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Funding of Studies Supporting IA Guideline Recommendations in Cardiovascular Medicine-A Systematic Review.

J Am Heart Assoc 2021 May 7:e019513. Epub 2021 May 7.

Heart and Vascular Center Dartmouth-Hitchcock Medical Center Lebanon NH.

Each guideline recommendation from the American Heart Association and the American College of Cardiology includes an indication of the level of supporting evidence and the associated strength of recommendation with "IA" recommendations representing those with the highest quality supporting evidence and the least amount of uncertainty for benefit. In this analysis, study type and funding sources were systematically tabulated across these IA guideline recommendations over the past 5 years. Nearly half of studies supporting IA guideline recommendations were randomized controlled trials (45%). Read More

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Bibliography of published COVID-19 in children literature.

Arch Dis Child 2021 May 6. Epub 2021 May 6.

Department of Health Sciences, University of Leicester, Leicester, UK.

Background: The COVID-19 pandemic is the biggest worldwide health challenge in this century. Research concerning the role of children in the spread of SARS-CoV-2, and investigating the clinical effects of infection in children, has been vital. This paper describes the publication trend for pertinent scientific literature relating to COVID-19 in children during the first 6 months of the pandemic. Read More

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Workplace measures against COVID-19 during the winter third wave in Japan: Company size-based differences.

J Occup Health 2021 Jan;63(1):e12224

Department of Environmental Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.

Objectives: Little is known about workplace measures against coronavirus disease 2019 (COVID-19) in Japan during the winter of 2020, especially in micro-, small-, and medium-sized enterprises (MSMEs). This study aimed to provide an overview of the current situation of anti-COVID-19 measures in Japanese enterprises during the winter, considering company size.

Methods: This study was an Internet-based nationwide cross-sectional study. Read More

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January 2021

Factors influencing likelihood of COVID-19 vaccination: A survey of Tennessee adults.

Am J Health Syst Pharm 2021 05;78(10):879-889

College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA.

Purpose: To examine the vaccine-related beliefs and behaviors associated with likely hesitancy toward vaccination against coronavirus disease 2019 (COVID-19) among nonelderly adults.

Methods: A cross-sectional survey was conducted in June 2020. Responses were sought from Tennessee adults 18 to 64 years of age who were not healthcare providers. Read More

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Association between Periodontal Disease and Comorbidities in Saudi's Eastern Province.

Biomed Res Int 2021 16;2021:5518195. Epub 2021 Apr 16.

Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam 31411, P.O. Box 1982, Saudi Arabia.

The incidence of periodontal diseases is associated with multiple comorbidities that influence a patient's treatment planning. This study evaluates the relation between periodontal disease and multiple comorbidities reported in the Saudi population from the Eastern province. This study was conducted on 190 patients, who visited the periodontology clinics at Imam Abdulrahman Bin Faisal University, Saudi Arabia. Read More

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Lessons From Learners: Adapting Medical Student Education During and Post-COVID-19.

Acad Med 2021 May 4. Epub 2021 May 4.

M.R.H. Castro is a third-year medical student, University of California San Francisco School of Medicine, San Francisco, California; ORCID: https://orcid.org/0000-0002-2085-4893. L.M. Calthorpe is a third-year medical student, University of California San Francisco School of Medicine, San Francisco, California; ORCID: https://orcid.org/0000-0002-0496-9471. S.E. Fogh is associate professor, Department of Radiation Oncology, University of California San Francisco School of Medicine, San Francisco, California. S. McAllister is a third-year medical student, University of California San Francisco School of Medicine, San Francisco, California. C.L Johnson is a third-year medical student, University of California San Francisco School of Medicine, San Francisco, California. E.D. Isaacs is professor of emergency medicine, Department of Emergency Medicine, University of California San Francisco, San Francisco, California. A. Ishizaki is manager, Clinical Microsystems Clerkship, University of California San Francisco School of Medicine, San Francisco, California. A. Kozas is curriculum coordinator, Clinical Microsystems Clerkship, University of California San Francisco School of Medicine, San Francisco, California. D. Lo is assistant professor of medicine, Division of Geriatrics, Department of Medicine, University of California San Francisco School of Medicine; and Department of Geriatrics and Extended Care, San Francisco Veterans Affairs Health Care System, San Francisco, California. S. Rennke is professor of medicine, Division of Hospital Medicine, Department of Medicine, University of California San Francisco School of Medicine, San Francisco, California. J. Davis is professor of medicine and associate dean for curriculum, University of California San Francisco School of Medicine, San Francisco, California. A. Chang is professor of medicine, Division of Geriatrics, Department of Medicine, University of California San Francisco, San Francisco, California.

