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Clin Exp Med 2021 Apr 10. Epub 2021 Apr 10.

Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Mesangial IgM deposition is found in patients with immunoglobulin A nephropathy (IgAN). This study aims to investigate the relationships between mesangial IgM deposition and disease progression in IgAN patients. A total of 1239 patients with biopsy-proven primary IgAN were enrolled in this multicenter, observational study between January 2013 and August 2017. Read More

BMC Genom Data 2021 Apr 9;22(1):14. Epub 2021 Apr 9.

School of Health, Guizhou Medical University, 550025, Guiyang, China.

Background: Hyperlipidemia plays an important role in the etiology of cardio-cerebrovascular disease. Over recent years, a number of studies have explored the impact of apolipoprotein genetic polymorphisms in hyperlipidemia, but considerable differences and uncertainty have been found in their association with different populations from different regions.

Results: A total of 59 articles were included, containing in total 13,843 hyperlipidemia patients in the case group and 15,398 healthy controls in the control group. Read More

Mol Med 2021 Apr 9;27(1):37. Epub 2021 Apr 9.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Objective: Ovarian tumour domain deubiquitinase with linear linkage specificity (OTULIN) is a potent negative regulator of the nuclear factor-κB (NF-κB) signalling pathway, and it plays a strong neuroprotective role following acute ischemic stroke. Electroacupuncture (EA) is an effective adjuvant treatment for reducing brain injury and neuroinflammation via the inhibition of NF-κB p65 nuclear translocation, but the underlying mechanism is not clear. The present study investigated whether OTULIN was necessary for EA to mitigate brain injury and glial cell activation in a transient middle cerebral artery occlusion (tMCAO) model in rats. Read More

JAMA Netw Open 2021 Apr 1;4(4):e215302. Epub 2021 Apr 1.

School of Public Health, Capital Medical University, Beijing, China.

Importance: The World Health Organization End TB (Tuberculosis) Strategy aims to decrease the global incidence and mortality of TB by 90% and 95%, respectively, as of 2035.

Objective: To characterize the recent epidemiological trend of pulmonary TB (PTB) in mainland China based on the national surveillance data.

Design, Setting, And Participants: This cross-sectional study collected demographic and clinical data of all patients reported in the national Tuberculosis Information Management System of China from January 1, 2005, to November 21, 2016. Read More

J Integr Neurosci 2021 Mar;20(1):33-41

Molecular Medical Laboratory, Institute of Life Science, Chongqing Medical University, 400016 Chongqing, P. R. China.

Ethanol is the active ingredient in alcoholic beverages. As ethanol consumption increases from zero to very high, it is still unknown which metabolites are present at different times and which are essential to normal functioning. In this article, we used an intermittent-access 20% ethanol drinking paradigm to make Wistar male rats voluntarily drink large amounts of ethanol for 10, 20, 30, and 50 days, respectively. Read More

Front Microbiol 2021 23;12:647119. Epub 2021 Mar 23.

State Key Laboratory of Veterinary Etiological Biology, National Professional Laboratory for Animal Echinococcosis, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.

The larva of Taeniidae species can infect a wide range of mammals, causing major public health and food safety hazards worldwide. The Qinghai-Tibet Plateau (QTP), a biodiversity hotspot, is home to many species of rodents, which act as the critical intermediate hosts of many Taeniidae species. In this study, we identified two new larvae of spp. Read More

Sci Rep 2021 Apr 8;11(1):7706. Epub 2021 Apr 8.

Guizhou Provincial Center for Disease Control and Prevention, The Institute of Tuberculosis Control and Prevention, Guiyang, 550001, Guizhou, China.

The incidence of Tuberculosis (TB) in Guizhou province has ranked to be the top four among the 31 China provinces. The spatial distribution and influencing factors of adverse outcomes of TB in Guizhou are unclear. In our study, the cases information of TB in Guizhou province from 2013 to 2018 was collected, we analyzed the spatial distribution and clusters of five adverse outcomes of TB with ArcMap10. Read More

Plant Dis 2021 Apr 8. Epub 2021 Apr 8.

Guiyang , China;

Chinese rose (Rosa chinensis Jacq.) is cultivated for edible flowers in southwestern China (Zhang et al. 2014). Read More

Mitochondrial DNA B Resour 2021 Mar 26;6(3):1209-1211. Epub 2021 Mar 26.

