103,939 results match your criteria growth inhibitory

Progesterone Modulates Mitochondrial Functions in Human Glioblastoma Cells.

Mol Neurobiol 2021 Apr 13. Epub 2021 Apr 13.

Brain Research Laboratory, Department of Emergency Medicine, Emory University School of Medicine, Whitehead Biomedical Research Building, Room 655A, Atlanta, GA, 30322, USA.

A substantial literature supports the notion that cancer is a metabolic disease. Mitochondria are sexually dimorphic, and progesterone (P4) plays a key regulatory role in mitochondrial functions. We investigated the effect of P4 on mitochondrial functions in three human glioblastoma multiforme (GBM) cell lines. Read More

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In vitro interactions of Alternaria mycotoxins, an emerging class of food contaminants, with the gut microbiota: a bidirectional relationship.

Arch Toxicol 2021 Apr 13. Epub 2021 Apr 13.

Department of Food Chemistry and Toxicology, University of Vienna, Währinger Str. 38, 1090, Wien, Austria.

The human gut microbiota plays an important role in the maintenance of human health. Factors able to modify its composition might predispose the host to the development of pathologies. Among the various xenobiotics introduced through the diet, Alternaria mycotoxins are speculated to represent a threat for human health. Read More

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Effect of suberoylanilide hydroxamic acid on peripheral blood mononuclear cell cytotoxicity towards tumor cells in canines.

T Oyamada S Okano

Pol J Vet Sci 2021 Mar;24(1):35-41

Department of Small Animal Surgery 2, School of Veterinary Medicine, Kitasato University, Higashi 23-35-1, Towada, Aomori, 034-8628, Japan.

Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase inhibitor (HDACi) that suppresses the growth of tumor cells in humans and canines. SAHA reportedly enhances the antitumor activity of human peripheral blood mononuclear cell (PBMC). However, it is unclear whether a similar effect is exerted in canines. Read More

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Inhibitory effects of terrein on lung cancer cell metastasis and angiogenesis.

Oncol Rep 2021 Jun 13;45(6). Epub 2021 Apr 13.

Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.

Cancer metastasis is the leading cause of mortality in cancer patients. Over 70% of lung cancer patients are diagnosed at advanced or metastatic stages, and this results in an increased incidence of mortality. Terrein is a secondary bioactive fungal metabolite isolated from . Read More

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Progesterone suppresses the progression of colonic carcinoma by increasing the activity of the GADD45α/JNK/c‑Jun signalling pathway.

Oncol Rep 2021 Jun 13;45(6). Epub 2021 Apr 13.

College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan 610031, P.R. China.

Colorectal cancer (CRC) is the third most diagnosed cancer worldwide. Progesterone is associated with a decreased risk of CRC and leads to a favourable prognosis. However, the specific mechanism by which progesterone suppresses malignant progression remains to be elucidated. Read More

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PRIMA‑1 induces autophagy in colorectal cancer cells through upregulation of the mTOR/AMPK‑ULK1‑Vps34 signaling cascade.

Oncol Rep 2021 May 13;45(5). Epub 2021 Apr 13.

Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215001, P.R. China.

p53‑reactivation and induction of massive apoptosis‑1, APR‑017 methylated (PRIMA‑1; APR246) targets mutant p53 to restore its wild‑type structure and function. It was previously demonstrated that PRIMA‑1 effectively inhibited the growth of colorectal cancer (CRC) cells in a p53‑independent manner, and distinctly induced apoptosis by upregulating Noxa in p53‑mutant cell lines. The present study including experiments of western blotting, acridine orange staining and transmission electron microscopy revealed that PRIMA‑1 induced autophagy in CRC cells independently of p53 status. Read More

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MicroRNA‑29‑3p regulates the β‑catenin pathway by targeting IGF1 to inhibit the proliferation of prolactinoma cells.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Department of Pediatrics, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan 650500, P.R. China.

