2,504 results match your criteria hand fits


PI3K, mTOR AND GSK3 MODULATE CYTOKINES' PRODUCTION IN PERIPHERAL LEUKOCYTE IN TEMPORAL LOBE EPILEPSY.

Neurosci Lett 2021 May 9:135948. Epub 2021 May 9.

Neuroscience Program, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Department of Pharmacology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:

Introduction: Epilepsy is a common pathological condition that predisposes individuals to seizures, as well as cognitive and emotional dysfunctions. Different studies have demonstrated that inflammation contributes to the pathophysiology of epilepsy. Indeed, seizures change the peripheral inflammatory pattern, which, in turn, could contribute to seizures. Read More

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Comparison of an artificial neural network and Gompertz model for predicting the dynamics of deaths from COVID-19 in México.

Nonlinear Dyn 2021 Apr 30:1-15. Epub 2021 Apr 30.

Facultad de Ciencias Químicas-Centro de Investigación en Recursos Energéticos y Sustentables, Universidad Veracruzana, Campus Coatzacoalcos, Av. Universidad km. 7.5, Col. Santa Isabel, Coatzacoalcos CP, 96538 Veracruz, México.

The present work is focused on modeling and predicting the cumulative number of deaths from COVID-19 in México by comparing an artificial neural network (ANN) with a Gompertz model applying multiple optimization algorithms for the estimation of coefficients and parameters, respectively. For the modeling process, the data published by the daily technical report COVID-19 in Mexico from March 19th to September 30th were used. The data published in the month of October were included to carry out the prediction. Read More

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Reduced impact of viral load of HHV-6 in liquor on severity of AESD due to exanthema subitum: A case report and literature review.

Brain Dev 2021 May 7. Epub 2021 May 7.

Department of Neurology, Nagano Children's Hospital, Azumino, Japan. Electronic address:

Background: The most common causative pathogen of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) was reported as HHV-6. Although excitotoxic injury with delayed neuronal death is considered to be a possible pathogenesis of AESD, the detailed pathophysiology remains unclear.

Case Presentation: We present a twelve-month-old girl with AESD due to HHV-6 primary infection. Read More

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Time Is Brain: Acute Control of Repetitive Seizures and Status Epilepticus Using Alternative Routes of Administration of Benzodiazepines.

J Clin Med 2021 Apr 17;10(8). Epub 2021 Apr 17.

Department of Pharmacotherapy and Outcomes Science, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.

Time plays a major role in seizure evaluation and treatment. Acute repetitive seizures and status epilepticus are medical emergencies that require immediate assessment and treatment for optimal therapeutic response. Benzodiazepines are considered the first-line agent for rapid seizure control. Read More

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Removal of Perirolandic Cavernoma with Direct Cortical Stimulation and Neuronavigation with DTI.

Neurol India 2021 Mar-Apr;69(2):304-306

Deprartment of Neuroanaesthesia, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

Background And Introduction: Intraoperative neuromonitoring for eloquent cortical lesions is irreplaceable in present-day neurosurgery.

Objective: We report a novel technique of combining awake craniotomy with direct cortical stimulation of the motor cortex using the NIM nerve monitoring system.

Technique: A 17-year-old boy presenting with focal motor seizures, diagnosed with left perirolandinc cavernoma, underwent awake craniotomy and complete excision under direct cortical stimulation with NIM monopolar stimulator electrode to locate the motor cortex. Read More

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A case report of simultaneous autoimmune and COVID-19 encephalitis.

J Neurovirol 2021 Apr 26. Epub 2021 Apr 26.

Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

COVID-19 encephalitis is a rare condition usually presenting with altered mental status. Simultaneous presence of anti-NMDAR antibody and SARS-CoV-2 virus in CSF is a very rare condition described in a few case reports so far. On the other hand, brain edema is an unusual presentation of anti-NMDAR encephalitis. Read More

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The many-body expansion for aqueous systems revisited: III. Hofmeister ion-water interactions.

Phys Chem Chem Phys 2021 Apr 26. Epub 2021 Apr 26.

