42,823 results match your criteria growth restriction

A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease.

Cell Metab 2021 Apr 9. Epub 2021 Apr 9.

Department of Internal Medicine and Division of Nephrology, UT Southwestern Medical Center Dallas, TX 75390, USA. Electronic address:

Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disorder marked by numerous progressively enlarging kidney cysts. Mettl3, a methyltransferase that catalyzes the abundant N-methyladenosine (mA) RNA modification, is implicated in development, but its role in most diseases is unknown. Here, we show that Mettl3 and mA levels are increased in mouse and human ADPKD samples and that kidney-specific transgenic Mettl3 expression produces tubular cysts. Read More

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Quantifying The Relationship Between Lockdowns, Mobility, and Effective Reproduction Number (Rt) During The COVID-19 Pandemic in The Greater Toronto Area.

Res Sq 2021 Apr 8. Epub 2021 Apr 8.

: The effectiveness of lockdowns in mitigating the spread of COVID-19 has been the subject of intense debate. Data on the relationship between public health restrictions, mobility, and pandemic growth has so far been conflicting. : We assessed the relationship between public health restriction tiers, mobility, and COVID-19 spread in five contiguous public health units (PHUs) in the Greater Toronto Area (GTA) in Ontario, Canada. Read More

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Effects of ethanol and nicotine co-administration on follicular atresia and placental histo-morphology in the first-generation mice pups during intrauterine development and lactation periods.

Toxicol Rep 2021 2;8:793-803. Epub 2021 Apr 2.

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

This study is evaluating the effects of ethanol and nicotine exposure during pregnancy and lactation on placenta histology and follicular atresia in the first-generation (f1) mice pups. The experimental groups were 5 groups of NMRI pregnant mice, including: control, vehicle (received normal saline) ethanol (3 g/kg/day, 20 % v/v intraperitoneally), nicotine (1 mg/kg/day, subcutaneously), and ethanol plus nicotine which received both. Pregnant animals in each group were then divided into two groups, one group for examining the placenta that was treated for 18 days and the other group for the ovary of one-day-old (PND1) and fifty-six-day-old (PND56) female offspring who were treated for 42 days (during intrauterine development and lactation). Read More

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Interferon-Independent Restriction of RNA Virus Entry and Replication by a Class of Damage-Associated Molecular Patterns.

mBio 2021 Apr 13;12(2). Epub 2021 Apr 13.

Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, Massachusetts, USA

Mammalian cells detect microbial molecules known as pathogen-associated molecular patterns (PAMPs) as indicators of potential infection. Upon PAMP detection, diverse defensive responses are induced by the host, including those that promote inflammation and cell-intrinsic antimicrobial activities. Host-encoded molecules released from dying or damaged cells, known as damage-associated molecular patterns (DAMPs), also induce defensive responses. Read More

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The risks of recurrent small for gestational age infants at term is dependent on the number of previous affected births.

Am J Obstet Gynecol 2021 Apr 10. Epub 2021 Apr 10.

Mater Research Institute-University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, Queensland 4101, Australia,; Mater Mothers' Hospital, Raymond Terrace, South Brisbane, Queensland 4101, Australia,; Faculty of Medicine, The University of Queensland, Australia,. Electronic address:

Background: Small-for-gestational age (SGA) infants are at significantly increased risk of perinatal complications, but the risk of recurrent SGA is not well known, particularly as there are many demographic and obstetric factors that interact and modify this risk. We investigated the relationship between previous SGA births and the risk of recurrence at term in a large Australian cohort.

Objective(s): We aimed to identify key demographic and obstetric variables that influence the risk of recurrence of an SGA infant at term. Read More

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Therapeutic plasma exchange and dextran-sulfate plasma adsorption as extracorporeal treatments of extremely preterm preeclampsia with fetal growth restriction.

J Clin Apher 2021 Apr 13. Epub 2021 Apr 13.

Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Aim: To evaluate effectiveness and safety of therapeutic plasma exchange (TPE) and dextran-sulfate plasma adsorption (DSA) for extracorporeal removal of soluble Fms-like tyrosine kinase-1 (sFlt-1) as part of expectant management of preeclampsia at extremely preterm gestational age.