School of Karst Sciences, Guizhou Normal University, Guiyang, Guizhou, PR China.

belong to the genus (Teleostei, Nemacheilidae), endemic to Guizhou Province, Southwestern China. In this study, the complete mitochondrial genome of was sequenced and reported for the first time. The circular mitogenome was 16,576 bp in length and consisted of 13 protein-coding genes, 2 ribosomal RNA (rRNA) genes, 22 transfer RNA (tRNA) genes, and 1 non-coding control region. Read More

Sci Rep 2021 Apr 7;11(1):7641. Epub 2021 Apr 7.

College of Mathematics and Statistics, Chongqing Technology and Business University, Chongqing, 400067, China.

This paper presents the assessment of water resource security in the Guizhou karst area, China. A mean impact value and back-propagation (MIV-BP) neural network was used to understand the influencing factors. Thirty-one indices involving five aspects, the water quality subsystem, water quantity subsystem, engineering water shortage subsystem, water resource vulnerability subsystem, and water resource carrying capacity subsystem, were selected to establish an evaluation index of water resource security. Read More

BMC Med Genomics 2021 Apr 7;14(1):97. Epub 2021 Apr 7.

Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China.

Background: α-thalassemia is relatively endemic in Guizhou province of southwestern China. To predict the clinical manifestations of α-globin gene aberration for genetic counseling, we examined the prevalence of the α-globin triplication and the genotype-phenotype correlation in this subpopulation METHODS: A cohort of 7644 subjects was selected from nine ethnicities covering four regions in Guizhou province of China. Peripheral blood was collected from each participant for routine blood testing and hemoglobin electrophoresis. Read More

Biol Trace Elem Res 2021 Apr 6. Epub 2021 Apr 6.

College of Agriculture, Guizhou University, Guiyang, 550025, Guizhou, China.

This study investigated the feasibility of using the mineral element contents and Sr/Sr ratios of blueberries to trace their origins. The contents of 28 mineral elements, including K, Al, and Mg, were determined in 104 blueberry samples from three blueberry-producing areas in Guizhou Province, China. Also determined were both the Sr/Sr ratios in 48 blueberry samples as well as the type of soil in which the blueberries were grown. Read More

Biodivers Data J 2021 26;9:e63864. Epub 2021 Mar 26.

Engineering Research Centre of the Utilization for Characteristic Bio-Pharmaceutical Resources in Southwest, Ministry of Education, Guizhou University, Guiyang, Guizhou Province 550025, China Engineering Research Centre of the Utilization for Characteristic Bio-Pharmaceutical Resources in Southwest, Ministry of Education, Guizhou University Guiyang, Guizhou Province 550025 China.

Background: In this study, we introduce a novel genus, , of the family Diatrypaceae comprising three species viz. sp. nov. Read More

BMC Gastroenterol 2021 Apr 6;21(1):151. Epub 2021 Apr 6.

Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, 563003, Guizhou Province, China.

Background: Ectopic pancreas (EP) is defined as pancreatic tissue that lacks anatomical or vascular communication with the normal body of the pancreas. Despite improvements in diagnostic endoscopy and imaging studies, differentiating ectopic pancreatic tissue from gastric submucosal diseases remains a challenge.

Case Presentation: Here, we present a case of a 44-year-old woman with severe epigastric pain. Read More

Int Immunopharmacol 2021 Apr 3;96:107580. Epub 2021 Apr 3.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Electronic address:

Corneal lymphangiogenesis induced by macrophages played a critical role in corneal allograft rejection (CGR). However, there are few Food and Drug Administration (FDA)-approved drugs that target lymphangiogenesis. The aim of our study is to evaluate the effects of dimethyl fumarate (DMF) on corneal allograft survival in rats. Read More

Mol Plant Microbe Interact 2021 Apr 6. Epub 2021 Apr 6.

Guizhou University, 71206, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Huaxi street, Guiyang City, Guizhou Province, Guiyang, China, 550025;

Diseases caused by fungi can affect the quality and yield of the leaves of tea plants [Camellia sinensis (L.) Kuntze]. At present, the availability of highly effective and safe fungicides for controlling tea plants remains limited. Read More

Acta Neurochir (Wien) 2021 Apr 5. Epub 2021 Apr 5.