Department of Chemistry, University of Washington, Seattle, WA 98195, USA. and Advanced Computing, Mathematics and Data Division, Pacific Northwest National Laboratory, 902 Battelle Boulevard, P.O. Box 999, MS K1-83, WA 99352, USA.

We report a Many Body Energy (MBE) analysis of aqueous ionic clusters containing anions and cations at the two opposite ends of the Hofmeister series, viz. the kosmotropes Ca2+ and SO42- and the chaotropes NH4+ and ClO4-, with 9 water molecules to quantify how these ions alter the interaction between the water molecules in their immediate surroundings. We specifically aim at quantifying how various ions (depending on their position in the Hofmeister series) affect the interaction between the surrounding water molecules and probe whether there is a qualitatively different behavior between kosmotropic vs. Read More

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"If the glove fits": Hospital-wide universal gloving is associated with improved hand hygiene and may reduce infection.

Infect Control Hosp Epidemiol 2021 Apr 23:1-5. Epub 2021 Apr 23.

University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York.

Objective: To determine whether a hospital-wide universal gloving program resulted in increased hand hygiene compliance and reduced inpatient Clostridioides difficile infection (CDI) rates.

Design: We carried out a multiple-year before-and-after quasi-experimental quality improvement study. Gloving and hand hygiene compliance data as well as hospital-acquired infection rates were prospectively collected from January 1, 2015, to December 31, 2017, by secret monitors. Read More

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Functional neurological disorder in the emergency department.

Acad Emerg Med 2021 Apr 18. Epub 2021 Apr 18.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

We provide a narrative review of functional neurological disorder (FND, or conversion disorder) for the emergency department (ED). Diagnosis of FND has shifted from a "rule-out" disorder to one now based on the recognition of positive clinical signs, allowing the ED physician to make a suspected or likely diagnosis of FND. PubMed, Google Scholar, academic books, and a hand search through review article references were used to conduct a literature review. Read More

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Epilepsy surgery in COVID times-a unique conundrum.

Childs Nerv Syst 2021 Apr 10. Epub 2021 Apr 10.

Department of Neurosurgery, Neurosciences Centre, All India Institute of Medical Sciences, Room No. 607, New Delhi, 110029, India.

The COVID-19 pandemic has forced hospitals to prioritize admissions. Epilepsy surgeries have been postponed at most centers. As the pandemic continues with no definite end in sight in the near future, the question arises until when such patients should be denied appropriate treatment. Read More

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Primary Care implementation of Germ Defence, a digital behaviour change intervention to improve household infection control during the COVID-19 pandemic: A structured summary of a study protocol for a randomised controlled trial.

Trials 2021 Apr 9;22(1):263. Epub 2021 Apr 9.

National Institute for Health Research, Applied Research Collaboration West (NIHR ARC West) University Hospitals Bristol and Weston NHS Foundation Trust, 9th Floor, Whitefriars, Lewins Mead, Bristol, BS1 2NT, UK.

Objectives: To examine the effectiveness of randomising dissemination of the Germ Defence behaviour change website via GP practices across England UK.

Trial Design: A two-arm (1:1 ratio) cluster randomised controlled trial implementing Germ Defence via GP practices compared with usual care.

Participants: Setting: All Primary care GP practices in England. Read More

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Assessment of postoperative risk factors for EEG abnormalities in routine clinical management after paediatric cardiopulmonary bypass.

Interact Cardiovasc Thorac Surg 2021 Apr 6. Epub 2021 Apr 6.

Heart Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong, China.

Objectives: The postoperative risk factors for electroencephalogram(EEG) abnormalities after paediatric cardiopulmonary bypass (CPB) remain to be identified. We investigated the characteristics of EEG abnormalities and risk factors in routine clinical management post-CPB.

Methods: EEG and cerebral oxygen saturation (ScO2) were monitored in 96 patients (aged 3 days, 37 months, median 5 months) for 72 h post-CPB. Read More

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Vector Arithmetic in the Triangular Grid.

Entropy (Basel) 2021 Mar 20;23(3). Epub 2021 Mar 20.

Department of Mathematics, Faculty of Arts and Sciences, Eastern Mediterranean University, via Mersin 10, Famagusta 99450, Turkey.

