132 results match your criteria hamper preventive


A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies.

Front Pharmacol 2021 29;12:639840. Epub 2021 Mar 29.

Lake Erie College of Osteopathic Medicine, Bradenton, FL, United States.

Natural product-based cancer preventive and therapeutic entities, such as flavonoids and their derivatives, are shown to have a noticeable capability to suppress tumor formation and cancer cell growth. Naringin, a natural flavanone glycoside present in various plant species, has been indicated to modulate different signaling pathways and interact with numerous cell signaling molecules, which allows for an extensive variety of pharmacological actions, such as amelioration of inflammation, oxidative stress, metabolic syndromes, bone disorders, and cancer. The purpose of this systematic review is to present a critical and comprehensive assessment of the antitumor ability of naringin and associated molecular targets in various cancers. Read More

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Effects of the COVID-19 Emergency and National Lockdown on Italian Citizens' Economic Concerns, Government Trust, and Health Engagement: Evidence From a Two-Wave Panel Study.

Milbank Q 2021 Apr 6. Epub 2021 Apr 6.

EngageMinds HUB, Consumer, Food, and Health Engagement Research Center, Università Cattolica del Sacro Cuore.

Policy Points Preventive measures such as the national lockdown in Italy have been effective in slowing the spread of COVID-19. However, they also had psychological and economic impacts on people's lives, which should not be neglected as they may reduce citizens' trust and compliance with future health mandates. Engaging citizens in their own health management and in the collaboration with health care professionals and authorities via the adoption of a collaborative approach to health policy development is fundamental to fostering such measures' effectiveness. Read More

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Impact of COVID-19 on workload burden of a complex radiotherapy facility.

Radiol Med 2021 Mar 1. Epub 2021 Mar 1.

Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.

Background And Purpose: COVID-19 constitutes a worldwide threat, prompting Italian Government to implement specific measures on March 8, 2020, to protect patients and health workers from disease transmission. The impact of preventive measures on daily activity of a radiotherapy facility may hamper the ability to fulfill normal workload burden. Thus, we assessed the number of delivered treatments in a specific observation period after the adoption of preventive measures (since March 11 to April 24, 2020) and compared it with the corresponding period of the year 2019. Read More

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Recommendations for participation in leisure-time physical activity and competitive sports in patients with arrhythmias and potentially arrhythmogenic conditions: Part 1: Supraventricular arrhythmias. A position statement of the Section of Sports Cardiology and Exercise from the European Association of Preventive Cardiology (EAPC) and the European Heart Rhythm Association (EHRA), both associations of the European Society of Cardiology.

Eur J Prev Cardiol 2020 Jun 29. Epub 2020 Jun 29.

Italian National Olympic Committee, Institute of Sport Medicine and Science, Italy.

Symptoms attributable to arrhythmias are frequently encountered in clinical practice. Cardiologists and sport physicians are required to identify high-risk individuals harbouring such conditions and provide appropriate advice regarding participation in regular exercise programmes and competitive sport. The three aspects that need to be considered are: (a) the risk of life-threatening arrhythmias by participating in sports; (b) control of symptoms due to arrhythmias that are not life-threatening but may hamper performance and/or reduce the quality of life; and (c) the impact of sports on the natural progression of the underlying arrhythmogenic condition. Read More

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How effective are three methods of teaching oral hygiene for adolescents undergoing orthodontic treatment? The MAHO protocol: an RCT comparing visual, auditory and kinesthetic methods.

Trials 2021 Feb 15;22(1):144. Epub 2021 Feb 15.

Univ Rennes, ISCR, CNRS-UMR 6226, CHU Rennes, Pôle Odontologie, 2 av. du Professeur Léon Bernard, Bât. 15, 35043, Rennes Cedex, France.

Background: Fixed orthodontic appliances hamper oral hygiene procedures. The consequences are gingivitis and white spot lesions. Fifty to 70% of patients treated with braces encounter these problems. Read More

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February 2021

Mobile Phone Use and Acceptability for the Delivery of Mental Health Information Among Perinatal Adolescents in Nigeria: Survey Study.

