19,741 results match your criteria han population


Spatial distribution, homologue patterns and ecological risks of chlorinated paraffins in mangrove sediments along the South China Coast.

Environ Pollut 2021 Dec 3;294:118623. Epub 2021 Dec 3.

Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality, Jinan University, Guangzhou, 511443, China. Electronic address:

The spatial distribution, homologue patterns, and ecological risks of chlorinated paraffins (CPs) were investigated in sediments from sixteen mangrove wetlands along the South China Coast (SCS). The total concentrations of CPs in mangrove sediments from Guangdong, Fujian, Guangxi, and Hainan were in the range of 933-4760, 619-2300, 375-1550, and 271-658 ng/g dry weight, respectively. The contamination levels and spatial distribution of short-chain and medium-chain CPs (SCCPs and MCCPs, respectively) in mangrove sediments were mainly affected by local population scale and CP industries. Read More

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December 2021

Multi-membrane search algorithm.

PLoS One 2021 6;16(12):e0260512. Epub 2021 Dec 6.

School of Electrical and Information Engineering, Anhui University of Science and Technology, Huainan, China.

This research proposes a new multi-membrane search algorithm (MSA) based on cell biological behavior. Cell secretion protein behavior and cell division and fusion strategy are the main inspirations for the algorithm. In order to verify the performance of the algorithm, we used 19 benchmark functions to compare the MSA test results with MVO, GWO, MFO and ALO. Read More

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December 2021

Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity.

Hepatology 2021 Dec 6. Epub 2021 Dec 6.

School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, China.

Background And Aims: Iron overload is a frequent finding in the general population. As the major iron storage site, liver is subject to iron toxicity. Farnesoid X receptor (FXR) regulates bile acid metabolism and is implicated in various liver diseases. Read More

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December 2021

Sociodemographic Correlates of Organized Sports Participation in a Sample of Middle School Students in China.

Front Public Health 2021 18;9:730555. Epub 2021 Nov 18.

Centre for Science and Experiment, Nanjing Sport Institute, Nanjing, China.

Organized sport participation (OSP) is considered as one method with the potential to increase overall physical activity (PA) levels in young people. It is essential to understand the correlates of OSP to inform future PA interventions. This study aimed to explore the sociodemographic correlates of OSP among middle school students from the Nanjing City of China. Read More

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November 2021

The Health Effect of the Number of Children on Chinese Elders: An Analysis Based on Hukou Category.

Front Public Health 2021 16;9:700024. Epub 2021 Nov 16.

School of International and Public Affairs, Shanghai Jiaotong University, Shanghai, China.

Based on the 2018 China Health and Retirement Longitudinal Study (CHARLS 2018), from the perspective of urban-rural disparity, this paper investigates how fertility affects Chinese elders' health. We exploit the enactment of the one-child policy in 1979 to construct instrumental variables capturing the health effect of having only one child rather than multiple children. The empirical results show that the health condition of rural elders having only one child is worse than elders having multiple children, while the negative health effect of lower fertility becomes statistically insignificant for urban elderly parents. Read More

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November 2021

High-Quality Genomes and High-Density Genetic Map Facilitate the Identification of Genes From a Weedy Rice.

Front Plant Sci 2021 19;12:775051. Epub 2021 Nov 19.

National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.

Genes have been lost or weakened from cultivated rice during rice domestication and breeding. Weedy rice ( f. ) is usually recognized as the progeny between cultivated rice and wild rice and is also known to harbor an gene pool for rice breeding. Read More

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November 2021

Compelling Evidence Linking CD40 Gene With Graves' Disease in the Chinese Han Population.

Front Endocrinol (Lausanne) 2021 18;12:759597. Epub 2021 Nov 18.

Department of Molecular Diagnostic and Endocrinology, The Core Laboratory in Medical Center of Clinical Research, The Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Mutations in have been widely reported to be risk factors for Graves' disease (GD). The gene, along with its cognate ligand CD40L, may regulate pro-inflammatory and immune responses. Rs1883832, located at the -1 position of the Kozak sequence, is the most well-studied single nucleotide polymorphism (SNP) of , and has been confirmed to predispose those with the alteration to GD, regardless of ethnicity. Read More

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November 2021

The Positivity Rate of IA-2A and ZnT8A in the Chinese Han Population With Type 1 Diabetes Mellitus: Association With rs1143627 and rs1143643 Polymorphisms in the IL1B Gene.

