733 results match your criteria gsh efficiently

RIP1 kinase inactivation protects against acetaminophen-induced acute liver injury in mice.

Free Radic Biol Med 2021 Jul 26. Epub 2021 Jul 26.

Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing, 210094, China. Electronic address:

Many studies have investigated the role of receptor-interacting protein 1 (RIP1) kinase in acetaminophen (APAP) overdose-induced acute liver injury. However, the results were not consistent and there still remain controversies. Importantly, in these previous studies, the usage of DMSO to dissolve the RIP1 kinase inhibitor Nec-1, resulted in misleading conclusion. Read More

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GAS6 ameliorates advanced age-associated meiotic defects in mouse oocytes by modulating mitochondrial function.

Aging (Albany NY) 2021 Jul 26;13(undefined). Epub 2021 Jul 26.

Department of Biomedical Science, Institute of Reproductive Medicine, College of Life Science, CHA University, Seongnam-si, Gyeonggi-do 13488, Korea.

Previously, we reported that the silencing of () expression in oocytes impairs cytoplasmic maturation by suppressing mitophagy and inducing mitochondrial dysfunction, resulting in fertilization failure. Here, we show that oocyte aging is accompanied by an increase in meiotic defects associated with chromosome misalignment and abnormal spindle organization. Intriguingly, decreased mRNA and protein expression were observed in aged oocytes from older females. Read More

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Investigation of thiolysis of 4-substituted SBD derivatives and rational design of a GSH-selective fluorescent probe.

Org Biomol Chem 2021 Jul;19(29):6527-6533

State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, National Pesticide Engineering Research Center, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, 300071, China.

In order to evaluate 7-sulfonamide benzoxadiazole (SBD) derivatives for the development of fluorescent probes, herein we investigated the thiolysis reactivity and selectivity of a series of SBD compounds with different atoms (N/O/S/Se) at the 4-position. Both SBD-amine and SBD-ether are stable toward biothiols in buffer (pH 7.4), while SBD-selenoether can react efficiently with biothiols GSH/Hcy, Cys, and H2S to produce SBD-SG/S-Hcy, SBD-NH-Cys, and SBD-SH, respectively, with three different sets of spectral signals. Read More

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Amplification of tumor oxidative stresses by Poly(disulfide acetal) for multidrug resistance reversal.

Biomaterials 2021 Jul 7;276:121005. Epub 2021 Jul 7.

School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, 510006, PR China; Key Laboratory of Biomedical Engineering of Guangdong Province and Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, PR China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510006, PR China. Electronic address:

Discovering new strategies to overcome multidrug resistance (MDR) is still urgently needed. MDR is associated with the overexpression of transmembrane efflux pumps, and adenosine triphosphate (ATP) is indispensable for its function. Herein, we developed a pH- and glutathione (GSH)-responsive amphiphilic poly(disulfide acetal) (PCS) containing cinnamaldehyde (CA) and disulfide groups that amplify oxidative stress for anticancer drug delivery and simultaneously overcome drug resistance in cancer cells. Read More

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The facile formation of hierarchical mesoporous silica nanocarriers for tumor-selective multimodal theranostics.

Biomater Sci 2021 Jul;9(15):5237-5246

Department of Chemical Engineering, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institute of Polymer Science in Chemical Engineering, School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.

The combination of therapeutic and diagnostic functions in a single platform has aroused great interest due to the more optimal synergistic effects that can be obtained as compared to any single theranostic approach alone. However, current nanotheranostics are normally formed via complicated construction steps involving the pre-synthesis of each component and further conjugation via chemical bonds, which may cause low integration efficiency and limit production and applications. Herein, a tumor-targeting and tumor-responsive all-in-one nanoplatform based on mesoporous silica nanocarriers (MSNs) was fabricated via a facile approach utilizing efficient and nondestructive physical interactions for long-wavelength fluorescence imaging-guided synergistic chemo-catalytic-photothermal tumor therapy. Read More

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Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing.

J Ethnopharmacol 2021 Jun 25;279:114374. Epub 2021 Jun 25.

Department of Animal Biology & Physiology, Faculty of Sciences, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

Ethnopharmacological Relevance: Information collected from local traditional healers reported that Eremomastax speciosa (Hochst.) Cufod. has for a long time been used to manage gastric ulcers in many regions of Cameroon and beyond. Read More

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Chemodynamic therapy agents Cu(II) complexes of quinoline derivatives induced ER stress and mitochondria-mediated apoptosis in SK-OV-3 cells.

