273,630 results match your criteria growth rate


Growth and challenges of China's nursing workforce from 1998 to 2018: A retrospective data analysis.

Int J Nurs Stud 2021 Sep 5;124:104084. Epub 2021 Sep 5.

School of Nursing, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100190, China. Electronic address:

Background: Nurses play a vitally important role in promoting equitable and essential care. China undertook bold reforms in its education and healthcare systems since 1990s. The effect of these reforms on the nursing workforce has not been assessed systematically. Read More

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September 2021

Platelet lysate functionalized GelMA microspheres for improving angiogenesis in endodontic regeneration.

Acta Biomater 2021 Sep 19. Epub 2021 Sep 19.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Chengdu Shiliankangjian Biotechnology Co., Ltd.. Electronic address:

Rapid angiogenesis is one of the challenges in endodontic regeneration. Recently, tailored polymeric microsphere system that loaded pro-angiogenic growth factors (GFs) is promising in facilitating vascularization in dental pulp regeneration. In addition, the synergistic effect of multiple GFs is considered more beneficial, but combination usage of them is rather complex and costly. Read More

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September 2021

Associations between DNA methylation and telomere length during early life: insight from wild zebra finches (Taeniopygia guttata).

Mol Ecol 2021 Sep 22. Epub 2021 Sep 22.

Department of Biological Sciences, Macquarie University, Sydney, New South Wales, Australia.

Telomere length and DNA methylation (DNAm) are two promising biomarkers of biological age. Environmental factors and life history traits are known to affect variation in both these biomarkers, especially during early life, yet surprisingly little is known about their reciprocal association, especially in natural populations. Here, we explore how variation in DNAm, growth rate, and early-life conditions are associated with telomere length changes during development. Read More

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September 2021

Growth After Adenotonsillectomy for Obstructive Sleep Apnea: Revisited.

Laryngoscope 2021 Sep 22. Epub 2021 Sep 22.

Department of Otolaryngology, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado, U.S.A.

Objectives/hypothesis: To reanalyze the growth trajectory and assess longitudinal changes of children undergoing adenotonsillectomy (AT) versus watchful waiting (WW) enrolled in the Childhood Adenotonsillectomy Trial (CHAT) study and to determine if an AT increases the risk of obesity in children.

Study Design: Reanalysis of prospective cohort investigation.

Methods: The study analyzed publicly available data from CHAT, including 3 months visit data not previously included in a prior publication. Read More

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September 2021

Phase II Prospective Study of Trastuzumab in Combination with S-1 and Oxaliplatin (SOX100) Therapy for HER2-Positive Advanced Gastric Cancer.

J Gastrointest Cancer 2021 Sep 22. Epub 2021 Sep 22.

Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.

Purpose: The standard first-line treatment for human epidermal growth factor receptor type 2 (HER2)-positive advanced gastric cancer (AGC) is trastuzumab in combination with cisplatin and fluoropyrimidines. We evaluated the efficacy and safety of S-1 and oxaliplatin (100 mg/m) (SOX100) combined with trastuzumab, a monoclonal antibody against HER2 for HER2-positive AGC.

Methods: In this single-arm, multicenter phase II study, patients with HER2-positive AGC received S-1 (80-120 mg per day) orally on days 1-14, oxaliplatin (100 mg/m) intravenously on day 1, and trastuzumab (8 mg/kg on day 1 of the first cycle, followed by 6 mg/kg every 3 weeks) intravenously. Read More

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September 2021

Research on the improvement of total factor productivity in China's power industry: a perspective of technological heterogeneity.

Environ Sci Pollut Res Int 2021 Sep 22. Epub 2021 Sep 22.

Department of Economics and Management, North China Electric Power University, Baoding, China.

An improvement in total factor productivity of the power industry (TFPPI) is crucial for achieving China's green transformation and high-quality development. Considering the technological heterogeneity of different regions, the Meta-frontier Global Malmquist-Luenberger(MGML) index was constructed to measure TFPPI in China's 30 provinces from 2003 to 2017, and then we investigated the dynamic evolution and regional differences of TFPPI. On this basis, the two-step system GMM method was used to explore the influencing factors of TFPPI. Read More

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September 2021

Competitive coexistence of seasonal breeders.