Front Pharmacol 2021 11;12:729890. Epub 2021 Nov 11.

National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China.

To investigate the association between susceptibility to type 1 diabetes mellitus (T1DM) and polymorphisms (rs1143627 and rs1143643) in the interleukin 1 beta (IL1B) gene in the Chinese Han population. The Meso Scale Discovery (MSD) method was used to detect the concentration of IL-1β in 24 T1DM patients and 27 healthy controls. MassARRAY was used to analyze the polymorphisms in the IL1B gene in 510 patients with classic T1DM and 531 healthy controls. Read More

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November 2021

Gene polymorphisms of SIRT1 in patients with rheumatoid arthritis.

Int J Rheum Dis 2021 Dec 5. Epub 2021 Dec 5.

Department of Rheumatology and Immunology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Aim: Previous studies have shown that silent information regulator 1 (SIRT1) expression is elevated in rheumatoid arthritis (RA) patients. However, whether gene polymorphisms in SIRT1 gene associated with RA in a Chinese Han population remains to be discussed.

Method: In this case-control study, 529 RA patients and 700 healthy controls were selected, and association of 11 SIRT1 gene polymorphisms (rs12415800, rs3740051, rs932658, rs3740053, rs7895833, rs10509291, rs33957861, rs7069102, rs2273773, rs3818292, rs1467568) with RA susceptibility was evaluated. Read More

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December 2021

Association of genetic variants in with high myopia in the Han population of southwestern China.

Ophthalmic Genet 2021 Dec 5:1-7. Epub 2021 Dec 5.

Health Management Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Purpose: To investigate the associations of 11 genetic single nucleotide polymorphisms (SNPs) in FRAP1 and PDGFRA with high myopia (HM) in a Han Chinese population.

Methods: A total of 442 HM patients and 947 healthy controls were recruited for this study. Five genetic models were analysed to further evaluate the association of target SNPs with HM. Read More

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December 2021

Acromegaly and cardiovascular outcomes: a cohort study.

Eur Heart J 2021 Dec 4. Epub 2021 Dec 4.

Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29, Saemunan-ro, Jongno-gu, Seoul 03181, Republic of Korea.

Aims: Cardiovascular disease is a common complication in acromegaly. We investigated the risk of cardiovascular disease and mortality in patients with acromegaly in a large-scale population using nationwide data in Korea.

Methods And Results: We performed a nationwide, retrospective, observational, cohort study of patients with acromegaly (n = 1874) and age- and sex-matched subjects without acromegaly (n = 9370) for a mean follow-up of 7. Read More

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December 2021

Association of clinical and social factors with risk of fracture in children with atopic dermatitis.

Pediatr Allergy Immunol 2021 Dec 4. Epub 2021 Dec 4.

Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.

Background: Children with atopic dermatitis (AD) have multiple risk factors for accidental fractures, injuries that can lead to significant morbidity and mortality. However, little is known about the factors that mediate the relationship between AD and fracture in children.

Objective: Our purpose was to examine the association of AD with fracture and to identify potential mediating factors. Read More

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December 2021

The allelopathy and underlying mechanism of Skeletonema costatum on Karenia mikimotoi integrating transcriptomics profiling.

Aquat Toxicol 2021 Nov 22;242:106042. Epub 2021 Nov 22.

Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao, 266100, China. Electronic address:

The roles of allelopathy for succession of marine phytoplankton communities remain controversial, especially for the development of blooms. Physiological parameters measurement (Fv/Fm value, MDA content, SOD activity, Na/K, Ca/ Mg-ATPase activity, cell size, chlorophyll content, apoptosis and cell cycle) and whole transcriptome profiling analysis were used to investigate allelopathy effect of Skeletonema costatum on Karenia mikimotoi. Filtrate and extracts from S. Read More

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November 2021

Alcohol consumption, poor lifestyle choices, and air pollution worsen cognitive function in seniors: a cohort study in China.