In response to the COVID-19 pandemic, many medical schools suspended clinical clerkships and implemented newly adapted curricula to facilitate continued educational progress. While the implementation of these new curricula has been described, an understanding of the impact on student learning outcomes is lacking. In 2020, the authors followed Kern's 6-step approach to curricular development to create and evaluate a novel COVID-19 curriculum for medical students at the University of California San Francisco School of Medicine and evaluate its learning outcomes. Read More

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Epidemiology of Parkinson's Disease in Rural Gujarat, India.

Neuroepidemiology 2021 May 5:1-8. Epub 2021 May 5.

Department of Neurology, Charutar Arorgya Mandal, Shree Krishna Hospital and Pramukhswami Medical College, Bhaikaka University, Anand, India.

Introduction: In India, there have been only few published studies of Parkinson's disease (PD) showing a wide range of prevalence. We conducted this study to determine the prevalence of PD in the rural population of Gujarat, in the western region of India.

Methods: This cross-sectional descriptive study was conducted in the villages of Anand, a district of Gujarat, India, between September 2019 and February 2020. Read More

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Ultrasound-guided pediatric vascular cannulation by inexperienced operators: outcomes in a training model.

J Ultrasound 2021 May 4. Epub 2021 May 4.

Department of Clinical Sciences, Fernando Pessoa Canarias University, Las Palmas de Gran Canaria, Spain.

Objective: To present the results of an ultrasound vascular cannulation (UGVC) training program for inexperienced operators using a training model.

Method: This was a descriptive observational study developed in the paediatric intensive care unit (PICU) of a third-level hospital. Operators received basic theoretical training in the USVC technique, followed by practical training with a model designed for USVC-inexperienced healthcare professionals. Read More

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Apoptosis induction by siRNA targeting integrin-β1 and regorafenib/DDAB-mPEG-PCL hybrid nanoparticles in regorafenib-resistant colon cancer cells.

Am J Cancer Res 2021 15;11(4):1170-1184. Epub 2021 Apr 15.

Department of Clinical Biochemistry, School of Medicine, Zanjan University of Medical Sciences Zanjan, Iran.

Colorectal cancer (CRC) is regarded as the third most common cancer worldwide. Although Regorafenib as a receptor tyrosine kinase inhibitor (RTKI) disrupts tumor growth and angiogenesis in metastatic CRC (mCRC) patients, drug resistance leads to poor prognosis and survival. Integrin-β1 overexpression has been proposed to be the major player in this regard. Read More

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The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics.

J Clin Invest 2021 May 4. Epub 2021 May 4.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, United States of America.

Cutaneous melanoma remains the most lethal skin cancer, and ranks third among all malignancies in terms of years of life lost. Despite the advent of immune checkpoint and targeted therapies, only roughly half of patients with advanced melanoma achieves a durable remission. SIRT5 is a member of the sirtuin family of protein deacylases that regulate metabolism and other biological processes. Read More

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The incidence of construction site injuries to women in Delhi: capture-recapture study.

BMC Public Health 2021 May 3;21(1):858. Epub 2021 May 3.

Department of Global Health and Development, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

Background: In India, the construction sector provides the main alternative to agricultural work - seasonal migration to and from construction work is widespread and construction work remains the second-largest employer of women in the country behind agriculture. Occupational injuries, which kill over 300,000 people annually, are a serious public health concern. However, data on construction site injuries to women are lacking, as India does not publish statistics on occupational injuries and illnesses. Read More

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Spontaneous face- and eye-touching: Infection risk versus potential microbiome gain.

Ocul Surf 2021 Apr 30. Epub 2021 Apr 30.

