70,456 results match your criteria guidelines recommendations

Drugs in Pregnancy and Lactation - Medications used in Swiss Obstetrics.

Z Geburtshilfe Neonatol 2021 Jul 22. Epub 2021 Jul 22.

Obstetrics, University Hospital Zurich, Zurich, Switzerland.

Background: In order to improve the safety of drugs in pregnancy and lactation, it is imperative that data on clinical practice be collected and validated.

Methods: Data on routinely used medications were requested from 9 Swiss perinatal centres (5 university hospitals for obstetrics and 4 non-university centres). Furthermore, recommendations and guidelines from scientific societies for the fields of application were sought. Read More

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Updated treatment recommendations for newly diagnosed epithelial ovarian carcinoma from the ESMO Clinical Practice Guidelines.

Ann Oncol 2021 Jul 14. Epub 2021 Jul 14.

UCL Cancer Institute, University College London, London; UCL Hospitals, London, United Kingdom.

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Use of a Daratumumab-Specific Immunofixation Assay to Assess Possible Immunotherapy Interference at a Major Cancer Center: Our Experience and Recommendations.

J Appl Lab Med 2021 Jul 22. Epub 2021 Jul 22.

Clinical Chemistry Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Background: The incorporation of monoclonal antibodies, such as daratumumab, into multiple myeloma treatment regimens has led to the issue of false-positive interference in both serum protein electrophoresis (SPEP) and immunofixation (IF). The Hydrashift assay removes daratumumab interference from IF, allowing for correct interpretation. Here, we retrospectively examined the use of the Hydrashift assay at a large cancer center and provide guidelines on its most appropriate use. Read More

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Poor adherence to lifestyle recommendations in patients with coronary heart disease: results from the EUROASPIRE surveys.

Eur J Prev Cardiol 2021 Jul 19. Epub 2021 Jul 19.

National Institute for Prevention and Cardiovascular Health, National University of Ireland, Galway, Ireland.

Aims : Despite the high use of cardioprotective medications, the risk factor control in patients with coronary heart disease (CHD) is still inadequate. Guidelines identify healthy lifestyles as equally important in secondary prevention as pharmacotherapy. Here, we describe reasons for poor lifestyle adherence from the patient's perspective. Read More

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Sexually Transmitted Infections Treatment Guidelines, 2021.

MMWR Recomm Rep 2021 Jul 23;70(4):1-187. Epub 2021 Jul 23.

These guidelines for the treatment of persons who have or are at risk for sexually transmitted infections (STIs) were updated by CDC after consultation with professionals knowledgeable in the field of STIs who met in Atlanta, Georgia, June 11-14, 2019. The information in this report updates the 2015 guidelines. These guidelines discuss 1) updated recommendations for treatment of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis; 2) addition of metronidazole to the recommended treatment regimen for pelvic inflammatory disease; 3) alternative treatment options for bacterial vaginosis; 4) management of Mycoplasma genitalium; 5) human papillomavirus vaccine recommendations and counseling messages; 6) expanded risk factors for syphilis testing among pregnant women; 7) one-time testing for hepatitis C infection; 8) evaluation of men who have sex with men after sexual assault; and 9) two-step testing for serologic diagnosis of genital herpes simplex virus. Read More

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Primary vitreoretinal lymphoma: short review of the literature, results of a European survey and French guidelines of the LOC network for diagnosis, treatment and follow-up.

Curr Opin Oncol 2021 Jul 20. Epub 2021 Jul 20.

Institut Curie, Ophthalmology Department, Paris Institut Curie, PSL University, Inserm U1288, Laboratoire d'Imagerie Translationnelle en Oncologie, Orsay Member of European Reference Network on Rare Hematological Diseases (ERN-EuroBloodNet) Sorbonne Université, IHU, ICM, Department of Neuro-Oncology, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris French Network for Oculo-cerebral Lymphomas (LOC network) Sorbonne Université, Department of Ophthalmology Sorbonne Université, Department of Clinical Hematology Sorbonne Université, Department of Biological Hematology, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris Institut Curie, PSL Research University, Department of Pathology, Department of Theranostic and Diagnostic Medicine Sorbonne Université, Department of Radiotherapy, Hôpital Pitié- Salpêtrière, Assistance Publique-Hôpitaux de Paris Université de Paris, UMR 144 CNRS Institut Curie, Site de Saint-Cloud, Hematology Department, Saint-Cloud INSERM U932 Institut Curie, PSL Research University, Paris, France.

Purpose Of Review: The aim of this study was to highlight the diagnostic and management challenges of primary vitreoretinal lymphoma (PVRL) through a review of the literature and a European survey on real-life practices for PVRL.