Methods: Retrospective case series of six patients with preeclampsia at <28 weeks of gestation, treated with DSA or TPE. Laboratory results, clinical characteristics and neonatal outcomes were collected from charts and National Perinatal Information System. Read More

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Five-vessel umbilical cord and fetal outcome: an obstetric overview.

J Matern Fetal Neonatal Med 2021 Apr 13:1-4. Epub 2021 Apr 13.

Department of Obstetrics and Gynaecology, ASTT LECCO, Ospedale Leopoldo Mandic, Lecco, Italy.

Purpose: The birth of a child with an increased number of blood vessels in the umbilical cord (UC) is a rare event and has been previously reported to be associated with a higher incidence of congenital anomalies.

Methods: A case of a healthy female infant with an intra-uterine growth restriction (IUGR), born from a bicornuate uterus at 37 weeks of gestation and weighing 2500 g with a diagnosis of five-vessel UC made post-natally, on gross examination of the UC and confirmed by histopathological examination is documented. In particular, sections from the UC showed four umbilical arteries (UA) and one umbilical vein (UV). Read More

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The effects of hypothyroidism and hyperthyroidism on placental Hofbauer cells of pregnant rats.

Biotech Histochem 2021 Apr 13:1-10. Epub 2021 Apr 13.

Department of Histology and Embryology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.

We investigated the effects of maternal thyroid disorders on Hofbauer cells of both the placenta and the fetus in pregnant rats. We divided 21 rats into three groups: control group, induced hypothyroidism (hypo) group and induced hyperthyroidism (hyper) group. Hypothyroidism was induced using propylthiouracil and hyperthyroidism was induced using L-thyroxine. Read More

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Risk factors for pregnancy morbidity in women with antiphospholipid syndrome.

J Reprod Immunol 2021 Mar 29;145:103315. Epub 2021 Mar 29.

Obstetrics and Gynecology Department, Peking University People's Hospital, Beijing, China. Electronic address:

Antiphospholipid syndrome (APS) increases the risk of obstetric complications, but risk factors for pregnancy morbidity in women with APS remain incompletely characterized. This retrospective study included pregnant women with APS and a control group without APS admitted to Peking University People's Hospital between January 2013 and September 2019. Clinical data were extracted from medical records. Read More

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Morphea: progress to date and the road ahead.

Ann Transl Med 2021 Mar;9(5):437

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Morphea is a rare autoimmune condition causing inflammation and sclerosis of the skin and underlying soft tissue. It is characterized by periods of activity (inflammation admixed with fibrosis), ultimately resulting in permanent damage (pigment change and tissue loss). Damage resulting from unchecked activity can lead to devastating, permanent cosmetic and functional sequelae including hair loss; cutaneous, soft tissue and bony atrophy; joint contractures; and growth restriction of the affected body site in children. Read More

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Two DNA Methyltransferases for Site-Specific 6mA and 5mC DNA Modification in .

Front Plant Sci 2021 24;12:621466. Epub 2021 Mar 24.

Department of Plant Science and Technology, Chung-Ang University, Anseong, South Korea.

() is a gram-negative phytopathogenic bacterium that causes bacterial spot disease in tomato/pepper leading to economic losses in plantations. DNA methyltransferases (MTases) are critical for the survival of prokaryotes; however, their functions in phytopathogenic bacteria remain unclear. In this study, we characterized the functions of two putative DNA MTases, XvDMT1 and XvDMT2, in by generating XvDMT1- and XvDMT2-overexpressing strains, (XvDMT1) and (XvDMT2), respectively. Read More

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The Relationship Between Dental Agenesis and Maxillary Hypoplasia in Patients With Cleft Lip and Palate.

J Craniofac Surg 2021 Apr 5. Epub 2021 Apr 5.

Northwestern University, Feinberg School of Medicine Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL Case Western Reserve University, School of Dental Medicine, Cleveland, OH.

