45,648 results match your criteria guidelines- conducted


Ann Pharm Fr 2021 Jun 19. Epub 2021 Jun 19.

Department of Pharmaceutical Analysis, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, 530045, Andhra Pradesh, India. Electronic address:

Objective: The objective of the present study is to develop and validate a simple, rapid stability indicating high performance liquid chromatography method for the simultaneous quantification of metformin, empagliflozin, linagliptin in bulk and pharmaceutical dosage form.

Materials & Methods: The chromatographic separation was achieved on C18 X-bridge phenyl column (250×4.6mm, 5µm particle size). Read More

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Comment on the paper: Evidence-based treatment recommendations for neck and low back pain across Europe: A systematic review of guidelines.

Eur J Pain 2021 Jun 22. Epub 2021 Jun 22.

Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Corp et al. conducted an important study to synthesize the evidence from European guidelines on neck and lower back pain to identify appropriate recommendations (Corp et al., 2021). Read More

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Implementation of new ECMO centers during the COVID-19 pandemic: experience and results from the Middle East and India.

Intensive Care Med 2021 Jun 22. Epub 2021 Jun 22.

Intensive Care Department, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Purpose: Extracorporeal membrane oxygenation (ECMO) use for severe coronavirus disease 2019 (COVID-19) patients has increased during the course of the pandemic. As uncertainty existed regarding patient's outcomes, early guidelines recommended against establishing new ECMO centers. We aimed to explore the epidemiology and outcomes of ECMO for COVID-19 related cardiopulmonary failure in five countries in the Middle East and India and to evaluate the results of ECMO in 5 new centers. Read More

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The best treatment approach for lower calyceal stones ≤ 20 mm in maximal diameter: mini percutaneous nephrolithotripsy, retrograde intrarenal surgery or shock wave lithotripsy. A systematic review and meta-analysis of the literature conducted by the European Section of Uro-Technology and Young Academic Urologists.

Minerva Urol Nephrol 2021 Jun 22. Epub 2021 Jun 22.

European Section of Uro-Technology, European Association of Urology, Arnhem, The Netherlands.

Introduction: The highest in quality data in the literature which compared mini percutaneous nephrolithotripsy (mPCNL), retrograde intrarenal surgery (RIRS) and shock wave lithotripsy (SWL) for the management of lower pole stone (LPS) with a maximal diameter ≤20mm were investigated by means of systematic review (SR) and meta-analysis.

Evidence Acquisition: A SR of the literature was conducted on PubMed®, Cochrane, SCOPUS® and EMBASE® in January 2020. The study complied with the PRISMA statement and recommendations of the EAU Guidelines office. Read More

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Professional perspectives on applying the NICE and British Psychological Society Guidelines for the management of Behaviours that Challenge in dementia care: an e-survey.

Br J Clin Psychol 2021 Jun 22. Epub 2021 Jun 22.

CNTW NHS Foundation Trust, Newcastle upon Tyne, UK.

Objectives: Behaviours that challenge (BtC) reflect the most costly and burdensome aspects of dementia where non-pharmacological interventions rather than antipsychotic medication have been recommended as first-line approaches for over a decade (NICE 2006). This paper outlines professionals' views about their application of the Dementia NICE Guideline 97 (2018) and a British Psychological Society, Division of Clinical Psychology (BPS-DCP) Briefing paper (2013) on alternatives to antipsychotics.

Methods: A mixed-methods 34-item e-survey, with five items about the use of the NICE Guideline 97 (2018) and the BPS-DCP Briefing paper (2013) for the management of BtC, was conducted. Read More

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Use of DPB1 T-cell epitope algorithm among italian transplant centers: a survey on behalf of Associazione Italiana di Immunogenetica e Biologia dei Trapianti.

HLA 2021 Jun 21. Epub 2021 Jun 21.

Laboratorio di Tipizzazione tissutale, Dipartimento di Medicina Trasfusionale, Azienda Sanitaria Universitaria Giuliano Isontina - ASUGI, Trieste, Italy.

