15,004 results match your criteria hashimoto's thyroiditis

Hashimoto's thyroiditis and coexisting disorders in correlation with HLA status-an overview.

Wien Med Wochenschr 2021 Sep 15. Epub 2021 Sep 15.

Teaching Unit, Medizinische Universität Wien/Medical University Vienna, Vienna, Austria.

Hashimoto's thyroiditis (HT), also known as chronic lymphocytic thyroiditis, is a frequent disorder of the thyroid gland caused by autoimmune-trigged lymphocytic infiltration and destruction of the thyroid gland. With the progressive destruction of the organ, the thyroid gland shrinks in size, thus commonly leading to hypothyroidism. Therapy of HT is mainly focused on managing the thyroid dysfunction by oral substitution of L‑thyroxine. Read More

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September 2021

Normal anatomy, variants and factors associated with the cervical vagus nerve topography: a high-resolution ultrasound study.

Surg Radiol Anat 2021 Sep 15. Epub 2021 Sep 15.

Department of Anatomy, School of Medicine, University of Crete, Heraklion, Crete, Greece.

Purpose: To describe the cervical vagus nerve (CVN) topography at the thyroid lobe (TL) level using high-resolution ultrasound and to investigate the possible association with anthropometric data, TL size, and thyroid disease.

Methods: We prospectively examined 550 CVNs in 275 (205 female, 70 male) individuals with normal thyroid (53/275, 19.3%), multinodular disease (167/275, 60. Read More

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September 2021

Comparison of the factors associated with the short-term prognosis between elderly and non-elderly patients with anti-neutrophil cytoplasmic antibody-associated vasculitis: a retrospective observational study.

Clin Exp Rheumatol 2021 Sep 9. Epub 2021 Sep 9.

Department of Nephrology, Shinshu University Hospital, Matsumoto, Japan.

Objectives: The difference in factors associated with the prognosis between elderly and non-elderly patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is uncertain. We aimed to elucidate the clinical factors associated with the short-term prognosis (within 6 months from the start of the treatment) and investigate the differences in the associated factors between elderly and non-elderly individuals.

Methods: We performed a dual centre retrospective observational study of patients newly treated with AAV (eosinophilic granulomatous with polyangiitis was excluded). Read More

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September 2021

Immunoregulated insulitis and slow-progressing type 1 diabetes after duodenopancreatectomy.

Diabetologia 2021 Sep 14. Epub 2021 Sep 14.

Institut Cochin, CNRS, Inserm, Université de Paris, Paris, France.

Aims/hypothesis: We report the case of a woman who underwent a partial pancreatectomy for a serous cystadenoma when aged 56 years. She had been diagnosed with diabetes 6 years before and had Hashimoto's thyroiditis. Despite positive anti-GAD autoantibodies (GADA) and previous surgery, she was transiently weaned off long-acting insulin. Read More

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September 2021

A Case of Steroid-Responsive Encephalopathy.

Cureus 2021 Aug 10;13(8):e17063. Epub 2021 Aug 10.

Neurology, Boca Raton Regional Hospital/Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.

Hashimoto's encephalopathy (HE), also known as steroid-responsive encephalopathy, is associated with autoimmune-mediated thyroiditis. Onset is typically gradual often with evolution over the course of months. Characteristic symptoms include impaired concentration and memory, delusions, hallucinations, personality changes, incoordination, tremor, hemiparesis, seizures, and speech difficulties. Read More

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Evaluation of the Relationship Between Environmental Factors, Nutrition, and Metabolic Changes in Children Diagnosed With Autism in North Cyprus: A Case-Control Study.

Cureus 2021 Aug 9;13(8):e17016. Epub 2021 Aug 9.

Pediatrics, Famagusta State Hospital, Famagusta, CYP.

Introduction Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders characterized by deficits in social behaviors and nonverbal interactions. The disorder is believed to be multifactorial regarding etiopathology. This study aimed to investigate the possible risk factors associated with the development of autism in the prenatal and postnatal periods. Read More

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Bioinformatics analysis identified shared differentially expressed genes as potential biomarkers for Hashimoto's thyroiditis-related papillary thyroid cancer.

Int J Med Sci 2021 13;18(15):3478-3487. Epub 2021 Aug 13.

Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Although the etiology of Hashimoto's thyroiditis (HT), a common autoimmune endocrine disease, is unknown, studies suggest a potential association with genetic factors and environmental conditions inducing excessive iodine intake. Additionally, HT patients have a high risk of papillary thyroid cancer (PTC), which is probably related to the chronic inflammation and autoimmune pathologic process occurring in HT, as it is thought to be associated with neoplastic transformation. Bioinformatics approaches can identify differentially expressed genes (DEGs) and analyze DEG functions in diseases. Read More

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[A Case of Non-Resectable Advanced Gastric Cancer for Which Nivolumab Was Markedly Effective].

