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Structural characteristics and improved in vitro hepatoprotective activities of Maillard reaction products of decapeptide IVTNWDDMEK and ribose.

J Food Sci 2021 Jul 27. Epub 2021 Jul 27.

School of Food Science and Technology, Dalian Polytechnic University, Dalian, P.R. China.

Here, a novel decapeptide IVTNWDDMEK with Maillard reactivity derived from scallop Chlamys farreri mantle was identified. The structural characteristics and in vitro hepatoprotective effects of IVTNWDDMEK conjugated with ribose were further investigated. The changes in decapeptide structures were determined by ultraviolet-visible (UV-vis), Fourier transform infrared (FTIR), and atomic force microscopy (AFM), and the modification sites induced by Maillard reaction of IVTNWDDMEK and ribose were monitored by high performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS). Read More

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{BiW8O30} Exerts Antitumor Effect by Triggering Pyroptosis and Upregulating Reactive Oxygen Species.

Angew Chem Int Ed Engl 2021 Jul 27. Epub 2021 Jul 27.

Harbin Medical University, Department of Biochemisty and Molecular Biology, 157 Baojian Road, 150081, Harbin, CHINA.

We successfully synthesized {BiW8}, a 10-nuclear heteroatom cluster modified {BiW8O30}. At 24 h post-incubation, the IC50 values of {BiW8} against HUVEC, MG63, RD, Hep3B, HepG2, and MCF7 cells were 895.8, 127. Read More

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Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway.

Am J Transl Res 2021 15;13(6):6031-6042. Epub 2021 Jun 15.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061, Shaanxi, People's Republic of China.

Acetaminophen (APAP) overdose has been considered responsible for the drug-induced liver injury for many years. Ferroptosis is defined as an iron-dependent form of cell death associated with lipid peroxide accumulation. Ferroptosis is involved in APAP-induced acute liver failure, and UTI is an effective drug treatment for acute liver failure. Read More

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AP39 ameliorates high fat diet-induced liver injury in young rats via alleviation of oxidative stress and mitochondrial impairment.

Exp Anim 2021 Jul 20. Epub 2021 Jul 20.

Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University.

Non-alcoholic fatty liver disease (NAFLD) is a complication of childhood obesity and an oxidative stress-related multisystem disease. A mitochondria-targeting hydrogen sulfide (H2S) donor AP39 has antioxidant property, while the mechanism underlying the function of AP39 on pediatric NAFLD remains undefined. Here, 3-week-old SD rats were received a high-fat diet (HFD) feeding and injected with AP39 (0. Read More

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Multidrug resistance-associated protein 2 is negatively regulated by oxidative stress in rat intestine via a posttranslational mechanism. Impact on its membrane barrier function.

Toxicology 2021 Jul 22:152873. Epub 2021 Jul 22.

Instituto de Fisiología Experimental (IFISE-CONICET)-Facultad de Ciencias Bioquímicas y Farmacéuticas-Universidad Nacional de Rosario, Rosario, Argentina. Electronic address:

Oxidative stress (OS) is a key factor in the development of gastrointestinal disorders, in which the intestinal barrier is altered. However, the Multidrug resistance-associated protein 2 (Mrp2) status, an essential component of the intestinal transcellular barrier exhibiting pharmaco-toxicological relevance by limiting the orally ingested toxicants and drugs absorption, has not been investigated. We here evaluated the short-term effect of OS on Mrp2 by treatment of isolated rat intestinal sacs with tert-butyl hydroperoxide (TBH) for 30 min. Read More

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Enhancement of salt tolerance in corn using Azospirillum brasilense: an approach on antioxidant systems.

J Plant Res 2021 Jul 24. Epub 2021 Jul 24.

Universidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Depto. de Biologia Aplicada à Agropecuária, Jaboticabal, SP, 14884-900, Brazil.

Salinity has become one of the major factors limiting agricultural production. In this regard, different cost-effective management strategies such as the use of plant growth-promoting bacteria (PGPB) as inoculants to alleviate salt-stress conditions and minimize plant productivity losses have been used in agricultural systems. The aim of this study was to characterize induced antioxidant responses in corn through inoculation with Azospirillum brasilense and examine the relationship between these responses and the acquired salt-stress tolerance. Read More

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Multibiomarker responses and bioaccumulation of fipronil in Prochilodus lineatus exposed to spiked sediments: Oxidative stress and antioxidant defenses.