The HLA-DPB1 locus has been demonstrated to have a significant role on patients' outcome after allogeneic HSCT, and the so-called T-cell epitope (TCE) algorithm has been incorporated in international guidelines for the selection of unrelated donors. The purpose of the present study is to measure, through a national survey conducted on behalf of the Associazione Italiana di Immunogenetica e Biologia dei Trapianti (AIBT), the extent of awareness and use of HLA-DPB1 TCE-based algorithms during the donor search. Eighty-nine percent of the HLA laboratories answered to a short questionnaire and the results showed a progressive increase of the laboratories typing DPB1 in patients and their potential donors during the search (from 44% to 79% during the 2010-2019 period) as well as the application of a TCE-based algorithm for the donor choice whenever possible (from 24 to 65% during the same period). Read More

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Proposal for developing treatment algorithms of women with symptomatic adenomyosis: A single-center experience.

J Obstet Gynaecol Res 2021 Jun 21. Epub 2021 Jun 21.

Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan.

Aims: The most common symptoms of adenomyosis include heavy menstrual bleeding and dysmenorrhea. A variety of medical or surgical techniques are utilized for the treatment of adenomyosis, but there are currently no specific treatment guidelines and best practice recommendations for management. The aim of this study is to summarize current treatment strategies for women with symptomatic adenomyosis in a single-center university hospital in order to provide reliable information for developing treatment algorithms. Read More

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Subgroup discovery in non-inferiority trials.

Stat Med 2021 Jun 22. Epub 2021 Jun 22.

Division of Biostatistics, Department of Epidemiology and Population, Albert Einstein College of Medicine, Bronx, New York, USA.

Approaches and guidelines for performing subgroup analysis to assess heterogeneity of treatment effect in clinical trials have been the topic of numerous papers in the statistical and clinical literature, but have been discussed predominantly in the context of conventional superiority trials. Concerns about treatment heterogeneity are the same if not greater in non-inferiority (NI) trials, especially since overall similarity between two treatment arms in a successful NI trial could be due to the existence of qualitative interactions that are more likely when comparing two active therapies. Even in unsuccessful NI trials, subgroup analyses can yield important insights about the potential reasons for failure to demonstrate non-inferiority of the experimental therapy. Read More

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Is heart rate variability biofeedback useful in children and adolescents? A systematic review.

J Child Psychol Psychiatry 2021 Jun 21. Epub 2021 Jun 21.

UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, Univ. Lille, CNRS, Lille, France.

Background: Heart rate variability (HRV) is considered as an index of both physical and emotional health, and biofeedback aiming to increase the level of HRV has demonstrated extensive beneficial effects. Although HRV biofeedback is commonly and reliably applied in adults, the use of this technique, alone or in addition to other treatments, in children and adolescents has not been widely explored to date.

Methods: This systematic review following PRISMA guidelines covers all human studies using HRV biofeedback in children and adolescents. Read More

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Systematic observation of mask adherence and distancing (SOMAD): Findings from Philadelphia.

Prev Med Rep 2021 Sep 13;23:101449. Epub 2021 Jun 13.

SDSU, Emeritus, United States.

Adherence to guidelines for face coverings and physical distancing are critical strategies to stem the COVID-19 pandemic but are not uniformly followed. Understanding factors associated with adherence to mask-wearing and physical distancing may help guide future control efforts. We conducted an observational study using Systematic Observation of Mask Adherence and Distancing (SOMAD) in August 2020 in parks, playgrounds and commercial streets in each of 10 City Council Districts in Philadelphia, PA. Read More

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September 2021

Pre-operative Intraperitoneal Drainage Under Local Anesthesia: A Promising Resuscitation Tool in Peritonitis Secondary to Hollow Viscus Perforation During the Corona Pandemic.

Cureus 2021 May 18;13(5):e15083. Epub 2021 May 18.

Surgery, Weill-Cornell Medicine Qatar, Doha, QAT.

Introduction To study the role of intraperitoneal drainage in the resuscitation of patients with perforation peritonitis during the corona pandemic. Materials and methods This retrospective study was conducted in the general surgery department of Nishtar Medical University/Hospital Multan from April 2020 to September 2020. Patients of peritonitis who presented with bilateral pulmonary crepitations, SpO2 less than 92%, PaO2 less than 60 mmHg on arterial blood gas (ABG), and chest x-ray (CXR) finding of bilateral infiltrates are included. Read More

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Evaluating the provision of Further Enabling Care at Home (FECH+) for informal caregivers of older adults discharged home from hospital: protocol for a multicentre randomised controlled trial.

BMJ Open 2021 Jun 21;11(6):e046600. Epub 2021 Jun 21.