J Math Biol 2021 Sep 22;83(4):38. Epub 2021 Sep 22.

Department of Mathematics and Statistics, and Department of Biology, University of Ottawa, Ottawa, ON, K1N6N5, Canada.

Many species are annual breeders who, between reproductive events, consume resources and may die. Their resource often reproduces continuously or has short, overlapping generations. An accurate model for such life cycles needs to represent both, the discrete- and the continuous-time processes in the community. Read More

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September 2021

Oncogenic Ras expression increases cellular formate production.

Amino Acids 2021 Sep 22. Epub 2021 Sep 22.

Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL, Canada.

One-carbon units, critical intermediates for cell growth, may be produced by a variety of means, one of which is via the production of formate. Excessive formate accumulation, known as formate overflow and a characteristic of oxidative cancer, has been observed in cancer cells. However, the basis for this high rate of formate production is unknown. Read More

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September 2021

Assessing the Prognostic Significance of Tumor-Infiltrating Lymphocytes in Patients With Melanoma Using Pathologic Features Identified by Natural Language Processing.

JAMA Netw Open 2021 Sep 1;4(9):e2126337. Epub 2021 Sep 1.

Division of General Internal Medicine and Primary Care, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Importance: Although tumor-infiltrating lymphocytes (TILs) are an important histopathologic characteristic reflecting host immune response in patients with melanoma, their prognostic value remains controversial. Because manual review of medical records is labor intensive, a survival analysis using a large patient cohort with comprehensive clinical and histopathologic characteristics is lacking.

Objective: To assess the prognostic significance of TILs among patients with cutaneous melanoma using a large cohort established through natural language processing (NLP) algorithms. Read More

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September 2021

Time trends of physical inactivity in Brazilian adults from 2009 to 2017.

Rev Assoc Med Bras (1992) 2021 Jun;67(5):681-689

Universidade Federal do Paraná, Department of Physical Education - Curitiba (PR), Brazil.

Objective: The aim was to evaluate the changes in the prevalence of physical inactivity in the Brazilian adults from 2009-2017.

Methods: This study used a time-series research design based on the cross-sectional data of 462,498 Brazilian adults from 2009-2017. Participants were classified as physically inactive if they indicated not participating in physical activity in the last three months. Read More

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Evaluation of microbial contamination in multi-dose fluorescein eyedrops in a reference eye center.

Arq Bras Oftalmol 2021 20;84(5):449-453. Epub 2021 Sep 20.

Department of Ophthalmology, Fundação Altino Ventura, Recife, PE, Brazil.

Purpose: To analyze the presence of microorganisms in fluorescein eyedrops used in a reference eye center in Recife-PE.

Methods: This real-life and masked study evaluated fluorescein eyedrops used at the Altino Ventura Foundation in May 2019. Cultures were performed according to exposure times; I) three eyedrop bottles were analyzed after one day of use, II) three eyedrop bottles after 4 d of use, III) three eyedrop bottles after 8 d of use, and IV) three unopened bottles used as control. Read More

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September 2021

Topically applied liposome-in-hydrogels for systematically targeted tumor photothermal therapy.

Drug Deliv 2021 Dec;28(1):1923-1931

School of Pharmacy, Nantong University, Nantong, China.

Transdermal drug delivery for local or systemic therapy provides a potential anticancer modality with a high patient compliance. However, the drug delivery efficiency across the skin is highly challenging due to the physiological barriers, which limit the desired therapeutic effects. In this study, we prepared liposome-in-hydrogels containing a tumor targeting photosensitizer IR780 (IR780/lipo/gels) for tumor photothermal therapy (PTT). Read More

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December 2021

RNAi silencing of the Arabidopsis thaliana ULCS1 gene results in pleiotropic phenotypes during plant growth and development.

Int J Dev Biol 2021 Aug 9. Epub 2021 Aug 9.

Laboratory of Virology, Directorate of Phytopathology, Benaki Phytopathological Institute, Athens, Greece.

