27,280 results match your criteria hair cells

Neuroplastin expression is essential for hearing and hair cell PMCA expression.

Brain Struct Funct 2021 Apr 12. Epub 2021 Apr 12.

Neurogenetics Laboratory, Leibniz Institute for Neurobiology, Brenneckestr. 6, 39118, Magdeburg, Germany.

Hearing deficits impact on the communication with the external world and severely compromise perception of the surrounding. Deafness can be caused by particular mutations in the neuroplastin (Nptn) gene, which encodes a transmembrane recognition molecule of the immunoglobulin (Ig) superfamily and plasma membrane Calcium ATPase (PMCA) accessory subunit. This study investigates whether the complete absence of neuroplastin or the loss of neuroplastin in the adult after normal development lead to hearing impairment in mice analyzed by behavioral, electrophysiological, and in vivo imaging measurements. Read More

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A Novel Homozygous TRNT1 Mutation in a Child With an Early Diagnosis of Common Variable Immunodeficiency Leading to Mild Hypogammaglobulinemia and Hemolytic Anemia.

J Pediatr Hematol Oncol 2021 Apr 9. Epub 2021 Apr 9.

Departments of Pediatrics Medical Genetics, Ege University Faculty of Medicine, Izmir, Turkey.

Although sideroblastic anemias (SAs) may be associated with different etiologies, deterioration of mitochondrial heme biosynthesis in bone marrow erythroid cells is a general abnormality. Congenital SA associated with immunodeficiency, periodic fever, and developmental delay is because of loss-of-function mutations in the TRNT1 gene. We report a patient with a novel homozygous mutation in the TRNT1 gene presenting with anemia with siderocytes, hypogammaglobulinemia, hepatosplenomegaly, and brittle hair but without periodic fever or developmental delay. Read More

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From hair to pancreas: transplanted hair follicle mesenchymal stem cells express pancreatic progenitor cell markers in a rat model of acute pancreatitis.

Am J Transl Res 2021 15;13(3):1389-1399. Epub 2021 Mar 15.

Department of Gastroenterology and Hepatology, The Second Affiliated Hospital, Harbin Medical University Harbin 150086, P. R. China.

Acute pancreatitis (AP) is commonly accompanied by intense pain and is associated with high mortality rates. However, the effectiveness of existing therapeutic approaches remains unsatisfactory. Stem cell therapy, which can promote the regeneration of damaged tissue and alleviate systemic inflammatory responses, has brought new possibility for patients suffering from AP. Read More

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Protective Effects of Deferoxamine on Vestibulotoxicity in Gentamicin-Induced Bilateral Vestibulopathy Rat Model.

Front Neurol 2021 24;12:650752. Epub 2021 Mar 24.

Department of Neurology, Seoul National University College of Medicine, Seoul, South Korea.

Administration of aminoglycoside (AG) antibiotics is one of the most common causes of ototoxicity. This study aimed to determine the protective effects of deferoxamine, an iron-chelating agent, on vestibulotoxicity using an intratympanic gentamicin injection (ITGM)-induced bilateral vestibulopathy rat model. Fifteen Sprague-Dawley rats were randomly assigned to the ITGM only ( = 5), the ITGM combined with intramuscular deferoxamine (DFO) injection (ITGM+DFO, = 5), or the intratympanic normal saline (control, = 5) group. Read More

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Epac1 signaling pathway mediates the damage and apoptosis of inner ear hair cells after noise exposure in a rat model.

Neuroscience 2021 Apr 7. Epub 2021 Apr 7.

Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of USTC, Hefei, 230001, China. Electronic address:

To investigate the role of the exchange protein directly activated by cAMP (Epac) signaling pathway in inner ear hair cell damage and apoptosis after noise exposure, we analyzed the expression level of Epac1 in a rat model of noise-induced hearing loss (NIHL), based on rat exposure to a 4-kHz and 106-dB sound pressure level (SPL) for 8 h. Loss of outer hair cells (OHCs), mitochondrial lesions, and hearing loss were examined after treatment with the Epac agonist, 8-CPT, or the Epac inhibitor, ESI-09. The effects of 8-CPT and ESI-09 on cell proliferation and apoptosis were examined by CCK-8 assays, holographic microscopy imaging, and Annexin-V FITC/PI staining in HEI-OC1 cells. Read More

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Mapping the regulatory landscape of auditory hair cells from single-cell multi-omics data.

Genome Res 2021 Apr 9. Epub 2021 Apr 9.

