Photodiagnosis Photodyn Ther 2021 Jul 18:102446. Epub 2021 Jul 18.
Department of Biochemistry, Laboratory of Biological Oxidations, State University of Maringá, Maringá 87020-900, Paraná, Brazil; Department of Biochemistry, Laboratory of Plant Biochemistry, State University of Maringá, Maringá 87020-900, Paraná, Brazil. Electronic address:
Background: The present study aimed to characterize the intrinsic and photodynamic effects of azure B (AB) on mitochondrial bioenergetics, as well as the consequences of its intrinsic effects on hepatic energy metabolism.
Methods: Two experimental systems were utilized: (a) isolated rat liver mitochondria and (b) isolated perfused rat liver.
Results: AB interacted with mitochondria regardless of photostimulation, but its binding degree was reduced by mitochondrial energization. Read More