260,340 results match your criteria guideline followedresults

[Background, Necessity and Methodology of the S3 Guideline "Perioperative Management of Gastrointestinal Tumours (POMGAT)"].

Zentralbl Chir 2021 Jun 21;146(3):241-248. Epub 2021 Jun 21.

Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax- und Gefäßchirurgie, Universitätsklinikum Bonn, Deutschland.

Malignancies are among the most common diseases, especially in old age, and are responsible for 25% of all deaths in Germany. Especially carcinomas of the gastrointestinal tract can be cured in most cases only through extensive surgery with significant morbidity. About 25 years ago, the multimodal, perioperative Fast Track (FT) concept for reducing postoperative complications was introduced and additional elements were added in the following years. Read More

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Disparities between Asian and Non-Asian Thrombolyzed Acute Ischemic Stroke Patients in the Enhanced Control of Hypertension and Thrombolysis Stroke Trial.

Cerebrovasc Dis 2021 Jun 21:1-7. Epub 2021 Jun 21.

The George Institute for Global Health, Faculty of Medicine, UNSW, Sydney, New South Wales, Australia.

Background And Purpose: As outcomes for acute ischemic stroke (AIS) vary according to clinical profile and management approaches, we aimed to determine disparities in clinical outcomes between Asian and non-Asian participants of the international, Enhanced Control of Hypertension and Thrombolysis Stroke study (ENCHANTED).

Methods: ENCHANTED was a multicenter, prospective, partial-factorial, randomized, open trial of low-dose (0.6 mg/kg) versus standard-dose (0. Read More

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The European multistakeholder PanCareFollowUp project: novel, person-centred survivorship care to improve care quality, effectiveness, cost-effectiveness and accessibility for cancer survivors and caregivers.

Eur J Cancer 2021 Jun 18;153:74-85. Epub 2021 Jun 18.

Princess Máxima Centre for Paediatric Oncology, Heidelberglaan 25, Utrecht, 3584 CS, the Netherlands.

Background: The majority of childhood cancer survivors are at risk of treatment-related adverse health outcomes. Survivorship care to mitigate these late effects is endorsed, but it is not available for many adult survivors of childhood cancer in Europe. The PanCareFollowUp project was initiated to improve their health and quality of life (QoL) by facilitating person-centred survivorship care. Read More

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A systematic review and recommendations on the use of plasma EBV DNA for nasopharyngeal carcinoma.

Eur J Cancer 2021 Jun 18;153:109-122. Epub 2021 Jun 18.

Coordinator of International Head and Neck Scientific Group, Padua, Italy.

Introduction: Nasopharyngeal carcinoma (NPC) is an endemic malignancy in Southeast Asia, particularly Southern China. The classical non-keratinising cell type is almost unanimously associated with latent Epstein-Barr virus (EBV) infection. Circulating plasma EBV DNA can be a useful biomarker in various clinical aspects, but comprehensive recommendations and international guidelines are still lacking. Read More

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Combination Biomarkers for Risk Stratification in Patients with Chronic Heart Failure Biomarkers Prognostication in HF.

J Card Fail 2021 Jun 18. Epub 2021 Jun 18.

Department of Medicine, UCLA Medical Center, Los Angeles, CA; UCLA Cardiac Arrhythmia Center, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Background: Current guidelines recommend measuring natriuretic peptide biomarkers to establish prognosis in patients with chronic heart failure with reduced ejection fraction (HFrEF). We assessed whether a combination biomarkers approach improve prognostication in stable HFrEF patients.

Methods: An observational cohort study recruited 202 stable HFrEF patients at a single center, tertiary care hospital undergoing elective cardiac resynchronization therapy device placement from 2013 to 2015. Read More

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Relationships between physical therapy intervention and opioid use: A scoping review.

PM R 2021 Jun 21. Epub 2021 Jun 21.

Informatics, Decision-Enhancement, and Analytic Sciences (IDEAS) Center of Innovation, VA, Salt Lake City, Utah.

Objective: Synthesize available evidence that have examined the relationship between physical therapy (PT) and opioid-use.

Literature Survey: Data sources including Google scholar, Embase, PubMed, Cochrane Library, and CINAHL were searched for English articles up to 10-24-2019 using terms ("physical therapy"[Title/Abstract] OR physiotherapy[Title/Abstract] OR rehabilitation[Title/Abstract]) AND (opiate*[Title/Abstract] OR opioid*[Title/Abstract]).

Methodology: Included studies evaluated a PT intervention and reported an opioid-use outcome. Read More

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Implementation of telehealth antimicrobial stewardship through partnership of an academic medical center and a community hospital.

Am J Health Syst Pharm 2021 Jun 21. Epub 2021 Jun 21.