Eur J Med Chem 2021 Jun 16;223:113636. Epub 2021 Jun 16.

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China. Electronic address:

Three Cu(II) complexes of quinoline derivatives as cancer chemodynamic therapy agents were synthesized and characterized. These complexes were heavily taken up by cells and reacted with cellular glutathione (GSH) to reduce Cu to Fenton-like Cu, which catalyzed endogenous HO to produce the highly toxic hydroxyl radicals (•OH) to kill cancer cells. Cu1 and Cu2 initiated CAT activity declines, mitochondrial membrane potential and ATP concentration decrease, mitochondrial Ca overload and ER stress response, leading to cell cycle arrest in sub-G1 and cancer cell caspase-dependent apoptosis. Read More

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Kinetin mitigates Cd-induced damagesto growth, photosynthesis and PS II photochemistry of Trigonella seedlings by up-regulating ascorbate-glutathione cycle.

PLoS One 2021 22;16(6):e0249230. Epub 2021 Jun 22.

Department of Plant Physiology, Slovak University of Agriculture, Nitra, Slovakia.

Cytokinins (CKs) plays a key role in plant adaptation over a range of different stress conditions. Here, we analyze the effects of a cytokinin (i.e. Read More

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A glutathione-responsive polyphenol - Constructed nanodevice for double roles in apoptosis and ferroptosis.

Colloids Surf B Biointerfaces 2021 Sep 4;205:111902. Epub 2021 Jun 4.

Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan, 430072, PR China. Electronic address:

Combination chemotherapy regimens have been put forward to achieve a synergistic effect and reduce drug doses for the clinical applications of cancer treatment. One of the principal approaches for killing cancer cells involves triggering apoptotic cell death with anti-cancer drugs. Nevertheless, the efficacy of apoptosis induction in tumors is often restricted on account of intrinsic or acquired resistance of cancer cells to apoptosis. Read More

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September 2021

Biodegradable Copper-Based Nanoparticles Augmented Chemodynamic Therapy through Deep Penetration and Suppressing Antioxidant Activity in Tumors.

Adv Healthc Mater 2021 Jul 2;10(14):e2100412. Epub 2021 Jun 2.

Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin, 130022, China.

Chemodynamic therapy (CDT) efficacy has been limited by the poor penetration ability of large nanoparticles (NPs) and the antioxidant activity of tumors, especially high heme oxygenase (HO-1) and glutathione (GSH) levels. Herein, PEGylated CuMoO -coated and zinc protoporphyrin IX (ZP)-loaded Cu (CCMZ) NPs are designed to afford rapid degradation ability and augmented CDT efficacy through inhibiting HO-1 activity and depleting GSH. The deep penetration of tumor can be achieved under the high levels of GSH, which triggers the degradation of CuMoO shell. Read More

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A Label-Free Fluorometric Glutathione Assay Based on a Conformational Switch of G-quadruplex.

Molecules 2021 May 7;26(9). Epub 2021 May 7.

School of Life Sciences, Central South University, Changsha 410013, China.

In this paper, a label-free fluorescent method for glutathione (GSH) detection based on a thioflavin T/G-quadruplex conformational switch is developed. The sensing assay is fabricated depending on the virtue of mercury ions to form a thymine-thymine mismatch, which collapses the distance between two ssDNA and directs the guanine-rich part to form an intra-strand asymmetric split G-quadruplex. The newly formed G-quadruplex efficiently reacts with thioflavin T and enhances the fluorescent intensity. Read More

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Fighting against drug-resistant tumors by the inhibition of γ-glutamyl transferase with supramolecular platinum prodrug nano-assemblies.

J Mater Chem B 2021 Jun;9(22):4587-4595

Department of Pharmacy, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan), Foshan, 528300, P. R. China.

Pt(ii)-based antitumor drugs (e.g. cisplatin and oxaliplatin) are one of the most successful and frequently used drugs in cancer chemotherapy at present. Read More

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Covalent Amide-Bonded Nanoflares for High-Fidelity Intracellular Sensing and Targeted Therapy: A Superstable Nanosystem Free of Nonspecific Interferences.

Anal Chem 2021 06 26;93(22):7879-7888. Epub 2021 May 26.

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.

A nanoflare, a conjugate of Au nanoparticles (NPs) and fluorescent nucleic acids, is believed to be a powerful nanoplatform for diagnosis and therapy. However, it highly suffers from the nonspecific detachment of nucleic acids from the AuNP surface because of the poor stability of Au-S linkages, thereby leading to the false-positive signal and serious side effects. To address these challenges, we report the use of covalent amide linkage and functional [email protected] (AuG) NP to fabricate a covalent conjugate system of DNA and AuG NP, label-rcDNA-AuG. Read More

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Phenolics-Enriched Fraction of Roxb. efficiently Reverses the Hepatocellular Carcinoma in NDEA-Induced HCC Rats.