Environ Sci Pollut Res Int 2021 Dec 3. Epub 2021 Dec 3.

Department of Biostatistics, School of Public Health, Peking University, No. 38, Xueyuan Road, Haidian District, Beijing City, 100191, China.

Based on the complexity of cognitive-related influences and the specificity of Chinese liquor culture, this study aimed to explore the associations and potential interactions between demographic characteristics, alcohol consumption, life and atmospheric environment, and cognitive function in seniors through a comprehensive analysis, in order to provide evidence support and feasible recommendations. The study sample was selected from the Chinese Longitudinal Healthy Longevity Survey, which included 40,583 seniors aged 65-115 years. Data analysis and processing were performed by R 4. Read More

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December 2021

Sociodemographic Characteristics, Comorbidities, and Mortality Among Persons Diagnosed With Tuberculosis and COVID-19 in Close Succession in California, 2020.

JAMA Netw Open 2021 12 1;4(12):e2136853. Epub 2021 Dec 1.

California Department of Public Health, Richmond.

Importance: Tuberculosis (TB) and COVID-19 are respiratory diseases that disproportionately occur among medically underserved populations; little is known about their epidemiologic intersection.

Objective: To characterize persons diagnosed with TB and COVID-19 in California.

Design, Setting, And Participants: This cross-sectional analysis of population-based public health surveillance data assessed the sociodemographic, clinical, and epidemiologic characteristics of California residents who were diagnosed with TB (including cases diagnosed and reported between September 3, 2019, and December 31, 2020) and COVID-19 (including confirmed cases based on positive results on polymerase chain reaction tests and probable cases based on positive results on antigen assays reported through February 2, 2021) in close succession compared with those who were diagnosed with TB before the COVID-19 pandemic (between January 1, 2017, and December 31, 2019) or diagnosed with COVID-19 alone (through February 2, 2021). Read More

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December 2021

Prenatal diagnosis of isolation of aortic brachiocephalic artery.

Acta Radiol 2021 Dec 3:2841851211058278. Epub 2021 Dec 3.

Beijing Key Laboratory of Maternal-Fetal Medicine and Fetal Heart Disease, 12667Beijing Anzhen Hospital, Capital Medical University, Beijing, PR China.

Background: Isolated aortic brachiocephalic artery (IABA) is a rare congenital aortic arch anomaly. It is difficult to diagnose IABA prenatally and the prevalence in the prenatal population is unknown.

Purpose: To evaluate the echocardiographic characteristics and associations in fetuses with IABA. Read More

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December 2021

Genetic Variations and Clinical Features of -Related Nephrotic Syndrome in Chinese Children: A Multicenter, Retrospective Study.

Front Med (Lausanne) 2021 11;8:771227. Epub 2021 Nov 11.

Department of Nephrology, Children's Hospital of Fudan University, Shanghai, China.

Few studies have addressed the genetic spectrum of variants in Chinese children with nephrotic syndrome. In this multicenter study, the clinical manifestations and features of variants in Chinese children with nephrotic syndrome were researched. Genotypical and phenotypical data from 30 children affected by variants were collected from a multicenter registration system in China and analyzed retrospectively. Read More

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November 2021

Socioeconomic Determinants of Melanoma-Related Health Literacy and Attitudes Among College Students in China: A Population-Based Cross-Sectional Study.

Front Public Health 2021 11;9:743368. Epub 2021 Nov 11.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

To investigate the association of gender, ethnicity, living region, and socioeconomic status (SES) with health literacy and attitudes toward nevi and melanoma in Chinese adolescents and to examine whether health literacy mediates the association of SES with attitudes. A multicenter cross-sectional study was conducted among newly enrolled college students. First-year students were recruited from five universities in different regions of China in 2018 using the cluster sampling method. Read More

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November 2021

Another New Year, Will the Chinese Residents Wear Face Masks Again? A Cross-Sectional Survey.

Front Public Health 2021 10;9:727234. Epub 2021 Nov 10.

Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

As more and more countries enter the low-transmission phase, maintaining prevention awareness among the population is critical to prevent a secondary outbreak. With large-scale interpersonal communication, whether Chinese residents can maintain a high awareness of prevention and control and adhere to the use of masks during the Chinese New Year of 2021 is worth studying. A cross-sectional survey was conducted in China from February 4 to 26, 2021. Read More

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November 2021

The safety and efficacy of immunotherapy with anti-programmed cell death 1 monoclonal antibody for lung cancer complicated with infection.

Transl Lung Cancer Res 2021 Oct;10(10):3929-3942

Department of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, School of Medicine, Tongji University, Shanghai, China.

Background: Anti-programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) immunotherapy has boosted the prognosis in advanced lung cancer. Meanwhile, accumulating cases showed the correlation between tuberculosis (TB) reactivation and anti-PD-1/PD-L1 immunotherapy. However, the safety and efficacy of anti-PD-1/PD-L1 immunotherapy for lung cancer complicated with TB infection could only be learned from real-world data. Read More

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October 2021

Application of SNP in Genetic Sex Identification and Effect of Estradiol on Gene Expression of Sex-Related Genes in .

Front Endocrinol (Lausanne) 2021 11;12:756530. Epub 2021 Nov 11.

Key Laboratory of Mariculture & Stock Enhancement in North China Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, Dalian, China.

Sea urchin () is an economically important mariculture species in Asia, and its gonads are the only edible part. The efficiency of genetic breeding in sea urchins is hampered due to the inability to distinguish gender by appearance. In this study, we first identified a sex-associated single nucleotide polymorphism (SNP) by combining type IIB endonuclease restriction site-associated DNA sequencing (2b-RAD-seq) and genome survey. Read More

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November 2021

Association of a Healthy Lifestyle With All-Cause and Cause-Specific Mortality Among Individuals With Type 2 Diabetes: A Prospective Study in UK Biobank.

Diabetes Care 2021 Dec 2. Epub 2021 Dec 2.

CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

Objective: To evaluate the association of a healthy lifestyle, involving seven low-risk factors mentioned in diabetes management guidelines (no current smoking, moderate alcohol consumption, regular physical activity, healthy diet, less sedentary behavior, adequate sleep duration, and appropriate social connection), with all-cause and cause-specific mortality among individuals with type 2 diabetes.

Research Design And Methods: This study included 13,366 participants with baseline type 2 diabetes from the UK Biobank free of cardiovascular disease (CVD) and cancer. Lifestyle information was collected through a baseline questionnaire. Read More

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December 2021

Analysis of gene single-nucleotide polymorphisms in a Han Chinese population with dilated cardiomyopathy.

Biomark Med 2021 Dec 3. Epub 2021 Dec 3.

Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China.

We aimed to investigate the association of gene polymorphisms with the susceptibility and prognosis of dilated cardiomyopathy (DCM) in a Chinese population. A total of 369 controls and 373 DCM patients were enrolled. Three tag single-nucleotide polymorphisms (rs2261612, rs2522138 and rs16950058) on were evaluated. Read More

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December 2021

Global estimates of viral suppression in children and adolescents and adults on antiretroviral therapy adjusted for missing viral load measurements: a multiregional, retrospective cohort study in 31 countries.

Lancet HIV 2021 Dec;8(12):e766-e775

The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.

Background: As countries move towards the UNAIDS's 95-95-95 targets and with strong evidence that undetectable equals untransmittable, it is increasingly important to assess whether those with HIV who are receiving antiretroviral therapy (ART) achieve viral suppression. We estimated the proportions of children and adolescents and adults with viral suppression at 1, 2, and 3 years after initiating ART.

Methods: In this retrospective cohort study, seven regional cohorts from the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium contributed data from individuals initiating ART between Jan 1, 2010, and Dec 31, 2019, at 148 sites in 31 countries with annual viral load monitoring. Read More

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December 2021

Neoadjuvant endocrine therapy expands stromal populations that predict poor prognosis in estrogen receptor-positive breast cancer.

Mol Carcinog 2021 Dec 2. Epub 2021 Dec 2.

Department of Medicine, Division of Medical Oncology, Anschutz Medical Campus, University of Colorado, Aurora, Colorado, USA.