Department of Medicine, Division of Infectious Diseases, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Purpose: Small community hospitals often lack the human, financial, and technological resources necessary to implement and maintain successful antimicrobial stewardship programs now required by national regulatory and accrediting bodies. Creative solutions are needed to address this problem.

Summary: A 3-stage, quasi-experimental study including patients receiving antibiotics for pneumonia, skin and soft tissue infections, and urinary tract infections at a community hospital in Wisconsin from June 2013 to December 2015 was conducted. Read More

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Designing and Implementing a COVID Language Resource Guide as a Response to an Acute Need.

J Soc Work End Life Palliat Care 2021 Jun 21:1-7. Epub 2021 Jun 21.

Advanced Palliative & Hospice Social Work Certification Program, Cary, North Carolina.

The rise of COVID-19 in March, 2020 led to an urgent and acute need for communication guidelines to help clinicians facing a novel disease, amidst a cacophony of voices and demands, find the words to use in the face of this public health emergency. We identified critical topics that arose at the interface of staff, patient and family to guide the structure and content of a guideline. Organized in an easy to read table, the guide was made available to a wide variety of websites, organizations and schools as a free PDF resource across the country and beyond. Read More

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Prioritizing and implementing HPV vaccination quality improvement programs in healthcare systems: the perspective of quality improvement leaders.

Hum Vaccin Immunother 2021 Jun 21:1-10. Epub 2021 Jun 21.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.

Human papillomavirus (HPV) vaccination could prevent most of the ~34,000 HPV-attributable cancers diagnosed annually in the US, but uptake remains suboptimal. Healthcare systems are key partners in implementing HPV vaccination quality improvement (QI) programs. To inform future system-level HPV vaccine initiatives, we sought to understand HPV vaccine QI from the perspective of QI program leaders in healthcare systems. Read More

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Management of Blood Pressure in Patients With Chronic Kidney Disease Not Receiving Dialysis: Synopsis of the 2021 KDIGO Clinical Practice Guideline.

Ann Intern Med 2021 Jun 22. Epub 2021 Jun 22.

Tufts University, Boston, Massachusetts (M.J.S.).

Description: The Kidney Disease: Improving Global Outcomes (KDIGO) 2021 clinical practice guideline for the management of blood pressure (BP) in patients with chronic kidney disease (CKD) not receiving dialysis is an update of the KDIGO 2012 guideline on the same topic and reflects new evidence on the risks and benefits of BP-lowering therapy among patients with CKD. It is intended to support shared decision making by health care professionals working with patients with CKD worldwide. This article is a synopsis of the full guideline. Read More

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Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating Circumstances: The CONSERVE 2021 Statement.

JAMA 2021 Jun 21. Epub 2021 Jun 21.

The Lancet , London, England.

Importance: Extenuating circumstances can trigger unplanned changes to randomized trials and introduce methodological, ethical, feasibility, and analytical challenges that can potentially compromise the validity of findings. Numerous randomized trials have required changes in response to the COVID-19 pandemic, but guidance for reporting such modifications is incomplete.

Objective: As a joint extension for the CONSORT and SPIRIT reporting guidelines, CONSERVE (CONSORT and SPIRIT Extension for RCTs Revised in Extenuating Circumstances) aims to improve reporting of trial protocols and completed trials that undergo important modifications in response to extenuating circumstances. Read More

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Chemical contaminants in Brazilian drinking water: a systematic review.

J Water Health 2021 Jun;19(3):351-369

Chemical Engineering Department, Federal University of Rio Grande do Sul, Luiz Englert s/n°, downtown, 90040-040, Porto Alegre-RS, Brazil E-mail:

The goals of this research are to evaluate which chemical contaminations were detected in Brazil's drinking water reported in papers published from 2012 to 2019, to propose guideline values for emerging contaminants and assess which are the priority parameters from a health risk perspective. The methodology used was a systematic review. The chemical contaminants quantified were evaluated according to Brazilian drinking-water standards, and Guideline Values were proposed for emerging pollutants using conservative endpoints from NOAEL and LOAEL available in literature. Read More

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Challenges With Developing Secure Mobile Health Applications: Systematic Review.

JMIR Mhealth Uhealth 2021 Jun 21;9(6):e15654. Epub 2021 Jun 21.

Centre for Research on Engineering Software Technologies, School of Computer Science, The University of Adelaide, Adelaide, Australia.

Background: Mobile health (mHealth) apps have gained significant popularity over the last few years due to their tremendous benefits, such as lowering health care costs and increasing patient awareness. However, the sensitivity of health care data makes the security of mHealth apps a serious concern. Poor security practices and lack of security knowledge on the developers' side can cause several vulnerabilities in mHealth apps. Read More

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European Academy of Neurology and European Federation of Neurorehabilitation Societies guideline on pharmacological support in early motor rehabilitation after acute ischaemic stroke.

