to assess the between-group differences in HbA1c and the incidence of large-for-gestational-age (LGA) neonates in CGM and glucometers users and analyze the potential association of novel CGM metrics with LGA risk in T1D pregnancies.

Material And Methods: The initial study cohort included 134 women with T1D treated with insulin pumps -75 CGM users and 59 patients who measured their glucose concentrations using glucometers. Read More

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September 2021

Isolation and characterization of bacteria from diabetic foot ulcer: amputation, antibiotic resistance and mortality rate.

Int J Diabetes Dev Ctries 2021 Sep 10:1-9. Epub 2021 Sep 10.

Clinical Pharmacy and Practice, Faculty of Pharmacy and Medical Sciences, Hebron University, P.O Box 40, Hebron, West Bank 00972 Palestine.

Background: Diabetic foot ulcer (DFU) is one of the most serious complications of diabetes mellitus with devastating outcomes. Poorly treated DFU leads to osteomyelitis, gangrene and limb amputation. There is an increased risk of mortality for the amputees and increased number of bacterial resistance in survived patients. Read More

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September 2021

Ten Years Follow-Up of a Community-Nurse Managed Intervention to Improve Diabetes Control.

Res Theory Nurs Pract 2021 Sep 13. Epub 2021 Sep 13.

Central District, Maccabi Healthcare Services and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Background And Purpose: Diabetes control measures were shown to improve, following multidisciplinary intervention managed by a nurse in short-term follow-ups. However, there is a lack of data regarding the long-term effects of such interventions. We assessed long-term diabetes management and control measures in a central multidisciplinary primary care clinic, following a brief intervention conducted by a community nurse. Read More

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September 2021

Impact of a screen, triage and treat program for identifying chronic disease risk in Indigenous children.

CMAJ 2021 Sep;193(36):E1415-E1422

Max Rady College of Medicine (Frejuk), University of Manitoba; Chronic Disease Innovation Centre (Harasemiw, Komenda, Di Nella, Ferguson, Martin), Seven Oaks General Hospital; Max Rady Department of Internal Medicine (Harasemiw, Komenda, Ferguson, Martin), University of Manitoba; First Nations Health and Social Secretariat of Manitoba (Lavallee, McLeod); Manitoba Keewatinowi Okimakanak Inc. (Lavallee, Chartrand); Department of Pediatrics and Child Health (Wicklow, Dart); Children's Hospital Research Institute of Manitoba (Wicklow, Dart), Winnipeg, Man.

Background: The First Nations Community Based Screening to Improve Kidney Health and Prevent Dialysis project was a point-of-care screening program in rural and remote First Nations communities in Manitoba that aimed to identify and treat hypertension, diabetes and chronic kidney disease. The program identified chronic disease in 20% of children screened. We aimed to characterize clinical screening practices before and after intervention in children aged 10-17 years old and compare outcomes with those who did not receive the intervention. Read More

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September 2021

Higher blood high density lipoprotein and apolipoprotein A1 levels are associated with reduced risk of developing amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2021 Sep 13. Epub 2021 Sep 13.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

Background: Premorbid body mass index, physical activity, diabetes and cardiovascular disease have been associated with an altered risk of developing amyotrophic lateral sclerosis (ALS). There is evidence of shared genetic risk between ALS and lipid metabolism. A very large prospective longitudinal population cohort permits the study of a range of metabolic parameters and the risk of subsequent diagnosis of ALS. Read More

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September 2021

Predictors of attendance at diabetic retinopathy screening among people with type 2 diabetes: Secondary analysis of data from primary care.

Prim Care Diabetes 2021 Sep 10. Epub 2021 Sep 10.

School of Public Health, University College Cork, Ireland.

Aims: To estimate the uptake of diabetic retinopathy screening among adults with type 2 diabetes and to identify and compare factors associated with attendance at the national diabetic retinal screening programme, and other screening services provided by ophthalmic surgeons, community ophthalmologists and optometrists.

Methods: An observational retrospective cohort study was carried out using data from the 2016 audit of care delivered by general practices (n = 30) enrolled in a structured diabetes care initiative. Attendance at any screening in the previous 12 months, and attendance across different types of service (national programme and other screening services) was calculated. Read More

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September 2021

Non-alcoholic fatty liver disease, metabolic goal achievement with incident cardiovascular disease and eGFR-based chronic kidney disease in patients with prediabetes and diabetes.

Metabolism 2021 Sep 10;124:154874. Epub 2021 Sep 10.

Karamay Municipal People's Hospital, Xinjiang, China.