WD40-repeat-containing proteins (WDRs) are highly abundant in all eukaryotes. Several of them have been implicated as subunits of multi-protein CRL E3 ligase complexes that regulate ubiquitination mediated protein degradation and thus various cellular and developmental processes. Impairment of the WDR protein ULCS1 from Arabidopsis causes pleiotropic phenotypes during plant development, including reduced lignification, anther indehiscence, and sterility. Read More

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Investigation of crystallization kinetics and its relationship with molecular dynamics for chiral fluorinated glassforming smectogen 3F5HPhH6.

Phys Chem Chem Phys 2021 Sep 15;23(35):19795-19810. Epub 2021 Sep 15.

Institute of Chemistry, Military University of Technology, Kaliskiego 2, PL-00908 Warsaw, Poland.

The phase transitions, crystallization kinetics and molecular dynamics of ()-4'-(1-methylheptylcarbonyl)biphenyl-4-yl 4-[5-(2,2,3,3,4,4,4-heptafluorobutoxy)pent-1-oxy] benzoate (3F5HPhH6) are investigated by differential scanning calorimetry, polarizing optical microscopy and broadband dielectric spectroscopy. The vitrification of the antiferroelectric hexatic phase is observed for cooling rates ≥5 K min and the fragility index determined from dielectric data is ≈ 90. Two regimes of non-isothermal cold crystallization are distinguished using the Kissinger and Augis-Bennett methods in the heating rate ranges of 1-5 K min (larger activation energy) and 8-20 K min (lower activation energy). Read More

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September 2021

Kombucha ameliorates LPS-induced sepsis in a mouse model.

Food Funct 2021 Sep 22. Epub 2021 Sep 22.

Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, Fujian Normal University, Fuzhou, Fujian Province 350117, PR China.

As a popular traditional fermented beverage, kombucha has been extensively studied for its health benefits. However, the science behind the anti-inflammatory effect of kombucha has not been well studied, and there is an urgent need to uncover the secrets of the anti-inflammatory properties of kombucha. Here, we investigate kombucha's protective effects against lipopolysaccharide (LPS)-induced sepsis and on the intestinal microecology in mice. Read More

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September 2021

Afatinib treatment response in advanced lung adenocarcinomas harboring uncommon mutations.

Thorac Cancer 2021 Sep 21. Epub 2021 Sep 21.

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have improved the prognosis of mutant lung cancer; however, the clinical application value of TKIs for nonclassical EGFR mutation is unclear, especially for patients with rare uncommon mutations.

Methods: A retrospective study based on electronic medical records was conducted to collect data on the effectiveness of afatinib in patients with stage IIIB/IV lung adenocarcinoma (LUAD) bearing uncommon mutations between January 2017 and January 2021.

Results: Forty-two patients with uncommon mutations treated with afatinib were enrolled. Read More

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September 2021

In-Situ Templating Growth of Homeostatic GeP Nano-Bar Corals with Fast Electron-Ion Transportation Pathways for High Performance Li-ion Batteries.

Angew Chem Int Ed Engl 2021 Sep 21. Epub 2021 Sep 21.

Sichuan University, Polymer Research Institute, State Key Laboratory of Polymer Materials Engineering, No 24, South Section 1, Yihuan Road, 610065, Chengdu, CHINA.

As a nascent anode material for lithium-ion batteries (LIBs) , layered germanium phosphide (GeP) boasts excellent potential due to its high capacity , decent conductivity, and excellent theoretically calculated Li + diffusion coefficient. However, in reality, GeP usually suffers from relatively slow Li + diffusion and poor cycling stability associated with its stiff bulky structure as synthesized using conventional mixing-sintering method, in which the predicted quickest electron-ion transport pathways tend to be concealed. Herein, for the first time, we propose an in-situ template method to directionally induce the construction of GeP nanobar (GeP-nb) coral s with an adjustable aspect ratio . Read More

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September 2021

Understanding the potential of root microbiome influencing salt-tolerance in plants and mechanisms involved at the transcriptional and translational level.

Physiol Plant 2021 Sep 22. Epub 2021 Sep 22.

Department of Botany, Acharya Prafulla Chandra Roy Government College, Himachal Vihar, Matigara, Dist. Darjeeling, West Bengal, India.