Gan To Kagaku Ryoho 2021 Sep;48(9):1165-1167

Dept. of Pharmacy, Koyama Memorial Hospital.

A 74-year-old man presented to our hospital because of anorexia. Upper gastrointestinal endoscopy revealed type 3 gastric cancer. Further examination disclosed metastasis to the perigastric lymph nodes and to the liver, and a diagnosis of non- resectable advanced gastric cancer(cT4N2H1P0M0)in cStage Ⅳ was made. Read More

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September 2021

[High frequency ultrasound combined with ultrasound-guided core needle biopsy for the diagnosis of primary thyroid lymphoma].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Aug;56(8):858-862

Department of Pathology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou 310016, China.

To investigate the sonographic features of primary thyroid lymphoma (PTL) and to evaluate the clinical significance of ultrasound-guided core needle biopsy (US-CNB) in PTL. A total of 24 patients with suspected PTL in Sir Run Run Shaw Hospital from January 2013 to June 2018 were analyzed retrospectively. All cases were confirmed by pathology, of them 23 patients received US-CNB and 1 patient chose operation without US-CNB, including 5 males and 19 females, aged from 39 to 75 years old. Read More

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A fungal powdery mildew pathogen induces extensive local and marginal systemic changes in the Arabidopsis thaliana microbiota.

Environ Microbiol 2021 Sep 14. Epub 2021 Sep 14.

RWTH Aachen University, Institute for Biology I, Unit of Plant Molecular Cell Biology, Worringerweg 1, 52056, Aachen, Germany.

Powdery mildew is a foliar disease caused by epiphytically growing obligate biotrophic ascomycete fungi. How powdery mildew colonization affects host resident microbial communities locally and systemically remains poorly explored. We performed powdery mildew (Golovinomyces orontii) infection experiments with Arabidopsis thaliana grown in either natural soil or a gnotobiotic system and studied the influence of pathogen invasion into standing natural multi-kingdom or synthetic bacterial communities (SynComs). Read More

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September 2021

Immune disorders associated with juvenile recurrent chronic parotitis.

An Pediatr (Engl Ed) 2021 Sep 10. Epub 2021 Sep 10.

Servicio de Pediatría, Hospital Universitari i Politècnic La Fe, Valencia, Spain. Electronic address:

Introduction: Juvenile recurrent chronic parotitis (JRCP) is a rare disease of unknown cause. There is a growing interest in its autoimmune aetiology and its relationship with dysfunctions of cellular and humoral immunity, although there is no agreed protocol for complementary investigations for its study. A consecutive series of cases is presented where the immune alterations and associated autoimmune disorders are investigated, proposing a study algorithm. Read More

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September 2021

Clinical Significance of Coexistence of Hashimoto Thyroiditis and Graves' Disease with Differentiated and Medullary Thyroid Cancer.

Exp Clin Endocrinol Diabetes 2021 Sep 13. Epub 2021 Sep 13.

Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

The association of Hashimoto thyroiditis and Graves' disease with papillary, follicular, and medullary thyroid cancer has not been comprehensively investigated until now. This comparative clinicopathological study of consecutive patients thyroidectomized at a surgical referral center aimed to explore interdependencies between chronic autoimmune thyroiditis and thyroid cancer. Altogether, there were 852 (58. Read More

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September 2021

Hearing Impairment and Audiological Alterations in Euthyroid Hashimoto's Thyroiditis.

ORL J Otorhinolaryngol Relat Spec 2021 Aug 11:1-9. Epub 2021 Aug 11.

Otorhinolaryngology & Head and Neck Surgery Clinics, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey.

Introduction: Hearing loss may be associated with autoimmune diseases, but it was less studied in Hashimoto's thyroiditis (HT). We aimed to evaluate hearing impairment and audiological alterations in adults with euthyroid HT.

Methods: Adult patients with euthyroid HT (normal thyroid functions, positive antithyroid peroxidase (anti-TPO)/anti-thyroglobulin, and sonographic findings) were compared with controls. Read More

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Clinical and Molecular Characterizations of Papillary Thyroid Cancer in Children and Young Adults: a Multicenter Retrospective Study.

Thyroid 2021 Sep 13. Epub 2021 Sep 13.

Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, 71140, Department of Head and Neck Surgery, Shanghai, China;

Background Papillary thyroid carcinoma (PTC) is a rare malignancy in children and young adults (CAYA). It often presents with aggressive disease patterns and advanced stages, which are clinically distinct from those in adult patients. Here, we sought to characterize and better understand the clinical variants of PTC in CAYA and explore the underlying mechanisms. Read More

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September 2021

A Case of Euthyroid Steroid-Responsive Encephalopathy With Subacute Dementia.

Cureus 2021 Sep 3;13(9):e17689. Epub 2021 Sep 3.