Pestic Biochem Physiol 2021 Aug 21;177:104876. Epub 2021 May 21.

Grupo de Estudios de Contaminación Antrópica de Peces (GECAP), Departamento de Ciencias Básicas e INEDES, Universidad Nacional de Luján (UNLu-CONICET), Rutas 5 y 7, Luján 6700, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address:

Fipronil is a current use pesticide, widely used in many crops, commonly adsorbed to sediments of aquatic environments. The purpose of this study was to evaluate the biomarker responses and fipronil distribution pattern in different matrixes (fish, sediment and water) after juveniles P. lineatus exposure at two environmental concentrations (5. Read More

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Chemical Characterization, Antiproliferative and Antioxidant Activities of Polyunsaturated Fatty Acid-Rich Extracts from sp. S14.

Molecules 2021 Jul 6;26(14). Epub 2021 Jul 6.

Discipline of Microbiology, School of Life Sciences, College of Agriculture, Engineering and Science, Westville Campus, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.

Microalgae is a rich source of polyunsaturated fatty acid. This study was conducted to identify and isolate microalgal strain with the potentials for producing polyunsaturated fatty acids (PUFAs) and determine its cytotoxic effect on some cancer cells. The algal strain ( sp. Read More

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Protein posttranslational modification (PTM) by glycation: Role in lens aging and age-related cataractogenesis.

Exp Eye Res 2021 Jul 20;210:108705. Epub 2021 Jul 20.

Department of Pathology, United States; Biochemistry, Case Western Reserve University, Cleveland, OH, United States.

Crystallins, the most prevalent lens proteins, have no turnover throughout the entire human lifespan. These long-lived proteins are susceptible to post-synthetic modifications, including oxidation and glycation, which are believed to be some of the primary mechanisms for age-related cataractogenesis. Thanks to high glutathione (GSH) and ascorbic acid (ASA) levels as well as low oxygen content, the human lens is able to maintain its transparency for several decades. Read More

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Oxidative stress and endoplasmic reticulum stress contributed to hepatotoxicity of decabromodiphenyl ethane (DBDPE) in L-02 cells.

Chemosphere 2021 Jul 13;286(Pt 1):131550. Epub 2021 Jul 13.

School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China. Electronic address:

Decabromodiphenyl ethane (DBDPE) is one of the most commonly used novel brominated flame retardants (NBFRs), and its mass production and widespread application have caused health threats to the human being. Existing studies have shown that DBDPE has hepatotoxicity. And we have found that DBDPE could change cytochrome P450 3A (CYP3A) expression levels in rat livers, whereas the mechanism is unclear. Read More

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Dynamic evaluation of the protective effect of Dendrobium officinale polysaccharide on acute alcoholic liver injury mice in vitro and in vivo by NIR fluorescence imaging.

Anal Bioanal Chem 2021 Jul 22. Epub 2021 Jul 22.

Hubei Key Laboratory of Nature Medicinal Chemistry and Resource Evaluation, Tongji Medical College of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China.

Acute alcoholic liver injury (AALI) is a threat to human health. Dendrobium officinale polysaccharide (DOP) has the potential to protect the liver by enhancing the anti-oxidative system to maintain the relative balance of ROS (active oxygen species) and antioxidants in AALI mice. However, the dynamic improvement effect of DOP on AALI is still not clear and accurate medication guidance is not available, which limits the clinical application of DOP. Read More

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Hepatoprotective Effects of Different Extracts From Against CCl-Induced Acute Liver Injury in Mice.

Front Pharmacol 2021 5;12:664607. Epub 2021 Jul 5.

State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

is a traditional polyherbal formula used in Indian Ayurvedic and Chinese Tibetan medicine. A wide range of biological activities have been attributed to , but the impact of various extraction methods on efficacy has not been determined. The study aimed to evaluate extracts obtained by various methods for their hepatoprotective effects and molecular mechanisms in a mouse model of carbon tetrachloride (CCl)-induced liver injury. Read More

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The photodynamic and intrinsic effects of Azure B on mitochondrial bioenergetics and the consequences of its intrinsic effects on hepatic energy metabolism.

Photodiagnosis Photodyn Ther 2021 Jul 18:102446. Epub 2021 Jul 18.

