1,572 results match your criteria gsp

Assessing Nigerian Butchers' Knowledge and Perception of Good Hygiene and Storage Practices: A Cattle Slaughterhouse Case Analysis.

Foods 2021 May 22;10(6). Epub 2021 May 22.

Department of Functional Food Products Development, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, 51-630 Wrocław, Poland.

In Nigeria, the National Agency for Food and Drug Administration and Control (NAFDAC) guides the inspection and production of beef meat and prescribes the good practices pertinent to beef products' handling, processing, and packaging. Specifically, good hygiene practice (GHP) assures beef product safety and consumer protection, whereas good storage practice (GSP) assures the continuity of hygiene activities within the storage stages. Relevant literature about butchers' knowledge and perception of good hygiene and storage practices within Nigeria slaughterhouses remains scant. Read More

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Cripto-1 as a Potential Target of Cancer Stem Cells for Immunotherapy.

Cancers (Basel) 2021 May 20;13(10). Epub 2021 May 20.

Laboratory of Nano-Biotechnology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama 700-8530, Japan.

The immune system has been found to be suppressed in cancer patients. Cancer cells are extremely resistant to chemotherapeutic drugs, conventional immunotherapy, or cancer antigen vaccine therapy. Cancer immunotherapy, which is mainly based on immune checkpoint inhibitors, such as those for PD-1, PD-L1, and CTLA4, is an effective treatment method. Read More

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Semi-supervised Perception Augmentation for Aerial Photo Topologies Understanding.

IEEE Trans Image Process 2021 May 18;PP. Epub 2021 May 18.

Intelligently understanding the sophisticated topological structures from aerial photographs is a useful technique in aerial image analysis. Conventional methods cannot fulfill this task due to the following challenges: 1) the topology number of an aerial photo increases exponentially with the topology size, which requires a fine-grained visual descriptor to discriminatively represent each topology; 2) identifying visually/semantically salient topologies within each aerial photo in a weakly-labeled context, owing to the unaffordable human resources required for pixel-level annotation; and 3) designing a cross-domain knowledge transferal module to augment aerial photo perception, since multi-resolution aerial photos are taken asynchronistically in practice. To handle the above problems, we propose a unified framework to understand aerial photo topologies, focusing on representing each aerial photo by a set of visually/semantically salient topologies based on human visual perception and further employing them for visual categorization. Read More

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Tunable reflective dual-band line-to-circular polarization convertor with opposite handedness based on graphene metasurfaces.

Opt Express 2021 Apr;29(9):13373-13387

In this letter, we propose a dual-band tunable reflective linear-to-circular (LTC) polarization converter, which is composed of a graphene sheet etched with an I-shaped carved-hollow array. In the mid-infrared region, two LTC bands with opposite handedness are simultaneously realized due to the excitation of the three graphene surface plasmon (GSP) modes. The band of line-to-right-circular-polarization (LTRCP) ranges from 9. Read More

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Multi-Enzymatic Cascades in the Synthesis of Modified Nucleosides: Comparison of the Thermophilic and Mesophilic Pathways.

Biomolecules 2021 Apr 16;11(4). Epub 2021 Apr 16.

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho-Maklaya 16/10, 117997 GSP, B-437 Moscow, Russia.

A comparative study of the possibilities of using ribokinase → phosphopentomutase → nucleoside phosphorylase cascades in the synthesis of modified nucleosides was carried out. Recombinant phosphopentomutase from HB27 was obtained for the first time: a strain producing a soluble form of the enzyme was created, and a method for its isolation and chromatographic purification was developed. It was shown that cascade syntheses of modified nucleosides can be carried out both by the mesophilic and thermophilic routes from D-pentoses: ribose, 2-deoxyribose, arabinose, xylose, and 2-deoxy-2-fluoroarabinose. Read More

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Effect of Sea Buckthorn on Plasma Glucose in Individuals with Impaired Glucose Regulation: A Two-Stage Randomized Crossover Intervention Study.

Foods 2021 Apr 8;10(4). Epub 2021 Apr 8.

Department of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing 100191, China.