Eur J Neurol 2021 Jun 21. Epub 2021 Jun 21.

RoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania.

Background And Purpose: Early pharmacological support for post-stroke neurorehabilitation has seen an abundance of mixed results from clinical trials, leaving practitioners at a loss regarding the best options to improve patient outcomes. The objective of this evidence-based guideline is to support clinical decision-making of healthcare professionals involved in the recovery of stroke survivors.

Methods: This guideline was developed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework. Read More

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The application of artificial intelligence and data integration in COVID-19 studies: a scoping review.

J Am Med Inform Assoc 2021 Jun 21. Epub 2021 Jun 21.

Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA.

Objective: To summarize how artificial intelligence (AI) is being applied in COVID-19 research and determine whether these AI applications integrated heterogenous data from different sources for modeling.

Materials And Methods: We searched 2 major COVID-19 literature databases, the National Institutes of Health's LitCovid and the World Health Organization's COVID-19 database on March 9, 2021. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline, 2 reviewers independently reviewed all the articles in 2 rounds of screening. Read More

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Intrauterine insemination with ovarian stimulation is a successful step prior to assisted reproductive technology for couples with unexplained infertility.

J Obstet Gynaecol 2021 Jun 21:1-6. Epub 2021 Jun 21.

Faculty of Medicine, Department of Gynaecology and Obstetrics, Ankara University, Ankara, Turkey.

The present retrospective cohort study analysed data of couples with unexplained infertility who underwent two to three intrauterine insemination (IUI) cycles. The inclusion criteria were age 20-40 years, failure to conceive for at least two years of unprotected intercourse, ovulation, normal semen analysis, and tubal patency. Total of 578 IUI cycles of 286 couples with unexplained infertility were included in the final analyses. Read More

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Covalent SO Bonding Enables Enhanced Photoelectrochemical Performance of Cu S/Fe O Heterojunction for Water Splitting.

Small 2021 Jun 21:e2100320. Epub 2021 Jun 21.

Laboratory for High Performance Ceramics, Empa, Swiss Federal Laboratories for Materials Science and Technology, Ueberlandstrasse 129, Dubendorf, CH-8600, Switzerland.

The severe charge recombination and the sluggish kinetic for oxygen evolution reaction have largely limited the application of hematite (α-Fe O ) for water splitting. Herein, the construction of Cu S/Fe O heterojunction and discover that the formation of covalent SO bonds between Cu S and Fe O can significantly improve the photoelectrochemical performance and stability for water splitting is reported. Compared with bare Fe O , the heterostructure of Cu S/Fe O endows the resulting electrode with enhanced charge separation and transfer, extended range for light absorption, and reduced charge recombination rate. Read More

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Care dependency of patients and residents at the end of life: A secondary data analysis of data from a cross-sectional study in hospitals and geriatric institutions.

J Clin Nurs 2021 Jun 20. Epub 2021 Jun 20.

Institute of Nursing Science, Medical University of Graz, Graz, Austria.

Aims And Objectives: The holistic care dependency concept can be applied to gain comprehensive insights into individuals' care needs in the end-of-life (EoL) phase. This study was carried out to measure and characterise the "care dependency" phenomenon in this phase and to obtain deeper knowledge about this phenomenon.

Background: The end of a human life is often characterised by a physical decline, often implying that a high amount of care is needed. Read More

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Management of Cancer-Associated Venous Thrombosis: A Nationwide Survey among Danish Oncologists.

TH Open 2021 Apr 16;5(2):e188-e194. Epub 2021 Jun 16.

Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.

 Treatment patterns for cancer-associated venous thrombosis (CAT) has been shown to be nonconsistent with contemporary guideline recommendations, resulting in poor patient outcomes.  The study aimed to describe contemporary CAT management in Danish oncology departments and identify knowledge gaps and inconsistencies between guidelines and clinical practice.  A survey questionnaire in Danish was developed based on contemporary national guidelines. Read More

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Spin Labeling of RNA Using "Click" Chemistry for Coarse-grained Structure Determination via Pulsed Electron-electron Double Resonance Spectroscopy.

Bio Protoc 2021 May 5;11(9):e4004. Epub 2021 May 5.

Institute of Physical and Theoretical Chemistry, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.

Understanding the function of oligonucleotides on a molecular level requires methods for studying their structure, conformational changes, and internal dynamics. Various biophysical methods exist to achieve this, including the whole toolbox of Electron Paramagnetic Resonance (EPR or ESR) spectroscopy. An EPR method widely used in this regard is Pulsed Electron-Electron Double Resonance (PELDOR or DEER), which provides distances in the nanometer range between electron spins in biomolecules with Angstrom precision, without restriction to the size of the biomolecule, and in solution. Read More

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Impaired Myocardial Function Is Prognostic for Severe Respiratory Failure in the Course of COVID-19 Infection.