Department of Biochemistry, Laboratory of Biological Oxidations, State University of Maringá, Maringá 87020-900, Paraná, Brazil; Department of Biochemistry, Laboratory of Plant Biochemistry, State University of Maringá, Maringá 87020-900, Paraná, Brazil. Electronic address:

Background: The present study aimed to characterize the intrinsic and photodynamic effects of azure B (AB) on mitochondrial bioenergetics, as well as the consequences of its intrinsic effects on hepatic energy metabolism.

Methods: Two experimental systems were utilized: (a) isolated rat liver mitochondria and (b) isolated perfused rat liver.

Results: AB interacted with mitochondria regardless of photostimulation, but its binding degree was reduced by mitochondrial energization. Read More

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The antagonistic effect of bisphenol A and nonylphenol on liver and kidney injury in rats.

Immunopharmacol Immunotoxicol 2021 Jul 20:1-9. Epub 2021 Jul 20.

Department of General surgery, General Hospital of Tianjin Medical University, Tianjin, China.

Objective: Bisphenol A (BPA) and nonylphenol (NP) are widely distributed endocrine-disrupting compounds. We aimed to estimate the combined toxicity of BPA and NP at a clinically safe dose (100 μg/kg) in rats.

Materials And Methods: Liver and kidney functions were evaluated by detecting the relevant indicators. Read More

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Effect of thioltransferase on oxidative stress induced by high glucose and advanced glycation end products in human lens epithelial cells.

Int J Ophthalmol 2021 18;14(7):965-972. Epub 2021 Jul 18.

Xi'an People's Hospital (Xi'an Fourth Hospital), Shaanxi Eye Hospital, Affiliated Guangren Hospital School of Medicine, Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.

Aim: To study the effect of thioltransferase (TTase) on oxidative stress in human lens epithelial cells (HLECs) induced by high glucose and advanced glycation end products (AGEs).

Methods: HLECs were treated with 35.5 mmol/L glucose or 1. Read More

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The combinations of sulfur and molybdenum fertilizations improved antioxidant capacity of grazing Guizhou semi-fine wool sheep under copper and cadmium stress.

Ecotoxicol Environ Saf 2021 Jul 17;222:112520. Epub 2021 Jul 17.

State Key Laboratory of Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural and Reclamation Sciences, Shihezi, China.

Mineral development and metal smelting are the main sources of heavy metal pollution, and copper (Cu) and cadmium (Cd) are the most serious mineral elements in heavy metal pollution. Food chain is the main channel for Cu and Cd to enter human body. Excessive accumulation of Cu and Cd can lead to a variety of diseases and threaten human health. Read More

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Protective effect of 5,6,7,8-trtrahydroxyflavone against acute hypobaric hypoxia induced-oxidative stress in mice.

Pak J Pharm Sci 2021 Mar;34(2):513-519

Department of Pharmacy, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, China.

Severe oxidative stress triggered by acute hypobaric hypoxia (AHH) is harmful for lots of organs in body, especial brain and heart. Flavonoids with antioxidant properties can protect organs from oxidative stress. Our previous study found that 5,6,7,8-trtrahydroxyflavone (5,6,7,8-THF), a flavones with four consecutive hydrogen group on ring A, showed excellent antioxidant properties in vitro. Read More

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Telmisartan alleviates alcohol-induced liver injury by activation of PPAR-γ/ Nrf-2 crosstalk in mice.

Int Immunopharmacol 2021 Jul 14;99:107963. Epub 2021 Jul 14.

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Mansoura University, Egypt. Electronic address:

Excessive consumption of alcohol may induce severe liver damage, in part via oxidative stress and inflammatory responses, which implicates these processes as potential therapeutic approaches. Prior literature has shown that Telmisartan (TEL) may provide protective effects, presumably mediated by its anti-oxidant and anti-inflammatory activities. The purpose of this study was to determine TEL's hepatoprotective effects and to identify its possible curative mechanisms in alcoholic liver disease. Read More

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Modulation of PTZ-induced convulsions in rats using topiramate alone or combined with low dose gamma irradiation: involving AKT/m-TOR pathway.