University of Michigan, Kresge Hearing Research Institute;

Auditory hair cells transduce sound to the brain and in mammals these cells reside together with supporting cells in the sensory epithelium of the cochlea, called the organ of Corti. To establish the organ's delicate function during development and differentiation, spatiotemporal gene expression is strictly controlled by chromatin accessibility and cell type-specific transcription factors, jointly representing the regulatory landscape. Bulk-sequencing technology and cellular heterogeneity obscured investigations on the interplay between transcription factors and chromatin accessibility in inner ear development. Read More

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Antiretroviral Hair Levels, Self-Reported Adherence and Virologic Failure in Second-Line Regimen Patients in Resource-Limited Settings.

AIDS 2021 Apr 6. Epub 2021 Apr 6.

HIV-NAT, TRCARC, Bangkok, Thailand Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brazil Harvard T.H. Chan School of Public Health, Boston, MA,USA Biostatistics Excellence Centre, Bangkok, Thailand The Kirby Institute, UNSW, Sydney, Australia University of Nebraska Medical Center, Omaha, USA Chulalongkorn University, Bangkok, Thailand Division of AIDS NIAID, NIH, Bethesda, USA University of Pennsylvania, PA,USA Social & Scientific Systems, Silver Spring, USA BARC-SA and Lancet Laboratories, South Africa Clinical HIV Research Unit, Helen Joseph Hospital, University of the Witwatersrand, Johannesburg, South Africa Kamuzu Central Hospital, Lilongwe, Malawi Durban International CRS, Durban, South Africa Hospital Nossa Senhora da Conceicao CRS, Rio Grande do Sul, Brazil Emory University, Atlanta, USA Frontier Science & Technology Research Foundation, Inc., Amherst, United States Family Centre for Research with Ubuntu (FAMCRU), Stellenbosch University, Cape Town, South Africa Research Institute for Health Sciences, Chiang Mai, Thailand Kamuzu Central Hospital, Lilongwe, Malawi CART, Clinical Research Site, VHS Infection Disease Medical Centre, Chennai, India Case Western Reserve University, Cleveland, USA University of Washington, Seattle, USA University of California, San Francisco, USA.

Objective: To evaluate associations between hair antiretroviral (ARV) hair concentrations as an objective, cumulative adherence metric, with self-reported adherence and virologic outcomes.

Design: Analysis of cohort A of the ACTG-A5288 study. These patients in resource-limited settings were failing second-line PI-based ART, but were susceptible to ≥1 NRTI and their PI, and continued taking their PI-based regimen. Read More

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Apelin-13 Prevents Apoptosis in the Cochlear Tissue of Noise-exposed Rat via Sirt-1 Regulation.

J Chem Neuroanat 2021 Apr 5:101956. Epub 2021 Apr 5.

Hearing Disorders Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Noise-induced hearing loss (NIHL) is the second most common cause of acquired hearing loss. Acoustic trauma can cause oxidative damage in the cochlear hair cells (HCs) through apoptotic pathways. Apelin is a newly discovered neuropeptide with neuroprotective effects against the oxidative stress in neurodegenerative disorder. Read More

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β-thymosin is an essential regulator of stem cell proliferation and neuron regeneration in planarian (Dugesia japonica).

Dev Comp Immunol 2021 Apr 5:104097. Epub 2021 Apr 5.

Anti-aging & Regenerative Medicine Research Institution,School of Life Sciences,Shandong University of Technology, Zibo, 255049, PR China; Laboratory of Developmental and Evolutionary Biology, School of Life Sciences, Shandong University of Technology, Zibo, 255049, PR China. Electronic address:

β-Thymosin is a multifunctional peptide ubiquitously expressed in vertebrates and invertebrates. Many studies have found β-thymosin is critical for wound healing, angiogenesis, cardiac repair, hair regrowth, and anti-fibrosis in vertebrates, and plays an important role in antimicrobial immunity in invertebrates. However, whether β-thymosin participates in the regeneration of organisms is still poorly understood. Read More

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Strain elastography for the assessment of skin nodules in dogs.

Vet Dermatol 2021 Apr 8. Epub 2021 Apr 8.

AniCura Istituto Veterinario Novara, Strada Provinciale 9, Granozzo con Monticello, NO, 28060, Italy.

Background: Strain elastography (SE) is a modern imaging technology that provides an additional way of evaluating the changes in soft tissue elasticity caused by pathophysiological processes. Despite its widespread use in human medicine, only a few studies on the application of SE in veterinary medicine are available.

Objectives: To evaluate the potential usefulness of SE as an integrative imaging model in the standard ultrasound technique to better discriminate between inflammatory and neoplastic skin nodules in dogs. Read More

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Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata.

JCI Insight 2021 Apr 8;6(7). Epub 2021 Apr 8.

Department of Dermatology and.