Nutr Cancer 2021 May 21:1-16. Epub 2021 May 21.

Pharmacology Division, CSIR-National Botanical Research Institute, Lucknow, India.

Hepatocellular Carcinoma is one of the most frequently diagnosed cancer and highly refractory for chemotherapeutics agents. Therefore, the study aims to explore the new therapeutic agents for HCC. Phenolics rich fraction of leaves of was studied against hepatic cancer cell lines (HepG2) and NDEA-induced HCC rat model system. Read More

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Defining the role of CFTR channel blocker and ClC-2 activator in DNBS induced gastrointestinal inflammation.

Saudi Pharm J 2021 Apr 10;29(4):291-304. Epub 2021 Mar 10.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Northern Border University, Rafha, Saudi Arabia.

In the present study, we have investigated and/or compared the role of glibenclamide, G as cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor, and lubiprostone, L as chloride channel-2 (ClC-2) activator in the 2,4-dinitrobenzene sulfonic acid (DNBS)-induced gastrointestinal inflammation. GI inflammation was induced by intrarectal administration of DNBS. Rats were randomly allocated in 5 groups as sham control, distilled water + DNBS, sulfasalazine (S) + DNBS, G + DNBS, and L + DNBS. Read More

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Synergistic effect of the anti-PD-1 antibody with blood stable and reduction sensitive curcumin micelles on colon cancer.

Drug Deliv 2021 Dec;28(1):930-942

Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is a potent anticancer drug with versatile biological activities, while the clinical translation of curcumin is severely limited due to its hydrophobicity, rapid elimination, and metabolism in the blood circulation. Herein, we aim to unravel the potential of curcumin as a synergistic agent with immunotherapy in the treatment of cancers. In an effort to minimize premature release and improve the systemic bioavailability, a superior blood stable and reduction sensitive curcumin micellar formulation, of which the release can be triggered by cancer cells, is rationally designed. Read More

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December 2021

Non-thermal plasma-induced DMPO-OH yields hydrogen peroxide.

Arch Biochem Biophys 2021 Jul 6;705:108901. Epub 2021 May 6.

Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Showa-Ku, Nagoya, 466-8550, Japan; Center for Low-temperature Plasma Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8603, Japan. Electronic address:

Recent developments in electronics have enabled the medical applications of non-thermal plasma (NTP), which elicits reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as hydroxyl radical (OH), hydrogen peroxide (HO), singlet oxygen (O), superoxide (O), ozone, and nitric oxide at near-physiological temperatures. In preclinical studies or human clinical trials, NTP promotes blood coagulation, eradication of bacterial, viral and biofilm-related infections, wound healing, and cancer cell death. To elucidate the solution-phase biological effects of NTP in the presence of biocompatible reducing agents, we employed electron paramagnetic resonance (EPR) spectroscopy to quantify OH using a spin-trapping probe, 5,5-dimethyl-1-pyrroline-N-oxide (DMPO); O using a fluorescent probe; and O and HO using luminescent probes in the presence of thiols or tempol. Read More

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Combined passivators regulate the heavy metal accumulation and antioxidant response of Brassica chinensis grown in multi-metal contaminated soils.

Environ Sci Pollut Res Int 2021 May 1. Epub 2021 May 1.

College of Resources and Environment, Huazhong Agricultural University, Wuhan, 430070, China.

Passivation of heavy metals is one of the most efficient techniques to remediate soil pollution. However, passivators with single component are usually unsatisfactory in the case of multi-metal contaminated soils. To resolve this problem, a series of combined passivators containing different ratios of Fe-Mn ore, Fe powder, zeolite, bentonite, etc. Read More

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BTH Treatment Delays the Senescence of Postharvest Pitaya Fruit in Relation to Enhancing Antioxidant System and Phenylpropanoid Pathway.

Foods 2021 Apr 13;10(4). Epub 2021 Apr 13.

South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China.

The plant resistance elicitor Benzo (1,2,3)-thiadiazole-7-carbothioic acid S-methyl ester (BTH) can enhance disease resistance of harvested fruit. Nonetheless, it is still unknown whether BTH plays a role in regulating fruit senescence. In this study, exogenous BTH treatment efficiently delayed the senescence of postharvest pitaya fruit with lower lipid peroxidation level. Read More

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Self-assembled multifunctional polymeric micelles for tumor-specific bioimaging and synergistic chemo-phototherapy of cancer.