Toxicol Mech Methods 2021 Jul 26:1-9. Epub 2021 Jul 26.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

The current study evaluates the anticonvulsant effect low dose whole body gamma irradiation (LDR) alone or combined with topiramate against pentylenetetrazole (PTZ)-induced convulsions. Male Wister rats received either saline or PTZ (75 mg/kg i.p. Read More

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Cinnabar protects serum-nutrient starvation induced apoptosis by improving intracellular oxidative stress and inhibiting the expression of CHOP and PERK.

Biochem Biophys Rep 2021 Sep 29;27:101055. Epub 2021 Jun 29.

Joint International Research Laboratory of Ethnomedicine, and Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, 563000, China.

Cinnabar has been used for treatment of various disorders for thousands of years. The medical use of cinnabar, however, has been controversial because of its heavy metal mercury content. A large quantity of studies indicate that the toxicity of cinnabar is far below other inorganic or organic mercury-containing compounds. Read More

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September 2021

The Protective Effect of Aspirin Eugenol Ester on Oxidative Stress to PC12 Cells Stimulated with HO through Regulating PI3K/Akt Signal Pathway.

Oxid Med Cell Longev 2021 24;2021:5527475. Epub 2021 Jun 24.

Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China.

Aspirin eugenol ester (AEE) is a new pharmaceutical compound esterified by aspirin and eugenol, which has anti-inflammatory, antioxidant, and other pharmacological activities. This study is aimed at identifying the protective effect of AEE against HO-induced apoptosis in rat adrenal pheochromocytoma PC12 cells and the possible mechanisms. The results of cell viability assay showed that AEE could increase the viability of PC12 cells stimulated by HO, while AEE alone had no significant effect on the viability of PC12 cells. Read More

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Redox-sensitive irinotecan liposomes with active ultra-high loading and enhanced intracellular drug release.

Colloids Surf B Biointerfaces 2021 Jul 6;206:111967. Epub 2021 Jul 6.

School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, PR China. Electronic address:

In this report, a novel irinotecan (IR) encapsulated redox-responsive liposome was developed. The redox-responsive liposomes were prepared based on disulfide phosphatidylcholine (SS-PC), DSPC, DSPE-PEG2000 and cholesterol by ethanol injection method. IR was actively loaded by triethylammonium sucrose octasulfate (TEA8-SOS) gradient method to generate IR/SS-PC liposomes (IR/SS-LP). Read More

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The effects of ammonia-N stress on immune parameters, antioxidant capacity, digestive function, and intestinal microflora of Chinese mitten crab, Eriocheir sinensis, and the protective effect of dietary supplement of melatonin.

Comp Biochem Physiol C Toxicol Pharmacol 2021 Jul 9:109127. Epub 2021 Jul 9.

National Demonstration Center for Experimental Fisheries Science Education, Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture, Engineering Research Center of Aquaculture, Shanghai Ocean University, Shanghai, China. Electronic address:

Ammonia nitrogen pollution seriously affects the economic benefits of Chinese mitten crab (Eriocheir sinensis) farming. In this study, we first evaluated the protective effects of melatonin (MT) on immune parameters, antioxidant capacity, and digestive enzymes of E. sinensis under acute ammonia nitrogen stress. Read More

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Sodium glutamate as a booster: Inducing Rhodosporidium paludigenum to enhance the inhibition of Penicillium expansum on pears.

J Appl Microbiol 2021 Jul 12. Epub 2021 Jul 12.

National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture, Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, People's Republic of China.

Aims: This research sought to improve the ability of biocontrol yeast to suppress postharvest fungal disease and explore possible mechanisms of action..

Methods And Results: The addition of 2% sodium glutamate (SG), which is edible and recognized as safe, enhances the inhibitory effect of Rhodosporidium paludigenum Fell & Tallman on Penicillium expansum in vivo and in vitro. Read More

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Relevance of vitamin D in COVID-19 infection.

Gene Rep 2021 Sep 7;24:101270. Epub 2021 Jul 7.

Centre For Research and Development, University of Kashmir, Hazratbal, Srinagar, J&K 190006, India.

SARS-CoV-2 virus, the main culprit for COVID-19 disaster, has triggered a gust of curiosity both in the mechanism of action of this infection as well as potential risk factors for disease generation and regimentation. The prime focus of the present review, which is basically a narrative one, is in utilizing the current concepts of vitamin D as an agent with myriad functions, one of them being immunocompetence and a promising weapon for both innate and adaptive immunity against COVID-19 infection. Some of the manifestations of SARS-CoV-2 virus such as Acute Respiratory Distress Syndrome (ARDS) overlap with the pathophysiological effects that are overcome due to already established role of vitamin D e. Read More

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September 2021

Polysaccharide from Potentilla anserina L ameliorate pulmonary edema induced by hypobaric hypoxia in rats.