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) are key intracellular mediators in the signal transduction of many cytokines and growth factors. Common γ chain cytokines and interferon-γ that use the JAK/STAT pathway to induce biological responses have been implicated in the pathogenesis of alopecia areata (AA), a T cell-mediated autoimmune disease of the hair follicle. We previously showed that therapeutic targeting of JAK/STAT pathways using the first-generation JAK1/2 inhibitor, ruxolitinib, and the pan-JAK inhibitor, tofacitinib, was highly effective in the treatment of human AA, as well as prevention and reversal of AA in the C3H/HeJ mouse model. Read More

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Evaluation of the vestibular system in individuals with presbycusis using video head impulse test and videonystagmography.

Acta Otolaryngol 2021 Apr 7:1-6. Epub 2021 Apr 7.

Department Of Otolaryngology, Bülent Ecevit University Medical Faculty, Zonguldak, Turkey.

Background: Vestibulo-ocular reflex (VOR) function is expected to be normal in patients with presbycusis during sudden head rotations.

Aim: This study aimed to determine whether presbycusis was accompanied by vestibular system pathologies. In addition, it was examined whether there was a difference existed between the patients with and without presbycusis in terms of normative data. Read More

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Change in gene expression levels of GABA, glutamate and neurosteroid pathways due to acoustic trauma in the cochlea.

J Neurogenet 2021 Apr 7:1-13. Epub 2021 Apr 7.

Department of Medical Genetics, School of Medicine, Erciyes University, Kayseri, Turkey.

The characteristic feature of noise-induced hearing loss (NIHL) is the loss or malfunction of the outer hair cells (OHC) and the inner hair cells (IHC) of the cochlea. 90-95% of the spiral ganglion neurons, forming the cell bodies of cochlear nerve, synapse with the IHCs. Glutamate is the most potent excitatory neurotransmitter for IHC-auditory nerve synapses. Read More

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New Tmc1 deafness mutations impact mechanotransduction in auditory hair cells.

J Neurosci 2021 Apr 2. Epub 2021 Apr 2.

Department of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706.

Transmembrane channel-like protein isoform 1 (TMC1) is a major component of the mechano-electrical transducer (MET) channel in cochlear hair cells and is subject to numerous mutations causing deafness. We report a new dominant human deafness mutation, p.T422K, and have characterized the homologous mouse mutant, p. Read More

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Combination photobiomodulation/N-acetyl-L-cysteine treatment appears to mitigate hair cell loss associated with noise-induced hearing loss in rats.

Lasers Med Sci 2021 Apr 6. Epub 2021 Apr 6.

Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan, 31116, Republic of Korea.

Sensorineural hearing loss is an intractable disease. Acoustic overstimulation creates hearing loss; many patients exhibit social and emotional dysfunctions. In a model of noise-induced hearing loss (NIHL), low-level laser photobiomodulation (PBM) at a near-infrared wavelength significantly improved auditory brainstem response (ABR) thresholds. Read More

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N-Acetylcysteine Combined With Dexamethasone Treatment Improves Sudden Sensorineural Hearing Loss and Attenuates Hair Cell Death Caused by ROS Stress.

Front Cell Dev Biol 2021 18;9:659486. Epub 2021 Mar 18.

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Sudden sensorineural hearing loss (SSNHL) is a common emergency in the world. Increasing evidence of imbalance of oxidant-antioxidant were found in SSNHL patients. Steroids combined with antioxidants may be a potential strategy for the treatment of SSNHL. Read More

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ER71/ETV2 Promotes Hair Regeneration from Chemotherapeutic Drug-Induced Hair Loss by Enhancing Angiogenesis.

Biomol Ther (Seoul) 2021 Apr 5. Epub 2021 Apr 5.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Chemotherapy-induced alopecia and hair loss can be stressful in patients with cancer. The hair grows back, but sometimes the hair tends to stay thin. Therefore, understanding mechanisms regulating hair regeneration may improve the management of chemotherapy-induced alopecia. Read More

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Wiad Lek 2021 ;74(3 cz 1):418-422


Objective: The aim is to develop a method of the acellular dermal matrix manufacturing from pig's skin dermis while preserving the native structure.

Patients And Methods: Materials and methods: Combination of physical and chemical effects on the dermis underlies in the process of an acellular dermal matrix manufacturing. Dermal collection of 1. Read More

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Cochlear protection against noise exposure requires serotonin type 3A receptor via the medial olivocochlear system.

FASEB J 2021 May;35(5):e21486

Department of Neuroscience and Cell Biology, Graduate School of Medicine, Osaka University, Suita, Japan.

The cochlear efferent feedback system plays important roles in auditory processing, including regulation of the dynamic range of hearing, and provides protection against acoustic trauma. These functions are performed through medial olivocochlear (MOC) neurons. However, the underlying cellular and molecular mechanisms are not fully understood. Read More

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Blockade of IL-7 signaling suppresses inflammatory responses and reverses alopecia areata in C3H/HeJ mice.