Department of Spine Surgery, Guizhou Province Osteological Hospital, 123 Shachong South Street, Nanming District, Guiyang, 550002, Guizhou Province, China.

Background: Spinal cord injuries (SCIs) can cause a loss of neurons and associated sensory and motor functionality below the injured site. No approaches to treating SCIs in humans have been developed to date. Exosomes are extracellular vesicles that hold promise as a potential therapeutic modality when treating such injuries. Read More

Sci Rep 2021 Apr 5;11(1):7485. Epub 2021 Apr 5.

College of Agronomy, Guizhou University, Guiyang, 550025, China.

A field experiment employing the rice cultivars Qyou6 and Yixiangyou2115 as materials and different nitrogen application rates was conducted in Huangping County, Guizhou Province in 2019 to determine the effects of nitrogen application rate on photosynthetic pigments, leaf fluorescence characteristics, yield, and their interrelations in indica hybrid rice. The results showed that photosynthetic pigment contents generally increased with increasing nitrogen application rate. As the nitrogen rate increased, the maximal quantum yield of PSII (F/F), actual quantum yield of PSII (Φ), and relative electron transfer rate at PSII (ETR) first decreased and then increased at the booting stage; F/F and Φ decreased while ETR first increased and then decreased at the heading stage; nevertheless, F/F and Φ first decreased and then increased but ETR was just the opposite at the maturity stage. Read More

Org Lett 2021 Apr 5. Epub 2021 Apr 5.

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.

Hymoins A-D (-), two pairs of light-induced transformative polyprenylated acylphloroglucinols with an unprecedented pentacyclic skeleton, were isolated from the flowers of . The first decarbonylative ring contraction of complex natural products was investigated by light irradiation. Their structures were elucidated by nuclear magnetic resonance analysis, X-ray crystallography, and electronic circular dichroism calculations. Read More

Int J Nurs Stud Adv 2021 Nov 28;3:100026. Epub 2021 Mar 28.

Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Huichuan District, Zunyi, Guizhou 563003, China.

Background: The Coronavirus disease (COVID-19) pandemic is an ongoing pandemic all over the world, leading to 126, 372, 442 people diagnosed and 2, 769, 696 deaths globally as of March 28, 2021. Nurses are providing care to patients with COVID-19 who require hospitalization. To ensure adequate response capacity and to maintain the health of nurses, it is important to analyse the actual work hours and the nurses reported preferred work hours per shift among frontline nurses. Read More

J Vet Res 2021 Mar 9;65(1):109-115. Epub 2021 Mar 9.

College of Animal Science and Veterinary Medicine, Qinghai University, Xining Qinghai Province 810016, People's Republic of China.

Introduction: Inflammation is one of the main causes of impaired health in livestock and some of its processes weaken animal productivity and impact human health. The present study was conducted to evaluate the effect of echinacea extract (cichoric acid - CA) on yak peripheral blood mononuclear cells (PBMCs), inflammatory-related factors, and the toll-like receptor (TLR)4 signalling pathway induced by lipopolysaccharide (LPS) in these PBMCs.

Material And Methods: Yak PBMCs were co-cultured with LPS and CA . Read More

Open Med (Wars) 2021 25;16(1):464-471. Epub 2021 Mar 25.

Department of Obstetrics, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 83 Feishan Street, Yunyan District, Guiyang City, Guizhou Province, 550003, China.

Gestational diabetes mellitus (GDM) is a metabolic dysregulation closely related to both obesity and type 2 diabetes; however, the molecular mechanism underlying GDM is still unclear. The purpose of this study was to investigate the effects of microRNA-377 (miR-377-3p) and fibronectin type III domain containing 5 (FNDC5) in regulating the cell growth of trophoblasts under high glucose (HG) conditions during the development of GDM. Serum miR-377-3p was upregulated and positively correlated with fasting blood glucose level in GDM patients. Read More

Biomed Res Int 2021 15;2021:5271291. Epub 2021 Mar 15.

The Orthopedic Surgery Department of Guiyang Maternal and Child Health-Care Hospital, Guiyang, Guizhou Province 550000, China.

Purpose: Osteosarcoma (Os) is the most frequent malignant tumor of the bone in the pediatric age group, and accumulating evidences show that lncRNAs play a key role in the development of Os. Thus, we investigated the role of RBM5-AS1 and its molecular mechanism.