JMIR Ment Health 2021 Jan 26;8(1):e20314. Epub 2021 Jan 26.

University of Washington Seattle, Seattle, WA, United States.

Background: There are several barriers that may hamper adolescent mothers' utilization of available health interventions for perinatal depression. Innovative treatment approaches are needed to increase adolescent mothers' access to mental health care for improved maternal and child health outcomes. Mobile phones have the potential to serve as important conduits to mental health care in Africa. Read More

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January 2021

PasoDoble, a Proposed Dance/Music for People With Parkinson's Disease and Their Caregivers.

Front Neurol 2020 12;11:567891. Epub 2020 Nov 12.

Department of Psychiatry and Forensic Medicine, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.

Managing the heterogeneity of Parkinson's disease symptoms and its progressive nature demands strategies targeting the hallmark disrupted neurotransmission but also the comorbid derangements and bolstering neuroprotection and regeneration. Strong efforts are done to find disease-modifying strategies, since slowing disease progression is not enough to hamper its burden and some motor symptoms are resistant to dopamine-replacement therapy. The inclusion of non-pharmacological strategies can provide such a multitarget umbrella approach. Read More

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November 2020

Spectrum of pleuropulmonary paragonimiasis: An analysis of 685 cases diagnosed over 22 years.

J Infect 2021 Jan 2;82(1):150-158. Epub 2020 Oct 2.

Department of Molecular Parasitology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 2066 Seobu-ro, Jangan-gu, Suwon 16419, Korea. Electronic address:

Objectives: Paragonimiasis is a global foodborne zoonosis. Overlapping clinical and imaging features with other lung pathologies hamper correct diagnosis and require differential diagnosis.

Methods: During 1982-2003, 49,012 samples were referred for immunodiagnosis of helminthiases. Read More

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January 2021

Association of occupational dust exposure with combined chronic obstructive pulmonary disease and pneumoconiosis: a cross-sectional study in China.

BMJ Open 2020 09 9;10(9):e038874. Epub 2020 Sep 9.

Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

Objectives: Occupational dust exposure may induce various lung diseases, including pneumoconiosis and chronic obstructive pulmonary disease (COPD). The features of combined COPD and pneumoconiosis have not been well described, and this may hamper the management. This study aimed to describe the prevalence and characteristics as well as the risk factors of the combined diseases. Read More

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September 2020

Perceived Risk of Being Infected With SARS-CoV-2: A Perspective From Indonesia.

Disaster Med Public Health Prep 2020 Sep 10:1-5. Epub 2020 Sep 10.

Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, Michigan.

Objectives: The aim of this study was to determine the level of coronavirus disease 2019 (COVID-19) risk perceptions in Indonesia and characterize predictors of perceptions.

Methods: An online cross-sectional study was conducted. A questionnaire assessed perceived risk and collected independent variables, including sociodemographic data. Read More

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September 2020

COVID-19 patients display distinct SARS-CoV-2 specific T-cell responses according to disease severity.

J Infect 2021 02 25;82(2):282-327. Epub 2020 Aug 25.

Department of Infectious Disease, University Hospital of Besançon, F-25000 Besançon, France; UMR-CNRS 6249 Chrono-Environnement, Université Bourgogne Franche-Comté, F-25000 Besançon, France. Electronic address:

Adaptive Immune responses generated by SARS-CoV-2 virus in convalescent patients according to disease severity remain poorly characterized. To this end, we designed a prospective study (NCT04365322) that included 60 COVID-19 convalescent patients (1-month post infection) in two cohorts respectively entitled mild illness and severe pneumonia. The monitoring of peripheral immune responses was performed using IFNᵧ ELISpot assay. Read More

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February 2021

Differences in cohort study data affect external validation of artificial intelligence models for predictive diagnostics of dementia - lessons for translation into clinical practice.