Front Cardiovasc Med 2021 4;8:584108. Epub 2021 Jun 4.

Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls Universität Tübingen, Tübingen, Germany.

COVID-19 may lead to severe acute respiratory distress syndrome (ARDS) resulting in increased morbidity and mortality. Heart failure and/or pre-existing cardiovascular disease may correlate with poor outcomes and thus require special attention from treating physicians. The present study sought to investigate a possible impact of impaired myocardial function as well as myocardial distress markers on mortality or ARDS with need for mechanical ventilation in 157 consecutive patients with confirmed SARS-CoV-2 infection. Read More

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Policy and Food Consumption: What Nutrition Guidelines Are Swiss Children Meeting and What Determines Adherence?

Front Nutr 2021 4;8:641799. Epub 2021 Jun 4.

BeCHANGE Research Group, Institute of Public Health and Institute of Public Communication, Universitá della Svizzera italiana, Lugano, Switzerland.

To describe the adherence of the children to the Swiss Society for Nutrition (SSN) dietary guidelines, assess determinants of adherence, and compare these findings with a previous study in the same population. Data from 312 children ages 5-12 were collected through a survey and a 2-day food record. The associations of children- and parent-related factors with adherence of the children to guidelines were assessed by logistic regression analyses. Read More

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Attitudes Toward and Use of Prostate-Specific Antigen Testing Among Urologists and General Practitioners in Germany: A Survey.

Front Oncol 2021 4;11:691197. Epub 2021 Jun 4.

University Hospital for Urology, Klinikum Oldenburg, Department of Human Medicine, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Background: In 2020, around 1.4 million new prostate cancer (PCa) cases were recorded worldwide. Early detection of PCa by prostate-specific antigen (PSA) screening remains debated, leading to different specialist-specific recommendations in PCa guidelines. Read More

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Airborne particulate matter in Tehran's ambient air.

J Environ Health Sci Eng 2021 Jun 7;19(1):1179-1191. Epub 2021 Jan 7.

Research Center for Environmental Health Technology, Iran University of Medical Sciences, Tehran, Iran.

In recent decades, particulate matter (PM) concentrations in Tehran have exceeded the World Health Organization's (WHO) guideline on most days. In this study, a search protocol was defined by identifying the keywords, to carry out a systematic review of the concentrations and composition of PM in Tehran's ambient air. For this purpose, searches were done in Scopus, PubMed, and Web of Science in 2019. Read More

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Spatial patterns and temporal variations of traffic-related air pollutants and estimating its health effects in Isfahan city, Iran.

J Environ Health Sci Eng 2021 Jun 18;19(1):781-791. Epub 2021 Mar 18.

Department of Environmental Health Engineering, Maragheh University of Medical Sciences, Maragheh, Iran.

Isfahan as an important industrial city has faced with air pollution recently. Thus, we assessed the spatial and temporal trends of ambient PM, CO, SO, and O and for estimating their health effect on Isfahan citizens between March 2018 and March 2019 through the AirQ+ software. Our results showed that citizens of Isfahan in almost 240, 167, and 134 of the days in the year has exposure to PM, SO, and O higher than the WHO daily guideline, respectively. Read More

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Patient Explanation of Adherence and Non-Adherence to Venous Leg Ulcer Treatment: A Qualitative Study.

Front Pharmacol 2021 3;12:663570. Epub 2021 Jun 3.

Monash Nursing and Midwifery, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VI, Australia.

The aim of this study was to understand which factors influence patients' adherence to venous leg ulcer treatment recommendations in primary care. We adopted a qualitative study design, conducting phone interviews with 31 people with venous leg ulcers in Melbourne, Australia. We conducted 31 semi-structured phone interviews between October and December 2019 with patients with clinically diagnosed venous leg ulcers. Read More

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Korean clinical practice guideline for pancreatic cancer 2021: A summary of evidence-based, multi-disciplinary diagnostic and therapeutic approaches.


Pancreatology 2021 May 19. Epub 2021 May 19.

Pancreatic cancer is the eighth most common cancer and the fifth most common cause of cancer-related death in Korea. To enable standardization of management and facilitate improvements in outcome, a total of 53 multi-disciplinary experts in gastroenterology, surgery, medical oncology, radiation oncology, radiology, nuclear medicine, and pathology in Korea developed new recommendations that integrate the most up-to-date, evidence-based research findings and expert opinions. Recommendations were made on imaging diagnosis, endoscopic management, surgery, radiotherapy, palliative chemotherapy, and specific management procedures, including neoadjuvant treatment or adjuvant treatment for patients with resectable, borderline resectable, and locally advanced unresectable pancreatic cancer. Read More

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