Sea buckthorn (SB) has been indicated to have hypoglycemic potential, but its effects on glucose in people with impaired glucose regulation (IGR) are still unclear. This work presents a randomized, double-blinded, two-way crossover study. A total of 38 subjects with IGR completed the intervention of consuming sea buckthorn fruit puree (SBFP, 90 mL/day, five weeks), washing out (four weeks), and then consuming placebo (90 mL/day, five weeks) or in reverse order. Read More

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Radical Dehalogenation and Purine Nucleoside Phosphorylase : How Does an Admixture of 2',3'-Anhydroinosine Hinder 2-fluoro-cordycepin Synthesis.

Biomolecules 2021 Apr 7;11(4). Epub 2021 Apr 7.

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho-Maklaya 16/10, 117997 GSP, B-437 Moscow, Russia.

During the preparative synthesis of 2-fluorocordycepin from 2-fluoroadenosine and 3'-deoxyinosine catalyzed by purine nucleoside phosphorylase, a slowdown of the reaction and decrease of yield down to 5% were encountered. An unknown nucleoside was found in the reaction mixture and its structure was established. This nucleoside is formed from the admixture of 2',3'-anhydroinosine, a byproduct in the preparation of 3-'deoxyinosine. Read More

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A systematic review of global surgery partnerships and a proposed framework for sustainability.

Can J Surg 2021 04 28;64(3):E280-E288. Epub 2021 Apr 28.

From the Department of Surgery, Division of General Surgery, University of British Columbia, Vancouver, BC (Jedrzejko, Margolick, Ball-Banting); the Faculty of Medicine, University of Toronto, Toronto, Ont. (Nguyen); the Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ont. (Ding); the Department of Surgery, Makerere University, Kampala, Uganda (Kisa); and Trauma Services, Vancouver General Hospital, Vancouver, BC (Hameed, Joos).

Background: Building surgical capacity through global surgery partnerships (GSPs) between high and low- and middle-income countries (LMICs) is a rising global health focus. Our aim was to conduct a systematic review to characterize strategies employed by GSPs to build capacity and promote sustainability and to propose a novel reproducible model for sustainability.

Methods: We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Read More

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A nonlinear evolution of the structure, morphology, and optical properties of PbS-CdS films with cadmium nitrate in the reaction mixture.

Phys Chem Chem Phys 2021 May;23(17):10600-10614

National Research University "Moscow Power Engineering Institute", 14 Krasnokazarmennaya str., Moscow, 111250, Russia.

Herein, we describe the nonlinear processes for the formation of thin films of the PbS-CdS system using chemical bath deposition with a gradual change in the cadmium nitrate content in the reaction mixture. The morphology of films was studied via scanning electron microscopy and atomic force microscopy. The mechanism for the formation of thin-film compounds can be considered as cluster-particle aggregation (diffusion-limited aggregation). Read More

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Genome wide association study of the whiteness and colour related traits of flour and dough sheets in common wheat.

Sci Rep 2021 Apr 22;11(1):8790. Epub 2021 Apr 22.

State Key Laboratory of Crop Biology, Key Laboratory of Crop Biology of Shandong Province, Group of Wheat Quality and Molecular Breeding, College of Agronomy, Shandong Agricultural University, Tai'an, 271000, Shandong, People's Republic of China.

Flour whiteness and colour are important factors that influence the quality of wheat flour and end-use products. In this study, a genome wide association study focusing on flour and dough sheet colour using a high density genetic map constructed with 90K single nucleotide polymorphism arrays in a panel of 205 elite winter wheat accessions was conducted in two different locations in 2 years. Eighty-six significant marker-trait associations (MTAs) were detected for flour whiteness and the brightness index (L* value), the redness index (a* value), and the yellowness index (b* value) of flour and dough sheets (P < 10) on homologous group 1, 2, 5 and 7, and chromosomes 3A, 3B, 4A, 6A and 6B. Read More

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HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis.

Proc Natl Acad Sci U S A 2021 Apr;118(17)

Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115

The position of recombination events established along chromosomes in early prophase I and the chromosome remodeling that takes place in late prophase I are intrinsically linked steps of meiosis that need to be tightly regulated to ensure accurate chromosome segregation and haploid gamete formation. Here, we show that RAD-51 foci, which form at the sites of programmed meiotic DNA double-strand breaks (DSBs), exhibit a biased distribution toward off-centered positions along the chromosomes in wild-type , and we identify two meiotic roles for chromatin-associated protein HIM-17 that ensure normal chromosome remodeling in late prophase I. During early prophase I, HIM-17 regulates the distribution of DSB-dependent RAD-51 foci and crossovers on chromosomes, which is critical for the formation of distinct chromosome subdomains (short and long arms of the bivalents) later during chromosome remodeling. Read More

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Moving toward a competency-based curriculum: Analyzing patients' information and students' evaluation in geriatric dentistry.