Department of Neurology, Kannur Medical College, Anjarakandy, Kannur, IND.

Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), frequently termed as Hashimoto's encephalopathy (HE), is characterized by reversible encephalopathy with the presence of elevated antithyroid antibodies. The condition was initially described due to its association with Hashimoto's thyroiditis. We report a case of euthyroid HE presenting as subacute dementia. Read More

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September 2021

Thyroxine Replacement for Subfertile Females With Subclinical Hypothyroidism and Autoimmune Thyroiditis: A Systematic Review.

Cureus 2021 Aug 4;13(8):e16872. Epub 2021 Aug 4.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

The second most prevalent endocrine condition affecting women of reproductive age is thyroid disease. The difference between an increased thyroid-stimulating hormone (TSH) concentration and a normal free thyroxine hormone level is used to identify subclinical hypothyroidism. Thyroid autoantibodies, independent of thyroid hormone levels, are used to diagnose autoimmune thyroid disease (ATD). Read More

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Novel Insights Into the Mechanism of GVHD-Induced Tissue Damage.

Front Immunol 2021 27;12:713631. Epub 2021 Aug 27.

Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.

Prophylaxis for and treatment of graft-versus-host disease (GVHD) are essential for successful allogeneic hematopoietic stem cell transplantation (allo-SCT) and mainly consist of immunosuppressants such as calcineurin inhibitors. However, profound immunosuppression can lead to tumor relapse and infectious complications, which emphasizes the necessity of developing novel management strategies for GVHD. Emerging evidence has revealed that tissue-specific mechanisms maintaining tissue homeostasis and promoting tissue tolerance to combat GVHD are damaged after allo-SCT, resulting in exacerbation and treatment refractoriness of GVHD. Read More

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Association between the severity of chronic spontaneous urticaria and sleep-disordered breathing.

Allergol Int 2021 Sep 9. Epub 2021 Sep 9.

Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan; Course of Allergy and Clinical Immunology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Center for Immunology and Allergology, Shonan Kamakura General Hospital, Kanagawa, Japan.

Background: Chronic spontaneous urticaria (CSU) is a common mast cell-driven disease, presenting with wheals, angioedema, or both. Sleep-disordered breathing (SDB) is also a common condition and contributes to various diseases by causing chronic inflammation. Recent studies have suggested an association between CSU and SDB. Read More

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September 2021

Altered T cell subpopulations and serum anti-TYRP2 and tyrosinase antibodies in the acute and chronic phase of alopecia areata in the C3H/HeJ mouse model.

J Dermatol Sci 2021 Sep 3. Epub 2021 Sep 3.

Kyoto R&D Center, Maruho Co., Ltd., Kyoto, Japan.

Background: C3H/HeJ mouse models progress gradually in hair loss from acute to chronic phase and reflect the symptoms of patients with alopecia areata (AA). However, the underlying pathological characteristics alteration associated with disease progression and autoantigens remain unclear.

Objective: We aimed at elucidating the pathological differences between acute and chronic-AA in the C3H/HeJ mouse model. Read More

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September 2021

Favorable clinical response and drug retention of anti-IL-6 receptor inhibitor in rheumatoid arthritis with high CRP levels: the ANSWER cohort study.

Scand J Rheumatol 2021 Sep 13:1-10. Epub 2021 Sep 13.

Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objective: Currently, biological disease-modifying anti-rheumatic drugs (bDMARDs) with different modes of action [tumour necrosis factor inhibitor (TNFi), interleukin-6 receptor inhibitor (IL-6Ri), or cytotoxic T-lymphocyte antigen 4-immunoglobulin (CTLA4-Ig)] are used in clinical practice to treat rheumatoid arthritis (RA). However, it is unclear which type of bDMARD is the most efficacious for a specific clinical situation. C-reactive protein (CRP) is an acute-phase reactant driven by IL-6 signalling. Read More

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September 2021

Hypothyroid cardiomyopathy: A reversible phenocopy of hypertrophic cardiomyopathy.

Echocardiography 2021 Sep 12. Epub 2021 Sep 12.

Internal Medicine Department, Hospital of the Government of the City of Buenos Aires "Dr. Cosme Argerich", Buenos Aires, Argentina.

We present the case of a 46-year-old patient with hypothyroidism secondary to Hashimoto's thyroiditis who was admitted with decompensation in the form of myxedema. A 2-D echocardiogram shows a septal asymmetric hypertrophy, with low-voltage QRS complex in the ECG and a bull's-eye map of longitudinal strain with preserved apical strain with reduction of mid and basal strain that results in "cherry on the top" pattern, similar to the most frequent phenocopy of hypertrophic cardiomyopathy, as is the cardiac amyloidosis, and that, unlike this pathology, reverted after the patient reached the euthyroid state. Read More

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September 2021

Potent efficacy of Stachybotrys microspora triprenyl phenol-7, a small molecule having anti-inflammatory and antioxidant activities, in a mouse model of acute kidney injury.