The present study aimed to analyze the effects and underlying mechanisms of microRNA (miR)‑29‑3p on the proliferation and secretory abilities of prolactinoma cells by targeting insulin‑like growth factor (IGF)‑1/β‑catenin. The relationship between miR‑29a‑3p and the survival of prolactinoma cells was analyzed with the Kaplan‑Meier method in reference to The Cancer Genome Atlas. The expression levels of miR‑29a‑3p and IGF‑1 in MMQ and GH3 cells were detected. Read More

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Propofol modulates the proliferation, invasion and migration of bladder cancer cells through the miR‑145‑5p/TOP2A axis.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Department of Anesthesiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China.

Propofol‑based anesthesia has been reported to reduce the recurrence and metastasis of a number of cancer types following surgical resection. However, the effects of propofol in bladder cancer (BC) are yet to be fully elucidated. The aim of the present study was to investigate the functions of propofol in BC and their underlying mechanisms. Read More

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Changes in the phosphorylation of nucleotide metabolism‑associated proteins by leukemia inhibitory factor in mouse embryonic stem cells.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Department of Microbiology, Jeonbuk National University Medical School, Jeonju, Jeollabuk 54896, Republic of Korea.

Leukemia inhibitory factor (LIF) is a stem cell growth factor that maintains self‑renewal of mouse embryonic stem cells (mESCs). LIF is a cytokine in the interleukin‑6 family and signals via the common receptor subunit gp130 and ligand‑specific LIF receptor. LIF causes heterodimerization of the LIF receptor and gp130, activating the Janus kinase/STAT and MAPK pathways, resulting in changes in protein phosphorylation. Read More

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An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy.

Commun Biol 2021 Apr 12;4(1):452. Epub 2021 Apr 12.

Cancer Biology Program, Stanford University School of Medicine, Stanford, CA, USA.

Leukemia inhibitory factor (LIF), a cytokine secreted by stromal myofibroblasts and tumor cells, has recently been highlighted to promote tumor progression in pancreatic and other cancers through KRAS-driven cell signaling. We engineered a high affinity soluble human LIF receptor (LIFR) decoy that sequesters human LIF and inhibits its signaling as a therapeutic strategy. This engineered 'ligand trap', fused to an antibody Fc-domain, has ~50-fold increased affinity (~20 pM) and improved LIF inhibition compared to wild-type LIFR-Fc, potently blocks LIF-mediated effects in pancreatic cancer cells, and slows the growth of pancreatic cancer xenograft tumors. Read More

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Tick defensin γ-core reduces Fusarium graminearum growth and abrogates mycotoxins production with high efficiency.

Sci Rep 2021 Apr 12;11(1):7962. Epub 2021 Apr 12.

INRAE, Mycology and Food Safety (MycSA), 33882, Villenave d'Ornon, France.

Fusarium graminearum is a major fungal pathogen affecting crops of worldwide importance. F. graminearum produces type B trichothecene mycotoxins (TCTB), which are not fully eliminated during food and feed processing. Read More

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Multisubstituted pyrimidines effectively inhibit bacterial growth and biofilm formation of Staphylococcus aureus.

Sci Rep 2021 Apr 12;11(1):7931. Epub 2021 Apr 12.

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, (Viikinkaari 5 E), FI-00014, Helsinki, Finland.

Biofilms are multicellular communities of microorganisms that generally attach to surfaces in a self-produced matrix. Unlike planktonic cells, biofilms can withstand conventional antibiotics, causing significant challenges in the healthcare system. Currently, new chemical entities are urgently needed to develop novel anti-biofilm agents. Read More

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A case of pericarditis caused by Mycoplasma hyorhinis in a weaned piglet.

Porcine Health Manag 2021 Apr 12;7(1):32. Epub 2021 Apr 12.

Peripheral Diagnostic Laboratory of Pordenone, Istituto Zooprofilattico Sperimentale delle Venezie, Cordenons, PN, Italy.