Department of Ophthalmology, Prince of Wales Hospital, Sydney, Australia; University of New South Wales, Sydney, Australia. Electronic address:

The COVID-19 pandemic has compelled a review of possible routes of microbial infection, of particular importance since the ocular surface is a likely portal of human Coronavirus invasion. As hand contamination is considered an important and potentially preventable factor for transmission, we have reviewed face touching in the context of a group of disorders known as the Body-Focused Repetitive Behaviours (BFRPs). Spontaneous face-touching is a poorly understood, atavistic, ingrained habit for humans, who engage in this activity approximately 26 times per hour. Read More

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The size and shape of the human pelvis: a comparative study of modern and medieval age populations.

Ann Anat 2021 Apr 30:151749. Epub 2021 Apr 30.

Department of Anatomy, Second Faculty of Medicine, Charles University, V Uvalu 84, 150 06, Prague 5, Czech Republic; Center for Integrated Studies of the Pelvis, Third Faculty of Medicine, Charles University, Ruska 87, 100 00, Prague 10, Czech Republic. Electronic address:

Introduction: Great variability in shape and size of the bony pelvis can be observed in the current population, but there is not enough data on how long the historical period must elapse to gain changes in pelvic shape and size. The aim of the study was to identify morphological changes in bony pelvis in males and females after a developmentally short period of approximately one thousand years.

Material And Methods: Seventeen defined external dimensions of pelvic bone from 120 adult individuals (two craniocaudal, two ventrodorsal, six mediolateral, three acetabular dimensions, and four dimension of the auricular surface) were measured. Read More

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Spontaneous psoas haematoma: a life-threatening complication of anticoagulation in COVID-19. A case series of four episodes.

Infect Dis (Lond) 2021 May 3:1-6. Epub 2021 May 3.

Department of Radiology, Trieste University Hospital, Trieste, Italy.

Background: Anticoagulant prophylaxis is part of the standard management of hospitalized COVID-19 patients. Despite adequate thromboprophylaxis, one-third of COVID-19 patients with pneumonia developed pulmonary embolism. This high rate of thrombotic complications has led to higher doses of anticoagulants according to clinical complexity (e. Read More

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Behavior in the use of face masks in the context of COVID-19.

Public Health Nurs 2021 May 3. Epub 2021 May 3.

UMIT - Private University for Health Sciences, Medical Informatics and Technology, Department of Nursing Science and Gerontology, Institute of Nursing Science, Hall in Tirol, Austria.

Objectives: Investigation of potential erroneous behavior in the general public's use of face masks during the COVID-19 pandemic.

Design: We conducted a naturalistic observational study in the period from April to June 2020.

Sample: In two western Austrian provinces, a total of 2080 persons were observed in front of 24 grocery stores. Read More

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Potential of Unconventional Seed Oils and Fats from West African Trees: A Review of Fatty Acid Composition and Perspectives.

Lipids 2021 May 3. Epub 2021 May 3.

Department of Food Science, Centre of Innovative Food Research, CiFood, Aarhus University, Agro Food Park 48, Aarhus N, 8200, Denmark.

Seed oils sourced from West Africa are generally not well-characterized, but likely to have an untapped potential. This review aims to make an overview of fatty acid (FA) composition of unconventional seed oils from semi-arid West African trees and evaluate potential for new and enhanced uses and for improving local livelihoods and biodiversity conservation. A total of 111 studies on FA composition were found, covering 31 species. Read More

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Differences in Family Planning and Fertility Among Female and Male Gynecologic Oncologists.

Womens Health Rep (New Rochelle) 2021 8;2(1):78-84. Epub 2021 Apr 8.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, Minnesota, USA.

The objective of the study was to compare family planning and infertility among female and male gynecologic oncologists in the United States This cross-sectional multiple choice survey was administered to the Society of Gynecologic Oncology gynecologic oncologists. The survey collected information on demographics and practice, family planning, and fertility and infertility experiences. Chi-square and Fisher's exact tests were used to compare experiences by gender. Read More

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A multicenter observational study on the distribution of orthopaedic fracture types across 17 low- and middle-income countries.

OTA Int 2019 Sep 9;2(3):e026. Epub 2019 Apr 9.

Division of Orthopedic Surgery, Centre for Evidence-Based Orthopedics.

Objectives: To describe the regional distribution of fractures sustained by women and health care system characteristics across 17 low- and middle-income countries (LMICs).