Recent Findings: The care of PVRL patients is heterogeneous between specialists and countries. Upfront systemic treatment based on high-dose methotrexate chemotherapy, with or without local treatment, might reduce or delay the risk of brain relapse. Read More

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Effective Treatment Recommendations for Type 2 Diabetes Management Using Reinforcement Learning: Treatment Recommendation Model Development and Validation.

J Med Internet Res 2021 Jul 22;23(7):e27858. Epub 2021 Jul 22.

Ping An Healthcare Technology, Beijing, China.

Background: Type 2 diabetes mellitus (T2DM) and its related complications represent a growing economic burden for many countries and health systems. Diabetes complications can be prevented through better disease control, but there is a large gap between the recommended treatment and the treatment that patients actually receive. The treatment of T2DM can be challenging because of different comprehensive therapeutic targets and individual variability of the patients, leading to the need for precise, personalized treatment. Read More

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Communicable Illness Mitigation Strategies for Traveling Elite Sporting Organizations.

Sports Health 2021 Jul 22:19417381211032226. Epub 2021 Jul 22.

Weill Cornell Medical College, New York, New York.

Context: Transmission of communicable diseases observed in sporting organizations is often preventable. Early detection, isolation, and treatment can significantly diminish time lost. Until recently, there has been a paucity of standardized guidelines outlining feasible, preventable measures to protect both athletes and staff from contagious illnesses. Read More

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Shining a light on cultural neuroscience: Recommendations on the use of fNIRS to study how sociocultural contexts shape the brain.

Cultur Divers Ethnic Minor Psychol 2021 Jul 22. Epub 2021 Jul 22.

Department of Human Development and Family Sciences.

Functional near-infrared spectroscopy (fNIRS) is a portable neuroimaging technique that may serve as a methodological tool for studying how sociocultural contexts can shape the human brain and impact cognition and behavior. The use of fNIRS in community-based research may (a) advance theoretical knowledge in psychology and neuroscience, particularly regarding underrepresented ethnic-racial communities; (b) increase diversity in samples; and (c) provide neurobiological evidence of sociocultural factors supporting human development. The review aims to introduce the use of fNIRS, including its practicalities and limitations, to new adopters inquiring how sociocultural inputs affect the brain. Read More

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Pathology and systemic therapy of non-clear cell renal cell carcinoma: an overview.

Expert Rev Anticancer Ther 2021 Jul 22. Epub 2021 Jul 22.

Medical Clinic II, J.W. Goethe University, Frankfurt, Germany.

Introduction: Non-clear cell renal cell carcinoma (nccRCC) represents a highly heterogenous group of kidney cancer entities. As most clinical trials predominantly include patients with clear cell RCC (ccRCC), nccRCC treatment guidelines are mainly extrapolated from recommendations in ccRCC. Here, we review and elucidate current data on the pathologic classification and treatment of nccRCC. Read More

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Comparison of the antimalarial activity of a Colombian traditional Uitoto remedy with laboratory preparations.

J Vector Borne Dis 2020 Apr-Jun;57(2):170-175

Universidad Nacional de Colombia, Sede Bogotá, Facultad de Ciencias, Departamento de Farmacia, FaMeTra research group (traditional and Popular medicine Pharmacology), Colombia.

Background & Objectives: In Colombian Amazonia, Uitoto indigenous people use a preparation of Curarea toxicofera (Menispermaceae) to prevent and treat malaria. To open the way for the production of a standardized herbal remedy, we compared the activity of the traditional preparation with laboratory preparations.

Methods: People were interviewed on their mode of use and preparation of what is considered the best remedy against fevers in this area. Read More

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[Oncology Society of Chinese Medical Association guideline for clinical diagnosis and treatment of lung cancer (2021 edition)].


Zhonghua Zhong Liu Za Zhi 2021 Jun;43(6):591-621

In China, the incidence and mortality of lung cancer are ranked the first among malignant tumors. In order to further standardize the prevention and treatment measures of lung cancer, improve the prognosis of patients, and provide professional evidence-based medical recommendations to clinical medical staffs, Oncology Society of Chinese Medical Association organized experts from departments of pulmonary medicine, oncology, thoracic surgery, radiotherapy, imaging and pathology, based on the international guidelines and clinical practices in China, integrated the latest evidence-based medical evidences in lung cancer pathology, genetic testing, immune molecular marker detection and treatment methods in recent years. After consensus meetings, the Oncology Society of Chinese Medical Association guideline for clinical diagnosis and treatment of lung cancer in China was conducted, which provided recommendations of lung cancer screening, diagnosis, pathology, treatment and follow-up to clinicians, imaging, laboratory, and rehabilitation professionals. Read More

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Pre-operative fasting times for clear liquids at a tertiary children's hospital; what can be improved?