J Dent Educ 2021 Apr 16. Epub 2021 Apr 16.

Thungyai Hospital, Nakhon Si Thammarat, Thailand.

Objective: There is no core competency for geriatric dentistry and special patient care (GSP) in Thailand. Therefore, GSP program was developed as a knowledge-based curriculum. This study aimed to describe the development and architecture of the GSP curriculum by analyzing patients' information and students' evaluation to move toward a competency-based curriculum. Read More

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Grape Seed Proanthocyanidins play the roles of radioprotection on Normal Lung and radiosensitization on Lung Cancer via differential regulation of the MAPK Signaling Pathway.

J Cancer 2021 15;12(10):2844-2854. Epub 2021 Mar 15.

Department of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, 800 Xiangyin Road, Shanghai, China, 200433.

Radiation-induced lung injury (RILI) is a common serious complication and dose-limiting factor caused by radiotherapy for lung cancer. This study was to investigate radioprotective effects of grape seed proanthocyanidins (GSP) on normal lung as well as radiosensitizing effects on lung cancer. , we demonstrated radioprotective effects of GSP on normal alveolar epithelial cells (MLE-12 and BEAS/2B) and radiosensitizing effects on lung cancer cells (LLC and A549). Read More

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Resolution of sclerotic lesions of dysosteosclerosis due to biallelic SLC29A3 variant in a Turkish girl.

Am J Med Genet A 2021 Jul 10;185(7):2271-2277. Epub 2021 Apr 10.

Department of Pediatric Genetics, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Dysosteosclerosis is a group of sclerosing bone dysplasia characterized by short stature, increased bone fragility, osteosclerosis, and platyspondyly. It is a genetically heterogeneous disorder caused by biallelic mutations in the SLC29A3, TNFRSF11A, TCIRG1, and CSF1R genes. To date, four dysosteosclerosis patients with SLC29A3 mutations have been reported. Read More

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Revealing the Complex Nature of Bonding in the Binary High-Pressure Compound FeO_{2}.

Phys Rev Lett 2021 Mar;126(10):106001

Bayerisches Geoinstitut, University of Bayreuth, D-95440 Bayreuth, Germany.

Extreme pressures and temperatures are known to drastically affect the chemistry of iron oxides, resulting in numerous compounds forming homologous series nFeOmFe_{2}O_{3} and the appearance of FeO_{2}. Here, based on the results of in situ single-crystal x-ray diffraction, Mössbauer spectroscopy, x-ray absorption spectroscopy, and density-functional theory+dynamical mean-field theory calculations, we demonstrate that iron in high-pressure cubic FeO_{2} and isostructural FeO_{2}H_{0.5} is ferric (Fe^{3+}), and oxygen has a formal valence less than 2. Read More

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Effect of grape seed power on the structural and physicochemical properties of wheat gluten in noodle preparation system.

Food Chem 2021 Sep 8;355:129500. Epub 2021 Mar 8.

School of Food Science and Biological Engineering, Hefei University of Technology, Hefei 230009, PR China; Collaborative Innovation Center for Food Production and Safety, School of Biological Science and Engineering, North Minzu University, Yinchuan 750021, PR China. Electronic address:

Noodles were prepared using wheat flour supplemented with 1%, 3%, and 5% grape seed power (GSP). The farinograph properties of wheat flour, the textural properties of the dough, and thermal properties of the gluten were determined. The microstructure was analyzed by scanning electron and atomic force microscopy, and the effects of the addition of GSP on the physicochemical and structural properties (free sulfhydryl content, surface hydrophobic region, and secondary structure) of wheat gluten protein were analyzed. Read More

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September 2021

Pandanipora fragilis-a new deep-water cyclostome bryozoan from the subequatorial Mid-Atlantic Ridge, Atlantic Ocean, and a review of Pandanipora worldwide.

Zootaxa 2020 Dec 17;4895(4):zootaxa.4895.4.9. Epub 2020 Dec 17.