EPMA J 2020 Sep 22;11(3):367-376. Epub 2020 Jun 22.

Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Schloss Birlinghoven, 53757 Sankt Augustin, Germany.

Artificial intelligence (AI) approaches pose a great opportunity for individualized, pre-symptomatic disease diagnosis which plays a key role in the context of personalized, predictive, and finally preventive medicine (PPPM). However, to translate PPPM into clinical practice, it is of utmost importance that AI-based models are carefully validated. The validation process comprises several steps, one of which is testing the model on patient-level data from an independent clinical cohort study. Read More

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September 2020

A Call for Preventive Medicine Attention for Indonesian Physicians.

Acta Med Indones 2020 Apr;52(2):99-101

1. School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia. 2. Department of Internal Medicine, Saint Carolus Hospital, Jakarta, Indonesia.

The year of 2020 teaches us to prevent is always better than to cure. It is an old phrase that is being used for decades, but it is never been implemented cordially by our society nowadays. Covid-19 is a good lesson that reminds us to carefully prevent the spread of coronavirus which is now a pandemic worldwide. Read More

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Recommendations for participation in leisure-time physical activity and competitive sports in patients with arrhythmias and potentially arrhythmogenic conditions: Part 1: Supraventricular arrhythmias. A position statement of the Section of Sports Cardiology and Exercise from the European Association of Preventive Cardiology (EAPC) and the European Heart Rhythm Association (EHRA), both associations of the European Society of Cardiology.

Eur J Prev Cardiol 2020 Jun 29:2047487320925635. Epub 2020 Jun 29.

Italian National Olympic Committee, Institute of Sport Medicine and Science, Italy.

Symptoms attributable to arrhythmias are frequently encountered in clinical practice. Cardiologists and sport physicians are required to identify high-risk individuals harbouring such conditions and provide appropriate advice regarding participation in regular exercise programmes and competitive sport. The three aspects that need to be considered are: (a) the risk of life-threatening arrhythmias by participating in sports; (b) control of symptoms due to arrhythmias that are not life-threatening but may hamper performance and/or reduce the quality of life; and (c) the impact of sports on the natural progression of the underlying arrhythmogenic condition. Read More

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Multicentric study of cervical cancer screening with human papillomavirus testing and assessment of triage methods in Latin America: the ESTAMPA screening study protocol.

BMJ Open 2020 05 24;10(5):e035796. Epub 2020 May 24.

Prevention and Implementation Group, International Agency for Research on Cancer, Lyon, Rhône-Alpes, France.

Introduction: Human papillomavirus (HPV) testing is replacing cytology in primary screening. Its limited specificity demands using a second (triage) test to better identify women at high-risk of cervical disease. Cytology represents the immediate triage but its low sensitivity might hamper HPV testing sensitivity, particularly in low-income and middle-income countries (LMICs), where cytology performance has been suboptimal. Read More

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Clinical prediction models for acute kidney injury.

Rev Bras Ter Intensiva 2020 Mar 8;32(1):123-132. Epub 2020 May 8.

Laboratory of Intensive Care Medicine, Academic Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Belgium.

Objective: To report on the currently available prediction models for the development of acute kidney injury in heterogeneous adult intensive care units.

Methods: A systematic review of clinical prediction models for acute kidney injury in adult intensive care unit populations was carried out. PubMed® was searched for publications reporting on the development of a novel prediction model, validation of an established model, or impact of an existing prediction model for early acute kidney injury diagnosis in intensive care units. Read More

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Influence of Parental Physical Activity and Screen Time on the BMI of Adult Offspring in a Saudi Population.

Healthcare (Basel) 2020 Apr 24;8(2). Epub 2020 Apr 24.

Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia.

Saudi Arabia is witnessing a drastic rise in adult obesity. Geographic limitations hamper somatic activities to counter this rise. Parental physical inactivity in the region has never been addressed. Read More

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Feasibility of the AusMed Diet Program: Translating the Mediterranean Diet for Older Australians.