Biomed Pharmacother 2021 Jul 7;139:111669. Epub 2021 May 7.

College of Life Science, Northwest Normal University, Lanzhou 730070, China; Institute of New Rural Development, Northwest Normal University, Lanzhou 730070, China; Bioactive Products Engineering Research Center for Gansu Distinctive Plants, Lanzhou 730070, China. Electronic address:

High-altitude pulmonary edema (HAPE) is a life-threatening disease occurs in hypobaric hypoxia (HH) environment, which could be treated by Dexamethasone, but might cause side-effects. Potentilla anserina L polysaccharide (PAP) holds promising physiological and pharmacological properties which could be beneficial for HAPE treatment. In our study, the anti-hypoxia effect of PAP was firstly investigated through anti-normobaric hypoxia test and anti-acute hypoxia test. Read More

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The protective role of etoricoxib against diethylnitrosamine/2-acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: The impact of NF-κB/COX-2/PGE2 signaling.

Curr Mol Pharmacol 2021 Jul 7. Epub 2021 Jul 7.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.

Background: Liver cancer ranks as the 7th and 5th leading cause of cancer morbidity worldwide in men and women, respectively. Hepatocellular carcinoma (HCC) is the most common type of liver cancer and is associated with an increasing global burden of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).

Objective: The present study aimed to investigate the possible chemopreventive effect of etoricoxib on diethylnitrosamine (DENA) and 2-acetylaminofluorene (2AAF)-induced HCC in male Wistar rats. Read More

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Alpha-Tocopherol Protects Human Dermal Fibroblasts by Modulating Nitric Oxide Release, Mitochondrial Function, Redox Status, and Inflammation.

Skin Pharmacol Physiol 2021 Jul 8:1-12. Epub 2021 Jul 8.

Department of Health Science, Dermatologic Unit, University of Eastern Piedmont, Novara, Italy.

Background: The altered balance between oxidants/antioxidants and inflammation, changes in nitric oxide (NO) release, and mitochondrial function have a role in skin aging through fibroblast modulation. Tocopherol is promising in counteracting the abovementioned events, but the effective mechanism of action needs to be clarified.

Objective: The aim of this study was to examine the effects of α-tocopherol on cell viability/proliferation, NO release, mitochondrial function, oxidants/antioxidants, and inflammation in human dermal fibroblasts (HDF) subjected to oxidative stress. Read More

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Effects of light regime on the hatching performance, body development and serum biochemical indexes in Beijing You Chicken.

Poult Sci 2021 Aug 21;100(8):101270. Epub 2021 May 21.

Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, #9 Shu-Guang Garden Mid-Road, Haidian District, Beijing 100097, P. R. China.

The paper aimed to study the effects of light regime during the incubation on hatching performance, body development and serum biochemical indexes in Beijing You Chicken (BYC). A total of 1,408 BYC eggs were randomly allocated into 4 groups: 24 h dark as the control (Inc); 3 light regimes were 8 h light and 16 h dark group (Inc); 12 h light and 12 h dark group (Inc); 16 h light and 8 h dark group (Inc), respectively. There were 352 eggs in each group, 4 replicates each group and 1 tray each replicate, 88 eggs each tray. Read More

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[N-acetylcysteine inhibits the proliferation of hydrogen peroxide treated fibroblast-like synoviocytes in rats with adjuvant arthritis (AA) via blocking Nrf2/Keap1 pathway].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Aug;37(8):687-692

Experimental Center of Morphology, Anhui Medical University, Hefei 230032, China. *Corresponding author, E-mail:

Objective To investigate the effect of N-acetylcysteine (NAC) on the proliferation of fibroblast-like synoviocytes (FLS) treated with low concentration of hydrogen peroxide (HO) in rats with adjuvant arthritis (AA) and its mechanism. Methods Twenty SD rats were divided into a normal group and a model group (10 rats in each group). The model group was established by subcutaneous injection of Freund's complete adjuvant into the toe of rats, and the rats were sacrificed 28 days later. Read More

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