School of Nursing and Midwifery Nathan and Gold Coast, Griffith University, Brisbane, Queensland, Australia.

Introduction: There are personal and societal benefits from caregiving; however, caregiving can jeopardise caregivers' health. The Further Enabling Care at Home (FECH+) programme provides structured nurse support, through telephone outreach, to informal caregivers of older adults following discharge from acute hospital care to home. The trial aims to evaluate the efficacy of the FECH+ programme on caregivers' health-related quality of life (HRQOL) after care recipients' hospital discharge. Read More

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IVC filters - Indications for placement and retrieval trends- experience from a tertiary referral centre in India type of submission- full paper.

Indian Heart J 2021 May-Jun;73(3):331-335. Epub 2021 Jan 20.

Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, 110029, India. Electronic address:

Objectives: There is wide variation in the practice of IVC filter placement and retrievals. We conducted a retrospective study to identify the trends in placement and retrievals of IVC filters in a tertiary referral centre in India.

Methods: The data of patients obtained from our hospital records, in whom IVC filter was placed between 2010 and 2018, were analysed for demographics, indications for placement of IVC filter, underlying comorbidities, characteristics of the filters as well as the retrieval rates. Read More

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January 2021

Methods for conducting international Delphi surveys to optimise global participation in core outcome set development: a case study in gastric cancer informed by a comprehensive literature review.

Trials 2021 Jun 21;22(1):410. Epub 2021 Jun 21.

Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Background: Core outcome sets (COS) should be relevant to key stakeholders and widely applicable and usable. Ideally, they are developed for international use to allow optimal data synthesis from trials. Electronic Delphi surveys are commonly used to facilitate global participation; however, this has limitations. Read More

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The household financial burden of non-communicable diseases in low- and middle-income countries: a systematic review.

Health Res Policy Syst 2021 Jun 21;19(1):96. Epub 2021 Jun 21.

Department of Global Public Health, Karolinska Institutet, Solna, Sweden.

Background: The chronic nature of noncommunicable diseases (NCD) and costs associated with long-term care can result in catastrophic health expenditure for the patient and their household pushing them deeper into poverty and entrenching inequality in society. As the full financial burden of NCDs is not known, the objective of this study was to explore existing evidence on the financial burden of NCDs in low- and middle-income countries (LMICs), specifically estimating the cost incurred by patients with NCDs and their households to inform the development of strategies to protect such households from catastrophic expenditure.

Methods: This systematic review followed the PRISMA guidelines, PROSPERO: CRD42019141088. Read More

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Assessment of an electronic patient record system on discharge prescribing errors in a Tertiary University Hospital.

BMC Med Inform Decis Mak 2021 Jun 21;21(1):195. Epub 2021 Jun 21.

Department of Pharmacology, Saint James Hospital, Dublin, Ireland.

Background: Prescribing error represent a significant source of preventable harm to patients. Prescribing errors at discharge, including omission of pre-admission medications (PAM), are particularly harmful as they frequently propagate following discharge. This study assesses the impact of an educational intervention and introduction of an electronic patient record (EPR) in the same centre on omission of PAM at discharge using a pragmatic design. Read More

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The effect of non-pharmacological interventions on physical restraint reduction in intensive care units: a protocol for an umbrella review of systematic reviews and meta-analysis.

Ann Palliat Med 2021 Jun 18. Epub 2021 Jun 18.

The Second Affiliated Hospital Zhejiang University School of Medicine (SAHZU), Hangzhou, China; Changxing Branch Hospital of SAHZU, Huzhou, China.

Background: As the last resort in intensive care units, physical restraint reduction is affected by various interventions. Several non-pharmacological interventions may directly reduce physical restraints, such as staff education, or indirectly reduce physical restraint, such as delirium prevention; however, their effectiveness has remained inconclusive. Therefore, we devised a protocol for umbrella reviews to summarize the evidence integrating data of different non-pharmacological interventions that may reduce physical restraint use. Read More

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Shenfu injection for heart failure based on the AMSTAR-2, PRISMA, and GRADE tools.

Ann Palliat Med 2021 Jun 15. Epub 2021 Jun 15.

Traditional Chinese Medicine Department, Zigong First People's Hospital, Zigong, China.

Background: Evidence of the efficacy of Shenfu injection (SFI) in the treatment of heart failure (HF) is inconsistent. This study aimed to strictly evaluate the methodological quality, reporting quality, and evidence quality of systematic reviews (SRs) and meta-analyses (MAs) on the efficacy of SFI.