Background: Mycoplasma hyorhinis (M. hyorhinis) is a bacterium commonly found in the upper respiratory tract of healthy pigs and an agent of polyserositis and polyarthritis. Moreover, it can carry antibiotic resistance genes (Wu et al, Vet. Read More

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Antifungal activity and potential mechanism of Asiatic acid alone and in combination with fluconazole against Candida albicans.

Biomed Pharmacother 2021 Apr 10;139:111568. Epub 2021 Apr 10.

Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, Shandong Province 250014, People's Republic of China. Electronic address:

Candida albicans (C. albicans) infection remains a challenge to clinicians due to the limited available antifungals. With the widespread use of antifungals in the clinic, the drug resistance has been emerging continuously, especially fluconazole. Read More

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4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.

Eur J Med Chem 2021 Apr 4;219:113402. Epub 2021 Apr 4.

Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR, 72467, USA. Electronic address:

A collection of potent antimicrobials consisting of novel 1,3-bis-benzoic acid and trifluoromethyl phenyl derived pyrazoles has been synthesized and tested for antibacterial activity. The majority of trifluoromethyl phenyl derivatives are highly potent growth inhibitors of Gram-positive bacteria and showed low toxicity to human cultured cells. In particular, two compounds (59 and 74) were selected for additional studies. Read More

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Design of novel peptide-inhibitors against the conserved bacterial transcription terminator, Rho.

J Biol Chem 2021 Apr 9:100653. Epub 2021 Apr 9.

Laboratory of Transcription, Center for DNA Fingerprinting and Diagnostics, Inner Ring Road, Uppal, Hyderabad-39, India. Electronic address:

The transcription terminator Rho regulates many physiological processes in bacteria, such as antibiotic sensitivity, DNA repair, RNA-remodeling, etc, and hence, is a potential antimicrobial target, which is unexplored. The bacteriophage P4 capsid protein, Psu, moonlights as a natural Rho antagonist. Here, we report the design of novel peptides based on the C-terminal region of Psu using phenotypic screening methods. Read More

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Endophytic Fungus Diaporthe caatingaensisMT192326 from Buchanania axillaris: An indicator to produce biocontrol agents in plant protection.

Environ Res 2021 Apr 9:111147. Epub 2021 Apr 9.

Department of Biotechnology, Bannari Amman Institute of Technology, Sathyamangalam, Erode District, Tamil Nadu, India.

The study aims at the Isolation, screening and antibacterial evaluation of Camptothecin (CPT) and its derivatives, an anticancer molecule from endophytic fungus Diaporthe caatingaensis MT192326 of the medicinal plant, Buchanania axillaris. Plant parts were collected from Sathyamangalam Tiger Reserve forest, Tamil Nadu. The fungus was isolated using DEKM07 medium was used as the screening medium for the presence of CPT. Read More

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J Parasitol 2021 Mar;107(2):284-288

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13 Inada-cho, Obihiro, Hokkaido 080-8555, Japan.

Malaria remains one of the most important infectious diseases in the world. In 2017 alone, approximately 219 million people were infected with malaria, and 435,000 people died of this disease. Plasmodium falciparum, which causes falciparum malaria, is becoming resistant to artemisinin (ART) in Southeast Asia; therefore, new antimalarial drugs are urgently needed. Read More

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Multiple inhibitory effects of succinic acid on : morphology, metabolomics, and gene expression.

Environ Technol 2021 Apr 11:1-0. Epub 2021 Apr 11.

College of Landscape Architecture, Nanjing Forestry University, Nanjing 210037, Jiangsu, China.

The cell membrane permeability, morphology, metabolomics, and gene expression of under various concentrations of succinic acid (SA) were evaluated to clarify the mechanism of SA inhibition of . The results showed that SA caused intracellular protein and nucleic acid extravasation by increasing the cell membrane permeability. Scanning electron microscopy suggested that a high dose of SA (60 mg L) could damage the cell membrane and even cause lysis in some cells. Read More

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Spirombandakamine A and Cyclombandakamines A and A, Polycyclic Naphthylisoquinoline Dimers, with Antiprotozoal Activity, from a Congolese Plant.