Aims/hypothesis: We aimed to evaluate the effect of NAFLD on the risk of incident cardiovascular disease (CVD) and estimated glomerular filtration rate (eGFR)-based chronic kidney disease (CKD), and further test the joint effects and interactions between NAFLD status and individual metabolic element, as well as the total 'ABCs' metabolic goal achievement, on the CVD and CKD risk among 101,296 patients with prediabetes or diabetes from a prospective cohort study.

Methods: We conducted the study based on the China Cardiometabolic Disease and Cancer Cohort (4C) study, a large-scale, population-based prospective cohort. After excluding alcohol abuse and other cause of hepatic diseases, we used fatty liver index (FLI) ≥ 60 as a proxy of NAFLD and stratified the probability of fibrosis by aspartate transaminase/alanine transaminase ratio (AAR) with cut-offs of 0. Read More

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September 2021

Rationality, Efficacy, Tolerability of Empagliflozin plus Linagliptin Combination for the Management of Type 2 Diabetes Mellitus: A Systematic review of randomized controlled trials and observational studies.

Curr Diabetes Rev 2021 Sep 10. Epub 2021 Sep 10.

Junior Resident, SVSMCH, Hyderabad. India.

Background: Treatment of diabetes mellitus includes more than one drug of different groups, which may lead to high pill burden and non-adherence to drugs. We have aimed to systematically analyze the clinical efficacy, safety and pharmacoeconomic cost-effectiveness of the fixed-dose combination of empagliflozin plus a linagliptin in Type-2 Diabetes mellitus (T2DM) patients.

Methods: A literature search of PubMed/MEDLINE, SCOPUS, Google Scholar and EMBASE was performed using the MeSH terms and/or keywords"((Single-pill combination) OR ((Fixed-dose combination) OR (Combination therapy)) AND (Empagliflozin add on-to Linagliptin) OR (Empagliflozin combined with Linagliptin) OR ((Combination of Empagliflozin and Linagliptin)" from the inception to February2021. Read More

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September 2021

Nilotinib vs. imatinib in Japanese patients with newly diagnosed chronic myeloid leukemia in chronic phase: 10-year follow‑up of the Japanese subgroup of the randomized ENESTnd trial.

Int J Hematol 2021 Sep 11. Epub 2021 Sep 11.

Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan.

In the 10-year analysis of Japanese patients with newly diagnosed CML-CP in the ENESTnd trial, nilotinib yielded higher cumulative response rates. There were no new occurrences of disease progression or deaths since the 5-year analysis. Cumulative 10-year rates of MMR and MR were higher in the nilotinib arms [300 mg twice daily (BID), 86. Read More

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September 2021

First trimester glycosylated hemoglobin for gestational diabetes mellitus screening.

Taiwan J Obstet Gynecol 2021 Sep;60(5):899-902

Bahçeşehir University, School of Medicine, Department of Public Health, Istanbul, Turkey.

Objective: Our aim in this study is to evaluate the efficacy of HbA1c in screening for GDM during the first trimester of pregnancy.

Materials And Methods: In this retrospective cohort study, we evaluated the first trimester HbA1c (ft-HbA1c) levels of 195 pregnant women who attended our university hospital's obstetrics clinic. Blood samples were drawn from patients during 11-14 weeks of gestation. Read More

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September 2021

The BAriatic surgery SUbstitution and nutrition (BASUN) population: a data-driven exploration of predictors for obesity.

BMC Endocr Disord 2021 Sep 10;21(1):183. Epub 2021 Sep 10.

Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: The development of obesity is most likely due to a combination of biological and environmental factors some of which might still be unidentified. We used a machine learning technique to examine the relative importance of more than 100 clinical variables as predictors for BMI.

Methods: BASUN is a prospective non-randomized cohort study of 971 individuals that received medical or surgical treatment (treatment choice was based on patient's preferences and clinical criteria, not randomization) for obesity in the Västra Götaland county in Sweden between 2015 and 2017 with planned follow-up for 10 years. Read More

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September 2021

GLP-1 Analogs Are Superior in Mediating Weight Loss But Not Glycemic Control in Diabetic Patients on Antidepressant Medications: A Retrospective Cohort Study.

Prim Care Companion CNS Disord 2021 Sep 9;23(5). Epub 2021 Sep 9.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.