Methods: The expression of RBM5-AS1 in Os tissues and cell lines was detected by real-time polymerase chain reaction (QPCR). Read More

Environ Sci Pollut Res Int 2021 Apr 4. Epub 2021 Apr 4.

Nanjing Institute of Environmental Sciences, Ministry of Ecology and Environment, Nanjing, 210042, China.

The occurrence and distribution of antibiotics and antibiotic resistance genes (ARGs) in natural water has attracted worldwide attention. Antibiotic and ARG pollution in the surface water of drinking water sources might directly/indirectly affect human health. In this study, the distribution of 38 antibiotics, 10 ARGs, 2 integrons, and 16S r DNA in river-type water sources in a large city of China were monitored in winter, which was a period with high level of antibiotic pollution. Read More

Biochem Biophys Res Commun 2021 Apr 1;555:54-60. Epub 2021 Apr 1.

Department of Pathology and Pathophysiology, School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou province, PR China; Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou province, PR China. Electronic address:

Non-alcoholic fatty liver disease (NAFLD) is the pathological manifestation of metabolic syndrome in liver. Its pathological changes may evolve from the initial simple steatosis to non-alcoholic steatohepatitis, liver fibrosis and even liver cancer. Numerous studies have proved that platelets play a vital role in liver disease and homeostasis. Read More

Bioresour Technol 2021 Mar 26:125050. Epub 2021 Mar 26.

College of Environment and Ecology, Chongqing University, Chongqing 400044, China; State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing, 400044, China. Electronic address:

Ultra-high-strength liquor wastewater (UHS-LWW) is rich in organic matter, and the required treatment is expensive. Here, an extremophilic strain Monascus pilosus YX-1125 was isolated for the direct conversion of UHS-LWW to short-chain fatty acids (SCFAs). Strain YX-1125 is an efficient SCFA producer with carbohydrate metabolic flexibility under multiple-stress conditions. Read More

Enzyme Microb Technol 2021 May 11;146:109761. Epub 2021 Feb 11.

School of Liquor & Food Engineering, Guizhou University, National Forestry and Grassland Bureau Prickly Pear Engineering Technology Research Center, Key Laboratory of Agricultural and Animal Products Store and Processing of Guizhou Province, Guiyang, 550025, China.

Lactobacillus acidophilus is an important probiotic. The β-glucosidase produced by L. acidophilus GIM1. Read More

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Apr;29(2):439-444

Guizhou Ankang Medical Laboratory Center Co Ltd, Guiyang 550002, Guizhou Province, China,E-mail:

Objective: To analyze the relationship of the expression of transcription factor MYB targeted regulation by miR-96 to cell invasion and apoptosis in pediatric acute myeloid leukemia (AML).

Methods: A total of 65 children with AML in The 928 Hospital of PLA Joint Logistics Support Forces from January 2017 to November 2019 were selected, including 35 cases diagnosed as primary AML and 30 cases as complete remission AML. Thirty children with immune thrombocytopenia were selected as control group. Read More

Mol Divers 2021 Apr 3. Epub 2021 Apr 3.

State Key Laboratory of Functions and Applications of Medicinal Plants and College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases, Guizhou Medical University, Guiyang, 550004, People's Republic of China.

In order to discover novel antifungal agents, three series of simple 2-aminobenzoxazole derivatives were designed, synthesized and evaluated for their antifungal activities against eight phytopathogenic fungi. The in vitro antifungal results showed that most of the target compounds exhibited excellent and broad-spectrum antifungal activities to all the tested fungi. Particularly, the six compounds 3a, 3b, 3c, 3e, 3m and 3v displayed the most potent antifungal activity, with EC value of 1. Read More

Entropy (Basel) 2021 Mar 4;23(3). Epub 2021 Mar 4.

Key Laboratory of Complex Systems and Intelligent Computing and School of Mathematics and Statistics, Qiannan Normal University for Nationalities, Duyun 558000, China.

The satisfiability (SAT) problem is a core problem in computer science. Existing studies have shown that most industrial SAT instances can be effectively solved by modern SAT solvers while random SAT instances cannot. It is believed that the structural characteristics of different SAT formula classes are the reasons behind this difference. Read More