Vector arithmetic is a base of (coordinate) geometry, physics and various other disciplines. The usual method is based on Cartesian coordinate-system which fits both to continuous plane/space and digital rectangular-grids. The triangular grid is also regular, but it is not a point lattice: it is not closed under vector-addition, which gives a challenge. Read More

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Unravelling the Genetic Basis of Primary Aldosteronism.

Nutrients 2021 Mar 8;13(3). Epub 2021 Mar 8.

Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.

Primary aldosteronism (PA), a condition characterized by autonomous aldosterone hypersecretion, constitutes the most common cause of secondary hypertension. Over the last decade, major breakthroughs have been made in the field of genetics underpinning PA. The advent and wide application of Next Generation Sequencing (NGS) technology led to the identification of several somatic and germline mutations associated with sporadic and familial forms of PA. Read More

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The glucocorticoid receptor specific modulator CORT108297 reduces brain pathology following status epilepticus.

Exp Neurol 2021 Mar 18;341:113703. Epub 2021 Mar 18.

Cincinnati Children's Hospital Medical Center, Department of Anesthesia, USA; Cincinnati Children's Hospital Medical Center, Department of Pediatrics, USA; University of Cincinnati, Medical Scientist Training Program, USA; University of Cincinnati, Neuroscience Graduate Program, USA. Electronic address:

Objective: Glucocorticoid levels rise rapidly following status epilepticus and remain elevated for weeks after the injury. To determine whether glucocorticoid receptor activation contributes to the pathological sequelae of status epilepticus, mice were treated with a novel glucocorticoid receptor modulator, C108297.

Methods: Mice were treated with either C108297 or vehicle for 10 days beginning one day after pilocarpine-induced status epilepticus. Read More

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Alternative Medicines on the Farm: A Study of Dairy Farmers' Experiences in France.

Front Vet Sci 2021 25;8:563957. Epub 2021 Feb 25.

BIOEPAR, INRAE, ONIRIS, Nantes, France.

Despite being of debatable efficacy, alternative medicines are in regular use on both organic and conventional dairy farms as part of a strategy for limiting the on-farm use of antibiotics. The study presented here examined French dairy farmers' understanding of and experiences with these medicines, focusing on homeopathy, aromatherapy and phytotherapy. Adopting an interdisciplinary approach combining animal science and sociology, we considered how dairy farmers' use of alternative medicines fits into a holistic approach to herd health management, on the one hand, and into farmers' networks of professional relationships, on the other. Read More

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February 2021

Behavioral comorbidities of epilepsy and neuroinflammation: Evidence from experimental and clinical studies.

Epilepsy Behav 2021 04 5;117:107869. Epub 2021 Mar 5.

Institute of Higher Nervous Activity and Neurophysiology of RAS, 117485 Butlerova 5A, Moscow, Russia. Electronic address:

Currently, a significant amount of data is accumulated showing that neuroinflammation is one of the key processes in the development of brain pathology in trauma, neurodegenerative diseases, and epilepsy. Various brain insults, such as prolonged seizure activity, trigger the activation of microglia and astrocytes in the brain. These cells, in turn, begin to synthesize pro-inflammatory cytokines. Read More

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Consensus protocol for EEG and amplitude-integrated EEG assessment and monitoring in neonates.

Clin Neurophysiol 2021 Apr 3;132(4):886-903. Epub 2021 Feb 3.

Child Neuropsychiatric Unit, Neuroscience Section, Department of Medicine and Surgery, University of Parma, Italy.

The aim of this work is to establish inclusive guidelines on electroencephalography (EEG) applicable to all neonatal intensive care units (NICUs). Guidelines on ideal EEG monitoring for neonates are available, but there are significant barriers to their implementation in many centres around the world. These include barriers due to limited resources regarding the availability of equipment and technical and interpretive round-the-clock personnel. Read More

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A History of Fluid Management-From "One Size Fits All" to an Individualized Fluid Therapy in Burn Resuscitation.

Medicina (Kaunas) 2021 Feb 23;57(2). Epub 2021 Feb 23.

Department of Plastic, Aesthetic and Hand Surgery, Specialized Burn Center, Sana Klinikum Offenbach, Starkenburgring 66, 63069 Offenbach, Germany.