Anesth Pain Med (Seoul) 2021 Jul 21. Epub 2021 Jul 21.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Background: The goal of preoperative fasting is to prevent pulmonary aspiration during general anesthesia. Fasting times are often prolonged leading to patient discomfort and risk for adverse events. This retrospective quality improvement survey evaluated effective nil-per-os (NPO) times and causes for prolonged NPO times with the aim to suggest improvement strategies by a newly founded fasting task force. Read More

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Treatment strategies for Sjögren's syndrome with childhood onset: a systematic review of the literature.

Rheumatology (Oxford) 2021 Jul 20. Epub 2021 Jul 20.

Centre for Adolescent Rheumatology Versus Arthritis, Department of Medicine, University College London, Rayne Building, London, U.K.

Objectives: Sjögren's Syndrome (SS) with childhood onset is a rare autoimmune disease characterised by heterogeneous presentation. The lack of validated classification criteria makes it challenging to diagnose. Evidence-based guidelines for treatment of juvenile SS are not available due to the rarity of disease and the paucity of research in this patient population. Read More

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Electronic Charting of Radiation Therapy Planning and Treatment: Report of Task Group 262.

Med Phys 2021 Jul 20. Epub 2021 Jul 20.

Security Operations Center, Mayo Clinic, Rochester, MN, 55905, USA.

While most Radiation Oncology clinics have adopted electronic charting in one form or another, no consensus document exists that provides guidelines for safe and effective use of the Radiation Oncology electronic medical records (RO-EMR). Task Group 262 was formed to provide these guidelines as well as to provide recommendations to vendors for improving electronic charting functionality in the future. Guidelines are provided in the following areas: Implementation and training for the RO-EMR, acceptance testing and quality assurance (QA) of the RO-EMR, use of the RO-EMR as an information repository, use of the RO-EMR as a workflow manager, electronic charting for brachytherapy and non-standard treatments, and information technology (IT) considerations associated with the RO-EMR. Read More

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Smartphone-Based Interventions for Physical Activity Promotion: Scoping Review of the Evidence Over the Last 10 Years.

JMIR Mhealth Uhealth 2021 Jul 21;9(7):e24308. Epub 2021 Jul 21.

Research Group: Self-Regulation and Health, Department of Behavioural and Cognitive Sciences, University of Luxembourg, Esch-sur-Alzette, Luxembourg.

Background: Several reviews of mobile health (mHealth) physical activity (PA) interventions suggest their beneficial effects on behavior change in adolescents and adults. Owing to the ubiquitous presence of smartphones, their use in mHealth PA interventions seems obvious; nevertheless, there are gaps in the literature on the evaluation reporting processes and best practices of such interventions.

Objective: The primary objective of this review is to analyze the development and evaluation trajectory of smartphone-based mHealth PA interventions and to review systematic theory- and evidence-based practices and methods that are implemented along this trajectory. Read More

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Evidence-Based Pragmatic Approach to the Management of Borderline or High-Risk Breast Lesions.

AJR Am J Roentgenol 2021 Jul 21. Epub 2021 Jul 21.

Massachusetts General Hospital, 55 Fruit Street, WAC 240, Boston, Massachusetts 02114.

The management of borderline/high-risk breast lesions (HRLs) remains controversial. We propose a pragmatic evidence-based approach based on lesion type. For lobular carcinoma in situ with pleomorphism, papilloma with atypia, atypical ductal hyperplasia, and fibroepithelial lesion, surgical consultation and excision are recommended. Read More

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Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): A Phase II Randomised Controlled trial: Trial Protocol.

Wellcome Open Res 2021 23;6:160. Epub 2021 Jun 23.

Clinical Trials Facility, KEMRI-Wellcome Trust Research Programme, Kilifi, PO Box 230, Kenya.

Children hospitalised with severe acute malnutrition (SAM) are frequently complicated (>50%) by diarrhoea ( 3 watery stools/day) which is accompanied by poor outcomes. Rehydration guidelines for SAM are exceptionally conservative and controversial, based upon expert opinion. The guidelines only permit use of intravenous fluids for cases with advanced shock and exclusive use of low sodium intravenous and oral rehydration solutions (ORS) for fear of fluid and/or sodium overload. Read More

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Preventing Falls and Malnutrition among Older Adults in Municipal Residential Care in Sweden: A Registry Study.

SAGE Open Nurs 2021 Jan-Dec;7:23779608211026161. Epub 2021 Jul 7.