Department of Invertebrate Zoology and Aquatic Ecology, Biological Faculty, Perm State National Research University, Bukirev Street 15, GSP, Perm 614990, Russia A.V. Zhirmunsky National Scientific Center of Marine Biology, Far East Branch, Russian Academy of Sciences, Palchevskogo Street 17, Vladivostok 690041, Russia.

A new cyclostome bryozoan, Pandanipora fragilis n. sp., is described from 3453 m depth on the subequatorial Mid-Atlantic Ridge. Read More

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December 2020

Hypoglycemic Efficacy of Rh-aFGF Variants in Treatment of Diabetes in ZDF Rats.

Front Cell Dev Biol 2021 18;9:609383. Epub 2021 Feb 18.

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Acidic fibroblast growth factor (aFGF) is a promising regulator of glucose with no adverse effects of hypoglycemia. Previous researches revealed that aFGF mediated adipose tissue remodeling and insulin sensitivity. These findings supported rh-aFGF would be used as a new candidate for the treatment of insulin resistance and type 2 diabetes. Read More

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February 2021

Berberis kansuensis extract alleviates type 2 diabetes in rats by regulating gut microbiota composition.

J Ethnopharmacol 2021 Jun 4;273:113995. Epub 2021 Mar 4.

School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.

Background: The stem bark of Berberis kansuensis Schneid (BK) is a commonly used Tibetan medicine for the treatment of type 2 diabetes (T2D). However, its therapeutic mechanisms remain unclear.

Aim Of The Study: Our aim is to clarify the role of gut microbiota in the anti-diabetic activity of BK extract. Read More

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Protective Effect of Grape () Seed Powder and Zinc-Glycine Complex on Growth Traits and Gut Health of Broilers Following Challenge.

Antibiotics (Basel) 2021 Feb 14;10(2). Epub 2021 Feb 14.

Department of Animal Production, College of Food and Agriculture Science, King Saud University, Riadh 96400, Saudi Arabia.

The current study was conducted to evaluate the impact of grape () seed powder and zinc-glycine complex on growth parameters and cecal health of broiler following challenge. A total of 250 day-old male broilers (Hubbard) were distributed into five treatments as follows: I-negative control (basal diet); II-positive control ( challenge); III-group infected + Amprolium; IV-group coccidial infection + organic zinc (OZ) at 50 ppm + grape seed powder (GSP) at 2.5 g/kg; V-coccidial infection + organic zinc (OZ) at 50 ppm + grape seed powder (GSP) at 5. Read More

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February 2021

Grape seed proanthocyanidins protect PC12 cells from hydrogen peroxide-induced damage via the PI3K/AKT signaling pathway.

Neurosci Lett 2021 04 2;750:135793. Epub 2021 Mar 2.

Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu, 730000, China; Orthopaedics Key Laboratory of Gansu Province, Lanzhou, Gansu, 730000, China. Electronic address:

Grape seed proanthocyanidins (GSP) are natural flavonoids with strong antioxidant and anti-apoptotic effects. Oxidative stress and neuronal apoptosis are major contributors to spinal cord injury (SCI). In this study, we assessed the potential protective effects of GSP on hydrogen peroxide (HO)-damaged pheochromocytoma-12 (PC12) cells in an in vitro model of SCI as well as the putative mechanism of action. Read More

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Bioinspired Scene Classification by Deep Active Learning With Remote Sensing Applications.

IEEE Trans Cybern 2021 Feb 26;PP. Epub 2021 Feb 26.

Accurately classifying sceneries with different spatial configurations is an indispensable technique in computer vision and intelligent systems, for example, scene parsing, robot motion planning, and autonomous driving. Remarkable performance has been achieved by the deep recognition models in the past decade. As far as we know, however, these deep architectures are incapable of explicitly encoding the human visual perception, that is, the sequence of gaze movements and the subsequent cognitive processes. Read More

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February 2021

Combining anatomical and functional networks for neuropathology identification: A case study on autism spectrum disorder.

Med Image Anal 2021 04 31;69:101986. Epub 2021 Jan 31.

Center for Intelligent Systems, EPFL, Switzerland. Electronic address:

While the prevalence of Autism Spectrum Disorder (ASD) is increasing, research continues in an effort to identify common etiological and pathophysiological bases. In this regard, modern machine learning and network science pave the way for a better understanding of the neuropathology and the development of diagnosis aid systems. The present work addresses the classification of neurotypical and ASD subjects by combining knowledge about both the structure and the functional activity of the brain. Read More

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Massive-Scale Aerial Photo Categorization by Cross-Resolution Visual Perception Enhancement.