Fluid management is a cornerstone in the treatment of burns and, thus, many different formulas were tested for their ability to match the fluid requirements for an adequate resuscitation. Thereof, the Parkland-Baxter formula, first introduced in 1968, is still widely used since then. Though using nearly the same formula to start off, the definition of normovolemia and how to determine the volume status of burn patients has changed dramatically over years. Read More

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February 2021

LONP1 Regulates Mitochondrial Accumulations of HMGB1 and Caspase-3 in CA1 and PV Neurons Following Status Epilepticus.

Int J Mol Sci 2021 Feb 25;22(5). Epub 2021 Feb 25.

Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym Unversity, Chuncheon 24252, Korea.

Lon protease 1 (LONP1) is a highly conserved serine peptidase that plays an important role in the protein quality control system in mammalian mitochondria. LONP1 catalyzes the degradation of oxidized, dysfunctional, and misfolded matrix proteins inside mitochondria and regulates mitochondrial gene expression and genome integrity. Therefore, LONP1 is up-regulated and suppresses cell death in response to oxidative stress, heat shock, and nutrient starvation. Read More

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February 2021

Irreversible Cerebellar Atrophy as a Complication of Short-Term Phenytoin Exposure: Clinical Improvement Following Discontinuation of the Culprit.

J Epilepsy Res 2020 Dec 31;10(2):96-99. Epub 2020 Dec 31.

College of Medicine, King Khalid University, Abha, Saudi Arabia.

Phenytoin (diphenylhydantoin) is a widely used antiepileptic drug for controlling both generalized and partial seizures. Reversible cerebellar symptoms, including cerebellar ataxia, have been recognized as an adverse event of phenytoin use for many years. On the other hand, cerebellar degeneration has been reported with chronic use in an epileptic patient treated with this drug. Read More

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December 2020

Understanding Sunflower syndrome: Results of an online questionnaire.

Epilepsy Behav 2021 04 24;117:107856. Epub 2021 Feb 24.

Pediatric Epilepsy Program, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

Objective: To characterize the clinical phenotype, treatments, and impact on quality of life of Sunflower syndrome.

Methods: A 138-question survey was created focusing on seizure description, disease course, treatment history, medical history, family history, and aspects of quality of life of individuals with Sunflower syndrome. The survey was administered to individuals with Sunflower syndrome who experience hand waving episodes (HWE) and/or their caregivers via Research Electronic Data Capture (REDCap). Read More

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Dr. Strangelove demystified: Disconnection of hand and language dominance explains alien-hand syndrome after corpus callosotomy.

Seizure 2021 Mar 16;86:147-151. Epub 2021 Feb 16.

Department of Neurosurgery, Geneva University Medical Center & Faculty of Medicine, Geneva, Switzerland.

Background: Alien hand syndrome (AHS) is a disabling condition in which one hand behaves in a way that the person finds "alien". This feeling of alienation is related to the occurrence of movements of the respective hand performed without or against conscious intention. Most information on AHS stems from single case observations in patients with frontal, callosal, or parietal brain damage. Read More

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Quality of life and its associated factors among epileptic patients attending public hospitals in North Wollo Zone, Northeast Ethiopia: A cross-sectional study.

PLoS One 2021 23;16(2):e0247336. Epub 2021 Feb 23.

School of Public Health, College of Health Sciences, Woldia University, Woldia, Amhara, Ethiopia.

Background: Epilepsy is thought to be caused by witchcraft, evil spirit, and God's punishment for sins in many developing countries. As a result, people with epilepsy and their families usually suffer from stigma, discrimination, depression, and other psychiatric problems. Thus, this study aimed to assess the quality of life and its associated factors among epileptic patients attending public hospitals in North Wollo Zone, Northeast Ethiopia. Read More

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February 2021

KCNQ2-DEE: developmental or epileptic encephalopathy?

Ann Clin Transl Neurol 2021 03 22;8(3):666-676. Epub 2021 Feb 22.

Epilepsy Genetics Program, Department of Neurology, Boston Children's Hospital, Boston, Massachusetts, USA.