Nutrients 2020 Apr 10;12(4). Epub 2020 Apr 10.

School of Health Sciences, Faculty of Health, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia.

The Mediterranean diet pattern (MEDI) is associated with a lower risk of chronic conditions related to ageing. Adherence research mostly comes from Mediterranean countries with high cultural acceptability. This study examines the feasibility of a MEDI intervention designed specifically for older Australians (AusMed). Read More

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Prevalence and pattern of caries in primary anterior teeth of preschool children: An observational study.

J Indian Soc Pedod Prev Dent 2020 Jan-Mar;38(1):26-33

Departement of Pedodontic and Preventive Dentistry, Faculty of Dental Sciences, Institute of Medical Sciences, BHU, Varanasi, Uttar Pradesh, India.

Introduction: Primary teeth are prone to caries. Consequences of caries may hamper eruption and function of the succedaneous teeth. The aim of the study is to find the prevalence and patterns of dental caries in maxillary and mandibular primary anterior teeth of preschool children. Read More

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Re- and demineralization characteristics of dentin depending on fluoride application and baseline characteristics in situ.

J Dent 2020 03 26;94:103305. Epub 2020 Feb 26.

Department of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, 3010 Bern, Switzerland.

Objectives: The aim of this double-blinded, randomized, cross-over in situ study was to evaluate the re- and demineralization characteristics of sound dentin as well as highly and lowly demineralized dentin after the application of different fluoride concentrations.

Methods: In each of four experimental legs of four weeks 20 participants wore intraoral mandibular appliances containing two (highly demineralized [E]) bovine enamel and four (lowly and highly demineralized [D,D]) bovine dentin specimens (n = 480). Each specimen included one sound (ST) and one demineralized lesion area (DT). Read More

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Study protocol for efficacy and safety of steroid-containing mouthwash to prevent chemotherapy-induced stomatitis in women with breast cancer: a multicentre, open-label, randomised phase 2 study.

BMJ Open 2020 02 13;10(2):e033446. Epub 2020 Feb 13.

Surgery, Nagasaki University School of Medicine Graduate School of Biomedical Sciences, Nagasaki, Japan.

Introduction: Stomatitis is a frequent adverse event in patients undergoing chemotherapy for breast cancer. Stomatitis can hamper oral nutrition resulting in malnutrition, reduce quality of life and introduce the need for dose reductions and interruption of chemotherapy; however, there is currently no standard approach for preventing chemotherapy-induced stomatitis. We aimed to assess the safety and efficacy of a dexamethasone-based elixir mouthwash for preventing chemotherapy-induced stomatitis in patients with early breast cancer. Read More

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February 2020

Spatially Adjusted Time-varying Reproductive Numbers: Understanding the Geographical Expansion of Urban Dengue Outbreaks.

Sci Rep 2019 12 16;9(1):19172. Epub 2019 Dec 16.

Department of Geography, National Taiwan University, Taipei City, 106, Taiwan.

The basic reproductive number (R) is a fundamental measure used to quantify the transmission potential of an epidemic in public health practice. However, R cannot reflect the time-varying nature of an epidemic. A time-varying effective reproductive number R can provide more information because it tracks the subsequent evolution of transmission. Read More

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December 2019

The AURORA Study: a longitudinal, multimodal library of brain biology and function after traumatic stress exposure.

Mol Psychiatry 2020 02 19;25(2):283-296. Epub 2019 Nov 19.

Department of Health Care Policy, Harvard Medical School, Boston, MA, USA.

Adverse posttraumatic neuropsychiatric sequelae (APNS) are common among civilian trauma survivors and military veterans. These APNS, as traditionally classified, include posttraumatic stress, postconcussion syndrome, depression, and regional or widespread pain. Traditional classifications have come to hamper scientific progress because they artificially fragment APNS into siloed, syndromic diagnoses unmoored to discrete components of brain functioning and studied in isolation. Read More

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February 2020

Innovative strategies for the elimination of viral hepatitis at a national level: A country case series.