Methods: From inception to December 2020, using standardized search strategies, we searched for relevant SRs and MAs in the following seven databases: Cochrane library, Embase, PubMed, SinoMed, China National Knowledge Infrastructure (CNKI), Wanfang Database, and VIP Database. Read More

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Same goals, different challenges: a systematic review of perspectives of people with diabetes and healthcare professionals on Type 2 diabetes care.

Diabet Med 2021 Jun 21:e14625. Epub 2021 Jun 21.

Centre for Health Services Research, The University of Queensland, Brisbane, Australia.

Aims: To identify the views of people with diabetes (PWD) and healthcare professionals (HCP) about Type 2 diabetes care.

Methods: A systematic review of qualitative studies reporting both groups' views using thematic synthesis frameworked by the eHealth Enhanced Chronic Care Model was conducted.

Results: We searched six electronic databases between 2010-2020, identified 6,999 studies and included 21. Read More

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Early neuro-prognostication with the Patient State Index and suppression ratio in post-cardiac arrest patients.

J Crit Care 2021 Jun 7;65:149-155. Epub 2021 Jun 7.

Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea. Electronic address:

Purpose: Cardiopulmonary resuscitation guidelines recommend multimodal neuro-prognostication after cardiac arrest using neurological examination, electroencephalography, biomarkers, and brain imaging. The Patient State Index (PSI) and suppression ratio (SR) represent the depth and degree of sedation, respectively. We evaluated the predictive ability of PSI and SR for neuro-prognostication of post-cardiac arrest patients who underwent targeted temperature management. Read More

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A systematic review and recommendations on the use of plasma EBV DNA for nasopharyngeal carcinoma.

Eur J Cancer 2021 Jun 18;153:109-122. Epub 2021 Jun 18.

Coordinator of International Head and Neck Scientific Group, Padua, Italy.

Introduction: Nasopharyngeal carcinoma (NPC) is an endemic malignancy in Southeast Asia, particularly Southern China. The classical non-keratinising cell type is almost unanimously associated with latent Epstein-Barr virus (EBV) infection. Circulating plasma EBV DNA can be a useful biomarker in various clinical aspects, but comprehensive recommendations and international guidelines are still lacking. Read More

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Occupational and Personal Consequences of the COVID-19 Pandemic on US Oncologist Burnout and Well-Being: A Study From the ASCO Clinician Well-Being Task Force.

JCO Oncol Pract 2021 Jun 21:OP2100147. Epub 2021 Jun 21.

Northern California (NCAL), Kaiser Permanente, Oakland, CA.

Introduction: The COVID-19 pandemic is an unprecedented global crisis profoundly affecting oncology care delivery.

Purpose: This study will describe the occupational and personal consequences of the COVID-19 pandemic on oncologist well-being and patient care.

Materials And Methods: Four virtual focus groups were conducted with US ASCO member oncologists (September-November 2020). Read More

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Arthroscopy versus mini-arthrotomy approach for matrix-induced autologous chondrocyte implantation in the knee: a systematic review.

J Orthop Traumatol 2021 Jun 16;22(1):23. Epub 2021 Jun 16.

Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081, Baronissi, SA, Italy.

Background: Matrix-induced autologous chondrocyte implantation (mACI) can be performed in a full arthroscopic or mini-open fashion. A systematic review was conducted to investigate whether arthroscopy provides better surgical outcomes compared with the mini-open approach for mACI in the knee at midterm follow-up.

Methods: This systematic review was conducted following the PRISMA guidelines. Read More

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Lived Experiences of Family Members of Patients With Severe COVID-19 Who Died in Intensive Care Units in France.

JAMA Netw Open 2021 Jun 1;4(6):e2113355. Epub 2021 Jun 1.

Famiréa Research Group, Medical Intensive Care Unit, Assistance Publique-Hȏpitaux de Paris, Saint Louis University Hospital, Paris, France.

Importance: During the initial surge of the COVID-19 pandemic, family members were often separated from their loved ones admitted to intensive care units (ICUs), with a potential for negative experiences and psychological burden.

Objective: To better understand the experiences of bereaved family members of patients who died in an ICU during the COVID-19 pandemic, from the time of hospital admission until after the patient's death.