Sci Adv 2021 Apr 2;7(14). Epub 2021 Apr 2.

Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

The interleukin-7 (IL-7) signaling pathway plays an important role in regulation of T cell function and survival. We detected overexpression of IL-7 in lesional skin from both humans and C3H/HeJ mice with alopecia areata (AA), a T cell-mediated autoimmune disease of the hair follicle. We found that exogenous IL-7 accelerated the onset of AA by augmenting the expansion of alopecic T cells. Read More

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Maintaining Inducibility of Dermal Follicle Cells on Silk Fibroin/Sodium Alginate Scaffold for Enhanced Hair Follicle Regeneration.

Biology (Basel) 2021 Mar 26;10(4). Epub 2021 Mar 26.

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.

The extracellular matrix (ECM) is important for maintaining cell phenotype and promoting cell proliferation and differentiation. In order to better solve the problem of skin appendage regeneration, a combination of mechanical/enzymatic digestion methods was used to self-extract dermal papilla cells (DPCs), which were seeded on silk fibroin/sodium alginate scaffolds as seed cells to evaluate the possibility of skin regeneration/regeneration of accessory organs. Scanning electron microscopy (SEM) graphs showed that the interconnected pores inside the scaffold had a pore diameter in the range of 153-311 μm and a porosity of 41-82%. Read More

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Immunological Properties of Atopic Dermatitis-Associated Alopecia Areata.

Int J Mol Sci 2021 Mar 5;22(5). Epub 2021 Mar 5.

Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.

Alopecia areata (AA) is regarded as a tissue-specific and cell-mediated autoimmune disorder. Regarding the cytokine balance, AA has been considered a type 1 inflammatory disease. On the other hand, AA often complicates atopic dermatitis (AD) and AD is regarded as type 2 inflammatory disease. Read More

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Fabrication of Adipose-Derived Stem Cell-Based Self-Assembled Scaffold under Hypoxia and Mechanical Stimulation for Urethral Tissue Engineering.

Int J Mol Sci 2021 Mar 25;22(7). Epub 2021 Mar 25.

Centre for Tissue Engineering and Regenerative Medicine, Universiti Kebangsaan Malaysia Medical Centre, 12th Floor, Clinical Block, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia.

Long urethral strictures are often treated with autologous genital skin and buccal mucosa grafts; however, risk of hair ingrowth and donor site morbidity, restrict their application. To overcome this, we introduced a tissue-engineered human urethra comprising adipose-derived stem cell (ASC)-based self-assembled scaffold, human urothelial cells (UCs) and smooth muscle cells (SMCs). ASCs were cultured with ascorbic acid to stimulate extracellular matrix (ECM) production. Read More

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A Novel Pro-Melanogenic Effect of Standardized Dry Olive Leaf Extract on Primary Human Melanocytes from Lightly Pigmented and Moderately Pigmented Skin.

Pharmaceuticals (Basel) 2021 Mar 11;14(3). Epub 2021 Mar 11.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794-5281, USA.

Benolea (EFLA943) is a standardized dry olive leaf extract (DOLE) considered safe for food consumption and has demonstrated superior pharmaceutical benefits such as antioxidant, anti-obesity, and anti-hypertensive activities. However, there is no study on its effects on melanogenesis yet. Disruption in the sequence of steps in melanogenesis can lead to hypopigmentary disorders which occur due to reduced production or export of pigment melanin in the skin. Read More

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Preventive effect of edaravone ointment on cyclophosphamide-chemotherapy induced alopecia.

Support Care Cancer 2021 Apr 2. Epub 2021 Apr 2.

Department of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.

Purpose: We evaluated the preventive effect of the antioxidant edaravone (EDR) on chemotherapy-induced alopecia (CIA) to improve quality of life in cancer patients.

Methods: Hair loss was induced by intraperitoneally administering cyclophosphamide (CPA, 75 mg/kg) to rats, and topically applying EDR ointment (100 mg/day) once daily for 16 days (when hair loss starts) or 21 days (just before hair growth). The rats were divided into four groups: control group (without CPA or EDR), EDR 0% group (CPA + EDR 0%), EDR 3% group (CPA + EDR 3%), and EDR 30% group (CPA + EDR 30%). Read More

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Androgenetic Alopecia in a Patient with Klinefelter Syndrome: Case Report and Literature Review.

Skin Appendage Disord 2021 Feb 7;7(2):135-138. Epub 2020 Dec 7.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

Introduction: Klinefelter syndrome (KS) is defined as (a chromosomal disorder in which males have an extra X chromosome). KS presents clinically with signs of androgen deficiency including low testosterone. Androgenetic alopecia (AGA) develops as a response of the hair follicle cells to androgens in individuals with genetic predisposition. Read More

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February 2021