Int J Pharm 2021 Jun 27;602:120651. Epub 2021 Apr 27.

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address:

Integration of multiple therapies into one nanoplatform holds great promise to overcome the shortcomings of traditional single-modal therapy and achieve favorable antitumor efficacy. Herein, we constructed a dual receptor-targeting nanomicelle system with GSH-responsive drug release for precise fluorescence imaging and superior chemo-phototherapy of cancer. The synthetic amphiphilic hyaluronic acid derivative (FHSV) could self-assemble into nanomicelles in aqueous media. Read More

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A MnO nanosheet-mediated photo-controlled DNAzyme for intracellular miRNA cleavage to suppress cell growth.

Analyst 2021 May 20;146(10):3391-3398. Epub 2021 Apr 20.

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, P. R. China.

Certain miRNAs, called oncomiRs, play a causal role in the onset and maintenance of cancer when overexpressed, thus, representing a potential new class of targets for therapeutic intervention. RNA-cleaving DNAzymes, mainly aimed at mRNA, have shown potential as therapeutic agents for various diseases. However, it's rarely reported that a DNAzyme was used for intracellular miRNA cleavage to suppress cell growth. Read More

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Biodegradable Nanosonosensitizers with the Multiple Modulation of Tumor Microenvironment for Enhanced Sonodynamic Therapy.

Int J Nanomedicine 2021 6;16:2633-2646. Epub 2021 Apr 6.

In-Patient Ultrasound Department, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China.

Background: The specific microenvironment of solid tumors, which is characterized by hypoxia, overexpression of glutathione (GSH), and high accumulation of anti-inflammatory tumor-associated macrophages (TAMs), limits the efficiency of sonodynamic therapy (SDT).

Method And Results: Herein, a multifunctional nanoplatform was engineered to modulate the tumor microenvironment for highly efficient SDT. In this system, sonosensitizers and catalase were encapsulated in disulfide-bridged mesoporous organosilicon nanoparticles with high loading, which protected the activity of catalase and ensure the stability of sonosensitizers and enzyme. Read More

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Highly sensitive and selective detection and intracellular imaging of glutathione using MnO nanosheets assisted enhanced fluorescence of gold nanoclusters.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 24;256:119743. Epub 2021 Mar 24.

School of Marine Science and Technology, Harbin Institute of Technology, Weihai 264209, People's Republic of China.

Glutathione (GSH) plays a critical role in biological defense system and is associated with numerous human pathologies. However, it still remains a challenge for fluorescent detection of GSH over cysteine (Cys) and homocysteine (Hcy) because of their similar structures. In this work, MnO nanosheets can efficiently quench the fluorescence of gold nanoclusters (Met-AuNCs) prepared by blending methionine and HAuCl owing to their superior absorption capability. Read More

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Gram Scale Synthesis of Dual-Responsive Dendritic Polyglycerol Sulfate as Drug Delivery System.

Polymers (Basel) 2021 Mar 23;13(6). Epub 2021 Mar 23.

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany.

Biocompatible polymers with the ability to load and release a cargo at the site of action in a smart response to stimuli have attracted great attention in the field of drug delivery and cancer therapy. In this work, we synthesize a dual-responsive dendritic polyglycerol sulfate (DR-dPGS) drug delivery system by copolymerization of glycidol, ε-caprolactone and an epoxide monomer bearing a disulfide bond (SSG), followed by sulfation of terminal hydroxyl groups of the copolymer. The effect of different catalysts, including Lewis acids and organic bases, on the molecular weight, monomer content and polymer structure was investigated. Read More

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Confining copper nanoclusters on exfoliation-free 2D boehmite nanosheets: Fabrication of ultra-sensitive sensing platform for α-glucosidase activity monitoring and natural anti-diabetes drug screening.

Biosens Bioelectron 2021 Jun 26;182:113198. Epub 2021 Mar 26.

College of Chemistry, Jilin University, Changchun, 130012, China; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, College of Life Sciences, Jilin University, Changchun, 130012, China. Electronic address:

α-Glucosidase (α-Glu) and its inhibitors play critical roles in diabetes therapy. Herein, a simple and ultra-sensitive fluorescence sensing approach was fabricated for α-Glu activity monitoring and natural inhibitor screening by electrostatically confining negatively charged glutathione-capped copper nanoclusters (GSH-CuNCs) on exfoliation-free and positively charged 2D boehmite (Boe) nanosheets. Boe significantly improved the fluorescence emission/stability of GSH-CuNCs and simultaneously led to an obvious blue-shift of the excitation peak of CuNCs from 365 nm to 330 nm. Read More

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Using Fluorescence On/Off to Trace Tandem Nanofiber Assembly/Disassembly in Living Cells.