Eur J Pharmacol 2021 Sep 7;910:174496. Epub 2021 Sep 7.

Division of Pharmacology, Department of Pharmacology, Toxicology and Therapeutics, School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan; Pharmacological Research Center, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.

Acute kidney injury (AKI) increases the risk of chronic kidney disease (CKD), complicates existing CKD, and can lead to the end-stage renal disease. However, there are no approved effective therapeutics for AKI. Recent studies have suggested that inflammation and oxidative stress are the primary causes of AKI. Read More

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September 2021

Acute upper airway obstruction by a goitre due to Hashimoto's thyroiditis.

BMJ Case Rep 2021 Sep 8;14(9). Epub 2021 Sep 8.

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, Shimotsuga-gun, Tochigi, Japan

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September 2021

Gait training with a wearable curara® robot for cerebellar ataxia: a single-arm study.

Biomed Eng Online 2021 Sep 8;20(1):90. Epub 2021 Sep 8.

Department of Neurology, JA Nagano Koseiren Kakeyu-Misayama Rehabilitation Center Kakeyu Hospital, Ueda, Japan.

Background: Ataxic gait is one of the most common and disabling symptoms in people with degenerative cerebellar ataxia. Intensive and well-coordinated inpatient rehabilitation improves ataxic gait. In addition to therapist-assisted gait training, robot-assisted gait training has been used for several neurological disorders; however, only a small number of trials have been conducted for degenerative cerebellar ataxia. Read More

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September 2021

Simulation model for Hashimoto's Autoimmune Thyroiditis disease.

Endocrinology 2021 Sep 8. Epub 2021 Sep 8.

Centro de Investigación y Estudios Avanzados del Maule (CIEAM), Vicerrectoría de Investigación y Posgrado, Universidad Católica del Maule. Talca, Chile.

Hashimoto's Thyroiditis (HT) is a pathology which often causes a gradual thyroid insufficiency in affected patients due to the autoimmune destruction of this gland. The cellular immune response mediated by T helper lymphocytes TH1 and TH17 can induce the HT disease. In this pathologic condition, there is an imbalance between the TH17 and Treg lymphocytes as well as a gut microbiota dysfunction. Read More

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September 2021

Glycosylation in Autoimmune Diseases.

Adv Exp Med Biol 2021 ;1325:205-218

Department of Glycoconjugate Biochemistry, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Kraków, Poland.

Autoimmune diseases are accompanied by changes in protein glycosylation, in both the immune system and target tissues. The best-studied alteration in autoimmunity is agalactosylation of immunoglobulin G (IgG), characterized primarily in rheumatoid arthritis (RA), and then detected also in systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), and multiple sclerosis (MS). The rebuilding of IgG N-glycans in RA correlates with the relapses and remissions of the disease, is associated with physiological states such as pregnancy but also depends on applied anti-inflammatory therapy. Read More

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September 2021

Integrative Analyses of Genes Associated with Hashimoto's Thyroiditis.

J Immunol Res 2021 28;2021:8263829. Epub 2021 Aug 28.

Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Objective: Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis, is a common autoimmune thyroiditis, which mostly occurs in young and middle-aged women. It can be manifested as hyperthyroidism in the early stage; hypothyroidism may appear with the progression of the disease. Studies have shown that multiple factors such as heredity, environment, and autoimmunity are involved in the pathogenesis, but the specific mechanism is not clear. Read More

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Expression Patterns of Microenvironmental Factors and Tenascin-C at the Invasive Front of Stage II and III Colorectal Cancer: Novel Tumor Prognostic Markers.

Front Oncol 2021 19;11:690816. Epub 2021 Aug 19.

Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Shiwagun'yahabachou, Japan.

Background: Biological markers expressed in cancer cells and the surrounding cancer-associated fibroblasts (CAF) can be used for prediction of patient prognosis in colorectal cancer (CRC). Here, we used immunohistochemical techniques to evaluate cancer cells' expression of specific biomarkers that are closely associated with neoplastic progression.

Methods: Immunohistochemical markers included Ki-67, p53, β-catenin, MMP7, E-cadherin and HIF1-α. Read More

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TAFRO syndrome complicated by porto-sinusoidal vascular liver disease with portal hypertension: a case report.

Clin J Gastroenterol 2021 Sep 6. Epub 2021 Sep 6.

Department of Gastroenterology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan.

Porto-sinusoidal vascular liver disease (PSVD) is a disorder that can cause portal hypertension without liver cirrhosis. TAFRO syndrome is a systemic inflammatory disorder with a background of immunological abnormalities. We report a case of TAFRO syndrome complicated by PSVD with portal hypertension. Read More

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September 2021