The tumor microenvironment (TME) is an important modulator of response and resistance to endocrine therapy in estrogen receptor alpha (ER) positive breast cancer. Endocrine therapy is highly effective at reducing tumor burden and preventing recurrence in most estrogen receptor alpha (ER) positive breast cancers. Existing drugs work either directly by targeting tumor-cell ER or indirectly by inhibiting estrogen production in stromal cells with aromatase inhibitors (AI). Read More

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December 2021

Validation of the Turkish version of the Pain Sensitivity Questionnaire in patients with chronic pain.

J Int Med Res 2021 Dec;49(12):3000605211060158

Department of Anaesthesiology and Reanimation, Faculty of Medicine, Istanbul Medeniyet University, Istanbul 34000, Turkey.

Objective: The Pain Sensitivity Questionnaire (PSQ) is a clinically beneficial instrument that has been proven to be correlated with various experimental pain sensitivity assessments in healthy people and in patients with chronic pain. In this study, we aimed to translate the PSQ into Turkish (PSQ-T) and validate it for the measurement of pain sensitivity among Turkish people.

Methods: Seventy-three patients with chronic back pain who were planning to undergo an interventional procedure completed the Brief Pain Inventory-Short Form (BPI-SF), Beck Depression Inventory (BDI), Beck Anxiety Inventory, Pain Catastrophizing Scale, and PSQ prior to their procedure. Read More

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December 2021

Prevalence and risk factors of stroke in a rural area of northern China: a 10-year comparative study.

Aging Clin Exp Res 2021 Dec 2. Epub 2021 Dec 2.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background And Aims: Stroke is currently the leading cause of death in China; however, the past decade has produced no new epidemiological studies of stroke. Therefore, the current study aimed to compare the prevalence and risk factors of stroke between 2010 and 2019.

Methods: A comparative study was used to analyze the prevalence of risk factors for stroke in a population aged 65 years or older between 2010 and 2019. Read More

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December 2021

Association of COVID-19 Vaccination With SARS-CoV-2 Infection in Patients With Cancer: A US Nationwide Veterans Affairs Study.

JAMA Oncol 2021 Dec 2. Epub 2021 Dec 2.

VA Cooperative Studies Program, VA Boston Healthcare System, Boston, Massachusetts.

Importance: Patients with cancer are at increased risk for severe COVID-19, but it is unknown whether SARS-CoV-2 vaccination is effective for them.

Objective: To determine the association between SARS-CoV-2 vaccination and SARS-CoV-2 infections among a population of Veterans Affairs (VA) patients with cancer.

Design, Setting, And Participants: Retrospective, multicenter, nationwide cohort study of SARS-CoV-2 vaccination and infection among patients in the VA health care system from December 15, 2020, to May 4, 2021. Read More

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December 2021

Association of KCNQ1rs2237892C⟶T Gene with Type 2 Diabetes Mellitus: A Meta-Analysis.

J Diabetes Res 2021 22;2021:6606830. Epub 2021 Nov 22.

Health Management College, Anhui Medical University, Hefei, Anhui 230032, China.

Background: Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases in adults, causing high morbidity and mortality worldwide. In recent years, the prevalence of T2DM has been increasing significantly, and genome-wide association studies (GWAS) have shown that KCNQ1 significantly increases the risk of T2DM.

Objective: To find large-scale evidence on whether the KCNQ1rs2237892C⟶T gene polymorphism is associated with T2DM susceptibility. Read More

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November 2021

Characterization of Medication Trends for Chronic Kidney Disease: Mineral and Bone Disorder Treatment Using Electronic Health Record-Based Common Data Model.

Biomed Res Int 2021 22;2021:5504873. Epub 2021 Nov 22.

Department of Nephrology, Ajou University School of Medicine, 164, Worldcup-ro, Yeongtong-gu, Suwon, Gyeonggi-do 16499, Republic of Korea.

Chronic kidney disease-mineral bone disorder (CKD-MBD) is the most common complication in CKD patients. Although there is a consensus on treatment guidelines for CKD-MBD, it remains uncertain whether these treatment recommendations reflect actual practice. Therefore, the aim of this study was to investigate the CKD-MBD medication trend in real-world practice. Read More

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November 2021