Objective: KCNQ2-associated developmental and epileptic encephalopathies (DEE) present with seizures and developmental impairments. The relation between seizures and functional impairments in affected children and the relation of a specific genetic variant to seizure control remains unknown.

Methods: Parents of children with documented KCNQ2 variants who participated in a structured, online natural history survey provided information about seizure history, functional mobility, hand use, communication function, and feeding independence. Read More

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Role of high-density EEG (hdEEG) in pre-surgical epilepsy evaluation in children: case report and review of the literature.

Childs Nerv Syst 2021 May 18;37(5):1429-1437. Epub 2021 Feb 18.

Pediatric Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo F. Vito 1, 00168, Rome, Italy.

Introduction: Electrical source imaging (ESI) and especially hdEEG represent a noninvasive, low cost and accurate method of localizing epileptic zone (EZ). Such capability can greatly increase seizure freedom rate in surgically treated drug resistant epilepsy cases. Furthermore, ESI might be important in intracranial record planning. Read More

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Disentangling the links between habitat complexity and biodiversity in a kelp-dominated subantarctic community.

Ecol Evol 2021 Feb 15;11(3):1214-1224. Epub 2021 Jan 15.

Centro FONDAP de Investigación Dinámica de Ecosistemas Marinos de Altas Latitudes (IDEAL) Universidad Austral de Chile Valdivia Chile.

Habitat complexity is one of the most important factors modulating species diversity. This feature comprises several interrelated attributes, such as number, size, and spatial arrangement of complexity-forming elements. However, the separate and joint effects of these attributes on diversity and community structure are still not well understood. Read More

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February 2021

Polyethylene Glycol Coated Magnetic Nanoparticles: Hybrid Nanofluid Formulation, Properties and Drug Delivery Prospects.

Nanomaterials (Basel) 2021 Feb 9;11(2). Epub 2021 Feb 9.

Department of Physics, SCSVMV Deemed University, Kanchipuram 631561, India.

Magnetic nanoparticles (MNPs) are widely used materials for biomedical applications owing to their intriguing chemical, biological and magnetic properties. The evolution of MNP based biomedical applications (such as hyperthermia treatment and drug delivery) could be advanced using magnetic nanofluids (MNFs) designed with a biocompatible surface coating strategy. This study presents the first report on the drug loading/release capability of MNF formulated with methoxy polyethylene glycol (referred to as PEG) coated MNP in aqueous (phosphate buffer) fluid. Read More

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February 2021

Can semiology differentiate between bilateral tonic-clonic seizures of focal-onset and generalized-onset? A systematic review.

Epilepsy Behav 2021 03 5;116:107769. Epub 2021 Feb 5.

Department of Neuroscience, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia; Department of Neuroscience, Monash Medical Centre, Melbourne, Australia. Electronic address:

Objective: Bilateral tonic-clonic seizures are encountered in both focal and generalized epilepsies. We reviewed the literature regarding the presence of focal signs in generalized-onset tonic-clonic seizures (GOTCS) and the utility of semiology in differentiating those from focal to bilateral tonic-clonic seizures (FBTCS).

Methods: We conducted a comprehensive literature search using four electronic databases (Medline, Embase, Web of Science, and Psychinfo) and constructed a systematic review in keeping with the Preferred Items for Systematic Reviews and Meta-analyses guidelines. Read More

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Distinct dual cortico-cortical networks successfully identified between supplemental and primary motor areas during intracranial EEG for drug-resistant frontal lobe epilepsy.

Epilepsy Behav Rep 2021 19;15:100429. Epub 2021 Jan 19.

Division of Neurology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X3, Canada.

We present a case of drug-resistant focal motor seizures in which separate cortico-cortical epileptic networks within the supplementary motor area (SMA) proper and primary motor area (PMA) were proven by ictal high-frequency oscillation (HFO) and cortico-cortical evoked potential (CCEP). A 12-year-old girl presented with two types seizures: type A, tonic extension and subsequent clonic movements of the right arm; and type B, tonic and clonic movements of the right leg. MRI was normal and karyotype genetic analysis revealed 46,X,t(X;14)(q13;p12). Read More

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January 2021