Abstract: Both dental agenesis and maxillary growth restriction are well-recognized sequelae in patients with unilateral cleft lip and palate, but their etiology remains controversial. The aim of this study was to evaluate the relationship between hypodontia and maxillary volume. A retrospective review of patients age 6 to 9 with Veau III (unilateral) cleft palate who underwent Cone Beam Computer Tomography in preparation for alveolar bone grafting at 2 major Children's Hospitals between 2010 and 2016 was conducted and serial panoramic radiographs were reviewed. Read More

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Late Pregnancy Ultrasound to Screen for and Manage Potential Birth Complications in Nulliparous Women: A Cost-Effectiveness and Value of Information Analysis.

Value Health 2021 Apr 21;24(4):513-521. Epub 2021 Jan 21.

Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

Background: Fetal growth restriction is a major risk factor for stillbirth. A routine late-pregnancy ultrasound scan could help detect this, allowing intervention to reduce the risk of stillbirth. Such a scan could also detect fetal presentation and predict macrosomia. Read More

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PlGF (Placental Growth Factor) Testing in Clinical Practice: Evidence From a Canadian Tertiary Maternity Referral Center.

Hypertension 2021 Apr 12:HYPERTENSIONAHA12117047. Epub 2021 Apr 12.

Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine, Sinai Health System, Toronto, Canada. (K.M., J.W.S., M.C.A., S.R.H., R.C.W., S.C., J.C.K.).

There is little evidence evaluating angiogenic growth factor testing in real-world obstetric settings. This investigation evaluated maternal and perinatal pregnancy outcomes associated with maternal PlGF (placental growth factor) levels in real-world clinical care of high-risk pregnancies. From March 2017 to December 2019, 979 pregnant women with suspected risk of placental dysfunction, hypertensive disorders of pregnancy, or fetal growth restriction completed PlGF testing between 20+0 and 35+6 weeks of gestation. Read More

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Role of dietary modifications in the management of type 2 diabetic complications.

Pharmacol Res 2021 Apr 7:105602. Epub 2021 Apr 7.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, India. Electronic address:

Diabetes is a chronic metabolic disorder with a high rate of morbidity and mortality. Insufficient insulin secretion and insulin action are two major causes for the development of diabetes, which is characterized by a persistent increase in blood glucose level. Diet and sedentary life style play pivotal role in development of vascular complications in type 2 diabetes. Read More

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Construction of a full-length antibody phage display vector.

J Immunol Methods 2021 Apr 7:113052. Epub 2021 Apr 7.

Key Laboratory for Biological Medicine in Shandong Universities, Weifang Key Laboratory for Antibodies Medicine, School of Life Science and Technology, Weifang Medical University, Weifang 261053, China; World Research Hub Initiative (WRHI), Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan. Electronic address:

Antibody phage display technology plays an important role in the development of monoclonal antibodies, humanization, and affinity evolution of antibodies. Thus far, antibody phage display mainly focuses on the display of antibody variable region or antigen-binding fragments. In this study, we constructed a new phage display system that can display full-length IgG antibodies on M13 phage. Read More

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Association of various myositis-specific autoantibodies with dermatomyositis and polymyositis triggered by pregnancy.

Rheumatol Int 2021 Apr 10. Epub 2021 Apr 10.

Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

Although pregnancy is an important risk factor for autoimmune rheumatic diseases, little is known regarding the association between pregnancy and dermatomyositis (DM) or polymyositis (PM). Herein, we present two patients with DM that developed during the perinatal period. The first patient was positive for anti-aminoacyl synthetase (ARS) antibody and developed DM in the 14th week of pregnancy. Read More

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Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics.

Sci Rep 2021 Apr 9;11(1):7824. Epub 2021 Apr 9.

Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece.

Intrauterine growth restriction (IUGR) is a fetal adverse condition, ascribed by limited oxygen and nutrient supply from the mother to the fetus. Management of IUGR is an ongoing challenge because of its connection with increased fetal mortality, preterm delivery and postnatal pathologies. Untargeted nuclear magnetic resonance (H NMR) metabolomics was applied in 84 umbilical cord blood and maternal blood samples obtained from 48 IUGR and 36 appropriate for gestational age (AGA) deliveries. Read More

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The Association of Zygomaticomaxillary Complex Fractures with Naso-Orbitoethmoid Fractures in Pediatric Populations.

Plast Reconstr Surg 2021 Apr 7. Epub 2021 Apr 7.