Anal Chem 2021 04 31;93(14):5665-5669. Epub 2021 Mar 31.

Hefei National Laboratory of Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.

To track an intact biological process inside cells, continuous showing of the assembly/disassembly process is needed and fluorescence is advantageous in characterizing these processes. However, using fluorescence "on/off" to observe a sequential assembly/disassembly process in living cells has not been reported. Herein, we rationally designed a probe and employed its fluorescence "on/off" to trace tandem assembly/disassembly of nanofibers in living HeLa cells. Read More

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Hollow mesoporous MnO-carbon nanodot-based nanoplatform for GSH depletion enhanced chemodynamic therapy, chemotherapy, and normal/cancer cell differentiation.

Mikrochim Acta 2021 Mar 27;188(4):141. Epub 2021 Mar 27.

Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering, Hubei University, Wuhan, 430062, China.

A redox-responsive chemodynamic therapy (CDT)-based theranostic system composed of hollow mesoporous MnO (H-MnO), doxorubicin (DOX), and fluorescent (FL) carbon nanodots (CDs) is reported for the diagnosis and therapy of cancer. In general, since H-MnO can be degraded by intracellular glutathione (GSH) to form Mn with excellent Fenton-like activity to generate highly reactive ·OH, the normal antioxidant defense system can be injured via consumption of GSH. This in turn can potentiate the cytotoxicity of CDT and release DOX. Read More

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Maghemite nano-fertilization promotes fluoride tolerance in rice by restoring grain yield and modulating the ionome and physiome.

Ecotoxicol Environ Saf 2021 Jun 23;215:112055. Epub 2021 Mar 23.

Post Graduate Department of Biotechnology, St. Xavier's College (Autonomous), 30, Mother Teresa Sarani, Kolkata 700016, West Bengal, India. Electronic address:

The present manuscript elucidated the ameliorative potential of nano-maghemite (FeNPs) against the hazardous effects of fluoride toxicity in the sensitive rice cultivar, IR-64. Fluoride pollution triggered bioaccumulation in root, shoot and spikelets which inhibited reproduction, agronomic development and mineral uptake. Suppressed activity of enzymatic antioxidants and excessive cobalt translocation manifested severe ROS-induced oxidative injuries. Read More

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Optimized mesoporous silica nanoparticle-based drug delivery system with removable manganese oxide gatekeeper for controlled delivery of doxorubicin.

J Colloid Interface Sci 2021 Jun 19;592:227-236. Epub 2021 Feb 19.

Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

Rapid progress has been made for mesoporous silica nanoparticle (MSN) in recent years; however, efforts to fabricate MSN with adjustable size have been met with limited advancement in drug delivery, especially for the synthesis of MSN with adjustable size in the range of 150-300 nm. Herein we report the construction of a series of MSNs with adjustable specific surface area, size, and pore structure, depending on the different silicon monomers selected. The optimized MSN showed large specific surface area and appropriate size distribution for efficiently anchoring doxorubicin (DOX) through the imine linkage formed. Read More

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Amphiphilic Au Nanoclusters Modulated by Magnetic Gemini Surfactants as a Cysteine Chemosensor and an MRI Contrast Agent.

Langmuir 2021 03 3;37(10):3130-3138. Epub 2021 Mar 3.

Key Laboratory of Colloid and Interface Chemistry, Ministry of Education & State Key Laboratory of Crystal Materials & Key Laboratory of Special Aggregated Materials, Ministry of Education, Shandong University, Jinan 250100, P. R. China.

Cationic magnetic Gemini surfactants (mag-G-surfs), [CH(CH)N(CH)N(CH)CH]·2[XClBr] (14-2-14·2X, X = Ce, Gd, or Ho), efficiently induce the aggregation of glutathione-protected Au nanoclusters (NCs) (GSH-Au NCs). These magnetic luminescent aggregates not only possess aggregation-induced emission (AIE) behavior but also display aggregation-induced magnetic enhancement. In particular, 14-2-14·2Ce and 14-2-14·2Gd have a better effect on boosting the luminescence intensity, quantum yield (QY), and luminescence lifetime (τ). Read More

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