Both antipsychotic and antidepressant medications have been associated with weight gain and hyperglycemia. Our previously published retrospective cohort study suggests that GLP-1 (glucagon-like peptide-1) analogs may be superior to alternative regimens for both glycemic and weight control in patients on antipsychotic plus/minus antidepressant medications. In the current study, we asked whether GLP-1 analogs or SGLT-2 (sodium-glucose-transporter-2) inhibitors would be similarly beneficial in patients on antidepressant medications alone. Read More

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September 2021

Benchmarking care outcomes for young adults with type 1 diabetes in Australia after transition to adult care.

Endocrinol Diabetes Metab 2021 Sep 9:e00295. Epub 2021 Sep 9.

Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

Aim: To determine advantages conferred by a youth-specific transition clinic model for young adults with type 1 diabetes (T1D) at Westmead Hospital (WH) as compared with Australian registry data.

Methods: Prospectively collected data included age, diabetes duration, visit frequency, post code, BMI, mode of insulin delivery, continuous glucose monitoring, HbA1c, albumin creatinine ratio, BP, retinopathy and diabetic ketoacidosis (DKA) for all WH T1D clinic attendees aged 16-25 between January 2017 and June 2018 (n = 269). Results were compared with data collected during the same time period from 2 separate Australian data registries, one longitudinal (Australasian Diabetes Data Network, ADDN) and one a spot survey (the Australian National Diabetes Audit, ANDA). Read More

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September 2021

Gustatory sweating in people with type 1 and type 2 diabetes mellitus: Prevalence and risk factors.

Endocrinol Diabetes Metab 2021 Aug 10:e00290. Epub 2021 Aug 10.

Department of Endocrinology and Nephrology, Nordsjællands Hospital, Hillerød, Denmark.

Objective: Gustatory sweating (GS) is characterized by profuse sweating during or immediately after ingestion of food and is known as a complication of diabetes mellitus (DM). This study aimed to determine the prevalence of GS and to characterize the sweating in a cohort of patients with type 1 and type 2 diabetes mellitus (T1DM and T2DM) as compared with a control group.

Methods: In a cross-sectional study, 665 outpatients with T1DM and 505 outpatients with T2DM filled in an 8-point questionnaire about GS. Read More

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Comparison of the Efficacy, Tolerability and Side Effect Profile of Vildagliptin-Metformin with Metformin-GlibenclamideMamong Nigerian.

West Afr J Med 2021 08;38(8):756-761

Department of Medicine, Bayero University / Aminu Kano Teaching Hospital, Kano, Kano State, Nigeria. E-mail:

Background: The use of fixed dose combination oral antidiabetic drugs (OADs) in the therapeutic management of type 2 diabetes mellitus (DM) patients is becoming popular among clinicians. Reduced pill burden with fixed combination OADs is generally perceived to improve adherence and efficacy. The aim of this study was to compare the efficacy, tolerability and side effects (SEs) profile of vildagliptin-metformin (VM) combination with metformin-glibenclamide (MG) combination in type 2 DM patients at the Aminu Kano Teaching Hospital (AKTH). Read More

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Development and validation of an incidence risk prediction model for early foot ulcer in diabetes based on a high evidence systematic review and meta-analysis.

Diabetes Res Clin Pract 2021 Sep 6;180:109040. Epub 2021 Sep 6.

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China. Electronic address:

Objectives: To develop and validate a model for predicting the risk of early diabetic foot ulcer (DFU) based on systematic review and meta-analysis.

Methods: Data were analyzed from the risk factors of DFU with their corresponding risk ratio (RR) by meta-analysis. The DFU prediction model included statistically significant risk factors from the meta-analysis, all of which were scored by its weightings, and the prediction model was externally validated using a validation cohort from China. Read More

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September 2021

Lens fluorescence and skin fluorescence in the Copenhagen Twin Cohort Eye Study: Covariates and heritability.

PLoS One 2021 9;16(9):e0256975. Epub 2021 Sep 9.

Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark.

Lens and skin fluorescence are related to the systemic accumulation of advanced glycation end products, which is accelerated in diabetes. We have examined lens fluorescence and skin fluorescence in healthy adult twins. The study enrolled twins aged median 59 years from a national population-based registry. Read More

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September 2021

Association of Insulin treatment with gastric residue during an esophagogastroduodenoscopy.

J Diabetes Investig 2021 Sep 9. Epub 2021 Sep 9.

Division of Diabetes and Metabolism, The Institute of Medical Science, Asahi Life Foundation, 2-2-6, Nihonbashibakurocho, Chuo-ku, Tokyo, 103-0002, Japan.