From the Department of Plastic and Reconstructive Surgery, Johns Hopkins Hospital; the Department of Biostatistics, Boston University School of Public Health; and the Division of Plastic and Reconstructive Surgery, Department of Surgery, Rush Medical College.

Background: Naso-orbitoethmoid fractures associated with ipsilateral zygomaticomaxillary complex fractures are more challenging injuries than zygomaticomaxillary complex fractures alone. However, there is a paucity of information on this complex fracture pattern in the pediatric population. This study investigated the cause, treatment, and outcomes of combined zygomaticomaxillary complex and naso-orbitoethmoid fractures versus isolated zygomaticomaxillary complex fractures in pediatric patients. Read More

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[Impact of confined placental mosaicism on non-invasive prenatal testing and pregnancy outcomes].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Apr;38(4):335-338

Fujian Provincial Key Laboratory for Prenatal Diagnosis and Birth Defect, Fujian Provincial Maternity and Child Health Cave Hospital, the Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China.

Objective: To assess the impact of confined placental mosaicism (CPM) on non-invasive prenatal testing (NIPT) and pregnancy outcomes.

Methods: Copy number variation sequencing (CNV-seq) and single nucleotide polymorphism array (SNP-array) were carried out on placental specimen sampled from eight pregnancies with confirmed false-positive NIPT results. The impact of CPM on NIPT and pregnancy outcomes were analyzed based on the laboratory tests and clinical characteristics. Read More

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Maternal nutrient restriction in late pregnancy programs postnatal metabolism and pituitary development in beef heifers.

PLoS One 2021 8;16(4):e0249924. Epub 2021 Apr 8.

Department of Animal Science, Texas A&M University, College Station, Texas, United States of America.

Maternal undernutrition during pregnancy followed by ad libitum access to nutrients during postnatal life induces postnatal metabolic disruptions in multiple species. Therefore, an experiment was conducted to evaluate postnatal growth, metabolism, and development of beef heifers exposed to late gestation maternal nutrient restriction. Pregnancies were generated via transfer of in vitro embryos produced using X-bearing sperm from a single Angus sire. Read More

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Differential expression of mTOR related molecules in the placenta from gestational diabetes mellitus (GDM), intrauterine growth restriction (IUGR) and preeclampsia patients.

Reprod Biol 2021 Apr 4;21(2):100503. Epub 2021 Apr 4.

Lung and Placenta Research Laboratory, Brigham Young University, Department of Physiology and Developmental Biology, Provo, UT, USA. Electronic address:

The mechanistic target of rapamycin (mTOR) pathway is involved in the function and growth of the placenta during pregnancy. The mTOR pathway responds to nutrient availability and growth factors that regulate protein expression and cell growth. Disrupted mTOR signaling is associated with the development of several obstetric complications. Read More

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Glucose restriction drives spatial reorganization of mevalonate metabolism.

Elife 2021 Apr 7;10. Epub 2021 Apr 7.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, United States.

Eukaryotes compartmentalize metabolic pathways into sub-cellular domains, but the role of inter-organelle contacts in organizing metabolic reactions remains poorly understood. Here, we show that in response to acute glucose restriction (AGR) yeast undergo metabolic remodeling of their mevalonate pathway that is spatially coordinated at nucleus-vacuole junctions (NVJs). The NVJ serves as a metabolic platform by selectively retaining HMG-CoA Reductases (HMGCRs), driving mevalonate pathway flux in an Upc2-dependent manner. Read More

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Fetal Growth Diagnosis and Management among Perinatal Medical Professionals: A Survey of Practice and Literature Review.

Fetal Diagn Ther 2021 Apr 6:1-11. Epub 2021 Apr 6.

Department of Reproductive Health, Centre of Postgraduate Medical Education, Warsaw, Poland.

Introduction: This paper aimed to assess the knowledge of healthcare professionals (obstetric and gynecology residents, specialists, and midwives) in the field of perinatal medicine regarding fetal growth diagnosis and management.

Methods: A questionnaire was created consisting of a set of questions regarding demographic data, methods of growth assessment, and management. It was a handout survey. Read More

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First-trimester utero-placental (vascular) development and embryonic and fetal growth: The Rotterdam periconception cohort.

Placenta 2021 Mar 28;108:81-90. Epub 2021 Mar 28.