School of Health, Care and Social Welfare, Mälardalen University, Eskilstuna/Västerås, Sweden.

Introduction: Older adults in municipal residential care are among the most vulnerable and in need of most care. The prevalence of negative events, such as falls and malnutrition, is increased among these older adults. The need for strategies to prevent falls and malnutrition is emphasized in guidelines and systematic, individualized risk assessments are prerequisites for adequate interventions. Read More

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Developing Adult Vaccination Ecosystem in India: Current Perspective and the Way Forward.

Health Serv Res Manag Epidemiol 2021 Jan-Dec;8:23333928211030791. Epub 2021 Jul 7.

Medical and Scientific Affairs, Pfizer Limited, Mumbai, India.

Introduction: A high burden of vaccine-preventable diseases, increasing elderly population, immunosenescence, and emerging drug resistance emphasize the need for robust adult immunization in India. While immunization guidelines from various societies exist, there is inadequate implementation of the same.

Aim: We undertook this narrative review of the adult vaccination ecosystem in India to (i) gain insights into existing adult vaccination practices, (ii) identify barriers to adult vaccination and possible solutions, and (iii) improve collaboration between various stakeholders to help establish adult vaccination centers in the country. Read More

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A Systematic Review on Re-irradiation with Charged Particle Beam Therapy in the Management of Locally Recurrent Skull Base and Head and Neck Tumors.

Int J Part Ther 2021 25;8(1):131-154. Epub 2021 Jun 25.

Radiation Oncology, Mayo Clinic, Phoenix, AZ, USA.

Purpose: To evaluate the clinical outcomes and treatment related toxicities of charged particle-based re-irradiation (reRT; protons and carbon ions) for the definitive management of recurrent or second primary skull base and head and neck tumors.

Materials And Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were applied for the conduct of this systematic review. Published work in English language evaluating the role of definitive charged particle therapies in the clinical setting of reRT for recurrent or second primary skull base and head and neck tumors were eligible for this analysis. Read More

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Expert review and recommendations for the management of acute, chronic, and neuropathic pain in Qatar.

Qatar Med J 2021 7;2021(2):19. Epub 2021 Jul 7.

Neuromuscular Division, Hamad Medical Corporation, Doha, Qatar; Neurology Division, Department of Medicine, Al Khor Hospital, Doha, Qatar.

Background: Pain management is an evolving area of expertise in Qatar. Gaps in knowledge, inadequate training for physicians and nurses, and the absence of policies/guidelines are the main barriers to effective pain management in Qatar. In addition, the use of certain pain medication, especially opioids, is highly regulated, limiting their availability in outpatient pain management. Read More

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Challenges and Adaptation in Otorhinolaryngology Practice During Pandemic Lockdown: Experience from a Malaysian COVID-19 Hospital.

Malays J Med Sci 2021 Jun 30;28(3):143-150. Epub 2021 Jun 30.

Department of Otorhinolaryngology-Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

COVID-19 has taken the world by storm: since the first few cases appeared in Wuhan, China in December 2019 and by June 2020 there were more than 10 million cases of COVID-19 cases worldwide. Malaysia had its first case in January 2020 and acted promptly by implementing several drastic measures to contain the disease. Subsequently, the Ministry of Health Malaysia has implemented guidelines and recommendations on the management of COVID-19. Read More

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Non-Fellowship regional anesthesia training and assessment: an international Delphi study on a consensus curriculum.

Reg Anesth Pain Med 2021 Jul 20. Epub 2021 Jul 20.

Department of Anesthesiology and Pain Medicine, Ottawa Hospital, Ottawa, Ontario, Canada.

Background And Objectives: While there are several published recommendations and guidelines for trainees undertaking subspecialty Fellowships in regional anesthesia, a similar document describing a core regional anesthesia curriculum for non-fellowship trainees is less well defined. We aimed to produce an international consensus for the training and teaching of regional anesthesia that is applicable for the majority of worldwide anesthesiologists.

Methods: This anonymous, electronic Delphi study was conducted over two rounds and distributed to current and immediate past (within 5 years) directors of regional anesthesia training worldwide. Read More

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Saudi consensus statement on biologic treatment of chronic plaque psoriasis (2020).

J Dermatolog Treat 2021 Jul 20:1-15. Epub 2021 Jul 20.

King Abdullah Medical Complex, Jeddah, Saudi Arabia.

Psoriasis is a common chronic and complex inflammatory skin disease that affects over 125 million people worldwide. Management of psoriasis in daily clinical practice in Saudi Arabia is variable. Local preferences for management differ, which may have a bearing on the treatment selection. Read More

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