Design, Setting, And Participants: This qualitative study used semistructured, in-depth interviews to collect experiences from bereaved family members of patients who died from severe COVID-19 in 12 ICUs during the first wave of the pandemic in France. Read More

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Application of the ACMG/NSGC genetic referral guidelines for hereditary renal cell carcinoma at the University of Miami, from 2014 to 2017.

Am J Med Genet A 2021 Jun 21. Epub 2021 Jun 21.

Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA.

Identifying hereditary syndromes among patients with renal cell carcinoma (RCC) is essential for surveillance of affected individuals and their at-risk family members and for treatment optimization. We conducted a chart review to determine the percentage of patients with RCC who were seen at the University of Miami Health System (UHealth), and met the American College of Medical Genetics (ACMG) and the National Society of Genetic Counselors (NSGC) genetic referral criteria at the University of Miami. Subsequently, we determined the percentage of those who went on to receive genetic evaluation. Read More

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Uptake and outcomes of a novel community-based HIV post-exposure prophylaxis (PEP) programme in rural Kenya and Uganda.

J Int AIDS Soc 2021 Jun;24(6):e25670

Department of Medicine, University of California, San Francisco, CA, USA.

Introduction: Antiretroviral-based HIV prevention, including pre-exposure prophylaxis (PrEP), is expanding in generalized epidemic settings, but additional prevention options are needed for individuals with periodic, high-risk sexual exposures. Non-occupational post-exposure prophylaxis (PEP) is recommended in global guidelines. However, in Africa, awareness of and access to PEP for sexual exposures are limited. Read More

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The Associations of Plasma/Serum Carotenoids with Alzheimer's Disease: A Systematic Review and Meta-Analysis.

J Alzheimers Dis 2021 Jun 12. Epub 2021 Jun 12.

The PLA Rocket Force Characteristic Medical Center, Beijing, China.

Background: Multiple lines of evidence indicate protective effects of carotenoids in Alzheimer's disease (AD). However, previous epidemiological studies reported inconsistent results regarding the associations between carotenoids levels and the risk of AD.

Objective: Our study aims to evaluate the associations of six major members of carotenoids with the occurrence of AD by conducting a systematic review and meta-analysis. Read More

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A comprehensive scoping review of tibial cysts after anterior cruciate ligament reconstruction.

J Exp Orthop 2021 Jun 21;8(1):40. Epub 2021 Jun 21.

Centre Orthopédique Santy, Hopital Privé Jean Mermoz, Ramsay-Générale de Santé, Lyon, France.

Purpose: The purpose of this study was to perform a scoping review of published literature reporting on surgical management of tibial cysts which developed after ACLR.

Methods: A scoping review was conducted following the Arksey and O'Malley framework for scoping studies and Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) extension for scoping reviews (PRISMA-ScR) guidelines. A search strategy using the terms ["Tibial Cyst" AND "ACL"], ["Pretibial Cyst" AND "ACL"] was applied to the PUBMED database. Read More

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Assessment of the ESC quality indicators in patients with acute myocardial infarction: a systematic review.

Eur Heart J Acute Cardiovasc Care 2021 Jun 21. Epub 2021 Jun 21.

Cardiology Department, Health Research Institute of the Balearic Islands (IdISBa), Hospital Universitari Son Espases, Palma, Spain.

Aims: To help improving quality of care in patients with acute myocardial infarction (AMI), the European Society of Cardiology (ESC) set 20 quality indicators (QIs). There is a need to compile and summarize QI availability, feasibility, and global compliance in real-world registries.

Methods And Results: A systematic review of PubMed and Web of Science was conducted including all original articles reporting the use of the ESC QIs in AMI patients. Read More

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Physical Functioning After Admission to the PICU: A Scoping Review.

Crit Care Explor 2021 Jun 15;3(6):e0462. Epub 2021 Jun 15.

Centre of Expertise Urban Vitality, Faculty of Health, Amsterdam University of Applied Sciences, Amsterdam, The Netherlands.

Objectives: To conduct a scoping review to 1) describe findings and determinants of physical functioning in children during and/or after PICU stay, 2) identify which domains of physical functioning are measured, 3) and synthesize the clinical and research knowledge gaps.

Data Sources: A systematic search was conducted in PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, and Cochrane Library databases following the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews guidelines.

Study Selection: Two investigators independently screened and included studies against predetermined criteria. Read More

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