J Nat Prod 2021 Apr 12. Epub 2021 Apr 12.

Institute of Organic Chemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany.

Spirombandakamine A () is only the third known naphthylisoquinoline dimer with a spiro-fused novel molecular framework and the first such representative to possess a relative -configuration at the two chiral centers in both tetrahydroisoquinoline subunits. It was found in the leaves of a botanically as yet unidentified Congolese plant, which is morphologically closely related to the Central African taxon . Likewise isolated were the new cyclombandakamines A () and A (), which belong to another most recently discovered type of unusual oxygen-bridged naphthylisoquinoline dimers and two previously described "open-chain" analogues, mbandakamines C () and D (). Read More

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Multifunctional Aspects of the Synthesized Pyrazoline Derivatives for AP1 5L X60 Steel Protection Against MIC and Acidization: Electrochemical, In Silico, and SRB Insights.

ACS Omega 2021 Apr 19;6(13):8894-8907. Epub 2021 Mar 19.

Egyptian Petroleum Research Institute, Nasr City, 11727 Cairo, Egypt.

The inhibitory impact of low-cost synthesized pyrazoline derivatives named series ( and ) on the corrosion of API 5L X60 carbon steel in 5 M HCl was inspected to serve as corrosion inhibitors against such a solution for its usage in the oilfield well acidization process. Also, the same compounds were unitized as biocides for sulfate-reducing bacteria (SRBs) to inhibit the microbial-induced corrosion effect. This study was conducted via several electrochemical techniques, namely, electrochemical potentiodynamic polarization (EP) and electrochemical impedance spectroscopy (EIS), in addition to computational density functional theory (DFT). Read More

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Inhibitory Smads suppress pancreatic stellate cell activation through negative feedback in chronic pancreatitis.

Ann Transl Med 2021 Mar;9(5):384

Institute of Pancreas, Southeast University, Nanjing, China.

Background: Activation of pancreatic stellate cells (PSCs) is a key cause of chronic pancreatitis (CP), while inhibition of transforming growth factor-β (TGF-β) signaling renders PSCs inactive. Inhibitory Smads (I-Smads) impede TGF-β intracellular signaling and may provide a way to alleviate CP. Thus, we aimed to investigate the molecular mechanism of I-Smads in CP animals and freshly-isolated PSCs. Read More

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Chondroitinase ABC Promotes Axon Regeneration and Reduces Retrograde Apoptosis Signaling in Lamprey.

Front Cell Dev Biol 2021 25;9:653638. Epub 2021 Mar 25.

Shriners Hospitals Pediatric Research Center (Center for Neural Repair and Rehabilitation), Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Paralysis following spinal cord injury (SCI) is due to failure of axonal regeneration. It is believed that axon growth is inhibited by the presence of several types of inhibitory molecules in central nervous system (CNS), including the chondroitin sulfate proteoglycans (CSPGs). Many studies have shown that digestion of CSPGs with chondroitinase ABC (ChABC) can enhance axon growth and functional recovery after SCI. Read More

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FLVCR1 Predicts Poor Prognosis and Promotes Malignant Phenotype in Esophageal Squamous Cell Carcinoma Upregulating CSE1L.

Front Oncol 2021 25;11:660955. Epub 2021 Mar 25.

Department of Gastroenterology, The Affiliated Taizhou Hospital, Wenzhou Medical University, Taizhou, China.

Objective: Dysregulation of feline leukemia virus subgroup C receptor 1(FLVCR1) expression has been investigated in several tumors. However, the expression and role of FLVCR1 in esophageal squamous cell carcinoma (ESCC) remain largely unknown.

Methods: FLVCR1 expression in tissues was measured by immunohistochemical staining (IHC). Read More

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