IEEE Trans Neural Netw Learn Syst 2021 Feb 15;PP. Epub 2021 Feb 15.

Categorizing aerial photographs with varied weather/lighting conditions and sophisticated geomorphic factors is a key module in autonomous navigation, environmental evaluation, and so on. Previous image recognizers cannot fulfill this task due to three challenges: 1) localizing visually/semantically salient regions within each aerial photograph in a weakly annotated context due to the unaffordable human resources required for pixel-level annotation; 2) aerial photographs are generally with multiple informative attributes (e.g. Read More

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February 2021

Isolation and characterization of cancer stem cells derived from human glioblastoma.

Am J Cancer Res 2021 1;11(2):441-457. Epub 2021 Feb 1.

Laboratory of Nano-Biotechnology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University Okayama 700-8530, Japan.

Cancer stem cell (CSC) is considered as a cause of cancer recurrence and metastasis. Simultaneously CSCs are responsible for the heterogeneous population in tumor tissues due to their differentiation potential. However, the characterizations of CSCs are still not enough and cancer stem cell lines widely available is desired to be established for the advancement of cancer research. Read More

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February 2021

A Novel Artificially Humanized Anti-Cripto-1 Antibody Suppressing Cancer Cell Growth.

Int J Mol Sci 2021 Feb 8;22(4). Epub 2021 Feb 8.

Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama 700-8530, Japan.

Cripto-1 is a member of the EGF-CFC/FRL1/Cryptic family and is involved in embryonic development and carcinogenesis. We designed a novel anti-Cripto-1 artificial antibody and assessed the recognition to the antigen and the potential to suppress the growth of cancer stem cells. First, single chain antibody clones were isolated by bio-panning with the affinity to recombinant Cripto-1 protein from our original phage-display library. Read More

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February 2021

Cutting Edge of the Pathogenesis of Atopic Dermatitis: Sphingomyelin Deacylase, the Enzyme Involved in Its Ceramide Deficiency, Plays a Pivotal Role.

Genji Imokawa

Int J Mol Sci 2021 Feb 5;22(4). Epub 2021 Feb 5.

Center for Bioscience Research & Education and Utsunomiya University, 350 Mine Utsunomiya, Tochigi 321-8505, Japan.

Atopic dermatitis (AD) is characterized clinically by severe dry skin and functionally by both a cutaneous barrier disruption and an impaired water-holding capacity in the stratum corneum (SC) even in the nonlesional skin. The combination of the disrupted barrier and water-holding functions in nonlesional skin is closely linked to the disease severity of AD, which suggests that the barrier abnormality as well as the water deficiency are elicited as a result of the induced dermatitis and subsequently trigger the recurrence of dermatitis. These functional abnormalities of the SC are mainly attributable to significantly decreased levels of total ceramides and the altered ceramide profile in the SC. Read More

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February 2021

Pituitary tumors: genetic and molecular factors underlying pathogenesis and clinical behavior.

Neuroendocrinology 2021 Feb 1. Epub 2021 Feb 1.

Pituitary neuroendocrine tumors (PitNETs) are the most common intracranial neoplasms. Although generally benign, they can show a clinically aggressive course, with local invasion, recurrences and resistance to medical treatment. No universally accepted biomarkers of aggressiveness are available yet, and predicting clinical behavior of PitNETs remains a challenge. Read More

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February 2021

Comparison of functional and structural properties of ginkgo seed protein dried by spray and freeze process.

J Food Sci Technol 2021 Jan 28;58(1):175-185. Epub 2020 May 28.

Department of Food Science and Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, No. 2 Xuelin Road, Qixia, Nanjing, 210097 People's Republic of China.

The influences of spray-drying and freeze-drying processes on functional properties of ginkgo seed proteins (GSP) were systematically investigated. It was revealed that GSP dried by spray (SGSP) displays an significantly improved water holding capacity and superior emulsifying properties than the freezing-drying GSP (FGSP), whereas, the oil binding capacity is higher in FGSP. The difference in properties of SGSP and FGSP can be attributed to their different structural characteristics. Read More

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January 2021