Department of Obstetrics and Gynecology, Erasmus MC, University Medical Centre Rotterdam, PO Box 2040, 3000, CA, Rotterdam, the Netherlands. Electronic address:

Introduction: Impaired placental development is a major cause of fetal growth restriction (FGR) and early detection will therefore improve antenatal care and birth outcomes. Here we aim to investigate serial first-trimester ultrasound markers of utero-placental (vascular) development in association with embryonic and fetal growth.

Methods: In a prospective cohort, we periconceptionally included 214 pregnant women. Read More

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Large-Area Assembly of Metal-Organic Layered Ultrathin Films at the Liquid/Liquid Interface.

Langmuir 2021 Apr 6. Epub 2021 Apr 6.

Key Laboratory for Colloid and Interface Chemistry of Education Ministry, Shandong University, Jinan 250100, P. R. China.

Two-dimensional functional metal-organic frameworks and coordination polymers have attracted much attention and have been successfully prepared in solutions and at interfaces through the coordination of ligands to metal ions. However, the preparation of large-area ultrathin ordered films is still a challenge. Here, a modified liquid/liquid interfacial epitaxial growth method has been developed. Read More

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Comparing the cerebro-placental to umbilico-cerebral Doppler ratios for the prediction of adverse neonatal outcomes in pregnancies complicated by fetal growth restriction.

J Matern Fetal Neonatal Med 2021 Apr 5:1-5. Epub 2021 Apr 5.

Department of Obstetrics and Gynecology, University of South Florida Morsani College of Medicine, Tampa, FL, USA.

Objective: The cerebroplacental ratio (CPR) has shown utility as a surrogate marker for fetal growth restriction and can be used to stratify the risk for adverse perinatal outcomes in affected pregnancies. However, recent studies suggest that its inverse, the umbilico-cerebral ratio (UCR), may be a better predictor of such outcomes. The aim of this study was to compare the prognostic accuracy of CPR to that of UCR Doppler in predicting short-term adverse perinatal outcomes in growth-restricted fetuses. Read More

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Fetal umbilical artery Doppler as a tool for universal third trimester screening: A systematic review and meta-analysis of diagnostic test accuracy.

Placenta 2021 Mar 22;108:47-54. Epub 2021 Mar 22.

Department of Obstetrics and Gynaecology, University of Cambridge; NIHR Cambridge Comprehensive Biomedical Research Centre, CB2 2SW, United Kingdom. Electronic address:

The objective of this study was to investigate the accuracy of universal third trimester umbilical artery (UA) Doppler to predict adverse pregnancy outcome at term. We searched Medline, EMBASE, the Cochrane library and ClinicalTrials.gov from inception to October 2020 and we also analyzed previously unpublished data from a prospective cohort study of nulliparous women, the Pregnancy Outcome Prediction (POP) study. Read More

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Pregnancy outcomes among women with class III obesity with normal early glucola.

J Matern Fetal Neonatal Med 2021 Apr 4:1-6. Epub 2021 Apr 4.

Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.

Background: Because obese women are at increased risk for insulin resistance and development gestational diabetes (GDM), the American College of Obstetricians and Gynecologists (ACOG) recommends early GDM screening in this population. For obese women with a normal early 1-hour 50 g oral glucose challenge test (eGCT), the risk of developing GDM later in the pregnancy is unknown. Thus, we aimed to assess the risk of developing gestational diabetes based on the value of a normal eGCT. Read More

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Wiad Lek 2021 ;74(2):213-219


Objective: The aim: To elucidate the possible involvement of M1 and M2 macrophages in the placentas of women, whose pregnancies were complicated by fetal growth restriction (FGR) and resulted in term births after 37 weeks of gestation and preterm births up to 37 weeks of gestation.

Patients And Methods: Materials and methods: CD68+ and CD163+ macrophages were studied by immunohistochemical method, placental morphology in the placentas of 16 women whose pregnancies were complicated by FGR and resulted in term births at a gestational age after 37 weeks (1-st group, n = 7) or resulted in preterm births at a gestational age up to 37 weeks (2-nd group, n = 9). The control group consisted of 10 placentas of women with physiological pregnancies and births. Read More

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