Liver Int 2019 10 4;39(10):1818-1836. Epub 2019 Sep 4.

Burnet Institute, Melbourne, VIC, Australia.

Viral hepatitis is a leading cause of morbidity and mortality worldwide, but has long been neglected by national and international policymakers. Recent modelling studies suggest that investing in the global elimination of viral hepatitis is feasible and cost-effective. In 2016, all 194 member states of the World Health Organization endorsed the goal to eliminate viral hepatitis as a public health threat by 2030, but complex systemic and social realities hamper implementation efforts. Read More

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October 2019

Attrition rates in trials for adolescents and young adults at clinical high-risk for psychosis: A systematic review and meta-analysis.

Early Interv Psychiatry 2020 10 18;14(5):515-527. Epub 2019 Aug 18.

Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, Alberta, Canada.

Background: Treatment of those at clinical high-risk (CHR) for developing psychosis may lead to preventive strategies. However, attrition in trials may hamper efforts to detect effective changes and lead to bias. Our objective was to synthesize the relative attrition rates in clinical trials conducted in CHR for psychosis samples. Read More

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October 2020

Inter-rater Reliability in Assessing Exercise Fidelity for the Injury Prevention Exercise Programme Knee Control in Youth Football Players.

Sports Med Open 2019 Aug 7;5(1):35. Epub 2019 Aug 7.

Division of Physiotherapy, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.

Background: To receive maximum benefits from injury prevention exercise programmes (IPEP) such as Knee Control, players need to perform the exercises as prescribed. But, exercise fidelity in IPEPs is seldom evaluated. We developed a checklist to assess exercise fidelity in the Knee Control IPEP, and the primary aim was to evaluate its inter-rater reliability. Read More

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[Health care effects of cultural beliefs about physicians and perceived discrimination].

Rev Med Chil 2019 Feb;147(2):161-167

Departamento de Psicología, Facultad de Educación, Ciencias Sociales y Humanidades, Universidad de La Frontera, Temuco, Chile.

Background: Healthcare inequities may hamper physical and mental health.

Aim: To examine perceived discrimination in healthcare services in relation to socio-structural and cultural antecedents as well as their effect on psychological processes and health.

Material And Methods: Questionnaires on beliefs about physicians, perceived discrimination, emotions and affective states and avoidance consequences in health were answered by 337 child caregivers (85% women) attending preventive health care appointments at primary health care centers. Read More

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February 2019

Direct Estimation of HDL-Mediated Cholesterol Efflux Capacity from Serum.

Clin Chem 2019 08 17;65(8):1042-1050. Epub 2019 Apr 17.

Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland;

Background: HDL-mediated cholesterol efflux capacity (HDL-CEC) is a functional attribute that may have a protective role in atherogenesis. However, the estimation of HDL-CEC is based on in vitro cell assays that are laborious and hamper large-scale phenotyping.

Methods: Here, we present a cost-effective high-throughput nuclear magnetic resonance (NMR) spectroscopy method to estimate HDL-CEC directly from serum. Read More

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Healer Granules in Nonhealing Infected Wounds.

Ann Maxillofac Surg 2018 Jul-Dec;8(2):224-229

Department of OMFS, Vokkaligara Sangha Dental College and Hospital, Bengaluru, Karnataka, India.

Background: Head-and-neck infection is one of the most frequently encountered issues in the field of oral and maxillofacial surgery. Most of the cases with head-and-neck infections are managed by empirical antibiotic therapy and extraction of offending infected tooth/teeth. However, long-term systemic antibiotic therapy can have profound compromising effects on host immune defense and thereby hamper healing, which, in turn, may lead to life-threatening complications such as localized septic foci or widespread septicemia at times leading to death of an individual. Read More

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January 2019