Methods: The INternational ORthopaedic MUlticentre Study in fracture care (INORMUS) is an observational study collecting data on patients in LMICs who sustained a fracture or musculoskeletal injury. As a planned analysis for the INORMUS study, we explored differences in fracture locations and demographics reported among 9878 female patients who sustained a fracture within 17 LMICs in 5 regions (China, Africa, India, Other Asia, and Latin America). Read More

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September 2019

Lipoxin A4 Restores Septic Renal Function Blocking Crosstalk Between Inflammation and Premature Senescence.

Front Immunol 2021 15;12:637753. Epub 2021 Apr 15.

Department of Anesthesiology, Guangdong Medical University, HuiZhou First Hospital, Huizhou, China.

Acute kidney injury (AKI) occurs in half of patients with septic shock, resulting in unacceptably high mortality. However, effective preventive treatments are still lacking. We hypothesized that pretreatment with lipoxin A4 (LXA4), known to promote inflammation resolution, may attenuate septic AKI blocking crosstalk between inflammation and cellular senescence. Read More

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IR-61 Improves Voiding Function Mitochondrial Protection in Diabetic Rats.

Front Pharmacol 2021 14;12:608637. Epub 2021 Apr 14.

Department of Urology, The Third Affiliated Hospital (Gener Hospital) of Chongqing Medical University, Chongqing, China.

Diabetic bladder dysfunction (DBD) afflicts nearly half of diabetic patients, but effective treatment is lacking. In this study, IR-61, a novel heptamethine cyanine dye with potential antioxidant effects, was investigated to determine whether it can alleviate DBD. Rats were intraperitoneally injected with IR-61 or vehicle after diabetes was induced with streptozotocin. Read More

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Lifestyle and Cancer Prevention-Opinions and Behaviors Among Romanian University Students.

Int J Gen Med 2021 23;14:1525-1532. Epub 2021 Apr 23.

Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Background: Healthy lifestyle promotion represents an important component of cancer prevention. The aim of this study is the assessment of opinions and behavior related to healthy lifestyle and cancer prevention among Romanian university students.

Methods: A cross-sectional study was performed by anonymous questionnaires in 2017 among 400 university students from the four main universities from Cluj-Napoca, Romania. Read More

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Clinical phenotypes and prognosis of thyrotoxic heart failure and cardiomyopathy in patients hospitalized for acute heart failure.

ESC Heart Fail 2021 May 1. Epub 2021 May 1.

Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bhumisiri Mangkhalanusorn Building, M Floor, Zone C, 1873 Rama IV Rd, Bangkok, Pathumwan, 10330, Thailand.

Background: We sought to examine clinical characteristics and outcomes in patients hospitalized for acute heart failure (HF) and thyrotoxicosis.

Methods: Patients with thyrotoxic HF were compared with age and gender-matched patients hospitalized for acute HF (controls). Thyr-HF was defined by the Framingham criteria for HF and clinical hyperthyroidism. Read More

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"Is there a doctor on board?": willingness and confidence of physicians in the Kingdom of Saudi Arabia in assisting with in-flight medical emergencies.

BMC Emerg Med 2021 Apr 30;21(1):54. Epub 2021 Apr 30.

Department of Family and Community Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Background: In-flight medical emergencies (IMEs) are common, and for a traveling physician, it is very likely to encounter such a condition. Data discussing this issue are limited. Thus, this study aimed to evaluate the willingness and confidence of physicians in the Kingdom of Saudi Arabia (KSA) in responding to IMEs. Read More

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Quantitative Nano-Amperometric Measurement of Intravesicular Glutamate Content and of its Sub-Quantal Release by Living Neurons.

Angew Chem Int Ed Engl 2021 Apr 30. Epub 2021 Apr 30.

Wuhan University, College of Chemistry and Molecular Sciences, NO. 299, Bayi Road, Luojia Hill, Wuchang, 430072, Wuhan, CHINA.

Glutamate (Glu) is a crucial fundamental excitatory neurotransmitter released through vesicular exocytosis in the central nervous system. Hence, quantitative measurements of intravesicular Glu and of transient exocytotic release contents directly from individual living neurons are highly desired for understanding the mechanisms (full or sub-quantal release?) of synaptic transmission and plasticity. However, this could not be achieved so far due to the lack of adequate experimental strategies relying on selective and sensitive Glu nanosensors. Read More

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Aerobic and Resistance Exercise Improve Patient-reported Sleep Quality and is Associated with Cardiometabolic Biomarkers in Hispanic and Non-Hispanic Breast Cancer Survivors who are Overweight or Obese: Results from a Secondary Analysis.