The purpose of this study was investigating the association of glycemic control and diabetic treatment to gastric residue observed during an esophagogastroduodenoscopy. Among 6,592 subjects who had esophagogastroduodenoscopy at our clinic between 2003 and 2019, we retrospectively and longitudinally identified those who had gastric residue during an esophagogastroduodenoscopy. Other data collected were age, sex, diagnosis of diabetes, glycated hemoglobin (HbA1c) and diabetic medication. Read More

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September 2021

Inequalities in glycemic management in people living with type 2 diabetes mellitus and severe mental illnesses: cohort study from the UK over 10 years.

BMJ Open Diabetes Res Care 2021 Sep;9(1)

Clinical Effectiveness Group, Institute of Population Health Sciences, Queen Mary, University of London, London, UK.

Introduction: Using data from a a primary care pay-for-performance scheme targeting quality indicators, the objective of this study was to assess if people living with type 2 diabetes mellitus (T2DM) and severe mental illnesses (SMI) experienced poorer glycemic management compared with people living with T2DM alone, and if observed differences varied by race/ethnicity, deprivation, gender, or exclusion from the scheme.

Research Design And Methods: Primary care data from a cohort of 56 770 people with T2DM, including 2272 people with T2DM and SMI, from London (UK), diagnosed between January 17, 2008 and January 16, 2018, were used. Adjusted mean glycated hemoglobin (HbA1c) and HbA1c differences were assessed using multilevel regression models. Read More

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September 2021

External applicability of SGLT2 inhibitor cardiovascular outcome trials to patients with type 2 diabetes and cardiovascular disease.

Cardiovasc Diabetol 2021 09 8;20(1):181. Epub 2021 Sep 8.

Department of Vascular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Background: Recent treatment guidelines support the use of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with type 2 diabetes and cardiovascular disease based on the results of cardiovascular outcome trials (CVOTs). Applicability of these trials to everyday patients with type 2 diabetes and cardiovascular disease is however unknown. The aim of this study is to assess the external applicability of SGLT2i CVOTs in daily clinical practice type 2 diabetes patients with established cardiovascular disease. Read More

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September 2021

Risk factors and incidence over time for lower extremity amputations in people with type 1 diabetes: an observational cohort study of 46,088 patients from the Swedish National Diabetes Registry.

Diabetologia 2021 Sep 8. Epub 2021 Sep 8.

Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.

Aims/hypothesis: The aim of this work was to study the incidence over time of lower extremity amputations and determine variables associated with increased risk of amputations in people with type 1 diabetes.

Methods: Individuals with type 1 diabetes registered in the Swedish National Diabetes Registry with no previous amputation from 1 January 1998 and followed to 2 October 2019 were included. Time-updated Cox regression and gradient of risk per SD were used to evaluate the impact of risk factors on the incidence of amputation. Read More

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September 2021

Evaluation and management of COVID-19-related severity in people with type 2 diabetes.

BMJ Open Diabetes Res Care 2021 09;9(1)

Center for Biotechnology and Interdisciplinary Studies, Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA

Introduction: People with type 2 diabetes (T2D) have an increased rate of hospitalization and mortality related to COVID-19. To identify ahead of time those who are at risk of developing severe diseases and potentially in need of intensive care, we investigated the independent associations between longitudinal glycated hemoglobin (HbA1c), the impact of common medications (metformin, insulin, ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and corticosteroids) and COVID-19 severity in people with T2D.

Research Design And Methods: Retrospective cohort study was conducted using deidentified claims and electronic health record data from the OptumLabs Data Warehouse across the USA between January 2017 and November 2020, including 16 504 individuals with T2D and COVID-19. Read More

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September 2021

Screening attendance, prevalence and severity of diabetic retinopathy (DR) in a cohort of patients with diabetes mellitus secondary to chronic pancreatitis (DMsCP) in Northern Ireland.

BMJ Open Diabetes Res Care 2021 Sep;9(1)

The Belfast Pancreatic Diabetes Clinic, Belfast City Hospital Health and Social Services Trust, Belfast, UK

Introduction: This study investigated Northern Ireland Diabetic Eye Screening Programme (NIDESP) attendance and diabetic retinopathy (DR) prevalence/severity in patients with diabetes mellitus secondary to chronic pancreatitis (PwDMsCP).

Research Design And Methods: Medical/NIDESP records for all PwDMsCP attending the pancreatic diabetes clinic were analyzed in 2017 (n=78) and 2019 (n=94).

Results: Between 2017 and 2019, those without DR decreased (76% to 63%); mild non-proliferative DR (NPDR), severe NPDR and PDR were found in 30%, 2% and 5%, respectively (previously 18%, 4%, 2%); diabetic maculopathy (DMac) was present in 12% (previously 10%). Read More

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September 2021