Soil salinity severely affects plant growth and development and imparts inevitable losses to crop productivity. Increasing the concentration of salts in the vicinity of plant roots has severe consequences at the morphological, biochemical, and molecular levels. These include loss of chlorophyll, decrease in photosynthetic rate, reduction in cell division, ROS generation, inactivation of antioxidative enzymes, alterations in phytohormone biosynthesis and signalling, etc. Read More

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September 2021

Photosynthetic physiological response of water-saving and drought-resistant rice to severe drought under wetting-drying alternation irrigation.

Physiol Plant 2021 Sep 22. Epub 2021 Sep 22.

Agricultural College, Anhui Agricultural University, Hefei, Anhui, China.

Water-saving and drought-resistant rice (WDR) is widely grown in central China in recent years. However, studies have not explored the interaction effect of WDR and irrigation regimes on drought-resistance capacities under severe drought at sensitive growth periods. A pot experiment was conducted using a WDR cultivar Hanyou73 (HY73) and traditional high-yielding and drought-sensitive cultivar Huiliangyou 898 (HLY898). Read More

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September 2021

Container volume affects drought experiments in grapevines: insights on xylem anatomy and time of dehydration.

Physiol Plant 2021 Sep 22. Epub 2021 Sep 22.

Institute for Viticulture and Pomology, University of Natural Resources and Life Science Vienna, Tulln, Austria.

Plant stress experiments are commonly performed with plants grown in containers to better control environmental conditions. Nevertheless, the container can constrain plant growth and development, and this confounding effect is generally ignored, particularly in studies on woody species. Here, we evaluate the effect of the container volume in drought experiments using grapevine as a model plant. Read More

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September 2021

Effects of increasing dietary inclusion of camelina cake on growth performance of growing-finishing pigs.

Transl Anim Sci 2021 Jul 26;5(3):txab140. Epub 2021 Aug 26.

West Central Research and Outreach Center, University of Minnesota, Morris, MN, 56267, USA.

The objective of this experiment was to determine the dietary inclusion rate of camelina cake (CC) that would support the growth performance of growing-finishing pigs similar to that of a corn-soybean meal-based diet. Pigs ( = 192; BW = 35.2 kg; Duroc x (Yorkshire x Landrace)), balanced for sex and initial weight, were assigned to pens (8 pigs/pen) and pens were assigned randomly to one of four dietary treatments (6 pens/treatment). Read More

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Genomic and Phenotypic Characteristics for Infections.

Infect Drug Resist 2021 14;14:3721-3726. Epub 2021 Sep 14.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

Background: (VV) is a causative agent of foodborne diseases with high mortality. The aim of this study was to investigate the genomic and phenotypic profiles of VV.

Methods: Six VV isolates were collected and conducted whole-genome sequencing. Read More

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September 2021

International trade and Covid-19: City-level evidence from China's lockdown policy.

J Reg Sci 2021 Aug 22. Epub 2021 Aug 22.

School of International Trade and Economics University of International Business and Economics Beijing China.

This paper examines the impact of Covid-19 lockdowns on exports by Chinese cities. We use city-level export data at a monthly frequency from January 2018 through April 2020. Differences-in-differences estimates suggest cities in lockdown experienced a 34 percentage points reduction in the year-on-year growth rate of exports. Read More

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Employment impacts of the COVID-19 pandemic across metropolitan status and size.

Growth Change 2021 Aug 13. Epub 2021 Aug 13.

Department of Economics Program for the Study of Midwest Markets and Entrepreneurship (PSMME), Center for Agricultural and Rural Development (CARD), Iowa State University Ames IA USA.

We use individual-level data from the United States Current Population Survey to examine effects of the COVID-19 pandemic on employment losses across metropolitan area status and population size. Job losses spiked in April 2020, and partially recovered in subsequent months. Non-metropolitan and metropolitan areas of all sizes experienced significant employment losses, but the impacts were much larger in large metropolitan areas. Read More

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Clinical characteristics of advanced non-small cell lung cancer patients with EGFR exon 20 insertions.

Sci Rep 2021 Sep 21;11(1):18762. Epub 2021 Sep 21.