Sleep 2021 Apr 30. Epub 2021 Apr 30.

Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Study Objectives: Poor sleep quality affects nearly one third of breast cancer survivors and is associated with insulin resistance. The purpose of this secondary analysis was to examine the effects of a 16-week exercise intervention on patient-reported sleep quality among breast cancer survivors and assess whether changes in patient-reported sleep quality were associated with cardiometabolic biomarkers. We explored Hispanic ethnicity as a moderator of the effects of exercise on patient-reported sleep quality. Read More

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International Trends in Esophageal Squamous Cell Carcinoma and Adenocarcinoma Incidence.

Am J Gastroenterol 2021 May;116(5):1072-1076

Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France.

Introduction: We aimed to improve our understanding of the epidemiology of squamous cell carcinoma and adenocarcinoma of the esophagus.

Methods: We estimated average annual percent change and analyzed age-period-cohort trends on population-based cancer data.

Results: We found decreases in squamous cell carcinoma incidence in half of male populations (largest decrease in US black males [average annual percent change -7. Read More

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Males as victims of intimate partner violence - results from a clinical-forensic medical examination centre.

Int J Legal Med 2021 Apr 29. Epub 2021 Apr 29.

Department of Legal Medicine, University Medical Center Hamburg-Eppendorf, Butenfeld 34, 22529, Hamburg, Germany.

Only few studies have reported on males as victims of intimate partner violence (IPV) so far. The aim of the present study is to analyse frequency and case characteristics of physical violence against male IPV victims examined in a clinical-forensic medical examination centre for victims of violence in Germany over an 11-year period, contributing to a better understanding of IPV in men. Male victims represented 6. Read More

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The Use of Tibial Autogenous Cancellous Bone for Late Secondary Alveolar Bone Grafting in Cleft Patients: A Prospective Study.

J Maxillofac Oral Surg 2021 Jun 18;20(2):276-281. Epub 2020 Mar 18.

Department of Oral and Maxillofacial Surgery, Mamata Dental College, GiriPrasad Nagar, Khammam, Telangana 507002 India.

Objectives: To evaluate the management of alveolar cleft defects with proximal tibia bone grafts by late secondary alveolar bone grafting.

Materials And Methods: Fifteen patients were studied, nine males and six females within age range of 21-32 years. All the patients were treated with cancellous portion of the proximal tibial bone graft, harvested through the medial approach. Read More

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Pathogenic Variants in Greek Breast Cancer Patients: Evidence for Strong Associations with Estrogen Receptor Positivity, Overuse of Risk-Reducing Procedures and Population Founder Effects.

Cancers (Basel) 2021 Apr 27;13(9). Epub 2021 Apr 27.

Molecular Diagnostics Laboratory, INRaSTES, National Center for Scientific Research "Demokritos", 15341 Athens, Greece.

germline pathogenic variants predispose to breast cancer and possibly to other malignancies, with their spectrum and frequency being variable among populations. Τhe majority of -associated breast tumors are hormone receptor positive; however, relevant clinical outcomes are not well defined. Herein, we illustrate the histopathological characteristics and clinical outcomes of 52 Greek breast cancer patients who are carriers. Read More

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Scaling Up Molecular Diagnostic Tests for Drug-Resistant Tuberculosis in Uzbekistan from 2012-2019: Are We on the Right Track?

Int J Environ Res Public Health 2021 Apr 28;18(9). Epub 2021 Apr 28.

International Union against Tuberculosis and Lung Disease, 68 Boulevard Saint Michel, 75006 Paris, France.

Uzbekistan has a large burden of drug-resistant tuberculosis (TB). To deal with this public health threat, the National TB Program introduced rapid molecular diagnostic tests such as Xpert MTB/RIF (Xpert) and line probe assays (LPAs) for first-line and second-line drugs. We documented the scale-up of Xpert and LPAs from 2012-2019 and assessed whether this led to an increase in patients with laboratory-confirmed multidrug-resistant/rifampicin-resistant TB (MDR/RR-TB) and extensively drug-resistant TB (XDR-TB). Read More

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