Department of Thoracic Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Epidermal growth factor receptor (EGFR) exon 20 insertion mutations (Exon20ins) account for 4-12% of all EGFR mutations in non-small cell lung cancer (NSCLC) patients. Data on the differences in clinical characteristics between patients with Exon20ins and major mutations (M-mut) such as exon 19 deletion and L858R are limited. We retrospectively reviewed advanced NSCLC patients with EGFR mutations, who were treated with systemic therapy between January 2011 and December 2019. Read More

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September 2021

Suppression of 4.1R enhances the potency of NKG2D-CAR T cells against pancreatic carcinoma via activating ERK signaling pathway.

Oncogenesis 2021 Sep 21;10(9):62. Epub 2021 Sep 21.

Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 200241, Shanghai, China.

Pancreatic carcinoma (PC) is one of the most common malignancies. Chimeric antigen receptor (CAR)-modified T cells has achieved remarkable efficacy in the treatment of hematological malignancies. However, lack of tumor-specific targets and the existence of inhibitory factors limit the function of CAR T cells when treating solid tumors. Read More

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September 2021

First-In-Human Phase I Study of a Next-Generation, Oral, Transforming Growth Factor-Beta Receptor 1 Inhibitor, LY3200882 in Patients with Advanced Cancer.

Clin Cancer Res 2021 Sep 21. Epub 2021 Sep 21.

Medicine - Digestive Molecular Clinical Oncology Research Unit, University of Verona.

Purpose: A novel, selective, next-generation transforming growth factor-beta receptor type 1 small molecule inhibitor, LY3200882, demonstrated promising preclinical data. This first-in-human trial evaluated safety, tolerability, recommended phase 2 dose (RP2D), pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of LY3200882 as monotherapy or with other anticancer agents in patients with advanced cancer.

Experimental Design: This phase I multicenter study of oral LY3200882 (NCT02937272) comprised dose escalation, monotherapy expansion in grade 4 glioma, and combination therapy in solid tumors (LY3200882 and PD-L1 inhibitor LY3300054), pancreatic cancer (PC; LY3200882, gemcitabine and nab-paclitaxel), and head and neck squamous cell cancer (LY3200882, cisplatin and radiation). Read More

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September 2021

Perceptions from pharmaceutical stakeholders on how the pharmaceutical budget is allocated in South Africa.

J Pharm Policy Pract 2021 Sep 21;14(1):78. Epub 2021 Sep 21.

Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa.

Background: South Africa faces a heavy burden of disease, which impacts resource allocation. The needs of South Africa require efficient translation into pharmaceutical expenditure for medicine provision, to ensure availability of medicines. Given that South Africa faces various challenges with medicine provision accompanied by rising pharmaceutical expenditure, this study aimed to report on the considerations and methods used to determine the healthcare budget for South Africa, and how it is translated into pharmaceutical expenditure for medicines provision on the Standard Treatment Guidelines and Essential Medicines List and non-essential medicines in the public sector. Read More

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September 2021

Low-temperature grown vertically aligned carbon nanotube array for an optimal infrared bolometer.

Nanotechnology 2021 Sep 21. Epub 2021 Sep 21.

Santa Clara University, 500 El Camino Real, Santa Clara, California, 95053-4345, UNITED STATES.

Vertically aligned carbon nanotube (VACNT) arrays have been explored as an absorber of thermal-type photodetectors. A long and dense VACNT array absorbs a wide spectral range of incident light with high absorption rate, but has a high thermal mass that results in a low response speed. To achieve a small thermal mass, a shorter and less dense VACNT array is needed. Read More

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September 2021

Welfare and performance of slower growing broiler breeders during rearing.

Poult Sci 2021 Aug 19;100(11):101434. Epub 2021 Aug 19.

Department of Animal Biosciences, University of Guelph, Guelph, Ontario, N1G 2W1 Canada. Electronic address:

Current commercial strains of broiler breeders can only achieve an optimal reproductive performance under feed restriction. However, chronic feed restriction in broiler breeders is a welfare concern because of physiological and behavioral signs of hunger, lack of satiety, and frustrated feeding motivation. The objective of this research was to assess the welfare and performance of slower growing broiler breeders during rearing. Read More

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